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Volumn 39, Issue 5, 2011, Pages 1104-1112

The effect of heparin administration in animal models of sepsis: A prospective study in Escherichia coli-challenged mice and a systematic review and metaregression analysis of published studies

Author keywords

animal models; heparin; infection; metaregression analysis; pneumonia; sepsis; treatment

Indexed keywords

ANTIBIOTIC AGENT; FIBRINOGEN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEPARIN; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; PLACEBO; RANTES; SODIUM CHLORIDE; THROMBIN ANTITHROMBIN COMPLEX; TUMOR NECROSIS FACTOR ALPHA;

EID: 79955481485     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31820eb718     Document Type: Conference Paper
Times cited : (29)

References (54)
  • 3
    • 67650504236 scopus 로고    scopus 로고
    • Antithrom-bosis trials: Should we test therapeutic hep-arin adjusted based on activated partial thromboplastin time in septic shock?
    • Barochia AV, Li Y, Cui X, et al: Antithrom-bosis trials: Should we test therapeutic hep-arin adjusted based on activated partial thromboplastin time in septic shock? Crit Care Med 2009; 37:1486-1487
    • (2009) Crit Care Med , vol.37 , pp. 1486-1487
    • Barochia, A.V.1    Li, Y.2    Cui, X.3
  • 4
    • 67650470156 scopus 로고    scopus 로고
    • Unfractioned heparin for treatment of sepsis: A randomized clinical trial (The HETRASE Study)
    • Jaimes F, De La Rosa G, Morales C, et al: Unfractioned heparin for treatment of sepsis: A randomized clinical trial (The HETRASE Study). Crit Care Med 2009; 37:1185-1196
    • (2009) Crit Care Med , vol.37 , pp. 1185-1196
    • Jaimes, F.1    De La Rosa, G.2    Morales, C.3
  • 5
    • 56049115814 scopus 로고    scopus 로고
    • Early intravenous unfractionated heparin and mortality in septic shock
    • Zarychanski R, Doucette S, Fergusson D, et al: Early intravenous unfractionated heparin and mortality in septic shock. Crit Care Med 2008; 36:2973-2979
    • (2008) Crit Care Med , vol.36 , pp. 2973-2979
    • Zarychanski, R.1    Doucette, S.2    Fergusson, D.3
  • 6
    • 0034924156 scopus 로고    scopus 로고
    • Epidemiology of sepsis: An update
    • Angus DC, Wax RS: Epidemiology of sepsis: An update. Crit Care Med 2001; 29(Suppl 7):S109-S116 (Pubitemid 32681592)
    • (2001) Critical Care Medicine , vol.29 , Issue.7 SUPPL.
    • Angus, D.C.1    Wax, R.S.2
  • 8
    • 84872636119 scopus 로고
    • An approximate distribu-tion of estimates of variance components
    • Satterthwaite FE: An approximate distribu-tion of estimates of variance components. Biometrics 1946; 2:110-114
    • (1946) Biometrics , vol.2 , pp. 110-114
    • Satterthwaite, F.E.1
  • 11
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying het-erogeneity in a meta-analysis
    • Higgins JP, Thompson SG: Quantifying het-erogeneity in a meta-analysis. StatMed2002; 21:1539-1558
    • (2002) StatMed , vol.21 , pp. 1539-1558
    • Higgins, J.P.1    Thompson, S.G.2
  • 12
    • 0037186429 scopus 로고    scopus 로고
    • Advanced methods in meta-analysis: Multivariate approach and meta-regression
    • DOI 10.1002/sim.1040
    • van Houwelingen HC, Arends LR, Stijnen T: Advanced methods in meta-analysis: multi-variate approach and meta-regression. Stat Med 2002; 21:589-624 (Pubitemid 34141379)
    • (2002) Statistics in Medicine , vol.21 , Issue.4 , pp. 589-624
    • Van Houwelingen, H.C.1    Arends, L.R.2    Stijnen, T.3
  • 13
    • 0022992740 scopus 로고
    • Meta-analysis in clinical trials
    • DOI 10.1016/0197-2456(86)90046-2
    • DerSimonian R, Laird N: Meta-analysis in clinical trials. Control Clin Trials 1986; 7:177-188 (Pubitemid 17189972)
    • (1986) Controlled Clinical Trials , vol.7 , Issue.3 , pp. 177-188
    • DerSimonian, R.1    Laird, N.2
  • 14
  • 15
    • 0442309557 scopus 로고    scopus 로고
    • A nonparametric "trim and fill" method of accounting for publica-tion bias in meta-analysis
    • Duval S, Tweedie R: A nonparametric "trim and fill" method of accounting for publica-tion bias in meta-analysis. J Am Stat Assoc 2000; 95:89-98
    • (2000) J Am Stat Assoc , vol.95 , pp. 89-98
    • Duval, S.1    Tweedie, R.2
  • 16
    • 45949086068 scopus 로고    scopus 로고
    • Parenteral anticoagulants: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition)
    • DOI 10.1378/chest.08-0689
    • Hirsh J, Bauer KA, Donati MB, et al: Paren-teral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133(Suppl 6):141S-159S (Pubitemid 351892966)
    • (2008) Chest , vol.133 , Issue.6 SUPPL. 6
    • Hirsh, J.1    Bauer, K.A.2    Donati, M.B.3    Gould, M.4    Samama, M.M.5    Weitz, J.I.6
  • 17
    • 77953734976 scopus 로고    scopus 로고
    • SB203580, a p38 inhibitor, improved cardiac function but worsened lung injury and survival during Escherichia coli pneumonia in mice
    • Su J, Cui X, Li Y, et al: SB203580, a p38 inhibitor, improved cardiac function but worsened lung injury and survival during Escherichia coli pneumonia in mice. J Trauma 2010; 68:1317-1327
    • (2010) J Trauma , vol.68 , pp. 1317-1327
    • Su, J.1    Cui, X.2    Li, Y.3
  • 18
    • 0024330833 scopus 로고
    • Therapeutic modalities to ameliorate endotoxin induced DIC in the rats
    • Bahrami S, Paul E, Redl H, et al: Therapeutic modalities to ameliorate endotoxin induced DIC in the rats. Prog Clin Biol Res 1989; 308:977-982
    • (1989) Prog Clin Biol Res , vol.308 , pp. 977-982
    • Bahrami, S.1    Paul, E.2    Redl, H.3
  • 20
    • 0018082804 scopus 로고
    • Prolonged shock in the baboon subjected to infusion of E coli endotoxin
    • Coalson JJ, Benjamin B, Archer LT, et al: Prolonged shock in the baboon subjected to infusion of E. coli endotoxin. Circ Shock 1978; 5:423-437 (Pubitemid 9078598)
    • (1978) Circulatory Shock , vol.5 , Issue.4 , pp. 423-437
    • Coalson, J.J.1    Benjamin, B.2    Archer, L.T.3
  • 21
    • 0016468759 scopus 로고
    • Effect of heparin in experimental gram-negative septicemia
    • Corrigan JJ Jr, Kiernat JF: Effect of heparin in experimental gram-negative septicemia. JInfect Dis 1975; 131:138-143
    • (1975) JInfect Dis , vol.131 , pp. 138-143
    • Corrigan Jr., J.J.1    Kiernat, J.F.2
  • 22
    • 0019495667 scopus 로고
    • The effects of heparin and low molecular weight dextran on survival after fibrinopurulent peritonitis
    • Davidson RK, Cardenas A, Buruttil RW: The effects of heparin and low molecular weight dextran on survival after fibrinopurulent peri-tonitis. Surg Gynecol Obstet 1981; 153: 327-331 (Pubitemid 11057161)
    • (1981) Surgery Gynecology and Obstetrics , vol.153 , Issue.3 , pp. 327-331
    • Davidson, R.K.1    Cardenas, A.2    Busuttil, R.W.3
  • 23
    • 0028363413 scopus 로고
    • Combination of antibiotic treatment with the thrombin inhibitor recombinant hirudin for the therapy of experimental Klebsiella pneumoniae sepsis
    • Dickneite G, Czech J: Combination of anti-biotic treatment with the thrombin inhibitor recombinant hirudin for the therapy of ex-perimental Klebsiella pneumoniae sepsis. Thromb Haemost 1994; 71:768-772 (Pubitemid 24177967)
    • (1994) Thrombosis and Haemostasis , vol.71 , Issue.6 , pp. 768-772
    • Dickneite, G.1    Czech, J.2
  • 25
    • 0035019731 scopus 로고    scopus 로고
    • Tumor necrosis factor-dependent adhesions as a major protective mechanism early in septic peritonitis in mice
    • DOI 10.1128/IAI.69.6.3550-3555.2001
    • Echtenacher B, Weigl K, Lehn N, et al: Tu-mor necrosis factor-dependent adhesions as a major protective mechanism early in septic peritonitis in mice. Infect Immun 2001; 69: 3550-3555 (Pubitemid 32493266)
    • (2001) Infection and Immunity , vol.69 , Issue.6 , pp. 3550-3555
    • Echtenacher, B.1    Weigl, K.2    Lehn, N.3    Mannel, D.N.4
  • 26
    • 0014537311 scopus 로고
    • An experimental study of current therapeutic approaches to endotoxin shock
    • Evangelista BS, Green TJ, Gwilt DJ, et al: An experimental study of current therapeutic approaches to endotoxin shock. Arch Int Pharmacodyn Ther 1969; 180:57-67
    • (1969) Arch Int Pharmacodyn Ther , vol.180 , pp. 57-67
    • Evangelista, B.S.1    Green, T.J.2    Gwilt, D.J.3
  • 27
    • 0014288965 scopus 로고
    • Heparin protection in endotoxin shock
    • Filkins JP, Di Luzio NR: Heparin protection in endotoxin shock. Am J Physiol 1968; 214: 1074-1077
    • (1968) Am J Physiol , vol.214 , pp. 1074-1077
    • Filkins, J.P.1    Di Luzio, N.R.2
  • 30
    • 0021825339 scopus 로고
    • Low-dose heparin in ex-perimental peritonitis
    • Gupta S, Jain PK: Low-dose heparin in ex-perimental peritonitis. Eur Surg Res 1985; 17:167-172
    • (1985) Eur Surg Res , vol.17 , pp. 167-172
    • Gupta, S.1    Jain, P.K.2
  • 31
    • 0017797402 scopus 로고
    • Heparin in the treat-ment of experimental peritonitis
    • Hau T, Simmons RL: Heparin in the treat-ment of experimental peritonitis. Ann Surg 1978; 187:294-298
    • (1978) Ann Surg , vol.187 , pp. 294-298
    • Hau, T.1    Simmons, R.L.2
  • 32
    • 0016053109 scopus 로고
    • Im-proved survival in refractory endotoxin shock with heparin and dextrose
    • Herlache JL, Winkler JM, Gehrke C: Im-proved survival in refractory endotoxin shock with heparin and dextrose. Mich Med 1974; 73:191-194
    • (1974) Mich Med , vol.73 , pp. 191-194
    • Herlache, J.L.1    Winkler, J.M.2    Gehrke, C.3
  • 33
    • 0022497222 scopus 로고
    • The effects of heparin and splenectomy on survival and plasma fibronectin levels in rat peritonitis
    • DOI 10.1016/0022-4804(86)90105-8
    • Hirano T, Forbes SR, Robinson GT, et al: The effects of heparin and splenectomy on sur-vival and plasma fibronectin levels in rat peritonitis. J Surg Res 1986; 40:611-616 (Pubitemid 16033069)
    • (1986) Journal of Surgical Research , vol.40 , Issue.6 , pp. 611-616
    • Hirano, T.1    Forbes, S.R.2    Robinson, G.T.3
  • 34
    • 0001927692 scopus 로고
    • The effect of heparin on endotoxin shock in the rat
    • Margaretten W, McKay DG, Phillips LL: The effect of heparin on endotoxin shock in the rat. Am J Pathol 1967; 51:61-68
    • (1967) Am J Pathol , vol.51 , pp. 61-68
    • Margaretten, W.1    McKay, D.G.2    Phillips, L.L.3
  • 36
    • 0022645016 scopus 로고
    • Ultrastructural studies of experimental endotoxin shock in the liver and spleen: Therapeutic effects of low-dose heparin on reticuloendothelial disturbances
    • Onda M, Toba M, Andoh T, et al: Ultrastruc-tural studies of experimental endotoxin shock in the liver and spleen: Therapeutic effects of low-dose heparin on reticuloendothelial distur-bances. Circ Shock 1986; 18:11-19 (Pubitemid 16174738)
    • (1986) Circulatory Shock , vol.18 , Issue.1 , pp. 11-19
    • Onda, M.1    Toba, M.2    Andoh, T.3    Shirota, A.4
  • 37
    • 0015044277 scopus 로고
    • Lack of significant protection afforded by heparin during endotoxic shock
    • Priano LL, Wilson RD, Traber DL: Lack of significant protection afforded by heparin during endotoxic shock. Am J Physiol 1971; 220:901-905
    • (1971) Am J Physiol , vol.220 , pp. 901-905
    • Priano, L.L.1    Wilson, R.D.2    Traber, D.L.3
  • 38
    • 0022977687 scopus 로고
    • Effect of heparin and heparin fractions on experimental abscess formation
    • Prinz RA, Shuber Z, Fareed J, et al: Effect of heparin and heparin fractions on experimen-tal abscess formation. Arch Surg 1986; 121: 1173-1176 (Pubitemid 17177262)
    • (1986) Archives of Surgery , vol.121 , Issue.10 , pp. 1173-1176
    • Prinz, R.A.1    Shuber, Z.2    Fareed, J.3
  • 39
    • 0036884205 scopus 로고    scopus 로고
    • Evaluation of unfractionated heparin and recombinant hirudin on survival in a sustained ovine endotoxin shock model
    • Schiffer ER, Reber G, De Moerloose P, et al: Evaluation of unfractionated heparin and recombinant hirudin on survival in a sustained ovine endotoxin shock model. Crit Care Med 2002; 30:2689-2699 (Pubitemid 36870571)
    • (2002) Critical Care Medicine , vol.30 , Issue.12 , pp. 2689-2699
    • Schiffer, E.R.C.1    Reber, G.2    De Moerloose, P.3    Morel, D.R.4
  • 40
    • 20444476178 scopus 로고    scopus 로고
    • Low molecular weight heparin attenuates multiple organ failure in a murine model of disseminated intravascular coagulation
    • DOI 10.1097/01.CCM.0000166370.94927.B6
    • Slofstra SH, van't Veer C, Buurman WA, et al: Low molecular weight heparin attenuates multiple organ failure in a murine model of disseminated intravascular coagulation. Crit Care Med 2005; 33:1365-1370 (Pubitemid 40827391)
    • (2005) Critical Care Medicine , vol.33 , Issue.6 , pp. 1365-1370
    • Slofstra, S.H.1    Van't Veer, C.2    Buurman, W.A.3    Reitsma, P.H.4    Ten Cate, H.5    Spek, C.A.6
  • 41
    • 0023942922 scopus 로고
    • Effect of the thrombolytic agent, streptoki-nase, on the responses to endotoxemia in conscious rats
    • Smith EF 3rd, Kinter LB, Jugus M, et al: Effect of the thrombolytic agent, streptoki-nase, on the responses to endotoxemia in conscious rats. Circ Shock 1988; 25:85-94
    • (1988) Circ Shock , vol.25 , pp. 85-94
    • Smith III, E.F.1    Kinter, L.B.2    Jugus, M.3
  • 42
    • 0030813172 scopus 로고    scopus 로고
    • The effect of heparinization on intra-abdominal infection and acute pulmonary failure
    • Sun Y, Williams CH, Hardaway RM, et al: The effect of heparinization on intra-abdominal infection and acute pulmonary failure. Int Surg 1997; 82:367-370 (Pubitemid 27500939)
    • (1997) International Surgery , vol.82 , Issue.4 , pp. 367-370
    • Sun, Y.1    Williams, C.H.2    Hardaway, R.M.3    Shen, J.4
  • 43
    • 0032902250 scopus 로고    scopus 로고
    • The effects of minidose heparin and low molecular weight heparin on peritonitis in the rat
    • Vela AR, Littleton JC, O'Leary JP: The effects of minidose heparin and low molecular weight heparin on peritonitis in the rat. Am Surg 1999; 65:473-477 (Pubitemid 29200915)
    • (1999) American Surgeon , vol.65 , Issue.5 , pp. 473-477
    • Vela, A.R.1    Littleton, J.C.2    O'Leary, J.P.3
  • 44
    • 0028719299 scopus 로고
    • The efficacy of heparin and antithrombin III in fluid-resuscitated cecal ligation and puncture
    • Yang S, Hauptman JG: The efficacy of heparin and antithrombin III in fluid-resuscitated cecal ligation and puncture. Shock 1994; 2:433-437
    • (1994) Shock , vol.2 , pp. 433-437
    • Yang, S.1    Hauptman, J.G.2
  • 45
    • 26544474958 scopus 로고
    • Ben-eficial effect of heparin on a lethal constant rate infusion of E. coli endotoxin in sheep
    • Pittet J-F, Morel DR, Steinig DA, et al: Ben-eficial effect of heparin on a lethal constant rate infusion of E. coli endotoxin in sheep. Am Rev Respir Dis 1989; 139:A271
    • (1989) Am Rev Respir Dis , vol.139
    • Pittet, J.-F.1    Morel, D.R.2    Steinig, D.A.3
  • 46
    • 79955485441 scopus 로고
    • Heparin's effect on the natural history of sepsis in the rat
    • Schirmer WJ, Schirmer JM, Naff GB, et al: Heparin's effect on the natural history of sepsis in the rat. Circ Shock 1987; 21:363
    • (1987) Circ Shock , vol.21 , pp. 363
    • Schirmer, W.J.1    Schirmer, J.M.2    Naff, G.B.3
  • 49
    • 77954060987 scopus 로고    scopus 로고
    • Proteolysis of human thrombin generates novel host defense peptides
    • Papareddy P, Rydengard V, Pasupuleti M, et al: Proteolysis of human thrombin generates novel host defense peptides. PLoS Pathog 2010; 6:e1000857
    • (2010) PLoS Pathog , vol.6
    • Papareddy, P.1    Rydengard, V.2    Pasupuleti, M.3
  • 50
    • 60849087371 scopus 로고    scopus 로고
    • Reduced thrombin generation increases host suscep-tibility to group A streptococcal infection
    • Sun H, Wang X, Degen JL, et al: Reduced thrombin generation increases host suscep-tibility to group A streptococcal infection. Blood 2009; 113:1358-1364
    • (2009) Blood , vol.113 , pp. 1358-1364
    • Sun, H.1    Wang, X.2    Degen, J.L.3
  • 51
    • 0031459708 scopus 로고    scopus 로고
    • Expression of tissue factor and tissue factor pathway inhibitor in rat lungs with lipopolysaccharide-induced disseminated intravascular coagulation
    • Hara S, Asada Y, Hatakeyama K, et al: Ex-pression of tissue factor and tissue factor pathway inhibitor in rats lungs with lipopo-lysaccharide-induced disseminated intravas-cular coagulation. Lab Invest 1997; 77: 581-589 (Pubitemid 28018778)
    • (1997) Laboratory Investigation , vol.77 , Issue.6 , pp. 581-589
    • Hara, S.1    Asada, Y.2    Hatakeyama, K.3    Marutsuka, K.4    Sato, Y.5    Kisanuki, A.6    Sumiyoshi, A.7
  • 52
    • 0033678605 scopus 로고    scopus 로고
    • A single endotoxin injection in the rabbit causes pro-longed blood vessel dysfunction and a proco-agulant state
    • Leclerc J, Pu Q, Corseaux D, et al: A single endotoxin injection in the rabbit causes pro-longed blood vessel dysfunction and a proco-agulant state. Crit Care Med 2000; 28: 3672-3678
    • (2000) Crit Care Med , vol.28 , pp. 3672-3678
    • Leclerc, J.1    Pu, Q.2    Corseaux, D.3
  • 53
    • 77949910861 scopus 로고    scopus 로고
    • Nebulized antithrombin limits bacterial out-growth and lung injury in Streptococcus pneumoniae pneumonia in rats
    • Hofstra JJ, Cornet AD, de Rooy BF, et al: Nebulized antithrombin limits bacterial out-growth and lung injury in Streptococcus pneumoniae pneumonia in rats. Crit Care 2009; 13:R145
    • (2009) Crit Care , vol.13
    • Hofstra, J.J.1    Cornet, A.D.2    De Rooy, B.F.3
  • 54
    • 69149107727 scopus 로고    scopus 로고
    • The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explana-tion and elaboration
    • Liberati A, Altman DG, Tetzlaff J, et al: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explana-tion and elaboration. Ann Intern Med 2009; 151:w65-w94
    • (2009) Ann Intern Med , vol.151
    • Liberati, A.1    Altman, D.G.2    Tetzlaff, J.3


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