메뉴 건너뛰기




Volumn 29, Issue 12, 2012, Pages 570-576

Low-dose dexmedetomidine facilitates the carotid body response to low oxygen tension in vitro via α2-adrenergic receptor activation in rabbits

Author keywords

2 adrenergic receptor; Action potential; Carotid body; Dexmedetomidine; Low oxygen tension; Respiratory system; Yohimbine

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; DEXMEDETOMIDINE; POTASSIUM ION; YOHIMBINE;

EID: 84872231461     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1097/EJA.0b013e328356fba5     Document Type: Article
Times cited : (4)

References (25)
  • 3
    • 0033623230 scopus 로고    scopus 로고
    • Clinical uses of a2-adrenergic agonists
    • Kamibayashi T, Maze M. Clinical uses of a2-adrenergic agonists. Anesthesiology 2000; 93:1345-1349.
    • (2000) Anesthesiology , vol.93 , pp. 1345-1349
    • Kamibayashi, T.1    Maze, M.2
  • 4
    • 0033860761 scopus 로고    scopus 로고
    • The effects of increasing plasma concentrations of dexmedetomidine in humans
    • Ebert TJ, Hall JE, Barney JA, et al. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology 2000; 93:382-394.
    • (2000) Anesthesiology , vol.93 , pp. 382-394
    • Ebert, T.J.1    Hall, J.E.2    Barney, J.A.3
  • 5
    • 0033803263 scopus 로고    scopus 로고
    • Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care
    • Venn RM, Hell J, Grounds RM. Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care. Crit Care 2000; 4:302- 308.
    • (2000) Crit Care , vol.4 , pp. 302-308
    • Venn, R.M.1    Hell, J.2    Grounds, R.M.3
  • 6
    • 0036020316 scopus 로고    scopus 로고
    • The effects of dexmedetomidine on the ventilatory response to hypercapnia in rabbits
    • Nishida T, Nishimura M, Kagawa K, et al. The effects of dexmedetomidine on the ventilatory response to hypercapnia in rabbits. Intensive Care Med 2002; 28:969-975.
    • (2002) Intensive Care Med , vol.28 , pp. 969-975
    • Nishida, T.1    Nishimura, M.2    Kagawa, K.3
  • 7
    • 33751320650 scopus 로고    scopus 로고
    • Effects of dexmedetomidine on respiratory mechanics and control of breathing in normal rats
    • Fernandes FC, Ferreira HC, Cagido VR, et al. Effects of dexmedetomidine on respiratory mechanics and control of breathing in normal rats. Respir Physiol Neurobiol 2006; 154:342-350.
    • (2006) Respir Physiol Neurobiol , vol.154 , pp. 342-350
    • Fernandes, F.C.1    Ferreira, H.C.2    Cagido, V.R.3
  • 8
    • 0026555580 scopus 로고
    • Ventilatory effects of dexmedetomidine, atipamezole, and isoflurane in dogs
    • Nguyen D, Abdul-Rasool I, Ward D, et al. Ventilatory effects of dexmedetomidine, atipamezole, and isoflurane in dogs. Anesthesiology 1992; 76:573-579.
    • (1992) Anesthesiology , vol.76 , pp. 573-579
    • Nguyen, D.1    Abdul-Rasool, I.2    Ward, D.3
  • 9
    • 33645086134 scopus 로고    scopus 로고
    • O2 sensing at the mammalian carotid body: Why multiple O2 sensors and multiple transmitters?
    • Prabhakar NR. O2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters? Exp Physiol 2006; 91:17-23.
    • (2006) Exp Physiol , vol.91 , pp. 17-23
    • Prabhakar, N.R.1
  • 10
    • 0034284753 scopus 로고    scopus 로고
    • Cellular mechanisms of oxygen sensing at the carotid body: Heme proteins and ion channels
    • Prabhakar NR, Overholt JL. Cellular mechanisms of oxygen sensing at the carotid body: heme proteins and ion channels. Respir Physiol 2000; 122:209-221.
    • (2000) Respir Physiol , vol.122 , pp. 209-221
    • Prabhakar, N.R.1    Overholt, J.L.2
  • 11
    • 0025963644 scopus 로고
    • Role of alpha 2-adrenergic receptors in the carotid body response to isocapnic hypoxia
    • Kou YR, Ernsberger P, Cragg PA, et al. Role of alpha 2-adrenergic receptors in the carotid body response to isocapnic hypoxia. Respir Physiol 1991; 83:353-364.
    • (1991) Respir Physiol , vol.83 , pp. 353-364
    • Kou, Y.R.1    Ernsberger, P.2    Cragg, P.A.3
  • 12
    • 0028105748 scopus 로고
    • Inhibitory sympathetic action on the carotid body responses to sustained hypoxia
    • Prabhakar NR, Kou YR. Inhibitory sympathetic action on the carotid body responses to sustained hypoxia. Respir Physiol 1994; 95:67-79.
    • (1994) Respir Physiol , vol.95 , pp. 67-79
    • Prabhakar, N.R.1    Kou, Y.R.2
  • 13
    • 0031594922 scopus 로고    scopus 로고
    • Carotid body I1-imidazoline receptors: Binding, visualization and modulatory function
    • Ernsberger P, Kou YR, Prabhakar NR. Carotid body I1-imidazoline receptors: binding, visualization and modulatory function. Respir Physiol 1998; 112:239-251.
    • (1998) Respir Physiol , vol.112 , pp. 239-251
    • Ernsberger, P.1    Kou, Y.R.2    Prabhakar, N.R.3
  • 14
    • 11444252151 scopus 로고    scopus 로고
    • Effect of propofol on carotid body chemosensitivity and cholinergic chemotransduction
    • Jonsson MM, Lindahl SG, Eriksson LI. Effect of propofol on carotid body chemosensitivity and cholinergic chemotransduction. Anesthesiology 2005; 102:110-116.
    • (2005) Anesthesiology , vol.102 , pp. 110-116
    • Jonsson, M.M.1    Lindahl, S.G.2    Eriksson, L.I.3
  • 15
    • 44449134213 scopus 로고    scopus 로고
    • Pronounced depression by propofol on carotid body response to CO2 and Ko-induced carotid body activation
    • Akada S, Fagerlund MJ, Lindahl SG, et al. Pronounced depression by propofol on carotid body response to CO2 and Ko-induced carotid body activation. Respir Physiol Neurobiol 2008; 160:284-288.
    • (2008) Respir Physiol Neurobiol , vol.160 , pp. 284-288
    • Akada, S.1    Fagerlund, M.J.2    Lindahl, S.G.3
  • 16
    • 33644750792 scopus 로고    scopus 로고
    • Midazolam depresses carotid body chemoreceptor activity
    • Kim C, Shvarev Y, Takeda S, et al. Midazolam depresses carotid body chemoreceptor activity. Acta Anaesthesiol Scand 2006; 50:144-149.
    • (2006) Acta Anaesthesiol Scand , vol.50 , pp. 144-149
    • Kim, C.1    Shvarev, Y.2    Takeda, S.3
  • 17
    • 0026621830 scopus 로고
    • Effects of intravenous dexmedetomidine in humans. I: Sedation, ventilation, and metabolic rate
    • Belleville JP, Ward DS, Bloor BC, Maze M. Effects of intravenous dexmedetomidine in humans. I: Sedation, ventilation, and metabolic rate. Anesthesiology 1992; 77:1125-1133.
    • (1992) Anesthesiology , vol.77 , pp. 1125-1133
    • Belleville, J.P.1    Ward, D.S.2    Bloor, B.C.3    Maze, M.4
  • 18
    • 7244239373 scopus 로고    scopus 로고
    • Dexmedetomidine pharmacodynamics. Part I: Crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers
    • Hsu YW, Cortinez LI, Robertson KM, et al. Dexmedetomidine pharmacodynamics. Part I: Crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers. Anesthesiology 2004; 101:1066-1076.
    • (2004) Anesthesiology , vol.101 , pp. 1066-1076
    • Hsu, Y.W.1    Cortinez, L.I.2    Robertson, K.M.3
  • 19
    • 0034745457 scopus 로고    scopus 로고
    • A2 Adrenergic receptors and the central control of breathing in the cane toad, Bufo marinus
    • Rives JE, Bernard DG. a2 Adrenergic receptors and the central control of breathing in the cane toad, Bufo marinus. Respir Physiol 2001; 125:213- 223.
    • (2001) Respir Physiol , vol.125 , pp. 213-223
    • Rives, J.E.1    Bernard, D.G.2
  • 20
    • 0032965831 scopus 로고    scopus 로고
    • Acetylcholine contributes to hypoxic chemotransmission in co-cultures of rat type 1 cells and petrosal neurons
    • Nurse CA, Zhang M. Acetylcholine contributes to hypoxic chemotransmission in co-cultures of rat type 1 cells and petrosal neurons. Respir Physiol 1999; 115:189-199.
    • (1999) Respir Physiol , vol.115 , pp. 189-199
    • Nurse, C.A.1    Zhang, M.2
  • 21
    • 0142042947 scopus 로고    scopus 로고
    • ACh and ATP mediate excitatory transmission in cat carotid identified chemoreceptor units in vitro
    • Varas R, Alcayaga J, Iturriaga R. ACh and ATP mediate excitatory transmission in cat carotid identified chemoreceptor units in vitro. Brain Res 2003; 988:154-163.
    • (2003) Brain Res , vol.988 , pp. 154-163
    • Varas, R.1    Alcayaga, J.2    Iturriaga, R.3
  • 22
    • 0036112575 scopus 로고    scopus 로고
    • Atracurium and vecuronium block nicotine-induced carotid body chemoreceptor responses
    • Jonsson M, Kim C, Yamamoto Y, et al. Atracurium and vecuronium block nicotine-induced carotid body chemoreceptor responses. Acta Anaestheiol Scand 2002; 46:488-494.
    • (2002) Acta Anaestheiol Scand , vol.46 , pp. 488-494
    • Jonsson, M.1    Kim, C.2    Yamamoto, Y.3
  • 23
    • 0036139403 scopus 로고    scopus 로고
    • Vecuronium directly inhibits hypoxic neurotransmission of the rat carotid body
    • Igarashi A, Amagasa S, Horikawa H, Shirahata M. Vecuronium directly inhibits hypoxic neurotransmission of the rat carotid body. Anesth Analg 2002; 94:117-122.
    • (2002) Anesth Analg , vol.94 , pp. 117-122
    • Igarashi, A.1    Amagasa, S.2    Horikawa, H.3    Shirahata, M.4
  • 24
    • 77954341541 scopus 로고    scopus 로고
    • High concentrations of dexmedetomidine inhibit compound action potentials in frog sciatic nerves without a2 adrenoceptor activation
    • Kosugi T, Mizuta K, Fujita T, et al. High concentrations of dexmedetomidine inhibit compound action potentials in frog sciatic nerves without a2 adrenoceptor activation. Br J Pharmacol 2010; 160:1662-1676.
    • (2010) Br J Pharmacol , vol.160 , pp. 1662-1676
    • Kosugi, T.1    Mizuta, K.2    Fujita, T.3
  • 25
    • 0030862290 scopus 로고    scopus 로고
    • Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine
    • Talke P, Richardson CA, Scheinin M, Fisher DM. Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine. Anesth Analg 1997; 85:1136-1142.
    • (1997) Anesth Analg , vol.85 , pp. 1136-1142
    • Talke, P.1    Richardson, C.A.2    Scheinin, M.3    Fisher, D.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.