Effects of dexmedetomidine on respiratory mechanics and control of breathing in normal rats

Respiratory Physiology and Neurobiology

Volumn 154, Issue 3, 2006, Pages 342-350

  Fernandes, Fatima C ^a   Ferreira, Halina C ^a   Cagido, Viviane R ^a   Carvalho, Giovanna M C ^a   Pereira, Leonel S ^a   Faffe, Debora S ^a   Zin, Walter A ^a   Rocco, Patricia R M ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Blood gases; Elastance; Lung histology; Lung viscoelasticity; Mammals; Mechanics of breathing; Pathology; Rat; Ventilation

Indexed keywords

DEXMEDETOMIDINE; DIAZEPAM; PENTOBARBITAL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL BLOOD; ARTICLE; ARTIFICIAL VENTILATION; BREATHING MECHANICS; BREATHING PATTERN; BREATHING RATE; CONTROLLED STUDY; EXPIRATORY RESERVE VOLUME; HISTOLOGY; HYPERCAPNIA; INSPIRATORY RESERVE VOLUME; LUNG MINUTE VOLUME; MALE; MORPHOLOGY; MORPHOMETRICS; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; RAT; RESPIRATION CONTROL; RESPIRATION DEPRESSION; TIDAL VOLUME;

ADRENERGIC ALPHA-AGONISTS; ANESTHESIA; ANIMALS; DEXMEDETOMIDINE; DIAZEPAM; HYPNOTICS AND SEDATIVES; INHALATION; INJECTIONS, INTRAPERITONEAL; LUNG; MALE; PENTOBARBITAL; RATS; RATS, WISTAR; RESPIRATION; RESPIRATION, ARTIFICIAL; RESPIRATORY MECHANICS;

EID: 33751320650     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2006.02.002     Document Type: Article

References (35)

1. Angst M.S., Ramaswamy B., Davies M.F., and Maze M. Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and anfentanil in humans. Anesthesiology 101 (2004) 744-752
2. Bates J.H.T., Ludwig M.S., Sly P.D., Brown K.A., Martin J.G., and Fredberg J.J. Interrupter resistance elucidated by alveolar pressure measurement in open-chest normal dogs. J. Appl. Physiol. 65 (1988) 408-414
3. Baydur A., Behrakis P.K., Zin W.A., Jaeger M., and Milic-Emili J. A simple method for assessing the validity of the esophageal balloon technique. Am. Rev. Respir. Dis. 126 (1982) 788-791
4. Belleville J.P., Ward D.S., Bloor B.C., and Maze M. Effects of intravenous dexmedetomidine in humans. I. Sedation, ventilation and metabolic rate. Anesthesiology 77 (1992) 1125-1133
5. Bloor B.C., Frankland M., Alper G., Raybould D., Weitz J., and Shurtliff M. Hemodynamic and sedative effects of dexmedetomidine in dogs. J. Pharmacol. Exp. Ther. 263 (1992) 690-697
6. Bol C.J., Danhof M., Stanski D.R., and Mandema J.W. Pharmacokinetic-pharmacodynamic characterization of the cardiovascular, hypnotic, EEG and ventilatory responses to dexmedetomidine in the rat. J. Pharmacol. Exp. Ther. 283 (1997) 1051-1058
7. Caldeira M.P.R., Saldiva P.H.N., and Zin W.A. Vagal influences on respiratory mechanics, pressures, anc control in rats. Respir. Physiol. 73 (1988) 43-54
8. Correa F.C.F., Ciminelli P.B., Falcão H., Alcântara B.J.C., Contador R.S., Medeiros A.S., Zin W.A., and Rocco P.R.M. Respiratory mechanics and lung histology in normal rats anesthetized with sevoflurane. J. Appl. Physiol. 91 (2001) 803-810
9. 2-adrenoceptors. Anesthesiology 71 (1989) 75-79
10. Ebert T.J., Hall J.E., Barney J.A., Uhrich T.D., and Colinco M.D. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology 93 (2000) 382-394
11. 2-adrenoceptor agonist dexmedetomidine on bronchoconstriction in dogs. Anesthesiology 100 (2004) 359-363
12. Grundström N., Andersson R.G., and Wikberg J.E. Inhibition of the excitatory non-adrenergic, non-cholinergic neurotransmission in the guinea pig tracheo-bronchial tree mediated by alpha2 adrenoceptors. Acta Pharmacol. Toxicol. 54 (1984) 8-14
13. Grundström N., and Andersson R.G. Inhibition of the cholinergic neurotransmission in human airways via prejunctional alpha-2-adrenoceptors. Acta Physiol. Scand. 125 (1985) 513-517
14. 2-adrenergic agonist dexmedetomidine. Anesthesiology 88 (1988) 1634-1642
15. Hall J.E., Uhrich T.D., Barney J.A., Arain S.R., and Ebert T.J. Sedative, amnestic, and properties of small-dose dexmedetomidine infusions. Anesth. Analg. 90 (2000) 699-705
16. Hsu Y.W., Cortinez L.I., Robertson K.M., Keifer J.C., Sum-Ping S.T., Moretti E.W., Young C.C., Wright D.R., MacLeod D.B., and Somma J. Dexmedetomidine pharmacodynamics. Part I. Crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers. Anesthesiology 101 (2004) 1066-1076
17. Kneussl M.P., and Richardson J.B. Alpha-adrenergic receptors in human and canine tracheal and bronchial smooth muscle. J. Appl. Physiol. 45 (1978) 307-311
18. Manders W.T., and Vatner S.F. Effects of sodium pentobarbital anesthesia on left ventricular function and distribution of cardiac output in dogs, with particular reference to the mechanism for tachycardia. Circ. Res. 39 (1976) 512-517
19. Milic-Emili J., and Grunstein M.M. Drive and timing components of ventilation. Chest 70 (1976) 131-133
20. Mortola J.P., and Noworaj A. Two-sidearm tracheal cannula for respiratory airflow measurements in small animals. J. Appl. Physiol. 55 (1983) 250-253
21. Nagase T., Lei M., Robatto F.M., Eidelman D.H., and Ludwig M.S. Tissue viscance during induced constriction in rabbit lung: morphological-physiological correlation. J. Appl. Physiol. 73 (1992) 1900-1907
22. Nguyen D., Abdul-Rasool I., Ward D., Hsieh J., Kobayashi D., Hadlock S., Singer F., and Bloor B. Ventilatory effects of dexmedetomidine, atipamezole and isoflurane in dogs. Anesthesiology 76 (1992) 573-579
23. Nishida T., Nishimura M., Kagawa K., Hayashi Y., and Mashimo T. The effects of dexmedetomidine on the ventilatory response to hypercapnia in rabbits. Intensive Care Med. 28 (2002) 969-975
24. Ramsay M.A., and Luterman D.L. Dexmedetomidine as a total intravenous anesthetic agent. Anesthesiology 101 (2004) 787-790
25. Reta G.S., Riva J.A., Piriz H., Medeiros A.S., Rocco P.R.M., and Zin W.A. Effects of halothane on respiratory mechanics and lung histopathology in normal rats. Br. J. Anaesth. 84 (2000) 372-377
26. Rocco P.R.M., Faffe D.S., Feijoó M., Menezes S.L., Vasconcellos F.P., and Zin W.A. Effects of uni- and bilateral phrenicotomy on active and passive respiratory mechanics in rats. Respir. Physiol. 110 (1997) 9-18
27. Sakae R.S., Leme A.S., Dolnikoff M., Pereira P.M., Warth M.P.T.N., Zin W.A., Saldiva P.H.N., and Martins M.A. Neonatal capsaicin treatment decreases airway and pulmonary tissue responsiveness to methacholine. Am. J. Physiol. Lung Cell Mol. Physiol. 266 (1994) L23-L29
28. Salmenpera M.T., Szlam F., and Hug Jr. C.C. Anesthetic and hemodynamic interactions of dexmedetomidine and fentanyl in dogs. Anesthesiology 80 (1994) 837-846
29. Similowski T., Levy P., Corbeil C., Albala M., Pariente R., Derenne J.P., Bates J.H.T., Jonson B., and Milic-Emili J. Viscoelastic behavior of lung and chest wall in dogs determined by flow interruption. J. Appl. Physiol. 67 (1989) 2219-2229
30. Venn M., Newman J., and Grounds M. A phase II study to evaluate the efficacy of dexmedetomidine for sedation in the medical intensive care unit. Intensive Care Med. 29 (2003) 201-207
31. Weibel E.R. Morphometry: stereological theory and practical methods. In: Gil J. (Ed). Models of Lung Disease-Microscopy and Structural Methods (1990), Marcel Decker, New York 199-247
32. Whitelaw W.A., Derenne J.-P., and Milic-Emili J. Occlusion pressure as a measure of respiratory center output in conscious man. Respir. Physiol. 23 (1975) 181-199
33. Yamada K.A., Moerschbaecher J.M., Hamosh P., and Gillis R.A. Pentobarbital causes cardiorespiratory depression by interacting with a GABAergic system at the ventral surface of the medulla. J. Pharmacol. Exp. Ther. 226 (1983) 349-355
34. 2-adrenergic agonist, dexmedetomidine. Neuropharmacology 30 (1991) 1065-1071
35. Zornow M.H., Scheller M.S., Sheehan P.B., Strnat M.A.P., and Matsumoto M. Intracranial pressure effects of dexmedetomidine in rabbits. Anesth. Analg. 75 (1992) 232-237