High Throughput Phenotypic Selection of Mycobacterium tuberculosis Mutants with Impaired Resistance to Reactive Oxygen Species Identifies Genes Important for Intracellular Growth

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Mestre, Olga ^a   Hurtado Ortiz, Raquel ^a   Dos Vultos, Tiago ^a,e   Namouchi, Amine ^a   Cimino, Mena ^a   Pimentel, Madalena ^b   Neyrolles, Olivier ^c,d   Gicquel, Brigitte ^a  

^a INSTITUT PASTEUR   (France)

^b RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^c INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^d UNIVERSITÉ PAUL SABATIER   (France)

^e F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; REACTIVE OXYGEN METABOLITE;

ARTICLE; BACTERIAL GENOME; BACTERIAL GROWTH; BACTERIAL MEMBRANE; BACTERIAL METABOLISM; BACTERIAL SURVIVAL; BACTERIUM MUTANT; CELL PROTECTION; CONTROLLED STUDY; GENE FUNCTION; GENE IDENTIFICATION; GENE LIBRARY; GENETIC POLYMORPHISM; HIGH THROUGHPUT SCREENING; HOST CELL; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; TRANSPOSON; BACTERIAL GENE; DISEASE RESISTANCE; DRUG EFFECTS; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIOLOGY; MUTATION; PATHOLOGY; PHYSIOLOGY; TUBERCULOSIS, PULMONARY;

MYCOBACTERIUM TUBERCULOSIS;

DISEASE RESISTANCE; GENES, BACTERIAL; HIGH-THROUGHPUT SCREENING ASSAYS; HOST-PATHOGEN INTERACTIONS; HUMANS; MACROPHAGES; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PHENOTYPE; REACTIVE OXYGEN SPECIES; TUBERCULOSIS, PULMONARY;

EID: 84872193109     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053486     Document Type: Article

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