Glast-expressing progenitor cells contribute to heterotopic ossification

Bone

Volumn 53, Issue 1, 2013, Pages 194-203

  Kan, Lixin ^a   Peng, Chian Yu ^a   McGuire, Tammy L ^a   Kessler, John A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Bone morphogenetic protein (BMP); Fibrodysplasia ossificans progressiva (FOP); FoxD1 cre; Genetic lineage tracing; Glast creERT; Heterotopic ossification (HO)

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALVASCULIN; CRE RECOMBINASE; EXCITATORY AMINO ACID TRANSPORTER; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXD1; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LABELING; CELL POPULATION; CONTROLLED STUDY; HETEROTOPIC OSSIFICATION; HINDLIMB; INTERSTITIUM; LOXP SITE; MESENCHYME CELL; MOUSE; NONHUMAN; OSSIFICATION; PATHOGENESIS; PROTEIN EXPRESSION; SKELETAL MUSCLE; STEM CELL; SUBCUTANEOUS TISSUE;

ANIMALS; FORKHEAD TRANSCRIPTION FACTORS; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; OSSIFICATION, HETEROTOPIC; RECOMBINATION, GENETIC; STEM CELLS;

EID: 84872195498     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2012.12.008     Document Type: Article

References (39)

1. Potter B.K., Forsberg J.A., Davis T.A., Evans K.N., Hawksworth J.S., Tadaki D., et al. Heterotopic ossification following combat-related trauma. J Bone Joint Surg Am 2010, 92(Suppl. 2):74-89.
2. Shore E.M. Fibrodysplasia ossificans progressiva (FOP): a human genetic disorder of extra-skeletal bone formation, or - how does one tissue become another?. Wiley Interdiscip Rev Dev Biol 2012, 1:153-165.
3. Shore E.M., Kaplan F.S. Role of altered signal transduction in heterotopic ossification and fibrodysplasia ossificans progressiva. Curr Osteoporos Rep 2011, 9:83-88.
4. Kan L., Lounev V.Y., Pignolo R.J., Duan L., Liu Y., Stock S.R., et al. Substance P signaling mediates BMP-dependent heterotopic ossification. J Cell Biochem 2011, 112:2759-2772.
5. de Vlam K., Lories R.J., Luyten F.P. Mechanisms of pathologic new bone formation. Curr Rheumatol Rep 2006, 8:332-337.
6. Puzas J.E., Miller M.D., Rosier R.N. Pathologic bone formation. Clin Orthop Relat Res 1989, 269-281.
7. Lounev V.Y., Ramachandran R., Wosczyna M.N., Yamamoto M., Maidment A.D., Shore E.M., et al. Identification of progenitor cells that contribute to heterotopic skeletogenesis. J Bone Joint Surg Am 2009, 91:652-663.
8. Suda R.K., Billings P.C., Egan K.P., Kim J.H., McCarrick-Walmsley R., Glaser D.L., et al. Circulating osteogenic precursor cells in heterotopic bone formation. Stem Cells 2009, 27:2209-2219.
9. Mavrogenis A.F., Soucacos P.N., Papagelopoulos P.J. Heterotopic ossification revisited. Orthopedics 2011, 34:177.
10. Buring K. On the origin of cells in heterotopic bone formation. Clin Orthop Relat Res 1975, 293-301.
11. Friedenstein A., Kuralesova A.I. Osteogenic precursor cells of bone marrow in radiation chimeras. Transplantation 1971, 12:99-108.
12. Diaz-Flores L., Gutierrez R., Lopez-Alonso A., Gonzalez R., Varela H. Pericytes as a supplementary source of osteoblasts in periosteal osteogenesis. Clin Orthop Relat Res 1992, 280-286.
13. Wosczyna M.N., Biswas A.A., Cogswell C.A., Goldhamer D.J. Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification. J Bone Miner Res 2012, 27(5):1004-1017.
14. Kan L., Liu Y., McGuire T.L., Berger D.M., Awatramani R.B., Dymecki S.M., et al. Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification. Stem Cells 2009, 27:150-156.
15. Sauer B. Inducible gene targeting in mice using the Cre/lox system. Methods 1998, 14:381-392.
16. Shore FSK Eileen M., Lounev Vitali Lack of pericyte contribution to BMP4-induced heterotopic ossification 2010.
17. Goritz C., Dias D.O., Tomilin N., Barbacid M., Shupliakov O., Frisen J. A pericyte origin of spinal cord scar tissue. Science 2011, 333:238-242.
18. Humphreys B.D., Lin S.L., Kobayashi A., Hudson T.E., Nowlin B.T., Bonventre J.V., et al. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 2010, 176:85-97.
19. Schmitt A., Asan E., Puschel B., Kugler P. Cellular and regional distribution of the glutamate transporter GLAST in the CNS of rats: nonradioactive in situ hybridization and comparative immunocytochemistry. J Neurosci 1997, 17:1-10.
20. Rothstein J.D., Martin L., Levey A.I., Dykes-Hoberg M., Jin L., Wu D., et al. Localization of neuronal and glial glutamate transporters. Neuron 1994, 13:713-725.
21. Watase K., Hashimoto K., Kano M., Yamada K., Watanabe M., Inoue Y., et al. Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur J Neurosci 1998, 10:976-988.
22. Berger U.V., Hediger M.A. Distribution of the glutamate transporters GLAST and GLT-1 in rat circumventricular organs, meninges, and dorsal root ganglia. J Comp Neurol 2000, 421:385-399.
23. Slezak M., Goritz C., Niemiec A., Frisen J., Chambon P., Metzger D., et al. Transgenic mice for conditional gene manipulation in astroglial cells. Glia 2007, 55:1565-1576.
24. Berger U.V., Hediger M.A. Distribution of the glutamate transporters GLT-1 (SLC1A2) and GLAST (SLC1A3) in peripheral organs. Anat Embryol (Berl) 2006, 211:595-606.
25. Carreres M.I., Escalante A., Murillo B., Chauvin G., Gaspar P., Vegar C., et al. Transcription factor Foxd1 is required for the specification of the temporal retina in mammals. J Neurosci 2011, 31:5673-5681.
26. Herrera E., Marcus R., Li S., Williams S.E., Erskine L., Lai E., et al. Foxd1 is required for proper formation of the optic chiasm. Development 2004, 131:5727-5739.
27. Lin L., Peng S.L. Coordination of NF-kappaB and NFAT antagonism by the forkhead transcription factor Foxd1. J Immunol 2006, 176:4793-4803.
28. Levinson R.S., Batourina E., Choi C., Vorontchikhina M., Kitajewski J., Mendelsohn C.L. Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development. Development 2005, 132:529-539.
29. Duffield J.S., Humphreys B.D. Origin of new cells in the adult kidney: results from genetic labeling techniques. Kidney Int 2011, 79:494-501.
30. Madisen L., Zwingman T.A., Sunkin S.M., Oh S.W., Zariwala H.A., Gu H., et al. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 2010, 13:133-140.
31. Kan L., Hu M., Gomes W.A., Kessler J.A. Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype. Am J Pathol 2004, 165:1107-1115.
32. Medici D., Shore E.M., Lounev V.Y., Kaplan F.S., Kalluri R., Olsen B.R. Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med 2010, 16:1400-1406.
33. De Palma M., Venneri M.A., Galli R., Sergi Sergi L., Politi L.S., Sampaolesi M., et al. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 2005, 8:211-226.
34. Dore-Duffy P., Katychev A., Wang X., Van Buren E. CNS microvascular pericytes exhibit multipotential stem cell activity. J Cereb Blood Flow Metab 2006, 26:613-624.
35. Crisan M., Yap S., Casteilla L., Chen C.W., Corselli M., Park T.S., et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 2008, 3:301-313.
36. Armulik A., Genove G., Betsholtz C. Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev Cell 2011, 21:193-215.
37. Diaz-Flores L., Gutierrez R., Madrid J.F., Varela H., Valladares F., Acosta E., et al. Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche. Histol Histopathol 2009, 24:909-969.
38. Anthony T.E., Heintz N. Genetic lineage tracing defines distinct neurogenic and gliogenic stages of ventral telencephalic radial glial development. Neural Dev 2008, 3:30.
39. Mori T., Tanaka K., Buffo A., Wurst W., Kuhn R., Gotz M. Inducible gene deletion in astroglia and radial glia-a valuable tool for functional and lineage analysis. Glia 2006, 54:21-34.