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Volumn 16, Issue 6, 2012, Pages

Bench-to-bedside review: Citrate for continuous renal replacement therapy, from science to practice

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CITRIC ACID; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; ANTICOAGULANT AGENT;

EID: 84872266922     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc11645     Document Type: Review
Times cited : (121)

References (85)
  • 2
    • 84856253734 scopus 로고    scopus 로고
    • Clinical review: anticoagulation for continuous renal replacement therapy - heparin or citrate?
    • 3222015, 21345279
    • Oudemans-Van Straaten HM, Kellum JA, Bellomo R. Clinical review: anticoagulation for continuous renal replacement therapy - heparin or citrate?. Crit Care 2011, 15:202. 3222015, 21345279.
    • (2011) Crit Care , vol.15 , pp. 202
    • Oudemans-Van Straaten, H.M.1    Kellum, J.A.2    Bellomo, R.3
  • 3
    • 0035050839 scopus 로고    scopus 로고
    • Increased total to ionized calcium ratio during continuous venovenous hemodialysis with regional citrate anticoagulation
    • 10.1097/00003246-200104000-00010, 11373461
    • Meier-Kriesche HU, Gitomer J, Finkel K, DuBose T. Increased total to ionized calcium ratio during continuous venovenous hemodialysis with regional citrate anticoagulation. Crit Care Med 2001, 29:748-752. 10.1097/00003246-200104000-00010, 11373461.
    • (2001) Crit Care Med , vol.29 , pp. 748-752
    • Meier-Kriesche, H.U.1    Gitomer, J.2    Finkel, K.3    DuBose, T.4
  • 6
    • 0346728945 scopus 로고    scopus 로고
    • Regional citrate anticoagulation for continuous venovenous hemodiafiltration using calcium-containing dialysate
    • 10.1053/j.ajkd.2003.09.014, 14712429
    • Gupta M, Wadhwa NK, Bukovsky R. Regional citrate anticoagulation for continuous venovenous hemodiafiltration using calcium-containing dialysate. Am J Kidney Dis 2004, 43:67-73. 10.1053/j.ajkd.2003.09.014, 14712429.
    • (2004) Am J Kidney Dis , vol.43 , pp. 67-73
    • Gupta, M.1    Wadhwa, N.K.2    Bukovsky, R.3
  • 7
    • 84855161269 scopus 로고    scopus 로고
    • Quantification of systemic delivery of substrates for intermediate metabolism during citrate anticoagulation of continuous renal replacement therapy
    • 10.1159/000334641, 22212643
    • Balik M, Zakharchenko M, Otahal M, Hruby J, Polak F, Rusinova K, Stach Z, Vavrova J, Jabor A. Quantification of systemic delivery of substrates for intermediate metabolism during citrate anticoagulation of continuous renal replacement therapy. Blood Purif 2012, 33:80-87. 10.1159/000334641, 22212643.
    • (2012) Blood Purif , vol.33 , pp. 80-87
    • Balik, M.1    Zakharchenko, M.2    Otahal, M.3    Hruby, J.4    Polak, F.5    Rusinova, K.6    Stach, Z.7    Vavrova, J.8    Jabor, A.9
  • 8
    • 0036947439 scopus 로고    scopus 로고
    • Citrate clearance in children receiving continuous venovenous renal replacement therapy
    • 10.1007/s00467-002-0963-6, 12376810
    • Chadha V, Garg U, Warady BA, Alon US. Citrate clearance in children receiving continuous venovenous renal replacement therapy. Pediatr Nephrol 2002, 17:819-824. 10.1007/s00467-002-0963-6, 12376810.
    • (2002) Pediatr Nephrol , vol.17 , pp. 819-824
    • Chadha, V.1    Garg, U.2    Warady, B.A.3    Alon, U.S.4
  • 10
    • 38149140050 scopus 로고    scopus 로고
    • Regional citrate versus heparin anticoagulation during venovenous hemofiltration in patients at low risk for bleeding: similar hemofilter survival but significantly less bleeding
    • Betjes MG, van Oosterom D, van Agteren M, van de Wetering J. Regional citrate versus heparin anticoagulation during venovenous hemofiltration in patients at low risk for bleeding: similar hemofilter survival but significantly less bleeding. J Nephrol 2007, 20:602-608.
    • (2007) J Nephrol , vol.20 , pp. 602-608
    • Betjes, M.G.1    van Oosterom, D.2    van Agteren, M.3    van de Wetering, J.4
  • 11
    • 0034824516 scopus 로고    scopus 로고
    • Citrate anticoagulation for extracorporeal circuits: effects on whole blood coagulation activation and clot formation
    • 10.1159/000046075, 11549910
    • Calatzis A, Toepfer M, Schramm W, Spannagl M, Schiffl H. Citrate anticoagulation for extracorporeal circuits: effects on whole blood coagulation activation and clot formation. Nephron 2001, 89:233-236. 10.1159/000046075, 11549910.
    • (2001) Nephron , vol.89 , pp. 233-236
    • Calatzis, A.1    Toepfer, M.2    Schramm, W.3    Spannagl, M.4    Schiffl, H.5
  • 12
    • 5644275193 scopus 로고    scopus 로고
    • Dose-response relationship between plasma ionized calcium concentration and thrombelastography
    • 10.1053/j.jvca.2004.07.016, 15578468
    • James MF, Roche AM. Dose-response relationship between plasma ionized calcium concentration and thrombelastography. J Cardiothorac Vasc Anesth 2004, 18:581-586. 10.1053/j.jvca.2004.07.016, 15578468.
    • (2004) J Cardiothorac Vasc Anesth , vol.18 , pp. 581-586
    • James, M.F.1    Roche, A.M.2
  • 13
    • 32844461837 scopus 로고    scopus 로고
    • Anticoagulation strategies in continuous renal replacement therapy: can the choice be evidence based?
    • 10.1007/s00134-005-0044-y, 16453140
    • Oudemans-Van Straaten HM, Wester JP, de Pont AC, Schetz MR. Anticoagulation strategies in continuous renal replacement therapy: can the choice be evidence based?. Intensive Care Med 2006, 32:188-202. 10.1007/s00134-005-0044-y, 16453140.
    • (2006) Intensive Care Med , vol.32 , pp. 188-202
    • Oudemans-Van Straaten, H.M.1    Wester, J.P.2    de Pont, A.C.3    Schetz, M.R.4
  • 14
    • 36249020143 scopus 로고    scopus 로고
    • Clinical review: Patency of the circuit in continuous renal replacement therapy
    • 10.1186/cc5937, 2206533, 17634148
    • Joannidis M, Oudemans-Van Straaten HM. Clinical review: Patency of the circuit in continuous renal replacement therapy. Crit Care 2007, 11:218. 10.1186/cc5937, 2206533, 17634148.
    • (2007) Crit Care , vol.11 , pp. 218
    • Joannidis, M.1    Oudemans-Van Straaten, H.M.2
  • 15
    • 82255194352 scopus 로고    scopus 로고
    • Blood and ultrafiltrate dosage of citrate as a useful and routine tool during continuous venovenous haemodiafiltration in septic shock patients
    • 10.1093/ndt/gfr106, 21385861
    • Mariano F, Morselli M, Bergamo D, Hollo Z, Scella S, Maio M, Tetta C, Dellavalle A, Stella M, Triolo G. Blood and ultrafiltrate dosage of citrate as a useful and routine tool during continuous venovenous haemodiafiltration in septic shock patients. Nephrol Dial Transplant 2011, 26:3882-3888. 10.1093/ndt/gfr106, 21385861.
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 3882-3888
    • Mariano, F.1    Morselli, M.2    Bergamo, D.3    Hollo, Z.4    Scella, S.5    Maio, M.6    Tetta, C.7    Dellavalle, A.8    Stella, M.9    Triolo, G.10
  • 16
    • 0025089550 scopus 로고
    • Regional citrate anticoagulation for continuous arteriovenous hemodialysis in critically ill patients
    • 10.1038/ki.1990.300, 2266683
    • Mehta RL, McDonald BR, Aguilar MM, Ward DM. Regional citrate anticoagulation for continuous arteriovenous hemodialysis in critically ill patients. Kidney Int 1990, 38:976-981. 10.1038/ki.1990.300, 2266683.
    • (1990) Kidney Int , vol.38 , pp. 976-981
    • Mehta, R.L.1    McDonald, B.R.2    Aguilar, M.M.3    Ward, D.M.4
  • 17
    • 23044466767 scopus 로고    scopus 로고
    • Regional citrate versus systemic heparin anticoagulation for continuous renal replacement in critically ill patients
    • 10.1111/j.1523-1755.2005.00342.x, 15882280
    • Kutsogiannis DJ, Gibney RT, Stollery D, Gao J. Regional citrate versus systemic heparin anticoagulation for continuous renal replacement in critically ill patients. Kidney Int 2005, 67:2361-2367. 10.1111/j.1523-1755.2005.00342.x, 15882280.
    • (2005) Kidney Int , vol.67 , pp. 2361-2367
    • Kutsogiannis, D.J.1    Gibney, R.T.2    Stollery, D.3    Gao, J.4
  • 18
    • 33646783908 scopus 로고    scopus 로고
    • A practical citrate anticoagulation continuous venovenous hemodiafiltration protocol for metabolic control and high solute clearance
    • Tolwani AJ, Prendergast MB, Speer RR, Stofan BS, Wille KM. A practical citrate anticoagulation continuous venovenous hemodiafiltration protocol for metabolic control and high solute clearance. Clin J Am Soc Nephrol 2006, 1:79-87.
    • (2006) Clin J Am Soc Nephrol , vol.1 , pp. 79-87
    • Tolwani, A.J.1    Prendergast, M.B.2    Speer, R.R.3    Stofan, B.S.4    Wille, K.M.5
  • 19
    • 4644362505 scopus 로고    scopus 로고
    • A simple, safe and effective citrate anticoagulation protocol for the genius dialysis system in acute renal failure
    • 10.1159/000079925, 15361702
    • Morgera S, Scholle C, Melzer C, Slowinski T, Liefeld L, Baumann G, Peters H, Neumayer HH. A simple, safe and effective citrate anticoagulation protocol for the genius dialysis system in acute renal failure. Nephron Clin Pract 2004, 98:c35-c40. 10.1159/000079925, 15361702.
    • (2004) Nephron Clin Pract , vol.98
    • Morgera, S.1    Scholle, C.2    Melzer, C.3    Slowinski, T.4    Liefeld, L.5    Baumann, G.6    Peters, H.7    Neumayer, H.H.8
  • 20
    • 1342268344 scopus 로고    scopus 로고
    • Citrate vs. heparin for anticoagulation in continuous venovenous hemofiltration: a prospective randomized study
    • 10.1007/s00134-003-2047-x, 14600809
    • Monchi M, Berghmans D, Ledoux D, Canivet JL, Dubois B, Damas P. Citrate vs. heparin for anticoagulation in continuous venovenous hemofiltration: a prospective randomized study. Intensive Care Med 2004, 30:260-265. 10.1007/s00134-003-2047-x, 14600809.
    • (2004) Intensive Care Med , vol.30 , pp. 260-265
    • Monchi, M.1    Berghmans, D.2    Ledoux, D.3    Canivet, J.L.4    Dubois, B.5    Damas, P.6
  • 21
    • 0038311022 scopus 로고    scopus 로고
    • A novel regional citrate anticoagulation protocol for CRRT using only commercially available solutions
    • 10.1053/jcrc.2003.50006, 12800123
    • Tobe SW, Aujla P, Walele AA, Oliver MJ, Naimark DM, Perkins NJ, Beardsall M. A novel regional citrate anticoagulation protocol for CRRT using only commercially available solutions. J Crit Care 2003, 18:121-129. 10.1053/jcrc.2003.50006, 12800123.
    • (2003) J Crit Care , vol.18 , pp. 121-129
    • Tobe, S.W.1    Aujla, P.2    Walele, A.A.3    Oliver, M.J.4    Naimark, D.M.5    Perkins, N.J.6    Beardsall, M.7
  • 22
    • 1242273866 scopus 로고    scopus 로고
    • Improving the delivery of continuous renal replacement therapy using regional citrate anticoagulation
    • Swartz R, Pasko D, O'Toole J, Starmann B. Improving the delivery of continuous renal replacement therapy using regional citrate anticoagulation. Clin Nephrol 2004, 61:134-143.
    • (2004) Clin Nephrol , vol.61 , pp. 134-143
    • Swartz, R.1    Pasko, D.2    O'Toole, J.3    Starmann, B.4
  • 23
    • 84855916678 scopus 로고    scopus 로고
    • Regional citrate anticoagulation in predilution continuous venovenous hemofiltration using prismocitrate 10/2 solution
    • 10.1111/j.1744-9987.2011.01001.x, 22248200
    • Shum HP, Chan KC, Yan WW. Regional citrate anticoagulation in predilution continuous venovenous hemofiltration using prismocitrate 10/2 solution. Ther Apher Dial 2012, 16:81-86. 10.1111/j.1744-9987.2011.01001.x, 22248200.
    • (2012) Ther Apher Dial , vol.16 , pp. 81-86
    • Shum, H.P.1    Chan, K.C.2    Yan, W.W.3
  • 24
    • 0032944876 scopus 로고    scopus 로고
    • Regional citrate anticoagulation in continuous venovenous hemofiltration in critically ill patients with a high risk of bleeding
    • 10.1046/j.1523-1755.1999.00444.x, 10231464
    • Palsson R, Niles JL. Regional citrate anticoagulation in continuous venovenous hemofiltration in critically ill patients with a high risk of bleeding. Kidney Int 1999, 55:1991-1997. 10.1046/j.1523-1755.1999.00444.x, 10231464.
    • (1999) Kidney Int , vol.55 , pp. 1991-1997
    • Palsson, R.1    Niles, J.L.2
  • 25
    • 0042667173 scopus 로고    scopus 로고
    • A novel citrate anticoagulation regimen for continuous venovenous hemodiafiltration
    • 10.1007/s00134-003-1801-4, 12761615
    • Dorval M, Madore F, Courteau S, Leblanc M. A novel citrate anticoagulation regimen for continuous venovenous hemodiafiltration. Intensive Care Med 2003, 29:1186-1189. 10.1007/s00134-003-1801-4, 12761615.
    • (2003) Intensive Care Med , vol.29 , pp. 1186-1189
    • Dorval, M.1    Madore, F.2    Courteau, S.3    Leblanc, M.4
  • 26
    • 0036390012 scopus 로고    scopus 로고
    • Citrate anticoagulation in continuous venovenous hemodiafiltration: a metabolic challenge
    • 10.1007/s00134-002-1443-y, 12373466
    • Gabutti L, Marone C, Colucci G, Duchini F, Schonholzer C. Citrate anticoagulation in continuous venovenous hemodiafiltration: a metabolic challenge. Intensive Care Med 2002, 28:1419-1425. 10.1007/s00134-002-1443-y, 12373466.
    • (2002) Intensive Care Med , vol.28 , pp. 1419-1425
    • Gabutti, L.1    Marone, C.2    Colucci, G.3    Duchini, F.4    Schonholzer, C.5
  • 27
    • 0037083899 scopus 로고    scopus 로고
    • Regional citrate anticoagulation using a citrate-based substitution solution for continuous venovenous hemofiltration in cardiac surgery patients
    • Thoenen M, Schmid ER, Binswanger U, Schuepbach R, Aerne D, Schmidlin D. Regional citrate anticoagulation using a citrate-based substitution solution for continuous venovenous hemofiltration in cardiac surgery patients. Wien Klin Wochenschr 2002, 114:108-114.
    • (2002) Wien Klin Wochenschr , vol.114 , pp. 108-114
    • Thoenen, M.1    Schmid, E.R.2    Binswanger, U.3    Schuepbach, R.4    Aerne, D.5    Schmidlin, D.6
  • 28
    • 42949089359 scopus 로고    scopus 로고
    • The acid-base effect of changing citrate solution for regional anticoagulation during continuous veno-venous hemofiltration
    • Egi M, Naka T, Bellomo R, Langenberg CC, Li W, Fealy N, Baldwin I. The acid-base effect of changing citrate solution for regional anticoagulation during continuous veno-venous hemofiltration. Int J Artif Organs 2008, 31:228-236.
    • (2008) Int J Artif Organs , vol.31 , pp. 228-236
    • Egi, M.1    Naka, T.2    Bellomo, R.3    Langenberg, C.C.4    Li, W.5    Fealy, N.6    Baldwin, I.7
  • 29
    • 77049085032 scopus 로고    scopus 로고
    • Metabolic effects of citrate- vs bicarbonate-based substitution fluid in continuous venovenous hemofiltration: a prospective sequential cohort study
    • 10.1016/j.jcrc.2009.02.013, 19427760
    • Aman J, Nurmohamed SA, Vervloet MG, Groeneveld AB. Metabolic effects of citrate- vs bicarbonate-based substitution fluid in continuous venovenous hemofiltration: a prospective sequential cohort study. J Crit Care 2010, 25:120-127. 10.1016/j.jcrc.2009.02.013, 19427760.
    • (2010) J Crit Care , vol.25 , pp. 120-127
    • Aman, J.1    Nurmohamed, S.A.2    Vervloet, M.G.3    Groeneveld, A.B.4
  • 30
    • 77951206570 scopus 로고    scopus 로고
    • The Stewart approach - one clinician's perspective
    • 2702213, 19565024
    • Morgan TJ. The Stewart approach - one clinician's perspective. Clin Biochem Rev 2009, 30:41-54. 2702213, 19565024.
    • (2009) Clin Biochem Rev , vol.30 , pp. 41-54
    • Morgan, T.J.1
  • 31
    • 30744475940 scopus 로고    scopus 로고
    • Choice of replacement solution and anticoagulant in continuous venovenous hemofiltration
    • Palsson R, Laliberte KA, Niles JL. Choice of replacement solution and anticoagulant in continuous venovenous hemofiltration. Clin Nephrol 2006, 65:34-42.
    • (2006) Clin Nephrol , vol.65 , pp. 34-42
    • Palsson, R.1    Laliberte, K.A.2    Niles, J.L.3
  • 32
    • 84859337936 scopus 로고    scopus 로고
    • Efficacy and safety of regional citrate anticoagulation in critically ill patients undergoing continuous renal replacement therapy
    • 10.1007/s00134-011-2438-3, 22124775
    • Zhang Z, Hongying N. Efficacy and safety of regional citrate anticoagulation in critically ill patients undergoing continuous renal replacement therapy. Intensive Care Med 2012, 38:20-28. 10.1007/s00134-011-2438-3, 22124775.
    • (2012) Intensive Care Med , vol.38 , pp. 20-28
    • Zhang, Z.1    Hongying, N.2
  • 33
    • 34250615521 scopus 로고    scopus 로고
    • A pilot randomized controlled crossover study comparing regional heparinization to regional citrate anticoagulation for continuous venovenous hemofiltration
    • Fealy N, Baldwin I, Johnstone M, Egi M, Bellomo R. A pilot randomized controlled crossover study comparing regional heparinization to regional citrate anticoagulation for continuous venovenous hemofiltration. Int J Artif Organs 2007, 30:301-307.
    • (2007) Int J Artif Organs , vol.30 , pp. 301-307
    • Fealy, N.1    Baldwin, I.2    Johnstone, M.3    Egi, M.4    Bellomo, R.5
  • 34
    • 84858793574 scopus 로고    scopus 로고
    • Regional citrate versus heparin anticoagulation for continuous renal replacement therapy: a meta-analysis of randomized controlled trials
    • 10.1053/j.ajkd.2011.11.030, 22226564
    • Wu MY, Hsu YH, Bai CH, Lin YF, Wu CH, Tam KW. Regional citrate versus heparin anticoagulation for continuous renal replacement therapy: a meta-analysis of randomized controlled trials. Am J Kidney Dis 2012, 59:810-818. 10.1053/j.ajkd.2011.11.030, 22226564.
    • (2012) Am J Kidney Dis , vol.59 , pp. 810-818
    • Wu, M.Y.1    Hsu, Y.H.2    Bai, C.H.3    Lin, Y.F.4    Wu, C.H.5    Tam, K.W.6
  • 36
    • 0034795798 scopus 로고    scopus 로고
    • Evidence of separate pathways for lactate uptake and release by the perfused rat heart
    • Chatham JC, Des RC, Forder JR. Evidence of separate pathways for lactate uptake and release by the perfused rat heart. Am J Physiol Endocrinol Metab 2001, 281:E794-E802.
    • (2001) Am J Physiol Endocrinol Metab , vol.281
    • Chatham, J.C.1    Des, R.C.2    Forder, J.R.3
  • 37
    • 0024996609 scopus 로고
    • Myocardial metabolism during hypoxia: maintained lactate oxidation during increased glycolysis
    • 10.1016/0026-0495(90)90300-2, 2202882
    • Mazer CD, Stanley WC, Hickey RF, Neese RA, Cason BA, Demas KA, Wisneski JA, Gertz EW. Myocardial metabolism during hypoxia: maintained lactate oxidation during increased glycolysis. Metabolism 1990, 39:913-918. 10.1016/0026-0495(90)90300-2, 2202882.
    • (1990) Metabolism , vol.39 , pp. 913-918
    • Mazer, C.D.1    Stanley, W.C.2    Hickey, R.F.3    Neese, R.A.4    Cason, B.A.5    Demas, K.A.6    Wisneski, J.A.7    Gertz, E.W.8
  • 38
    • 0034241950 scopus 로고    scopus 로고
    • Lactate improves cardiac efficiency after hemorrhagic shock
    • 10.1097/00024382-200014020-00023, 10947169
    • Kline JA, Thornton LR, Lopaschuk GD, Barbee RW, Watts JA. Lactate improves cardiac efficiency after hemorrhagic shock. Shock 2000, 14:215-221. 10.1097/00024382-200014020-00023, 10947169.
    • (2000) Shock , vol.14 , pp. 215-221
    • Kline, J.A.1    Thornton, L.R.2    Lopaschuk, G.D.3    Barbee, R.W.4    Watts, J.A.5
  • 39
    • 33847400579 scopus 로고    scopus 로고
    • Myocardial lactate deprivation is associated with decreased cardiovascular performance, decreased myocardial energetics, and early death in endotoxic shock
    • 10.1007/s00134-006-0523-9, 17242933
    • Levy B, Mansart A, Montemont C, Gibot S, Mallie JP, Regnault V, Lecompte T, Lacolley P. Myocardial lactate deprivation is associated with decreased cardiovascular performance, decreased myocardial energetics, and early death in endotoxic shock. Intensive Care Med 2007, 33:495-502. 10.1007/s00134-006-0523-9, 17242933.
    • (2007) Intensive Care Med , vol.33 , pp. 495-502
    • Levy, B.1    Mansart, A.2    Montemont, C.3    Gibot, S.4    Mallie, J.P.5    Regnault, V.6    Lecompte, T.7    Lacolley, P.8
  • 40
    • 52949145984 scopus 로고    scopus 로고
    • Half-molar sodium-lactate solution has a beneficial effect in patients after coronary artery bypass grafting
    • 10.1007/s00134-008-1165-x, 18563389
    • Leverve XM, Boon C, Hakim T, Anwar M, Siregar E, Mustafa I. Half-molar sodium-lactate solution has a beneficial effect in patients after coronary artery bypass grafting. Intensive Care Med 2008, 34:1796-1803. 10.1007/s00134-008-1165-x, 18563389.
    • (2008) Intensive Care Med , vol.34 , pp. 1796-1803
    • Leverve, X.M.1    Boon, C.2    Hakim, T.3    Anwar, M.4    Siregar, E.5    Mustafa, I.6
  • 41
    • 0037163021 scopus 로고    scopus 로고
    • The key role of anaplerosis and cataplerosis for citric acid cycle function
    • 10.1074/jbc.R200006200, 12087111
    • Owen OE, Kalhan SC, Hanson RW. The key role of anaplerosis and cataplerosis for citric acid cycle function. J Biol Chem 2002, 277:30409-30412. 10.1074/jbc.R200006200, 12087111.
    • (2002) J Biol Chem , vol.277 , pp. 30409-30412
    • Owen, O.E.1    Kalhan, S.C.2    Hanson, R.W.3
  • 42
    • 0034646270 scopus 로고    scopus 로고
    • Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates
    • 10.1073/pnas.97.6.2826, 16014, 10717001
    • Weinberg JM, Venkatachalam MA, Roeser NF, Nissim I. Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates. Proc Natl Acad Sci USA 2000, 97:2826-2831. 10.1073/pnas.97.6.2826, 16014, 10717001.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2826-2831
    • Weinberg, J.M.1    Venkatachalam, M.A.2    Roeser, N.F.3    Nissim, I.4
  • 43
    • 0032847523 scopus 로고    scopus 로고
    • Sepsis alters pyruvate dehydrogenase kinase activity in skeletal muscle
    • 10.1023/A:1006993910781, 10497885
    • Vary TC, Hazen S. Sepsis alters pyruvate dehydrogenase kinase activity in skeletal muscle. Mol Cell Biochem 1999, 198:113-118. 10.1023/A:1006993910781, 10497885.
    • (1999) Mol Cell Biochem , vol.198 , pp. 113-118
    • Vary, T.C.1    Hazen, S.2
  • 44
    • 0036339988 scopus 로고    scopus 로고
    • Lactate: A key metabolite in the intercellular metabolic interplay
    • 10.1186/cc1509, 137304, 12225597
    • Leverve XM, Mustafa I. Lactate: A key metabolite in the intercellular metabolic interplay. Crit Care 2002, 6:284-285. 10.1186/cc1509, 137304, 12225597.
    • (2002) Crit Care , vol.6 , pp. 284-285
    • Leverve, X.M.1    Mustafa, I.2
  • 46
    • 0022993226 scopus 로고
    • Characterization of fMet-Leu-Phe receptor-mediated Ca2+ influx across the plasma membrane of human neutrophils
    • Andersson T, Dahlgren C, Pozzan T, Stendahl O, Lew PD. Characterization of fMet-Leu-Phe receptor-mediated Ca2+ influx across the plasma membrane of human neutrophils. Mol Pharmacol 1986, 30:437-443.
    • (1986) Mol Pharmacol , vol.30 , pp. 437-443
    • Andersson, T.1    Dahlgren, C.2    Pozzan, T.3    Stendahl, O.4    Lew, P.D.5
  • 47
    • 0033848580 scopus 로고    scopus 로고
    • Effect of regional citrate anticoagulation on leukopenia, complement activation, and expression of leukocyte surface molecules during hemodialysis with unmodified cellulose membranes
    • 10.1159/000045683, 10940744
    • Dhondt A, Vanholder R, Tielemans C, Glorieux G, Waterloos MA, De SR, Lameire N. Effect of regional citrate anticoagulation on leukopenia, complement activation, and expression of leukocyte surface molecules during hemodialysis with unmodified cellulose membranes. Nephron 2000, 85:334-342. 10.1159/000045683, 10940744.
    • (2000) Nephron , vol.85 , pp. 334-342
    • Dhondt, A.1    Vanholder, R.2    Tielemans, C.3    Glorieux, G.4    Waterloos, M.A.5    De, S.R.6    Lameire, N.7
  • 48
    • 0038125598 scopus 로고    scopus 로고
    • Calcium signalling: dynamics, homeostasis and remodelling
    • 10.1038/nrm1155, 12838335
    • Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 2003, 4:517-529. 10.1038/nrm1155, 12838335.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 517-529
    • Berridge, M.J.1    Bootman, M.D.2    Roderick, H.L.3
  • 49
    • 77953680768 scopus 로고    scopus 로고
    • Pharmacological control of neutrophil-mediated inflammation: Strategies targeting calcium handling by activated polymorphonuclear leukocytes
    • 2761182, 19920897
    • Tintinger GR, Steel HC, Theron AJ, Anderson R. Pharmacological control of neutrophil-mediated inflammation: Strategies targeting calcium handling by activated polymorphonuclear leukocytes. Drug Des Devel Ther 2009, 2:95-104. 2761182, 19920897.
    • (2009) Drug Des Devel Ther , vol.2 , pp. 95-104
    • Tintinger, G.R.1    Steel, H.C.2    Theron, A.J.3    Anderson, R.4
  • 50
    • 0029881430 scopus 로고    scopus 로고
    • Reduction of granulocyte activation during hemodialysis with regional citrate anticoagulation: dissociation of complement activation and neutropenia from neutrophil degranulation
    • Bohler J, Schollmeyer P, Dressel B, Dobos G, Horl WH. Reduction of granulocyte activation during hemodialysis with regional citrate anticoagulation: dissociation of complement activation and neutropenia from neutrophil degranulation. J Am Soc Nephrol 1996, 7:234-241.
    • (1996) J Am Soc Nephrol , vol.7 , pp. 234-241
    • Bohler, J.1    Schollmeyer, P.2    Dressel, B.3    Dobos, G.4    Horl, W.H.5
  • 51
    • 0030789993 scopus 로고    scopus 로고
    • Low polymorphonuclear cell degranulation during citrate anticoagulation: a comparison between citrate and heparin dialysis
    • 10.1093/ndt/12.7.1387, 9249774
    • Bos JC, Grooteman MP, van Houte AJ, Schoorl M, van Limbeek J, Nube MJ. Low polymorphonuclear cell degranulation during citrate anticoagulation: a comparison between citrate and heparin dialysis. Nephrol Dial Transplant 1997, 12:1387-1393. 10.1093/ndt/12.7.1387, 9249774.
    • (1997) Nephrol Dial Transplant , vol.12 , pp. 1387-1393
    • Bos, J.C.1    Grooteman, M.P.2    van Houte, A.J.3    Schoorl, M.4    van Limbeek, J.5    Nube, M.J.6
  • 52
    • 16644392433 scopus 로고    scopus 로고
    • The favorable effect of regional citrate anticoagulation on interleukin-1beta release is dissociated from both coagulation and complement activation
    • Gabutti L, Ferrari N, Mombelli G, Keller F, Marone C. The favorable effect of regional citrate anticoagulation on interleukin-1beta release is dissociated from both coagulation and complement activation. J Nephrol 2004, 17:819-825.
    • (2004) J Nephrol , vol.17 , pp. 819-825
    • Gabutti, L.1    Ferrari, N.2    Mombelli, G.3    Keller, F.4    Marone, C.5
  • 55
    • 33645547305 scopus 로고    scopus 로고
    • Effect of regional citrate anticoagulation on thrombogenicity and biocompatibility during CVVHDF
    • 10.1080/08860220500530338, 16538967
    • Polanska K, Opatrny K, Rokyta R, Krouzecky A, Vit L, Kasal E. Effect of regional citrate anticoagulation on thrombogenicity and biocompatibility during CVVHDF. Ren Fail 2006, 28:107-118. 10.1080/08860220500530338, 16538967.
    • (2006) Ren Fail , vol.28 , pp. 107-118
    • Polanska, K.1    Opatrny, K.2    Rokyta, R.3    Krouzecky, A.4    Vit, L.5    Kasal, E.6
  • 56
    • 0032610504 scopus 로고    scopus 로고
    • Heparin in inflammation: potential therapeutic applications beyond anticoagulation
    • Tyrrell DJ, Horne AP, Holme KR, Preuss JM, Page CP. Heparin in inflammation: potential therapeutic applications beyond anticoagulation. Adv Pharmacol 1999, 46:151-208.
    • (1999) Adv Pharmacol , vol.46 , pp. 151-208
    • Tyrrell, D.J.1    Horne, A.P.2    Holme, K.R.3    Preuss, J.M.4    Page, C.P.5
  • 57
    • 79955481485 scopus 로고    scopus 로고
    • The effect of heparin administration in animal models of sepsis: a prospective study in Escherichia coli-challenged mice and a systematic review and metaregression analysis of published studies
    • 10.1097/CCM.0b013e31820eb718, 3389754, 21317646
    • Li Y, Sun JF, Cui X, Mani H, Danner RL, Li X, Su JW, Fitz Y, Eichacker PQ. The effect of heparin administration in animal models of sepsis: a prospective study in Escherichia coli-challenged mice and a systematic review and metaregression analysis of published studies. Crit Care Med 2011, 39:1104-1112. 10.1097/CCM.0b013e31820eb718, 3389754, 21317646.
    • (2011) Crit Care Med , vol.39 , pp. 1104-1112
    • Li, Y.1    Sun, J.F.2    Cui, X.3    Mani, H.4    Danner, R.L.5    Li, X.6    Su, J.W.7    Fitz, Y.8    Eichacker, P.Q.9
  • 58
    • 42249114676 scopus 로고    scopus 로고
    • Concentration-dependent roles for heparin in modifying lipopolysaccharide-induced activation of mononuclear cells in whole blood
    • Hochart H, Jenkins PV, Preston RJ, Smith OP, White B, O'Donnell J. Concentration-dependent roles for heparin in modifying lipopolysaccharide-induced activation of mononuclear cells in whole blood. Thromb Haemost 2008, 99:570-575.
    • (2008) Thromb Haemost , vol.99 , pp. 570-575
    • Hochart, H.1    Jenkins, P.V.2    Preston, R.J.3    Smith, O.P.4    White, B.5    O'Donnell, J.6
  • 59
    • 84865417529 scopus 로고    scopus 로고
    • Unfractionated heparin inhibits lipopolysaccharide-induced inflammatory response through blocking p38 MAPK and NF-kappaB activation on endothelial cell
    • 10.1016/j.cyto.2012.06.008, 22763042
    • Li X, Zheng Z, Li X, Ma X. Unfractionated heparin inhibits lipopolysaccharide-induced inflammatory response through blocking p38 MAPK and NF-kappaB activation on endothelial cell. Cytokine 2012, 60:114-121. 10.1016/j.cyto.2012.06.008, 22763042.
    • (2012) Cytokine , vol.60 , pp. 114-121
    • Li, X.1    Zheng, Z.2    Li, X.3    Ma, X.4
  • 61
    • 82355173316 scopus 로고    scopus 로고
    • Treatment with unfractionated heparin attenuates coagulation and inflammation in endotoxemic mice
    • 10.1016/j.thromres.2011.07.044, 21851968
    • Ding R, Zhao D, Guo R, Zhang Z, Ma X. Treatment with unfractionated heparin attenuates coagulation and inflammation in endotoxemic mice. Thromb Res 2011, 128:e160-e165. 10.1016/j.thromres.2011.07.044, 21851968.
    • (2011) Thromb Res , vol.128
    • Ding, R.1    Zhao, D.2    Guo, R.3    Zhang, Z.4    Ma, X.5
  • 62
    • 67650470156 scopus 로고    scopus 로고
    • Unfractioned heparin for treatment of sepsis: A randomized clinical trial (The HETRASE Study)
    • 10.1097/CCM.0b013e31819c06bc, 19242322
    • Jaimes F, De La Rosa G, Morales C, Fortich F, Arango C, Aguirre D, Munoz A. Unfractioned heparin for treatment of sepsis: A randomized clinical trial (The HETRASE Study). Crit Care Med 2009, 37:1185-1196. 10.1097/CCM.0b013e31819c06bc, 19242322.
    • (2009) Crit Care Med , vol.37 , pp. 1185-1196
    • Jaimes, F.1    De La Rosa, G.2    Morales, C.3    Fortich, F.4    Arango, C.5    Aguirre, D.6    Munoz, A.7
  • 63
    • 0037085776 scopus 로고    scopus 로고
    • High-affinity binding sites for heparin generated on leukocytes during apoptosis arise from nuclear structures segregated during cell death
    • 10.1182/blood.V99.6.2221, 11877301
    • Gebska MA, Titley I, Paterson HF, Morilla RM, Davies DC, Gruszka-Westwood AM, Kakkar VV, Eccles S, Scully MF. High-affinity binding sites for heparin generated on leukocytes during apoptosis arise from nuclear structures segregated during cell death. Blood 2002, 99:2221-2227. 10.1182/blood.V99.6.2221, 11877301.
    • (2002) Blood , vol.99 , pp. 2221-2227
    • Gebska, M.A.1    Titley, I.2    Paterson, H.F.3    Morilla, R.M.4    Davies, D.C.5    Gruszka-Westwood, A.M.6    Kakkar, V.V.7    Eccles, S.8    Scully, M.F.9
  • 65
    • 29244443277 scopus 로고    scopus 로고
    • Myeloperoxidase as a marker of hemodialysis biocompatibility and oxidative stress: the underestimated modifying effects of heparin
    • 10.1053/j.ajkd.2005.10.001, 16377383
    • Borawski J. Myeloperoxidase as a marker of hemodialysis biocompatibility and oxidative stress: the underestimated modifying effects of heparin. Am J Kidney Dis 2006, 47:37-41. 10.1053/j.ajkd.2005.10.001, 16377383.
    • (2006) Am J Kidney Dis , vol.47 , pp. 37-41
    • Borawski, J.1
  • 67
    • 13544265657 scopus 로고    scopus 로고
    • Heparin binds to lipopolysaccharide (LPS)-binding protein, facilitates the transfer of LPS to CD14, and enhances LPS-induced activation of peripheral blood monocytes
    • Heinzelmann M, Bosshart H. Heparin binds to lipopolysaccharide (LPS)-binding protein, facilitates the transfer of LPS to CD14, and enhances LPS-induced activation of peripheral blood monocytes. J Immunol 2005, 174:2280-2287.
    • (2005) J Immunol , vol.174 , pp. 2280-2287
    • Heinzelmann, M.1    Bosshart, H.2
  • 69
    • 33746608575 scopus 로고    scopus 로고
    • Detection of citrate overdose in critically ill patients on citrate-anticoagulated venovenous haemofiltration: use of ionised and total/ionised calcium
    • Bakker AJ, Boerma EC, Keidel H, Kingma P, van der Voort PH. Detection of citrate overdose in critically ill patients on citrate-anticoagulated venovenous haemofiltration: use of ionised and total/ionised calcium. Clin Chem Lab Med 2006, 44:962-966.
    • (2006) Clin Chem Lab Med , vol.44 , pp. 962-966
    • Bakker, A.J.1    Boerma, E.C.2    Keidel, H.3    Kingma, P.4    van der Voort, P.H.5
  • 70
    • 33751010475 scopus 로고    scopus 로고
    • Citrate plasma levels in patients under regional anticoagulation in continuous venovenous hemofiltration
    • 10.1053/j.ajkd.2006.07.016, 17060000
    • Hetzel GR, Taskaya G, Sucker C, Hennersdorf M, Grabensee B, Schmitz M. Citrate plasma levels in patients under regional anticoagulation in continuous venovenous hemofiltration. Am J Kidney Dis 2006, 48:806-811. 10.1053/j.ajkd.2006.07.016, 17060000.
    • (2006) Am J Kidney Dis , vol.48 , pp. 806-811
    • Hetzel, G.R.1    Taskaya, G.2    Sucker, C.3    Hennersdorf, M.4    Grabensee, B.5    Schmitz, M.6
  • 71
    • 84861468522 scopus 로고    scopus 로고
    • Total-to-ionized calcium ratio predicts mortality in continuous renal replacement therapy with citrate anticoagulation in critically ill patients
    • 10.1186/cc11363, 22643456
    • Link A, Klingele M, Speer T, Rbah R, Poss J, Lerner-Graber A, Fliser D, Bohm M. Total-to-ionized calcium ratio predicts mortality in continuous renal replacement therapy with citrate anticoagulation in critically ill patients. Crit Care 2012, 16:R97. 10.1186/cc11363, 22643456.
    • (2012) Crit Care , vol.16
    • Link, A.1    Klingele, M.2    Speer, T.3    Rbah, R.4    Poss, J.5    Lerner-Graber, A.6    Fliser, D.7    Bohm, M.8
  • 73
    • 0026647465 scopus 로고
    • Low dose calcium administration increases mortality during septic peritonitis in rats
    • Zaloga GP, Sager A, Black KW, Prielipp R. Low dose calcium administration increases mortality during septic peritonitis in rats. Circ Shock 1992, 37:226-229.
    • (1992) Circ Shock , vol.37 , pp. 226-229
    • Zaloga, G.P.1    Sager, A.2    Black, K.W.3    Prielipp, R.4
  • 74
    • 0142025049 scopus 로고    scopus 로고
    • Citrate pharmacokinetics and metabolism in cirrhotic and noncirrhotic critically ill patients
    • 10.1097/01.CCM.0000084871.76568.E6, 14530750
    • Kramer L, Bauer E, Joukhadar C, Strobl W, Gendo A, Madl C, Gangl A. Citrate pharmacokinetics and metabolism in cirrhotic and noncirrhotic critically ill patients. Crit Care Med 2003, 31:2450-2455. 10.1097/01.CCM.0000084871.76568.E6, 14530750.
    • (2003) Crit Care Med , vol.31 , pp. 2450-2455
    • Kramer, L.1    Bauer, E.2    Joukhadar, C.3    Strobl, W.4    Gendo, A.5    Madl, C.6    Gangl, A.7
  • 76
    • 79251586161 scopus 로고    scopus 로고
    • Regional citrate anticoagulation in patients with liver failure supported by a molecular adsorbent recirculating system
    • 10.1097/CCM.0b013e3181fee8a4, 20975551
    • Faybik P, Hetz H, Mitterer G, Krenn CG, Schiefer J, Funk GC, Bacher A. Regional citrate anticoagulation in patients with liver failure supported by a molecular adsorbent recirculating system. Crit Care Med 2011, 39:273-279. 10.1097/CCM.0b013e3181fee8a4, 20975551.
    • (2011) Crit Care Med , vol.39 , pp. 273-279
    • Faybik, P.1    Hetz, H.2    Mitterer, G.3    Krenn, C.G.4    Schiefer, J.5    Funk, G.C.6    Bacher, A.7
  • 77
    • 84856439557 scopus 로고    scopus 로고
    • A prospective randomized open-label crossover trial of regional citrate anticoagulation vs. anticoagulation free liver dialysis by the Molecular Adsorbents Recirculating System
    • 10.1186/cc11180, 3396260, 22305273
    • Meijers B, Laleman W, Vermeersch P, Nevens F, Wilmer A, Evenepoel P. A prospective randomized open-label crossover trial of regional citrate anticoagulation vs. anticoagulation free liver dialysis by the Molecular Adsorbents Recirculating System. Crit Care 2012, 16:R20. 10.1186/cc11180, 3396260, 22305273.
    • (2012) Crit Care , vol.16
    • Meijers, B.1    Laleman, W.2    Vermeersch, P.3    Nevens, F.4    Wilmer, A.5    Evenepoel, P.6
  • 78
    • 84872275385 scopus 로고    scopus 로고
    • Multicenter prospective observational study on safety and efficacy of regional citrate anticoagulation in CVVHD in the presence of liver failure: the Liver Citrate Anticoagulation Treshold Study (L-CAT)
    • Slowinski T, Morgera S, Joannidis M, Kindgen-Milles D. Multicenter prospective observational study on safety and efficacy of regional citrate anticoagulation in CVVHD in the presence of liver failure: the Liver Citrate Anticoagulation Treshold Study (L-CAT). Crit Care 2011, 15(Suppl 1):P127.
    • (2011) Crit Care , vol.15 , Issue.SUPPL. 1
    • Slowinski, T.1    Morgera, S.2    Joannidis, M.3    Kindgen-Milles, D.4
  • 79
    • 9344259685 scopus 로고    scopus 로고
    • Bone resorption and "relative" immobilization hypercalcemia with prolonged continuous renal replacement therapy and citrate anticoagulation
    • 10.1053/j.ajkd.2004.09.001, 15558534
    • Wang PL, Meyer MM, Orloff SL, Anderson S. Bone resorption and "relative" immobilization hypercalcemia with prolonged continuous renal replacement therapy and citrate anticoagulation. Am J Kidney Dis 2004, 44:1110-1114. 10.1053/j.ajkd.2004.09.001, 15558534.
    • (2004) Am J Kidney Dis , vol.44 , pp. 1110-1114
    • Wang, P.L.1    Meyer, M.M.2    Orloff, S.L.3    Anderson, S.4
  • 80
    • 34447519145 scopus 로고    scopus 로고
    • An observational study on the effects of nadroparin-based and citrate-based continuous venovenous hemofiltration on calcium metabolism
    • 10.1159/000101853, 17446700
    • van der Voort PH, Postma SR, Kingma WP, Boerma EC, de Heide LJ, Bakker AJ. An observational study on the effects of nadroparin-based and citrate-based continuous venovenous hemofiltration on calcium metabolism. Blood Purif 2007, 25:267-273. 10.1159/000101853, 17446700.
    • (2007) Blood Purif , vol.25 , pp. 267-273
    • van der Voort, P.H.1    Postma, S.R.2    Kingma, W.P.3    Boerma, E.C.4    de Heide, L.J.5    Bakker, A.J.6
  • 81
    • 79960576822 scopus 로고    scopus 로고
    • Calcium flux in continuous venovenous haemodiafiltration with heparin and citrate anticoagulation
    • Brain M, Parkes S, Fowler P, Robertson I, Brown A. Calcium flux in continuous venovenous haemodiafiltration with heparin and citrate anticoagulation. Crit Care Resusc 2011, 13:72-81.
    • (2011) Crit Care Resusc , vol.13 , pp. 72-81
    • Brain, M.1    Parkes, S.2    Fowler, P.3    Robertson, I.4    Brown, A.5
  • 82
    • 77749318464 scopus 로고    scopus 로고
    • A mathematical model of regional citrate anticoagulation in hemodialysis
    • 10.1159/000245647, 20093827
    • Thijssen S, Kruse A, Raimann J, Bhalani V, Levin NW, Kotanko P. A mathematical model of regional citrate anticoagulation in hemodialysis. Blood Purif 2010, 29:197-203. 10.1159/000245647, 20093827.
    • (2010) Blood Purif , vol.29 , pp. 197-203
    • Thijssen, S.1    Kruse, A.2    Raimann, J.3    Bhalani, V.4    Levin, N.W.5    Kotanko, P.6
  • 83
    • 77749320518 scopus 로고    scopus 로고
    • Automated regional citrate anticoagulation: technological barriers and possible solutions
    • 10.1159/000245648, 20093828
    • Szamosfalvi B, Frinak S, Yee J. Automated regional citrate anticoagulation: technological barriers and possible solutions. Blood Purif 2010, 29:204-209. 10.1159/000245648, 20093828.
    • (2010) Blood Purif , vol.29 , pp. 204-209
    • Szamosfalvi, B.1    Frinak, S.2    Yee, J.3
  • 84
    • 80855132999 scopus 로고    scopus 로고
    • A target-orientated algorithm for regional citrate-calcium anticoagulation in extracorporeal therapies
    • 10.1159/000332394, 22085810
    • Brandl M, Strobl K, Hartmann J, Kellner K, Posnicek T, Falkenhagen D. A target-orientated algorithm for regional citrate-calcium anticoagulation in extracorporeal therapies. Blood Purif 2012, 33:7-20. 10.1159/000332394, 22085810.
    • (2012) Blood Purif , vol.33 , pp. 7-20
    • Brandl, M.1    Strobl, K.2    Hartmann, J.3    Kellner, K.4    Posnicek, T.5    Falkenhagen, D.6
  • 85
    • 84871117614 scopus 로고    scopus 로고
    • Kidney Disease: Improving Global Outcomes (KDIGO)
    • Kidney Disease: Improving Global Outcomes (KDIGO). , http://www.kdigo.org/


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