Sepsis alters pyruvate dehydrogenase kinase activity in skeletal muscle

Molecular and Cellular Biochemistry

Volumn 198, Issue 1-2, 1999, Pages 113-118

  Vary, Thomas C ^a   Hazen, Stacy ^b  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b LEBANON VALLEY COLLEGE   (United States)

Author keywords

Dichloroacetate; Pyruvate dehydrogenase complex; Pyruvate dehydrogenase kinase; Skeletal muscle

Indexed keywords

AGAR; DICHLOROACETIC ACID; MUSCLE ENZYME; PHOSPHOTRANSFERASE; PYRUVATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTEROIDES FRAGILIS; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; FECES; GEL CHROMATOGRAPHY; MUSCLE MITOCHONDRION; NONHUMAN; RAT; SEPSIS; SKELETAL MUSCLE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BACTERIAL INFECTIONS; CHROMATOGRAPHY, GEL; DICHLOROACETATE; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; RATS; SEPSIS;

EID: 0032847523     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006993910781     Document Type: Article

References (34)

1. Cerra FB: Hypermetabolism-organ failure syndrome: A metabolic response to injury. Crit Care Clin 5: 289-301, 1989
2. Vary TC, Siegel JH, Rivikind A: Clinical and therapeutic significance of metabolic patterns of lactic acidosis. Perspect Crit Care 1: 85-132, 1988
3. Cerra FB: Metabolic manifestations of multiple organ failure. Crit Care Clin 5: 119-131, 1989
4. Siegel JH, Rivikind AI, Dalal S, Goodari S: Early physiologic predictors of injury and death in blunt multiple trauma. Arch Surg 125: 498-508, 1990
5. Wilmore DW, Goodwin CW, Aulick LH, Powanda AC, Mason AD, Pruit BA: Effect of injury and infection on visceral metabolism and circulation. Ann Surg 192: 491-504, 1980
6. Dahn MS, Lange P, Lobell K, Hans B, Jacobs LA, Mitchell RA: Splanchnic and total oxygen consumption differences in septic and injured patients. Surgery 101: 69-80, 1987
7. Vary TC, Siegel JH, Zechnich A, Tall BD, Morris JG, Placko R, Jawor D: Pharmacological reversal of abnormal glucose regulation, BCAA utilization, and muscle catabolism by dichloroacetate. J Trauma 28: 1301-1311, 1988
8. Lang CH, Bagby GJ, Blakesley HL, Spitzer JJ: Glucose kinetics and pyruvate dehydrogenase activity in septic rats treated with dichlororacetate. Circ Shock 7: 13-21, 1987
9. Vary TC, Dardevet D, Obled C, Pouyet C, Breullie D, Grizard J: Modulation of skeletal muscle lactate metabolism following bacteremia by insulin or insulin-like growth factor-I: Effects of pentoxifylline. Shock 7: 432-438, 1997
10. Romanosky AJ, Bagby GL, Bockman L, Spitzer JJ: Increased muscle glucose uptake and lactate release after endotoxin administration. Am J Physiol 239: E311-E316, 1981
11. Curtis SE, Cain SM: Regional and systemic oxygen delivery/uptake relations and lactate flux in hyperdynamic, endotoxin-treated dogs. Ann Rev Respir Dis 145: 348-358, 1992
12. Bagby GJ, Lang CH, Giamo ME, Spitzer JJ: Increased glucose metabolism by epitrochlearis muscle removed from endotoxin-treated rats. Circ Shock 20: 171-179, 1986
13. Vary TC, Drnevich D, Jurasinski C, Brennan WA: Mechanisms regulating skeletal muscle glucose metabolism in sepsis. Shock 3: 403-410, 1995
14. Vary TC: Amrinone prevents the inhibition of muscle pyruvate dehydrogenase complex activity during sepsis. Shock 5: 229-232, 1996
15. Vary TC: Sepsis-induced alterations in pyruvate dehydrogenase complex activity in rat skeletal muscle: Effects on plasma lactate. Shock 6: 89-94, 1996
16. Vary TC, Martin LF: Potentiation of decreased pyruvate dehydrogenase activity by inflammatory stimuli in sepsis. Circ Shock 39: 299-305, 1993
17. Vary TC, Siegel JH, Tall BD, Morris JG: Altered glucose regulation in sepsis revealed by partial reversal of PDH inhibition by dichloroacetate. Circ Shock 24: 3-18, 1988
18. Vary TC, Murphy JM: Role of extra-splanchnic organs in the metabolic response to sepsis: Effect of insulin. Circ Shock 29: 41-57, 1989
19. Vary TC: Increased pyruvate dehydrogenase kinase activity in response to sepsis. Am J Physiol 250: E669-E674, 1991
20. Bowker-Kinley MM, Davis WI, Wu P, Harris RA, Popov KM: Evidence for existence of tissue specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem J 329: 191-196, 1998
21. Wu P, Sato J, Zhao Y, Jaskiewcz J, Popov KM, Harris RA: Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart. Biochem J 329: 197-201, 1998
22. Kerbey AL, Richardson LJ, Randle PJ: The roles of intrinsic kinase and of kinase/activator protein in the enhanced phosphorylation of pyruvate dehydrogenase complex in starvation. FEBS Lett 176: 115-119, 1984
23. Mistry SC, Priestman DA, Kerbey AL, Randle PJ: Evidence that rat liver pyruvate dehydrogenase kinase activator protein is a pyruvate dehydrogenase kinase. Biochem J 275: 775-779, 1991
24. Jones BS, Yeaman SJ: Long-term regulation of pyruvate dehydrogenase complex: Evidence that kinase-activator protein (KAP) is free pyruvate dehydrogenase kinase. Biochem J 275: 781-784, 1991
25. Presitman DA, Mistry SC, Kerbey AL, Randle PJ: Purification and partial characterization of rat liver pyruvate dehydrogenase kinase activator protein (free pyruvate dehydrogenase kinase). FEBS Lett 308: 83-86, 1992
26. Vary TC, Siegel JH, Nakatani T, Sato T, Aoyama H: Effect of sepsis on the activity of the pyruvate dehydrogenase complex in skeletal muscle and liver. Am J Physiol 250: E634-E640, 1986
27. Fuller SJ, Randle PJ: Reversible phosphorylation of pyruvate dehydrogenase in rat skeletal muscle mitochondria: Effects of starvation and diabetes. Biochem J 219: 635-646, 1984
28. Kerbey AL, Randle PJ, Cooper RH, Whitehouse S, Pask HT, Denton RM: Regulation of pyruvate dehydrogenase in rat heart. Biochem J 219: 635-646, 1976
29. Fantania HR, Vary TC, Randle PJ: Modulation of PDH kinase activity in cultured hepatocytes by glucagon and n-octanoate. Biochem J 234: 235-236, 1986
30. Whitehouse S, Copper RH, Randle PJ: Mechanism of action of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids. Biochem J 141: 761-774, 1974
31. Priestman DA, Mistry SC, Halsall A, Randle PJ: Role of protein synthesis and of fatty acid metabolism in the longer-term regulation of pyruvate dehydrogenase kinase. Biochem J 300: 659-664, 1994
32. Sugden MC, Fryer LG, Orfali KA, Priestman DA, Donald E, Holness MJ: Studies of the long-term regulation of hepatic pyruvate dehydrogenase kinase. Biochem J 329: 89-94, 1998
33. Vary TC, Placko R, Siegel JH: Pharmacologic modulation of increased release of gluconeogenic precursors from extra-splanchnic organs during sepsis. Circ Shock 29: 58-76, 1989
34. Vary TC, Siegel JC, Placko R, Tall BD, Morris JG: Effect of dichloroacetate on plasma and hepatic amino acids in sterile inflammation and sepsis. Arch Surg 124: 1071-1077, 1989