High concentrations of dexmedetomidine inhibit compound action potentials in frog sciatic nerves without 2 adrenoceptor activation

British Journal of Pharmacology

Volumn 160, Issue 7, 2010, Pages 1662-1676

  Kosugi, Toshifumi ^a   Mizuta, Kotaro ^a   Fujita, Tsugumi ^a   Nakashima, Mikio ^a   Kumamoto, Eiichi ^a  

^a SAGA UNIVERSITY   (Japan)

Author keywords

adrenoceptors; compound action potential; dexmedetomidine; frog; local anaesthetic; sciatic nerve; tetracaine

Indexed keywords

ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ATIPAMEZOLE; CLONIDINE; DEXMEDETOMIDINE; ISOPRENALINE; NORADRENALIN; OXYMETAZOLINE; PHENYLEPHRINE; TETRACAINE; YOHIMBINE;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ANTAGONISM; DRUG POTENCY; DRUG STRUCTURE; FEMALE; FROG; IC 50; MALE; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE;

ACTION POTENTIALS; ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ADRENERGIC ALPHA-2 RECEPTOR ANTAGONISTS; ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; DEXMEDETOMIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; MOLECULAR STRUCTURE; RANIDAE; SCIATIC NERVE;

EID: 77954341541     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00833.x     Document Type: Article

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