Molecular dissection of dystrophin identifies the docking site for nNOS

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 2, 2013, Pages 387-388

  Harper, Scott Q ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DYSTROPHIN; NEURONAL NITRIC OXIDE SYNTHASE; SPECTRIN;

AMINO ACID SEQUENCE; DNA STRUCTURE; DUCHENNE MUSCULAR DYSTROPHY; MOLECULAR BIOLOGY; MOLECULAR DOCKING; NOTE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANIMALS; CELL MEMBRANE; DYSTROPHIN; MUSCULAR DYSTROPHY, DUCHENNE; NEURONS; NITRIC OXIDE SYNTHASE TYPE I; PROTEIN STRUCTURE, SECONDARY;

EID: 84872202057     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1220256110     Document Type: Note

References (16)

1. Dunham I, et al.; ENCODE Project Consortium (2012) An integrated encyclopedia of DNA elements in the human genome. Nature 489(7414):57-74.
2. Lai Y, Zhao J, Yue Y, Duan D (2013) α2 and α3 helices of dystrophin R16 and R17 frame a microdomain in the α1 helix of dystrophin R17 for neuronal NOS binding. Proc Natl Acad Sci USA 110:525-530.
3. KoenigM, Monaco AP, Kunkel LM (1988) The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein. Cell 53(2):219-228.
4. Monaco AP, et al. (1986) Isolation of candidate cDNAs for portions of the Duchenne muscular dystrophy gene. Nature 323(6089):646-650.
5. Harper SQ, Crawford RW, DelloRusso C, Chamberlain JS (2002) Spectrin-like repeats from dystrophin and alpha-actinin-2 are not functionally interchangeable. Hum Mol Genet 11(16):1807-1815.
6. Harper SQ, et al. (2002) Modular flexibility of dystrophin: Implications for gene therapy of Duchenne muscular dystrophy. Nat Med 8(3):253-261.
7. Lai Y, et al. (2009) Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy. J Clin Invest 119(3):624-635.
8. Legardinier S, et al. (2008) Sub-domains of the dystrophin rod domain display contrasting lipid-binding and stability properties. Biochim Biophys Acta 1784(4):672-682.
9. Mirza A, Sagathevan M, Sahni N, Choi L, Menhart N (2010) A biophysical map of the dystrophin rod. Biochim Biophys Acta 1804(9):1796-1809.
10. Rybakova IN, Amann KJ, Ervasti JM (1996) A new model for the interaction of dystrophin with F-actin. J Cell Biol 135(3):661-672.
11. Asai A, et al. (2007) Primary role of functional ischemia, quantitative evidence for the two-hit mechanism, and phosphodiesterase-5 inhibitor therapy in mouse muscular dystrophy. PLoS ONE 2(8):e806.
12. Brenman JE, Chao DS, Xia H, Aldape K, Bredt DS (1995) Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy. Cell 82(5):743-752.
13. Li D, Yue Y, Lai Y, Hakim CH, Duan D (2011) Nitrosative stress elicited by nNOSμ delocalization inhibits muscle force in dystrophin-null mice. J Pathol 223(1):88-98.
14. Rando TA (2001) Role of nitric oxide in the pathogenesis of muscular dystrophies: A "two hit" hypothesis of the cause of muscle necrosis. Microsc Res Tech 55(4):223-235.
15. England SB, et al. (1990) Very mild muscular dystrophy associated with the deletion of 46% of dystrophin. Nature 343(6254):180-182.
16. Aartsma-Rus A (2012) Overview on DMD exon skipping. Methods Mol Biol 867:97-116.