Lon peptidase 1 (LONP1)-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells

Journal of Biological Chemistry

Volumn 286, Issue 30, 2011, Pages 26424-26430

  Tian, Qing ^a   Li, Ting ^a   Hou, Weihong ^a   Zheng, Jianyu ^a   Schrum, Laura W ^a,b   Bonkovsky, Herbert L ^a,b,c,d  

^a CAROLINAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5-AMINOLEVULINIC ACID; ATP-DEPENDENT PROTEASE; CHEMICAL COMPONENT; DATA SUPPORT; END-PRODUCTS; FEEDBACK REGULATORY MECHANISM; GENE TRANSCRIPTIONS; GENETIC DEFECTS; HEME BIOSYNTHESIS; HUMAN CELLS; HUMAN LIVER CELLS; METALLOPORPHYRINS; MITOCHONDRIAL MATRIX; MITOCHONDRIAL TRANSLOCATION; POTENT INHIBITOR; PROTEOLYTIC SYSTEM; PROTOPORPHYRINS; RATE-CONTROLLING; REGULATORY MECHANISM; SYNTHASES; UP-REGULATION;

BIOCHEMISTRY; BIOSYNTHESIS; FEEDBACK; GENES; MITOCHONDRIA; PROTEINS; TISSUE; TRANSCRIPTION;

PORPHYRINS;

5 AMINOLEVULINATE SYNTHASE; CATHEPSIN B; HEME; IRON; LON PEPTIDASE 1; METALLOPORPHYRIN; PEPTIDASE; PROTOPORPHYRIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL FRACTIONATION; CELL ISOLATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER; LIVER CELL; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; REGULATORY MECHANISM;

5-AMINOLEVULINATE SYNTHETASE; ACUTE DISEASE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEME; HUMANS; LIVER; MITOCHONDRIA, LIVER; MITOCHONDRIAL PROTEINS; PEPTIDE HYDROLASES; PORPHYRIAS; PROTEIN TRANSPORT; RNA STABILITY; TRANSCRIPTION, GENETIC;

EID: 79960659551     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.215772     Document Type: Article

References (27)

1. Bonkovsky, H. (1990) in Hepatology: A Textbook of Liver Disease (Zakim, D., and Boyer, T. D., eds), 2nd Ed., pp. 378-424, W.B. Saunders Co., Philadelphia
2. Meyer, U. A. (2007) Drug Metab. Rev. 39, 639-646
3. Fraser, D. J., Zumsteg, A., and Meyer, U. A. (2003) J. Biol. Chem. 278, 39392-39401
4. Podvinec, M., Handschin, C., Looser, R., and Meyer, U. A. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 9127-9132
5. Guengerich, F. P. (2003) Mol. Interv. 3, 194-204
6. Granick, S., Sinclair, P., Sassa, S., and Grieninger, G. (1975) J. Biol. Chem. 250, 9215-9225
7. Handschin, C., Lin, J., Rhee, J., Peyer, A. K., Chin, S., Wu, P. H., Meyer, U. A., and Spiegelman, B. M. (2005) Cell 122, 505-515
8. Correia, M. A., Sinclair, P. R., and De Matteis, F. (2011) Drug Metab. Rev. 43, 1-26
9. Elder, G. H. (1982) Semin. Liver Dis. 2, 87-99
10. Anderson, K. E., Bloomer, J. R., Bonkovsky, H. L., Kushner, J. P., Pierach, C. A., Pimstone, N. R., and Desnick, R. J. (2005) Ann. Intern. Med. 142, 439-450
11. Bonkowsky, H. L., Tschudy, D. P., Collins, A., Doherty, J., Bossenmaier, I., Cardinal, R., and Watson, C. J. (1971) Proc. Natl. Acad. Sci. U.S.A. 68, 2725-2729
12. Kolluri, S., Sadlon, T. J., May, B. K., and Bonkovsky, H. L. (2005) Biochem. J. 392, 173-180
13. Srivastava, G., Borthwick, I. A., Maguire, D. J., Elferink, C. J., Bawden, M. J., Mercer, J. F., and May, B. K. (1988) J. Biol. Chem. 263, 5202-5209
14. Cable, E. E., Miller, T. G., and Isom, H. C. (2000) Arch. Biochem. Biophys. 384, 280-295
15. Drew, P. D., and Ades, I. Z. (1989) Biochem. Biophys. Res. Commun. 162, 102-107
16. Hamilton, J. W., Bement, W. J., Sinclair, P. R., Sinclair, J. F., Alcedo, J. A., and Wetterhahn, K. E. (1991) Arch. Biochem. Biophys. 289, 387-392
17. Hayashi, N., Watanabe, N., and Kikuchi, G. (1983) Biochem. Biophys. Res. Commun. 115, 700-706
18. Lathrop, J. T., and Timko, M. P. (1993) Science 259, 522-525
19. Zheng, J., Shan, Y., Lambrecht, R. W., Donohue, S. E., and Bonkovsky, H. L. (2008) Mol. Cell Biochem. 319, 153-161
20. Yoshino, K., Munakata, H., Kuge, O., Ito, A., and Ogishima, T. (2007) J. Biochem. 142, 453-458
21. Hou, W. H., Rossi, L., Shan, Y., Zheng, J. Y., Lambrecht, R. W., and Bonkovsky, H. L. (2009) World J. Gastroenterol. 15, 4499-4510
22. Bayot, A., Basse, N., Lee, I., Gareil, M., Pirotte, B., Bulteau, A. L., Friguet, B., and Reboud-Ravaux, M. (2008) Biochimie 90, 260-269
23. Kim, I., Rodriguez-Enriquez, S., and Lemasters, J. J. (2007) Arch. Biochem. Biophys. 462, 245-253
24. Langer, T., and Neupert, W. (1996) Experientia 52, 1069-1076
25. Yan, L. J., Levine, R. L., and Sohal, R. S. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 11168-11172
26. Ogawa, K., Sun, J., Taketani, S., Nakajima, O., Nishitani, C., Sassa, S., Hayashi, N., Yamamoto, M., Shibahara, S., Fujita, H., and Igarashi, K. (2001) EMBO J. 20, 2835-2843
27. Pfeifer, K., Kim, K. S., Kogan, S., and Guarente, L. (1989) Cell 56, 291-301