Functionalized single-walled carbon nanotubes cause reversible acute lung injury and induce fibrosis in mice

Journal of Molecular Medicine

Volumn 91, Issue 1, 2013, Pages 117-128

  Zhang, Yanli ^a   Deng, Jiejie ^a   Zhang, Yanxu ^a   Guo, Feng ^a   Li, Chenggang ^a   Zou, Zhen ^a   Xi, Wen ^a   Tang, Jun ^a   Sun, Yang ^a   Yang, Peng ^a   Han, Zongsheng ^a   Li, Dangsheng ^b   Jiang, Chengyu ^a  

^a TSINGHUA UNIVERSITY   (China)

^b Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

Acute lung injury; Dexamethasone; f SWCNTs; Fibrosis; NF B

Indexed keywords

CORTICOSTEROID; CYTOKINE; DEXAMETHASONE; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METHYLPREDNISOLONE; NANOMATERIAL; SINGLE WALLED NANOTUBE;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DNA DAMAGE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LUNG EDEMA; LUNG FIBROSIS; LUNG GRANULOMA; LUNG LAVAGE; LUNG TOXICITY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; RISK ASSESSMENT; SIGNAL TRANSDUCTION; TREATMENT DURATION;

ACUTE LUNG INJURY; ADRENAL CORTEX HORMONES; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DEXAMETHASONE; GENE EXPRESSION; GENES, REPORTER; INSTILLATION, DRUG; INTUBATION, INTRATRACHEAL; LUCIFERASES; LUNG; MICE; MICE, INBRED C57BL; NANOTUBES, CARBON; NF-KAPPA B; PARTICLE SIZE; PULMONARY EDEMA; PULMONARY FIBROSIS; SIGNAL TRANSDUCTION;

EID: 84872284919     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-012-0940-x     Document Type: Article

References (35)

1. Xia T, Li N, Nel AE (2009) Potential health impact of nanoparticles. Annu Rev Public Health 30:137-150
2. Song Y, Li X, Du X (2009) Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma. Eur Respir J 34:559-567
3. Pope CA 3rd, Ezzati M, Dockery DW (2009) Fine-particulate air pollution and life expectancy in the United States. N Engl J Med 360:376-386
4. Kostarelos K, Bianco A, Prato M (2009) Promises, facts and challenges for carbon nanotubes in imaging and therapeutics. Nat Nanotechnol 4:627-633
5. Bianco A, Kostarelos K, Prato M (2005) Applications of carbon nanotubes in drug delivery. Curr Opin Chem Biol 9:674-679
6. Chen J, Chen S, Zhao X, Kuznetsova LV, Wong SS, Ojima I (2008) Functionalized single-walled carbon nanotubes as rationally designed vehicles for tumor-targeted drug delivery. J Am Chem Soc 130:16778-16785
7. Witzmann FA, Monteiro-Riviere NA (2006) Multi-walled carbon nanotube exposure alters protein expression in human keratinocytes. Nanomedicine 2:158-168
8. Ryman-Rasmussen JP, Cesta MF, Brody AR, Shipley-Phillips JK, Everitt JI, Tewksbury EW, Moss OR, Wong BA, Dodd DE, Andersen ME et al (2009) Inhaled carbon nanotubes reach the subpleural tissue in mice. Nat Nanotechnol 4:747-751
9. Bai Y, Zhang Y, Zhang J, Mu Q, Zhang W, Butch ER, Snyder SE, Yan B (2010) Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility. Nat Nanotechnol 5:683-689
10. Liu Z, Chen K, Davis C, Sherlock S, Cao Q, Chen X, Dai H (2008) Drug delivery with carbon nanotubes for in vivo cancer treatment. Cancer Res 68:6652-6660
11. Ruggiero A, Villa CH, Bander E, Rey DA, Bergkvist M, Batt CA, Manova-Todorova K, Deen WM, Scheinberg DA, McDevitt MR (2010) Paradoxical glomerular filtration of carbon nanotubes. Proc Natl Acad Sci USA 107:12369-12374
12. Manna SK, Sarkar S, Barr J, Wise K, Barrera EV, Jejelowo O, Rice-Ficht AC, Ramesh GT (2005) Single-walled carbon nanotube induces oxidative stress and activates nuclear transcription factor-kappaB in human keratinocytes. Nano Lett 5:1676-1684
13. Chou CC, Hsiao HY, Hong QS, Chen CH, Peng YW, Chen HW, Yang PC (2008) Single-walled carbon nanotubes can induce pulmonary injury in mouse model. Nano Lett 8:437-445
14. Shvedova AA, Fabisiak JP, Kisin ER, Murray AR, Roberts JR, Tyurina YY, Antonini JM, Feng WH, Kommineni C, Reynolds J et al (2008) Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity. Am J Respir Cell Mol Biol 38:579-590
15. Lam CW, James JT, McCluskey R, Hunter RL (2004) Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci 77:126-134
16. Delogu LG, Venturelli E, Manetti R, Pinna GA, Carru C, Madeddu R, Murgia L, Sgarrella F, Dumortier H, Bianco A (2012) Ex vivo impact of functionalized carbon nanotubes on human immune cells. Nanomedicine (Lond) 7:231-243
17. Zhang Y, Xu Y, Li Z, Chen T, Lantz SM, Howard PC, Paule MG, Slikker W Jr, Watanabe F, Mustafa T et al (2011) Mechanistic toxicity evaluation of uncoated and PEGylated single-walled carbon nanotubes in neuronal PC12 cells. ACS Nano 5:7020-7033
18. Patlolla A, McGinnis B, Tchounwou P (2011) Biochemical and histopathological evaluation of functionalized single-walled carbon nanotubes in Swiss-Webster mice. J Appl Toxicol 31:75-83
19. Konduru NV, Tyurina YY, Feng W, Basova LV, Belikova NA, Bayir H, Clark K, Rubin M, Stolz D, Vallhov H et al (2009) Phosphatidylserine targets single-walled carbon nanotubes to professional phagocytes in vitro and in vivo. PLoS One 4:e4398
20. Tong H, McGee JK, Saxena RK, Kodavanti UP, Devlin RB, Gilmour MI (2009) Influence of acid functionalization on the cardiopulmonary toxicity of carbon nanotubes and carbon black particles in mice. Toxicol Appl Pharmacol 239:224-232
21. Liu HL, Zhang YL, Yang N, Zhang YX, Liu XQ, Li CG, Zhao Y, Wang YG, Zhang GG, Yang P et al (2011) A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt-TSC2-mTOR signaling. Cell Death Dis 2:e159
22. Maynard AD, Baron PA, Foley M, Shvedova AA, Kisin ER, Castranova V (2004) Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material. J Toxicol Environ Health A 67:87-107
23. Schanen BC, Karakoti AS, Seal S, Drake DR 3rd, Warren WL, Self WT (2009) Exposure to titanium dioxide nanomaterials provokes inflammation of an in vitro human immune construct. ACS Nano 3:2523-2532
24. Adcock IM, Caramori G, Ito K (2006) New insights into the molecular mechanisms of corticosteroids actions. Curr Drug Targets 7:649-660
25. Tang BM, Craig JC, Eslick GD, Seppelt I, McLean AS (2009) Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care Med 37:1594-1603
26. Tyburski JG, Dente C, Wilson RF, Steffes C, Devlin J, Carlin AM, Flynn LM, Shanti C (2001) Differences in arterial and mixed venous IL-6 levels: the lungs as a source of cytokine storm in sepsis. Surgery 130:748-751, discussion 751-742
27. Nel A, Xia T, Madler L, Li N (2006) Toxic potential of materials at the nanolevel. Science 311:622-627
28. Mutlu GM, Budinger GR, Green AA, Urich D, Soberanes S, Chiarella SE, Alheid GF, McCrimmon DR, Szleifer I, Hersam MC (2010) Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity. Nano Lett 10:1664-1670
29. Bhattacharjee S, de Haan LH, Evers NM, Jiang X, Marcelis AT, Zuilhof H, Rietjens IM, Alink GM (2010) Role of surface charge and oxidative stress in cytotoxicity of organic monolayer-coated silicon nanoparticles towards macrophage NR8383 cells. Part Fibre Toxicol 7:25
30. Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE (2006) Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett 6:1794-1807
31. Kim BY, Jiang W, Oreopoulos J, Yip CM, Rutka JT, Chan WC (2008) Biodegradable quantum dot nanocomposites enable live cell labeling and imaging of cytoplasmic targets. Nano Lett 8:3887-3892
32. Stoeger T, Reinhard C, Takenaka S, Schroeppel A, Karg E, Ritter B, Heyder J, Schulz H (2006) Instillation of six different ultrafine carbon particles indicates a surface area threshold dose for acute lung inflammation in mice. Environ Health Perspect 114:328-333
33. Sager TM, Castranova V (2009) Surface area of particle administered versus mass in determining the pulmonary toxicity of ultrafine and fine carbon black: comparison to ultrafine titanium dioxide. Part Fibre Toxicol 6:15
34. Dick CA, Brown DM, Donaldson K, Stone V (2003) The role of free radicals in the toxic and inflammatory effects of four different ultrafine particle types. Inhal Toxicol 15:39-52
35. Necela BM, Cidlowski JA (2004) Mechanisms of glucocorticoid receptor action in noninflammatory and inflammatory cells. Proc Am Thorac Soc 1:239-246