메뉴 건너뛰기




Volumn 32, Issue 2, 2013, Pages 190-197

MNK kinases facilitate c-myc IRES activity in rapamycin-treated multiple myeloma cells

Author keywords

c myc; IRES activity; MNK kinases; mTOR inhibitors; multiple myeloma; rapamycin

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MNK KINASE; MYC PROTEIN; PHOSPHOTRANSFERASE; RAPAMYCIN; RNA; UNCLASSIFIED DRUG;

EID: 84872194815     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.43     Document Type: Article
Times cited : (25)

References (32)
  • 3
    • 10244229652 scopus 로고    scopus 로고
    • In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model
    • DOI 10.1182/blood-2004-03-1153
    • Frost P, Moatomed F, Hoang B, Shi Y, Gera J, Yan H et al. In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model. Blood 2004; 104: 4181-4187. (Pubitemid 39620172)
    • (2004) Blood , vol.104 , Issue.13 , pp. 4181-4187
    • Frost, P.1    Moatamed, F.2    Hoang, B.3    Shi, Y.4    Gera, J.5    Yan, H.6    Frost, P.7    Gibbons, J.8    Lichtenstein, A.9
  • 4
    • 0036735346 scopus 로고    scopus 로고
    • Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779
    • Shi Y, Gera J, Hu L, Hsu JH, Bookstein R, Li W et al. Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779. Cancer Res 2002; 62: 5027-5034. (Pubitemid 34984430)
    • (2002) Cancer Research , vol.62 , Issue.17 , pp. 5027-5034
    • Shi, Y.1    Gera, J.2    Hu, L.3    Hsu, J.-H.4    Bookstein, R.5    Li, W.6    Lichtenstein, A.7
  • 5
    • 15744386891 scopus 로고    scopus 로고
    • Cyclin d1 and c-myc iresdependent translation is regulated by akt activity and enhanced by rapamycin through a p38 mapk-And erk-dependent pathway
    • Shi Y, Sharma A, Wu H, Lichtenstein A, Gera J. Cyclin D1 and c-myc IRESdependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK-And ERK-dependent pathway. J Biol Chem 2005; 280: 10964-109973.
    • (2005) J Biol Chem , vol.280 , pp. 10964-109973
    • Shi, Y.1    Sharma, A.2    Wu, H.3    Lichtenstein, A.4    Gera, J.5
  • 6
    • 58149490636 scopus 로고    scopus 로고
    • Regulation of d-cyclin translation inhibition in myeloma cells treated with mtor inhibitors: Rationale for combined treatment with erk inhibitors and rapamycin
    • Frost P, Shi Y, Hoang B, Gera J, Lichtenstein A. Regulation of D-cyclin translation inhibition in myeloma cells treated with mTOR inhibitors: Rationale for combined treatment with ERK inhibitors and rapamycin. Mol Cancer Ther 2009; 8: 83-93.
    • (2009) Mol Cancer Ther , vol.8 , pp. 83-93
    • Frost, P.1    Shi, Y.2    Hoang, B.3    Gera, J.4    Lichtenstein, A.5
  • 7
    • 0035476376 scopus 로고    scopus 로고
    • Internal ribosome entry segment-mediated initiation of c-Myc protein synthesis following genotoxic stress
    • DOI 10.1042/0264-6021:3590183
    • Subkhankulova T, Mitchell SA, Willis AE. IRES-mediated initiation of c-myc protein synthesis following genotoxic stress. Biochem J 2001; 359: 183-192. (Pubitemid 32939220)
    • (2001) Biochemical Journal , vol.359 , Issue.1 , pp. 183-192
    • Subkhankulova, T.1    Mitchell, S.A.2    Willis, A.E.3
  • 9
    • 27844500638 scopus 로고    scopus 로고
    • Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties
    • DOI 10.1074/jbc.M508356200
    • Parra JL, Buxade M, Proud CG. Features of the catalytic domains and C termini of the MAPK signal-integrating kinases MNK1 and MNK2 determine their differing activities and regulatory properties. J Biol Chem 2005; 280: 37623-37633. (Pubitemid 41642371)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.45 , pp. 37623-37633
    • Parra, J.L.1    Buxade, M.2    Proud, C.G.3
  • 10
    • 35648962915 scopus 로고    scopus 로고
    • Inhibition of mtor induces pi3-kinase-dependent and mnk-mediated eif-4e phosphorylation
    • Wang X, Yue P, Chan C-B, Ye K, Ueda T, Watanabe-Fukunaga R et al. Inhibition of mTOR induces PI3-kinase-dependent and MNK-mediated eIF-4E phosphorylation. Mol Cell Biol 2007; 27: 7405-7413.
    • (2007) Mol Cell Biol , vol.27 , pp. 7405-7413
    • Wang, X.1    Yue, P.2    Chan, C.-B.3    Ye, K.4    Ueda, T.5    Watanabe-Fukunaga, R.6
  • 11
    • 33644947020 scopus 로고    scopus 로고
    • Mnk is a negative regulator of cap-dependent translation in aplysia neurons
    • Ross G, Dyer JR, Castellucci VF, Sossin WS. MNK is a negative regulator of cap-dependent translation in Aplysia neurons. J Neurochem 2006; 97: 79-91.
    • (2006) J Neurochem , vol.97 , pp. 79-91
    • Ross, G.1    Dyer, J.R.2    Castellucci, V.F.3    Sossin, W.S.4
  • 12
    • 23844516065 scopus 로고    scopus 로고
    • The Mnks are novel components in the control of TNFalpha biosynthesis and phosphorylate and regulate hnRNP A1
    • DOI 10.1016/j.immuni.2005.06.009, PII S1074761305002128
    • Buxade M, Parra JL, Rousseau S, Shpiro N, Marquez R, Morrice N et al. The MNKs are novel components in the control of TNF alpha biosynthesis andphosphorylate and regulate hnRNP A1. Immunity 2005; 23: 177-189. (Pubitemid 41169287)
    • (2005) Immunity , vol.23 , Issue.2 , pp. 177-189
    • Buxade, M.1    Parra, J.L.2    Rousseau, S.3    Shpiro, N.4    Marquez, R.5    Morrice, N.6    Bain, J.7    Espel, E.8    Proud, C.G.9
  • 13
    • 0035133659 scopus 로고    scopus 로고
    • The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells
    • DOI 10.1128/MCB.21.3.743-754.2001
    • Scheper GC, Morrice NA, Kleijn M, Proud CG. The mitogen-Activated protein kinase signal-integrating kinase MNK2 is an eIF-4E kinase with high levels of basal activity in mammalian cells. Mol Cell Biol 2001; 21: 743-754. (Pubitemid 32104723)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.3 , pp. 743-754
    • Scheper, G.C.1    Morrice, N.A.2    Kleijn, M.3    Proud, C.G.4
  • 15
    • 3242719457 scopus 로고    scopus 로고
    • Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development
    • DOI 10.1128/MCB.24.15.6539-6549.2004
    • Ueda T, Watanabe-Fukunaga R, Fukuyama H, Nagata S, Fukunaga R. MNK2 and MNK1 are essential for constitutive and inducible phosphorylation of eIF-4E but not for cell growth or development. Mol Cell Biol 2004; 24: 6539-6549. (Pubitemid 38944335)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.15 , pp. 6539-6549
    • Ueda, T.1    Watanabe-Fukunaga, R.2    Fukuyama, H.3    Nagata, S.4    Fukunaga, R.5
  • 16
    • 0242497942 scopus 로고    scopus 로고
    • Features in the N and C termini of the MAPK-interacting kinase Mnk1 mediate its nucleocytoplasmic shuttling
    • DOI 10.1074/jbc.M302398200
    • Parra-Palau JL, Scheper GC, Wilson ML, Proud CG. Features in the N and C termini of the MAPK-integrating kinase MNK1 mediate its nucleocytoplasmic shuttling. J Biol Chem 2003; 278: 44197-44204. (Pubitemid 37377163)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.45 , pp. 44197-44204
    • Parra-Palau, J.-L.1    Scheper, G.C.2    Wilson, M.L.3    Proud, C.G.4
  • 19
    • 2342633872 scopus 로고    scopus 로고
    • Cellular internal ribosome entry segments: Structures, trans-acting factors and regulation of gene expression
    • DOI 10.1038/sj.onc.1207551
    • Stoneley M, Willis AE. Cellular IRESes: structures, trans-Acting factors and regulation of gene expression. Oncogene 2004; 23: 3200-3207. (Pubitemid 38638831)
    • (2004) Oncogene , vol.23 , Issue.18 , pp. 3200-3207
    • Stoneley, M.1    Willis, A.E.2
  • 21
    • 0034618402 scopus 로고    scopus 로고
    • A mutation in the c-myc ires leads to enhanced internal ribosome entry in multiple myeloma: A novel mechanism of oncogene de-regulation
    • Chappell SA, LeQuesne JPC, Paulin FEM, deSchoolmeester ML, Stoneley M, Soutar RL et al. A mutation in the c-myc IRES leads to enhanced internal ribosome entry in multiple myeloma: A novel mechanism of oncogene de-regulation. Oncogene 2000; 19: 4437-4440.
    • (2000) Oncogene , vol.19 , pp. 4437-4440
    • Chappell, S.A.1    LeQuesne, J.P.C.2    Paulin, F.E.M.3    De Schoolmeester, M.L.4    Stoneley, M.5    Soutar, R.L.6
  • 22
    • 23844438209 scopus 로고    scopus 로고
    • Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
    • DOI 10.1158/0008-5472.CAN-05-0917
    • Sun S-Y, Rosenberg LM, Wang X, Zhou Z, Yue P, Fu H et al. Activation of AKT and eIF4E survival pathways by rapamycin-mediated mTOR inhibition. Cancer Res 2005; 65: 7052-7058. (Pubitemid 41161231)
    • (2005) Cancer Research , vol.65 , Issue.16 , pp. 7052-7058
    • Sun, S.-Y.1    Rosenberg, L.M.2    Wang, X.3    Zhou, Z.4    Yue, P.5    Fu, H.6    Khuri, F.R.7
  • 23
    • 57749102689 scopus 로고    scopus 로고
    • Il-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc ires function and the rna-binding protein hnrnp a1
    • Shi Y, Frost PJ, Hoang B, Benavides A, Sharma S, Gera J et al. IL-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc IRES function and the RNA-binding protein hnRNP A1. Cancer Res 2008; 68: 10215-10222.
    • (2008) Cancer Res , vol.68 , pp. 10215-10222
    • Shi, Y.1    Frost, P.J.2    Hoang, B.3    Benavides, A.4    Sharma, S.5    Gera, J.6
  • 24
    • 53149153190 scopus 로고    scopus 로고
    • Heterogeneous nuclear ribonucleoprotein a'1 regulates cyclin d and c-myc ires function through akt signaling
    • Jo OD, Martin J, Bernath A, Masri J, Lichtenstein A, Gera J. Heterogeneous nuclear ribonucleoprotein A'1 regulates cyclin D and c-myc IRES function through AKT signaling. J Biol Chem 2008; 283: 23274-23287.
    • (2008) J Biol Chem , vol.283 , pp. 23274-23287
    • Jo, O.D.1    Martin, J.2    Bernath, A.3    Masri, J.4    Lichtenstein, A.5    Gera, J.6
  • 25
    • 0037066071 scopus 로고    scopus 로고
    • Expression of poly(C)-binding proteins is differentially regulated by hypoxia and ischemia in cortical neurons
    • DOI 10.1016/S0306-4522(01)00522-X, PII S030645220100522X
    • Zhu Y, Sun Y, Mao O, Jin KL, Greenberg D. Expression of poly(C) binding proteins is differentially regulated by hypoxia and ischemia in cortical neurons. Neuroscience 2002; 110: 191-198. (Pubitemid 34214938)
    • (2002) Neuroscience , vol.110 , Issue.2 , pp. 191-198
    • Zhu, Y.1    Sun, Y.2    Mao, X.O.3    Jin, K.L.4    Greenberg, D.A.5
  • 26
    • 0345549480 scopus 로고    scopus 로고
    • Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo
    • DOI 10.1038/sj.onc.1206645
    • Evans JR, Mitchell SA, Spriggs KA, Ostrowski J, Bomsztyk K, Ostarek D et al. Members of the poly (rC) binding protein family stimulate the activity of the c-myc IRES in vitro and in vivo. Oncogene 2003; 22: 8012-8020. (Pubitemid 37175865)
    • (2003) Oncogene , vol.22 , Issue.39 , pp. 8012-8020
    • Evans, J.R.1    Mitchell, S.A.2    Spriggs, K.A.3    Ostrowski, J.4    Bomsztyk, K.5    Ostarek, D.6    Willis, A.E.7
  • 27
    • 67349241955 scopus 로고    scopus 로고
    • Deptor is an mtor inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
    • Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM et al. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 2009; 137: 1-14.
    • (2009) Cell , vol.137 , pp. 1-14
    • Peterson, T.R.1    Laplante, M.2    Thoreen, C.C.3    Sancak, Y.4    Kang, S.A.5    Kuehl, W.M.6
  • 28
    • 68649117850 scopus 로고    scopus 로고
    • Phase ii trial of temsirolimus in patients with relapsed or refractory multiple myeloma
    • Farag SS, Zhang S, Jansak BS, Wang X, Kraut E, Chan K et al. Phase II trial of temsirolimus in patients with relapsed or refractory multiple myeloma. Leuk Res 2009; 33: 1475-1480.
    • (2009) Leuk Res , vol.33 , pp. 1475-1480
    • Farag, S.S.1    Zhang, S.2    Jansak, B.S.3    Wang, X.4    Kraut, E.5    Chan, K.6
  • 31
    • 78649471733 scopus 로고    scopus 로고
    • Targeting torc2 in multiple myeloma with a new mtor kinase inhibitor
    • Hoang B, Frost P, Shi Y, Belanger E, Benavides A, Pezeshkpour G et al. Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor. Blood 2010; 116: 4560-4568.
    • (2010) Blood , vol.116 , pp. 4560-4568
    • Hoang, B.1    Frost, P.2    Shi, Y.3    Belanger, E.4    Benavides, A.5    Pezeshkpour, G.6
  • 32
    • 0030977269 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
    • DOI 10.1093/emboj/16.8.1909
    • Waskiewicz AJ, Flynn A, Proud CG, Cooper JA. Mitogen-Activated protein kinases activate the serine/threonine kinses MNK1 and MNK2. EMBO J 1997; 16: 1909-1920. (Pubitemid 27170952)
    • (1997) EMBO Journal , vol.16 , Issue.8 , pp. 1909-1920
    • Waskiewicz, A.J.1    Flynn, A.2    Proud, C.G.3    Cooper, J.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.