Distribution of the glutamate transporters GLT-1 (SLC1A2) and GLAST (SLC1A3) in peripheral organs

Anatomy and Embryology

Volumn 211, Issue 6, 2006, Pages 595-606

  Berger, Urs V ^a,b   Hediger, Matthias A ^a,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UB In Situ   (United States)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

Glutamate; Kidney; Liver; Macrophage; Peripheral organs; Transport

Indexed keywords

GLUTAMATE TRANSPORTER;

ADIPOCYTE; ARTICLE; ASTROCYTE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LACRIMAL DUCT; LACRIMAL GLAND; LEYDIG CELL; LYMPH NODE; LYMPHOCYTE; MACROPHAGE; MAMMARY GLAND; NEUROTRANSMISSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALIVARY GLAND; SPLEEN;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; EPITHELIUM; EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2; FEMALE; KIDNEY; LACRIMAL APPARATUS; LIVER; LYMPHOID TISSUE; MALE; MAMMARY GLANDS, ANIMAL; OVARY; PROSTATE; RATS; RATS, SPRAGUE-DAWLEY; SALIVARY GLANDS; TISSUE DISTRIBUTION; TONGUE; URETHRA; URINARY BLADDER;

EID: 33845370329     PISSN: 03402061     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00429-006-0109-x     Document Type: Article

References (44)

1. Arriza JL, Fairman WA, Wadiche JI, Murdoch GH, Kavanaugh MP, Amara SG (1994) Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J Neurosci 14:5559-5569
2. Berger UV, Hediger MA (1998) Comparative analysis of glutamate transporter expression in rat brain using differential double in situ hybridization. Anat Embryol (Berl) 198:13-30
3. Berger UV, Hediger MA (2000) Distribution of the glutamate transporters GLAST and GLT-1 in rat circumventricular organs, meninges, and dorsal root ganglia. J Comp Neurol 421:385-399
4. Berger UV, Hediger MA (2001) Differential distribution of the glutamate transporters GLT-1 and GLAST in tanycytes of the third ventricle. J Comp Neurol 433:101-114
5. Cadoret A, Ovejero C, Terris B, Souil E, Levy L, Lamers WH, Kitajewski J, Kahn A, Perret C (2002) New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism. Oncogene 21:8293-8301
6. Chen W, Mahadomrongkul V, Berger UV, Bassan M, DeSilva T, Tanaka K, Irwin N, Aoki C, Rosenberg PA (2004) The glutamate transporter GLT1a is expressed in excitatory axon terminals of mature hippocampal neurons. J Neurosci 24:1136-1148
7. Chretien F, Vallat-Decouvelaere AV, Bossuet C, Rimaniol AC, Le Grand R, Le Pavec G, Creminon C, Dormont D, Gray F, Gras G (2002) Expression of excitatory amino acid transporter-2 (EAAT-2) and glutamine synthetase (GS) in brain macrophages and microglia of SIVmac251-infected macaques. Neuropathol Appl Neurobiol 28:410-417
8. Costello LC, Franklin RB (2002) Testosterone and prolactin regulation of metabolic genes and citrate metabolism of prostate epithelial cells. Horm Metabol Res 34:417-424
9. Franklin RB, Zou J, Yu Z, Costello LC (2006) EAAC1 is expressed in rat and human prostate epithelial cells; functions as a high-affinity L-aspartate transporter; and is regulated by prolactin and testosterone. BMC Biochem 7:10
10. Furness DN, Hulme JA, Lawton DM, Hackney CM (2002) Distribution of the glutamate/aspartate transporter GLAST in relation to the afferent synapses of outer hair cells in the guinea pig cochlea. J Assoc Res Otolaryngol 3:234-247
11. Furness DN, Lehre KP (1997) Immunocytochemical localization of a high-affinity glutamate-aspartate transporter, GLAST, in the rat and guinea-pig cochlea. Eur J Neurosci 9:1961-1969
12. Haugeto O, Ullensvang K, Levy LM, Chaudhry FA, Honore T, Nielsen M, Lehre KP, Danbolt NC (1996) Brain glutamate transporter proteins form homomultimers. J Biol Chem 271:27715-27722
13. Hediger MA (1999) Glutamate transporters in kidney and brain. Am J Physiol 277:F487-F492
14. Hediger MA, Welbourne TC (1999) Introduction: glutamate transport, metabolism, and physiological responses. Am J Physiol 277:F477-F480
15. Howell JA, Matthews AD, Swanson KC, Harmon DL, Matthews JC (2001) Molecular identification of high-affinity glutamate transporters in sheep and cattle forestomach, intestine, liver, kidney, and pancreas. J Anim Sci 79:1329-1336
16. Howell JA, Matthews AD, Welbourne TC, Matthews JC (2003) Content of ileal EAAC1 and hepatic GLT-1 high-affinity glutamate transporters is increased in growing vs. nongrowing lambs, paralleling increased tissue D- and L-glutamate, plasma glutamine, and alanine concentrations. J Anim Sci 81:1030-1039
17. Kanai Y, Hediger MA (2004) The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects. Pflugers Arch 447:469-479
18. Kawakami H, Tanaka K, Nakayama T, Inoue K, Nakamura S (1994) Cloning and expression of a human glutamate transporter. Biochem Biophys Res Commun 199:171-176
19. Kirschner MA, Copeland NG, Gilbert DJ, Jenkins NA, Amara SG (1994) Mouse excitatory amino acid transporter EAAT2: isolation, characterization, and proximity to neuroexcitability loci on mouse chromosome 2. Genomics 24:218-224
20. Kondo K, Hashimoto H, Kitanaka J, Sawada M, Suzumura A, Marunouchi T, Baba A (1995) Expression of glutamate transporters in cultured glial cells. Neurosci Lett 188:140-142
21. Kugler P, Schmitt A (2003) Complementary neuronal and glial expression of two high-affinity glutamate transporter GLT1/EAAT2 forms in rat cerebral cortex. Histochem Cell Biol 119:425-435
22. Lao L, Franklin RB, Costello LC (1993) High-affinity L-aspartate transporter in prostate epithelial cells that is regulated by testosterone. Prostate 22:53-63
23. Lawton DM, Furness DN, Lindemann B, Hackney CM (2000) Localization of the glutamate-aspartate transporter, GLAST, in rat taste buds. Eur J Neurosci 12:3163-3171
24. Lehre KP, Levy LM, Ottersen OP, Storm-Mathisen J, Danbolt NC (1995) Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations. J Neurosci 15:1835-1853
25. Li HS, Niedzielski AS, Beisel KW, Hiel H, Wenthold RJ, Morley BJ (1994) Identification of a glutamate/aspartate transporter in the rat cochlea. Hear Res 78:235-242
26. Martinez-Lopez I, Garcia C, Barber T, Vina JR, Miralles VJ (1998) The L-glutamate transporters GLAST (EAAT1) and GLT-1 (EAAT2): expression and regulation in rat lactating mammary gland. Mol Membr Biol 15:237-242
27. Mason DJ (2004) The role of glutamate transporters in bone cell signalling. J Musculoskelet Neuronal Interact 4:128-131
28. Mason DJ, Suva LJ, Genever PG, Patton AJ, Steuckle S, Hillam RA, Skerry TM (1997) Mechanically regulated expression of a neural glutamate transporter in bone: a role for excitatory amino acids as osteotropic agents? Bone 20:199-205
29. Matsuzaki T, Suzuki T, Koyama H, Tanaka S, Takata K (1999) Water channel protein AQP3 is present in epithelia exposed to the environment of possible water loss. J Histochem Cytochem 47:1275-1286
30. Matthews JC, Beveridge MJ, Malandro MS, Rothstein JD, Campbell-Thompson M, Verlander JW, Kilberg MS, Novak DA (1998) Activity and protein localization of multiple glutamate transporters in gestation day 14 vs. day 20 rat placenta. Am J Physiol 274:C603-C614
31. Mirels L, Kopec L, Yagil C, Dickinson DP, Dziejman M, Tabak LA (1990) Expression of glutamine/glutamic acid-rich proteins in rat submandibular glands. Arch Oral Biol 35:1-5
32. Nauntofte B (1992) Regulation of electrolyte and fluid secretion in salivary acinar cells. Am J Physiol 263:G823-G837
33. Noda M, Nakanishi H, Akaike N (1999) Glutamate release from microglia via glutamate transporter is enhanced by amyloid-beta peptide. Neuroscience 92:1465-1474
34. Redecker P, Kreutz MR, Bockmann J, Gundelfinger ED, Boeckers TM (2003) Brain synaptic junctional proteins at the acrosome of rat testicular germ cells. J Histochem Cytochem 51:809-819
35. Redecker P, Pabst H (2000) Immunohistochemical study of the glutamate transporter proteins GLT-1 and GLAST in rat and gerbil pineal gland. J Pineal Res 28:179-184
36. Rimaniol AC, Haik S, Martin M, Le Grand R, Boussin FD, Dereuddre-Bosquet N, Gras G, Dormont D (2000) Na+-dependent high-affinity glutamate transport in macrophages. J Immunol 164:5430-5438
37. Rimaniol AC, Mialocq P, Clayette P, Dormont D, Gras G (2001) Role of glutamate transporters in the regulation of glutathione levels in human macrophages. Am J Physiol Cell Physiol 281:C1964-C1970
38. Shashidharan P, Wittenberg I, Plaitakis A (1994) Molecular cloning of human brain glutamate/aspartate transporter II. Biochim Biophys Acta 1191:393-396
39. Shayakul C, Kanai Y, Lee WS, Brown D, Rothstein JD, Hediger MA (1997) Localization of the high-affinity glutamate transporter EAAC1 in rat kidney. Am J Physiol 273:F1023-F1029
40. Tanaka K (1993) Expression cloning of a rat glutamate transporter. Neurosci Res 16:149-153
41. Utsunomiya-Tate N, Endou H, Kanai Y (1997) Tissue specific variants of glutamate transporter GLT-1. FEBS Lett 416:312-316
42. van Landeghem FK, Stover JF, Bechmann I, Bruck W, Unterberg A, Buhrer C, von Deimling A (2001) Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat. Glia 35:167-179
43. Wagenfeld A, Yeung CH, Lehnert W, Nieschlag E, Cooper TG (2002) Lack of glutamate transporter EAAC1 in the epididymis of infertile c-ros receptor tyrosine-kinase deficient mice. J Androl 23:772-782
44. Welbourne T, Routh R, Yudkoff M, Nissim I (2001) The glutamine/glutamate couplet and cellular function. News Physiol Sci16:157-160