-
1
-
-
27944458409
-
Enzymatic transition states and transition state analogues
-
Schramm V.L. Enzymatic transition states and transition state analogues. Curr Opin Struct Biol 2005, 15:604-613.
-
(2005)
Curr Opin Struct Biol
, vol.15
, pp. 604-613
-
-
Schramm, V.L.1
-
2
-
-
35348956350
-
Enzymatic transition state theory and transition state analogue design
-
Schramm V.L. Enzymatic transition state theory and transition state analogue design. J Biol Chem 2007, 282:28297-28300.
-
(2007)
J Biol Chem
, vol.282
, pp. 28297-28300
-
-
Schramm, V.L.1
-
6
-
-
0011963663
-
Transition state analysis using multiple kinetic isotope effects: mechanisms of enzymatic and non-enzymatic glycoside hydrolysis and transfer
-
Berti P.J., Tanaka K.S.E. Transition state analysis using multiple kinetic isotope effects: mechanisms of enzymatic and non-enzymatic glycoside hydrolysis and transfer. Adv Phys Org Chem 2002, 37:239-314.
-
(2002)
Adv Phys Org Chem
, vol.37
, pp. 239-314
-
-
Berti, P.J.1
Tanaka, K.S.E.2
-
9
-
-
0016832598
-
Steady-state analysis of kinetic isotope effects in enzymic reactions
-
Northrop D.B. Steady-state analysis of kinetic isotope effects in enzymic reactions. Biochemistry 1975, 14:2644-2651.
-
(1975)
Biochemistry
, vol.14
, pp. 2644-2651
-
-
Northrop, D.B.1
-
10
-
-
33750444252
-
Interpretation of V/K isotope effects for enzymatic reactions exhibiting multiple isotopically sensitive steps
-
Ruszczycky M.W., Anderson V.E. Interpretation of V/K isotope effects for enzymatic reactions exhibiting multiple isotopically sensitive steps. J Theor Biol 2006, 243:328-342.
-
(2006)
J Theor Biol
, vol.243
, pp. 328-342
-
-
Ruszczycky, M.W.1
Anderson, V.E.2
-
12
-
-
0000939121
-
High-precision simultaneous determination of multiple small kinetic isotope effects at natural abundance
-
Singleton D.A., Thomas A.A. High-precision simultaneous determination of multiple small kinetic isotope effects at natural abundance. J Am Chem Soc 1995, 117:9357-9358.
-
(1995)
J Am Chem Soc
, vol.117
, pp. 9357-9358
-
-
Singleton, D.A.1
Thomas, A.A.2
-
13
-
-
1642302768
-
Probing the transition states of four glucoside hydrolyses with C-13 kinetic isotope effects measured at natural abundance by NMR spectroscopy
-
Lee J.K., Bain A.D., Berti P.J. Probing the transition states of four glucoside hydrolyses with C-13 kinetic isotope effects measured at natural abundance by NMR spectroscopy. J Am Chem Soc 2004, 126:3769-3776.
-
(2004)
J Am Chem Soc
, vol.126
, pp. 3769-3776
-
-
Lee, J.K.1
Bain, A.D.2
Berti, P.J.3
-
14
-
-
0016809645
-
Equilibrium perturbation by isotope substitution
-
Schimerlik M.I., Rife J.E., Cleland W.W. Equilibrium perturbation by isotope substitution. Biochemistry 1975, 14:5347-5354.
-
(1975)
Biochemistry
, vol.14
, pp. 5347-5354
-
-
Schimerlik, M.I.1
Rife, J.E.2
Cleland, W.W.3
-
15
-
-
77952543565
-
A direct NMR method for the measurement of competitive kinetic isotope effects
-
Chan J., Lewis A.R., Gilbert M., Karwaski M.F., Bennet A.J. A direct NMR method for the measurement of competitive kinetic isotope effects. Nat Chem Biol 2010, 6:405-407.
-
(2010)
Nat Chem Biol
, vol.6
, pp. 405-407
-
-
Chan, J.1
Lewis, A.R.2
Gilbert, M.3
Karwaski, M.F.4
Bennet, A.J.5
-
16
-
-
84857720450
-
Transition state analysis of Vibrio cholerae sialidase-catalyzed hydrolyses of natural substrate analogues
-
Chan J., Lewis A.R., Indurugalla D., Schur M., Wakarchuk W., Bennet A.J. Transition state analysis of Vibrio cholerae sialidase-catalyzed hydrolyses of natural substrate analogues. J Am Chem Soc 2012, 134:3748-3757.
-
(2012)
J Am Chem Soc
, vol.134
, pp. 3748-3757
-
-
Chan, J.1
Lewis, A.R.2
Indurugalla, D.3
Schur, M.4
Wakarchuk, W.5
Bennet, A.J.6
-
17
-
-
82555168470
-
Glycoside cleavage by a new mechanism in unsaturated glucuronyl hydrolases
-
Jongkees S.A., Withers S.G. Glycoside cleavage by a new mechanism in unsaturated glucuronyl hydrolases. J Am Chem Soc 2011, 133:19334-19337.
-
(2011)
J Am Chem Soc
, vol.133
, pp. 19334-19337
-
-
Jongkees, S.A.1
Withers, S.G.2
-
19
-
-
84855926382
-
Ni reaction of α-d-glucopyranosyl fluoride: mechanistic implications for retaining glycosyltransferases
-
Ni reaction of α-d-glucopyranosyl fluoride: mechanistic implications for retaining glycosyltransferases. J Am Chem Soc 2012, 134:1212-1220.
-
(2012)
J Am Chem Soc
, vol.134
, pp. 1212-1220
-
-
Chan, J.1
Tang, A.2
Bennet, A.J.3
-
20
-
-
0034631781
-
Glycosyl fluorides in enzymatic reactions
-
Williams S.J., Withers S.G. Glycosyl fluorides in enzymatic reactions. Carbohydr Res 2000, 327:27-46.
-
(2000)
Carbohydr Res
, vol.327
, pp. 27-46
-
-
Williams, S.J.1
Withers, S.G.2
-
21
-
-
0030017879
-
cat for formate dehydrogenase determined using a continuous-flow stirred-tank reactor
-
cat for formate dehydrogenase determined using a continuous-flow stirred-tank reactor. J Am Chem Soc 1996, 118:5804-5805.
-
(1996)
J Am Chem Soc
, vol.118
, pp. 5804-5805
-
-
Xue, H.1
Wu, X.W.2
Huskey, W.P.3
-
22
-
-
0032561825
-
Kinetic isotope effects for dialkylglycine decarboxylase via a high-precision continuous-flow method
-
Zhou X., Toney M.D. Kinetic isotope effects for dialkylglycine decarboxylase via a high-precision continuous-flow method. J Am Chem Soc 1998, 120:13282-13283.
-
(1998)
J Am Chem Soc
, vol.120
, pp. 13282-13283
-
-
Zhou, X.1
Toney, M.D.2
-
23
-
-
79952260308
-
Turnover is rate-limited by deglycosylation for Micromonospora viridifaciens sialidase-catalyzed hydrolyses: conformational implications for the Michaelis complex
-
Chan J., Lu A., Bennet A.J. Turnover is rate-limited by deglycosylation for Micromonospora viridifaciens sialidase-catalyzed hydrolyses: conformational implications for the Michaelis complex. J Am Chem Soc 2011, 133:1877-1884.
-
(2011)
J Am Chem Soc
, vol.133
, pp. 1877-1884
-
-
Chan, J.1
Lu, A.2
Bennet, A.J.3
-
24
-
-
0022035907
-
18O substitution in the leaving group, and aglycone acidity on hydrolyses of aryl glucosides and glucosyl pyridinium ions by yeast α-glucosidase
-
18O substitution in the leaving group, and aglycone acidity on hydrolyses of aryl glucosides and glucosyl pyridinium ions by yeast α-glucosidase. Biochem J 1985, 226:437-446.
-
(1985)
Biochem J
, vol.226
, pp. 437-446
-
-
Hosie, L.1
Sinnott, M.L.2
-
26
-
-
35348833510
-
Binding isotope effects: boon and bane
-
Schramm V.L. Binding isotope effects: boon and bane. Curr Opin Chem Biol 2007, 11:529-536.
-
(2007)
Curr Opin Chem Biol
, vol.11
, pp. 529-536
-
-
Schramm, V.L.1
-
28
-
-
0037462127
-
Binding equilibrium isotope effects for glucose at the catalytic domain of human brain hexokinase
-
Lewis B.E., Schramm V.L. Binding equilibrium isotope effects for glucose at the catalytic domain of human brain hexokinase. J Am Chem Soc 2003, 125:4785-4798.
-
(2003)
J Am Chem Soc
, vol.125
, pp. 4785-4798
-
-
Lewis, B.E.1
Schramm, V.L.2
-
29
-
-
0037462109
-
Glucose binding isotope effects in the ternary complex of brain hexokinase demonstrate partial relief of ground-state destabilization
-
Lewis B.E., Schramm V.L. Glucose binding isotope effects in the ternary complex of brain hexokinase demonstrate partial relief of ground-state destabilization. J Am Chem Soc 2003, 125:4672-4673.
-
(2003)
J Am Chem Soc
, vol.125
, pp. 4672-4673
-
-
Lewis, B.E.1
Schramm, V.L.2
-
30
-
-
77951935988
-
Mechanism, structure, and inhibition of O-GlcNAc processing enzymes
-
Gloster T.M., Vocadlo D.J. Mechanism, structure, and inhibition of O-GlcNAc processing enzymes. Curr Signal Transduct Ther 2010, 5:74-91.
-
(2010)
Curr Signal Transduct Ther
, vol.5
, pp. 74-91
-
-
Gloster, T.M.1
Vocadlo, D.J.2
-
31
-
-
49449087287
-
Glycosyltransferases: structures, functions, and mechanisms
-
Lairson L.L., Henrissat B., Davies G.J., Withers S.G. Glycosyltransferases: structures, functions, and mechanisms. Annu Rev Biochem 2008, 77:521-555.
-
(2008)
Annu Rev Biochem
, vol.77
, pp. 521-555
-
-
Lairson, L.L.1
Henrissat, B.2
Davies, G.J.3
Withers, S.G.4
-
32
-
-
53849121583
-
Mechanistic insights into glycosidase chemistry
-
Vocadlo D.J., Davies G.J. Mechanistic insights into glycosidase chemistry. Curr Opin Chem Biol 2008, 12:539-555.
-
(2008)
Curr Opin Chem Biol
, vol.12
, pp. 539-555
-
-
Vocadlo, D.J.1
Davies, G.J.2
-
33
-
-
0015621418
-
The mechanism of action of β-galactosidase. Effect of aglycone nature and α-deuterium substitution on the hydrolysis of aryl galactosides
-
Sinnott M.L., Souchard I.J. The mechanism of action of β-galactosidase. Effect of aglycone nature and α-deuterium substitution on the hydrolysis of aryl galactosides. Biochem J 1973, 133:89-98.
-
(1973)
Biochem J
, vol.133
, pp. 89-98
-
-
Sinnott, M.L.1
Souchard, I.J.2
-
34
-
-
0030722604
-
Glucosidase-catalyzed hydrolysis of α-d-glucopyranosyl pyridinium salts: kinetic evidence for nucleophilic involvement at the glucosidation transition state
-
Huang X.C., Tanaka K.S.E., Bennet A.J. Glucosidase-catalyzed hydrolysis of α-d-glucopyranosyl pyridinium salts: kinetic evidence for nucleophilic involvement at the glucosidation transition state. J Am Chem Soc 1997, 119:11147-11154.
-
(1997)
J Am Chem Soc
, vol.119
, pp. 11147-11154
-
-
Huang, X.C.1
Tanaka, K.S.E.2
Bennet, A.J.3
-
36
-
-
33845210617
-
Measurement of the α-secondary kinetic isotope effect for the reaction catalyzed by mammalian protein farnesyltransferase
-
Pais J.E., Bowers K.E., Fierke C.A. Measurement of the α-secondary kinetic isotope effect for the reaction catalyzed by mammalian protein farnesyltransferase. J Am Chem Soc 2006, 128:15086-15087.
-
(2006)
J Am Chem Soc
, vol.128
, pp. 15086-15087
-
-
Pais, J.E.1
Bowers, K.E.2
Fierke, C.A.3
-
37
-
-
84862908683
-
Insights into the mechanistic dichotomy of the protein farnesyltransferase peptide substrates CVIM and CVLS
-
Yang Y., Wang B., Ucisik M.N., Cui G., Fierke C.A., Merz K.M. Insights into the mechanistic dichotomy of the protein farnesyltransferase peptide substrates CVIM and CVLS. J Am Chem Soc 2012, 134:820-823.
-
(2012)
J Am Chem Soc
, vol.134
, pp. 820-823
-
-
Yang, Y.1
Wang, B.2
Ucisik, M.N.3
Cui, G.4
Fierke, C.A.5
Merz, K.M.6
-
38
-
-
84864667677
-
Transition state analysis of enolpyruvylshikimate 3-phosphate (EPSP) synthase (AroA)-catalyzed EPSP hydrolysis
-
Lou M., Burger S.K., Gilpin M.E., Gawuga V., Capretta A., Berti P.J. Transition state analysis of enolpyruvylshikimate 3-phosphate (EPSP) synthase (AroA)-catalyzed EPSP hydrolysis. J Am Chem Soc 2012, 134:12958-12969.
-
(2012)
J Am Chem Soc
, vol.134
, pp. 12958-12969
-
-
Lou, M.1
Burger, S.K.2
Gilpin, M.E.3
Gawuga, V.4
Capretta, A.5
Berti, P.J.6
-
39
-
-
77955815606
-
Kinetic isotope effects for RNA cleavage by 2'-O-transphosphorylation: Nucleophilic activation by specific base
-
Harris M.E., Dai Q., Gu H., Kellerman D.L., Piccirilli J.A., Anderson V.E. Kinetic isotope effects for RNA cleavage by 2'-O-transphosphorylation: Nucleophilic activation by specific base. J Am Chem Soc 2010, 132:11613-11621.
-
(2010)
J Am Chem Soc
, vol.132
, pp. 11613-11621
-
-
Harris, M.E.1
Dai, Q.2
Gu, H.3
Kellerman, D.L.4
Piccirilli, J.A.5
Anderson, V.E.6
-
40
-
-
84862916561
-
Characterization of the reaction path and transition states for RNA transphosphorylation models from theory and experiment
-
Wong K.Y., Gu H., Zhang S., Piccirilli J.A., Harris M.E., York D.M. Characterization of the reaction path and transition states for RNA transphosphorylation models from theory and experiment. Angew Chem Int Ed Engl 2012, 51:647-651.
-
(2012)
Angew Chem Int Ed Engl
, vol.51
, pp. 647-651
-
-
Wong, K.Y.1
Gu, H.2
Zhang, S.3
Piccirilli, J.A.4
Harris, M.E.5
York, D.M.6
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