Cellular mechanisms of oxygen sensing at the carotid body: Heme proteins and ion channels

Respiration Physiology

Volumn 122, Issue 2-3, 2000, Pages 209-221

  Prabhakar, Nanduri R ^a   Overholt, Jeffrey L ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Carotid body; Ion channels; K+; O2 sensing; Oxygen, reactive species; Transduction, carotid body

Indexed keywords

ION CHANNEL; POTASSIUM CHANNEL;

CAROTID BODY; CHEMORECEPTOR; CONDUCTANCE; CONFERENCE PAPER; HUMAN; NEUROTRANSMITTER RELEASE; NONHUMAN; OXIMETRY; PRIORITY JOURNAL; REVIEW; SECOND MESSENGER;

ANIMALS; CAROTID BODY; CHEMORECEPTORS; HEMEPROTEINS; HUMANS; ION CHANNELS; OXYGEN; OXYGEN CONSUMPTION;

EID: 0034284753     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5687(00)00160-2     Document Type: Article

References (78)

1. 2 sensor in the rat carotid body. FEBS Lett. 256:1989;75-78.
2. Alcayaga J., Varas R., Arroyo J., Iturriaga R., Zapata P. Responses to hypoxia of petrosal ganglia in vitro. Brain Res. 845:1999;28-34.
3. 2-adrenoreceptor-mediated inhibition in rabbit carotid body. Am. J. Physiol. 272:1997;C628-C637.
4. 2+ in dissociated type I cells of the rabbit carotid body. J. Physiol. Lond. 416:1989;421-434.
5. Bisgard G.E. The role of arterial chemoreceptors in ventilatory acclimatization to hypoxia. Adv. Exp. Med. Biol. 360:1994;109-122.
6. Bright G.R., Agani F.H., Haque U., Overholt J.L., Prabhakar N.R. Heterogeneity in cytosolic calcium responses to hypoxia in carotid body cells. Brain Res. 706:1996;297-302.
7. Buckler K.J. A novel oxygen-sensitive potassium current in rat carotid body type I cells. J. Physiol. Lond. 498:(3):1997;649-662.
8. +-currents and oxygen sensing in carotid body type 1 cells. Respir. Physiol. 115:1999;179-187.
9. Cheng P.M., Donnelly D.F. Relationship between changes of glomus cell current and neural response of rat carotid body. J. Neurophysiol. 74:1995;2077-2086.
10. Chou C.L., Shirahata M. Two types of voltage-gated K channels in carotid body cells of adult cats. Brain Res. 742:1996;34-42.
11. Chugh D.K., Katayarna M., Mokashi A., Bebout D.E., Ray D.K., Lahiri S. Nitric oxide-related inhibition of carotid chemosensory nerve activity in the cat. Respir. Physiol. 97:1994;147-156.
12. 2 sensor protein in the rat carotid body. Biochem. J. 272:1990;743-747.
13. De Castro F. Sur la structure et l'innervation de la glande intercarotidienne (glomus caroticum) de l'homme et des mammifères, et sur un nouveau système d'innervation autonome du nerf glossopharyngien. Trab. Lab. Invest. Biol. Univ. Madrid. 25:1926;365-432.
14. + channel in the type-I cell of the rabbit carotid body. FEBS Lett. 249:1989;195-198.
15. Donnelly D.F. Chemoreceptor nerve excitation may not be proportional to catecholamine secretion. J. Appl. Physiol. 81:1996;657-664.
16. 2+ channels in adult rat carotid body chemoreceptor type I cells. J. Physiol. Lond. 89:1995;689-699.
17. Fidone S.J., Gonzalez C., Obeso A., Gomez-Nino A., Dinger B. Biogenic amine and neuropeptide transmitters in carotid body chemotransmission: experimental findings and perspectives. Sutton J.R., Coates G., Remmers J.E. Hypoxia: The Adaptions. 1990;116-126 B.C. Decker.
18. Fieber L.A., McCleskey E.W. L-type calcium channels in type I cells of the rat carotid body. J. Neurophysiol. 70:1993;1378-1384.
19. Fitzgerald R.S. Oxygen and carotid body chemotransduction: the cholinergic hypothesis - a brief history and new evaluation. Respir. Physiol. 120:2000;89-104.
20. 2 tension. Proc. Natl. Acad. Sci. USA. 88:1991;2927-2930.
21. Ganfornina M.D., Lopez-Barneo J. Potassium channel types in arterial chemoreceptor cells and their selective modulation by oxygen. J. Gen. Physiol. 100:1992;401-426.
22. Gonzalez C., Almaraz L., Obeso A., Rigual R. Carotid body chemoreceptors: from natural stimuli to sensory discharges. Physiol. Rev. 74:1994;829-898.
23. Gonzalez C., Lopez-Lopez J.R., Obeso A., Perez-Garcia M.T., Rocher A. Cellular mechanisms of oxygen chemoreception in the carotid body. Respir. Physiol. 102:1995;137-147.
24. Gorlach A., Holtermann G., Jelkmann W., Hancock J.T., Jones S.A., Jones O.T., Acker H. Photometric characteristics of haem proteins in erythropoietin-producing hepatoma cells (HepG2). Biochem. J. 290:(Pt 3):1993;771-776.
25. + channel beta subunit. Cell. 97:1999;943-952.
26. + currents in isolated rat type I carotid body cells: evidence against the involvement of cyclic nucleotides. Pflug. Arch. 433:1996;129-135.
27. Hatton C.J., Peers C. Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am. J. Physiol. 271:1996;C85-C92.
28. Hescheler J., Delpiano M.A., Acker H., Pietruschka R. Ionic currents on type-I cells of the rabbit carotid body measured by voltage-clamp experiments and the effect of hypoxia. Brain Res. 486:1989;79-88.
29. Jackson A., Nurse C. Dopaminergic properties of cultured rat carotid body chemoreceptors grown in normoxic and hypoxic environments. J. Neurochem. 69:1997;645-654.
30. Kim D., Oh E.K., Summers B., Prabhakar N.R., Kumar G.K. Hypoxia releases substance P from the rabbit carotid body: evidence for the involvement of Ca2+ channels (abstract). FASEB J. 14:2000;A394.
31. Kline D.D., Yang T., Huang P.L., Prabhakar N.R. Altered respiratory responses to hypoxia in mutant mice deficient in neuronal nitric oxide synthase. J. Physiol. Lond. 511:(Pt 1):1998;273-287.
32. 2-adrenergic receptors in the carotid body response to isocapnic hypoxia. Respir. Physiol. 83:1991;353-364.
33. Kummer W., Acker H. Immunohistochemical demonstration of four subunits of neutrophil NAD(P)H oxidase in type I cells of carotid body. J. Appl. Physiol. 78:1995;1904-1909.
34. Lahiri S., Ray D.K., Chugh D., Iturriaga R., Mokashi A. Co-binding chromophores in oxygen chemoreception in the carotid body. Adv. Exp. Med. Biol. 360:1994;149-153.
35. O2 in type I cells in rat carotid body is not a chemosensor. Brain Res. 794:1998;162-165.
36. Lahiri S., Ehleben W., Acker H. Chemoreceptor discharges and cytochrome redox changes of the rat carotid body: role of heme ligands. Proc. Natl. Acad. Sci. USA. 96:1999;9427-9432.
37. Lahiri S., Prabhakar N.R., Forster R.E. Oxygen Sensing: Molecule to Man. 2000;Plenum, New York.
38. Lopez-Barneo J. Oxygen-sensing by ion channels and the regulation of cellular functions. Trends Neurosci. 19:1996;435-440.
39. 2 in type I chemoreceptor cells. Science. 241:1988;580-582.
40. 2 selectively inhibits K channel activity in chemoreceptor cells of the mammalian carotid body. J. Gen. Physiol. 93:1989;1001-1015.
41. + current in chemoreceptor cells of rabbit carotid body. J. Physiol. Lond. 460:1993;15-32.
42. Lopez-Lopez J.R., González C., Perez-Garcia M.T. Properties of ionic currents from isolated adult rat carotid body chemoreceptor cells: effect of hypoxia. J. Physiol. Lond. 499:(Pt 2):1997;429-441.
43. McDonald D.M. Structure and function of reciprocal synapses interconnecting glomus cells and sensory nerve terminals in the rat carotid body. Coupland R.E., Fujita E. Enterochromaffin and Related Cells. 1975;375-394 Elsevier, Amsterdam.
44. McDonald D.M. Structure-function relationships of chemoreceptive nerves in the carotid body. Am. Rev. Respir. Dis. 115:1977;193-207.
45. Mintz I.M., Adams M.E., Bean B.P. P-type calcium channels in rat central and peripheral neurons. Neuron. 9:1992;85-95.
46. Montoro R.J., Urena J., Fernandez-Chacon R., Alvarez de Toledo G., Lopez-Barneo J. Oxygen sensing by ion channels and chemotransduction in single glomus cells. J. Gen. Physiol. 107:1996;133-143.
47. 2 by oligomycin and by antimycin A. Am. J. Physiol. 242:1982;C200-C206.
48. Nurse C.A., Zhang M. Acetylcholine contributes to hypoxic chemotransmission in co-cultures of rat type 1 cells and petrosal neurons. Respir. Physiol. 115:1999;189-199.
49. 2+ channels in stimulus-evoked catecholamine release from chemoreceptor cells of the carotid body. Neuroscience. 47:1992;463-472.
50. 2 transduction in rat and rabbit CB chemoreceptor cells. Am. J. Physiol. 276:1999;C593-C601.
51. 2+ channels. J. Neurophysiol. 78:1997;2467-2474.
52. 2+ current in carotid body glomus cells: evidence for a direct G protein mechanism. J. Neurophysiol. 81:1999;225-233.
53. Overholt J.L., Ficker E., Yang T., Shams H., Bright G.R., Prabhakar N.R. A HERG-like potassium current regulates the resting membrane potential in glomus cells of the rabbit carotid body. J. Neurophysiol. 83:2000;1150-1157.
54. Overholt J.L., Ficker E., Yang T., Shams H., Bright G.R., Prabhakar N.R. Chemosensing at the carotid body: involvement of a HERG-like potassium current in glomus cells. Adv. Exp. Med. Biol. 475:2000b;241-248.
55. Pang L., Eyzaguirre C. Different effects of hypoxia on the membrane potential and input resistance of isolated and clustered carotid body glomus cells. Brain Res. 575:1992;167-173.
56. Pang L., Eyzaguirre C. Hypoxia affects differently the intracellular pH of clustered and isolated glomus cells of the rat carotid body. Brain Res. 623:1993;349-355.
57. + current. Neurosci. Lett. 119:1990;253-256.
58. +- channels in rat carotid body type I cells by protein kinase C. J. Physiol. Lond. 512:(Pt 3):1998;743-750.
59. 2+ channel currents in type I carotid body cells of normoxic and chronically hypoxic neonatal rats. Brain Res. 739:1996;251-257.
60. Perrin D.G., Cutz E., Becker L.E., Bryan A.C., Madapallimaturn A., Sole M.J. Sudden infant death syndrome: increased carotid-body dopamine and noradrenaline content. Lancet. 2:1984;535-537.
61. Ponte J., Sadler C.L. Studies on the regenerated carotid sinus nerve of the rabbit. J. Physiol. Lond. 410:1989;411-424.
62. Prabhakar N.R. Neurotransmitters in the carotid body. Adv. Exp. Med. Biol. 360:1994;57-69.
63. Prabhakar N.R. NO and CO as second messengers in oxygen sensing in the carotid body. Respir. Physiol. 115:1999;161-168.
64. Prabhakar N.R., Kou Y.R. Inhibitory sympathetic action on the carotid body responses to sustained hypoxia. Respir. Physiol. 95:1994;67-79.
65. Prabhakar N.R., Kumar G.K., Chang C.H., Agani F.H., Haxhiu M.A. Nitric oxide in the sensory function of the carotid body. Brain Res. 625:1993;16-22.
66. Prabhakar N.R., Dinerman J.L., Agani F.H., Snyder S.H. Carbon monoxide: a role in carotid body chemoreception. Proc. Natl. Acad. Sci. USA. 92:1995;1994-1997.
67. 2+ channel currents in rat cerebellar granule neurons. J. Neurosci. 15:1995;2995-3012.
68. 2+ current in glomus cells of the rabbit carotid body via a cGMP-independent mechanism. J. Neurophysiol. 81:1999;1449-1457.
69. Summers B.A., Overholt J.L., Prabhakar N.R. Augmentation of calcium current by hypoxia in carotid body glomus cells. Adv. Exp. Med. Biol. 475:2000;589-599.
70. Sun M.K., Reis D.J. Dopamine or transmitter release from rat carotid body may not be essential to hypoxic chemoreception. Am. J. Physiol. 267:1994;R1632-R1639.
71. + channels by reactive oxygen species. Proc. Natl. Acad. Sci. USA. 94:1997;11698-11703.
72. Urena J., Lopez-Lopez J.R., Gonzalez C., Lopez-Barneo J. Ionic currents in dispersed chemoreceptor cells of the mammalian carotid body. J. Gen. Physiol. 93:1989;979-999.
73. Verna A., Roumy M., Leitner L.M. Loss of chemoreceptive properties of the rabbit carotid body after destruction of the glomus cells. Brain Res. 100:1975;13-23.
74. Verna A., Schamel A., Pequignot J.M. Noradrenergic glomus cells in the carotid body: an autoradiographic and immunocytochemical study in the rabbit and rat. Adv. Exp. Med. Biol. 337:1993;93-100.
75. Vicario I., Rigual R., Obeso A., Gonzalez C. Characterization of the synthesis and release of catecholamine in the rat carotid body in vitro. Am. J. Physiol. 278:(3):2000;C490-C499.
76. Wang Z.Z., Stensaas L.J., Bredt D.S., Dinger B., Fidone S.J. Localization and actions of nitric oxide in the cat carotid body. Neuroscience. 60:1994;275-286.
77. + channels in isolated type I cells of the neonatal rat carotid body. J. Physiol. Lond. 483:(Pt 3):1995;559-565.
78. + currents in carotid body chemoreceptor cells from normoxic and chronically hypoxic rats and their roles in hypoxic chemotransduction. Proc. Natl. Acad. Sci. USA. 92:1995;295-299.