Bacterial peptidoglycan (murein) hydrolases

FEMS Microbiology Reviews

Volumn 32, Issue 2, 2008, Pages 259-286

  Vollmer, Waldemar ^a,b   Joris, Bernard ^c   Charlier, Paulette ^c   Foster, Simon ^d  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF LIÈGE   (Belgium)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Amidase; Endopeptidase; Glucosaminidase; Lytic transglycosylase; Peptidoglycan; Peptidoglycan hydrolase

Indexed keywords

BACTERIAL ENZYME; BACTERIAL PROTEIN; BETA LACTAM ANTIBIOTIC; CARBOXYPEPTIDASE; DEXTRO ALANINE; GLYCOSYLTRANSFERASE; HYDROLASE; LYSOZYME; METALLOPROTEINASE; MURAMIC ACID; N ACETYL BETA GLUCOSAMINIDASE; N ACETYLMURAMOYLALANINE AMIDASE; PENICILLIN BINDING PROTEIN; PENICILLIN G; PEPTIDOGLYCAN; PROTEINASE; SIGNAL PEPTIDE; TRIPEPTIDE;

ACTINOMADURA; ACTINOMYCETALES; AMINO TERMINAL SEQUENCE; APOPTOSIS; AUTOLYSIS; BACILLUS SUBTILIS; BACTERIAL CELL WALL; BACTERIAL GENOME; BACTERIAL GROWTH; BACTERIAL IMMUNITY; BIOFILM; CARBOXY TERMINAL SEQUENCE; CELL GROWTH; CELLULAR DISTRIBUTION; CITROBACTER FREUNDII; CLOSTRIDIUM; COVALENT BOND; CYTOLYSIS; CYTOPLASM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INACTIVATION; ENZYME INDUCTION; ENZYME SPECIFICITY; GENETIC REGULATION; GENETIC TRANSFORMATION; GERMINATION; HOST PATHOGEN INTERACTION; IMMUNOCOMPETENT CELL; LACTOCOCCUS LACTIS; LISTERIA MONOCYTOGENES; MICROBIAL IMMUNITY; MICROBIAL POPULATION DYNAMICS; MICROSCOPY; MOLECULAR WEIGHT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PAENIBACILLUS POLYMYXA; PROTEIN ASSEMBLY; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROCESSING; REGULATORY MECHANISM; REVIEW; SEQUENCE HOMOLOGY; SPORE GERMINATION; SPOROGENESIS; STAPHYLOCOCCUS EPIDERMIDIS; STREPTOMYCES ALBUS;

BACTERIAL PHYSIOLOGY; BACTERIAL PROTEINS; BACTERIOLYSIS; CELL DIVISION; CELL WALL; N-ACETYLMURAMOYL-L-ALANINE AMIDASE; PEPTIDOGLYCAN; SPORES, BACTERIAL;

BACTERIA (MICROORGANISMS);

EID: 39149144016     PISSN: 01686445     EISSN: 15746976     Source Type: Journal    
DOI: 10.1111/j.1574-6976.2007.00099.x     Document Type: Review

References (274)

1. Abanes-De Mello A, Sun YL, Aung S Pogliano K (2002) A cytoskeleton-like role for the bacterial cell wall during engulfment of the Bacillus subtilis forespore. Genes Dev 16 : 3253 3264.
2. Ahn SJ Burne RA (2006) The atlA operon of Streptococcus mutans: role in autolysin maturation and cell surface biogenesis. J Bacteriol 188 : 6877 6888.
3. Antignac A, Sieradzki K Tomasz A (2007) Perturbation of cell wall synthesis suppresses autolysis in Staphylococcus aureus: evidence for co-regulation of cell wall synthetic and hydrolytic enzymes. J Bacteriol 189 : 7573 7580.
4. Archibald AR (1976) Cell wall assembly in Bacillus subtilis: development of bacteriophage-binding properties as a result of the pulsed incorporation of teichoic acid. J Bacteriol 127 : 956 960.
5. Arthur M, Depardieu F, Cabanie L, Reynolds P Courvalin P (1998) Requirement of the VanY and VanX d,d-peptidases for glycopeptide resistance in enterococci. Mol Microbiol 30 : 819 830.
6. Atrih A Foster SJ (2001) In vivo roles of the germination-specific lytic enzymes of Bacillus subtilis 168. Microbiology 147 : 2925 2932.
7. Atrih A, Zollner P, Allmaier G Foster SJ (1996) Structural analysis of Bacillus subtilis 168 endospore peptidoglycan and its role during differentiation. J Bacteriol 178 : 6173 6183.
8. Atrih A, Zollner P, Allmaier G, Williamson MP Foster SJ (1998) Peptidoglycan structural dynamics during germination of Bacillus subtilis 168 endospores. J Bacteriol 180 : 4603 4612.
9. Atrih A, Bacher G, Allmaier G, Williamson MP Foster SJ (1999) Analysis of peptidoglycan structure from vegetative cells of Bacillus subtilis 168 and role of PBP 5 in peptidoglycan maturation. J Bacteriol 181 : 3956 3966.
10. Baba T Schneewind O (1998) Targeting of muralytic enzymes to the cell division site of gram-positive bacteria: repeat domains direct autolysin to the equatorial surface ring of Staphylococcus aureus. Embo J 17 : 4639 4646.
11. Bagyan I Setlow P (2002) Localization of the cortex lytic enzyme CwlJ in spores of Bacillus subtilis. J Bacteriol 184 : 1219 1224.
12. Barrett JF, Dolinger DL, Schramm VL Shockman GD (1984) The mechanism of soluble peptidoglycan hydrolysis by an autolytic muramidase. A processive exodisaccharidase. J Biol Chem 259 : 11818 11827.
13. Bateman A Bycroft M (2000) The structure of a LysM domain from E. coli membrane-bound lytic murein transglycosylase D (MltD). J Mol Biol 299 : 1113 1119.
14. Bateman A Rawlings ND (2003) The CHAP domain: a large family of amidases including GSP amidase and peptidoglycan hydrolases. Trends Biochem Sci 28 : 234 237.
15. Bera A, Herbert S, Jakob A, Vollmer W Götz F (2005) Why are pathogenic staphylococci so lysozyme resistant? The peptidoglycan O-acetyltransferase OatA is the major determinant for lysozyme resistance of Staphylococcus aureus. Mol Microbiol 55 : 778 787.
16. Bernhardt TG de Boer PA (2003) The Escherichia coli amidase AmiC is a periplasmic septal ring component exported via the twin-arginine transport pathway. Mol Microbiol 48 : 1171 1182.
17. Bernhardt TG De Boer PA (2004) Screening for synthetic lethal mutants in Escherichia coli and identification of EnvC (YibP) as a periplasmic septal ring factor with murein hydrolase activity. Mol Microbiol 52 : 1255 1269.
18. Biswas R, Voggu L, Simon UK, Hentschel P, Thumm G Götz F (2006) Activity of the major staphylococcal autolysin Atl. FEMS Microbiol Lett 259 : 260 268.
19. Blackburn NT Clarke AJ (2001) Identification of four families of peptidoglycan lytic transglycosylases. J Mol Evol 52 : 78 84.
20. Blackman SA, Smith TJ Foster SJ (1998) The role of autolysins during vegetative growth of Bacillus subtilis 168. Microbiology 144 : 73 82.
21. Bochtler M, Odintsov SG, Marcyjaniak M Sabala I (2004) Similar active sites in lysostaphins and d-Ala-d-Ala metallopeptidases. Protein Sci 13 : 854 861.
22. Boland FM, Atrih A, Chirakkal H, Foster SJ Moir A (2000) Complete spore-cortex hydrolysis during germination of Bacillus subtilis 168 requires SleB and YpeB. Microbiology 146 : 57 64.
23. Bourgerie S, Karamanos Y, Grard T Julien R (1994) Purification and characterization of an endo-N-acetyl-beta-d-glucosaminidase from the culture medium of Stigmatella aurantiaca DW4. J Bacteriol 176 : 6170 6174.
24. Brunskill EW Bayles KW (1996) Identification of LytSR-regulated genes from Staphylococcus aureus. J Bacteriol 178 : 5810 5812.
25. Bussiere DE, Pratt SD, Katz L, Severin JM, Holzman T Park CH (1998) The structure of VanX reveals a novel amino-dipeptidase involved in mediating transposon-based vancomycin resistance. Mol Cell 2 : 75 84.
26. Calamita HG, Ehringer WD, Koch AL Doyle RJ (2001) Evidence that the cell wall of Bacillus subtilis is protonated during respiration. Proc Natl Acad Sci USA 98 : 15260 15263.
27. Carballido-Lopez R Errington J (2003) A dynamic bacterial cytoskeleton. Trends Cell Biol 13 : 577 583.
28. Carballido-Lopez R, Formstone A, Li Y, Ehrlich SD, Noirot P Errington J (2006) Actin homolog MreBH governs cell morphogenesis by localization of the cell wall hydrolase LytE. Dev Cell 11 : 399 409.
29. Catt DM Gregory RL (2005) Streptococcus mutans murein hydrolase. J Bacteriol 187 : 7863 7865.
30. Charlier P, Wery JP, Dideberg O Frere J-M (2003) Streptomyces albus G d-Ala-d-Ala carboxypeptidase. Handbook of Metalloproteins, Vol. 3 (Messerschmidt A, Bode W Cygler M, eds), pp. 164 175. Wiley, Chichester.
31. Chastanet A Losick R (2007) Engulfment during sporulation in Bacillus subtilis is governed by a multi-protein complex containing tandemly acting autolysins. Mol Microbiol 64 : 139 152.
32. Cheng X, Zhang X, Pflugrath JW Studier FW (1994) The structure of bacteriophage T7 lysozyme, a zinc amidase and an inhibitor of T7 RNA polymerase. Proc Natl Acad Sci USA 91 : 4034 4038.
33. Cheung HY Freese E (1985) Monovalent cations enable cell wall turnover of the turnover-deficient lyt-15 mutant of Bacillus subtilis. J Bacteriol 161 : 1222 1225.
34. Cheung HY, Vitkovic L Freese E (1983) Rates of peptidoglycan turnover and cell growth of Bacillus subtilis are correlated. J Bacteriol 156 : 1099 1106.
35. Chirakkal H, O'Rourke M, Atrih A, Foster SJ Moir A (2002) Analysis of spore cortex lytic enzymes and related proteins in Bacillus subtilis endospore germination. Microbiology 148 : 2383 2392.
36. Clarke AJ Dupont C (1992) O-acetylated peptidoglycan: its occurrence, pathobiological significance, and biosynthesis. Can J Microbiol 38 : 85 91.
37. Clausen VA, Bae W, Throup J, Burnham MK, Rosenberg M Wallis NG (2003) Biochemical characterization of the first essential two-component signal transduction system from Staphylococcus aureus and Streptococcus pneumoniae. J Mol Microbiol Biotechnol 5 : 252 260.
38. Claverys JP Havarstein LS (2007) Cannibalism and fratricide: mechanisms and raisons d'etre. Nat Rev Microbiol 5 : 219 229.
39. Cleveland RF, Wicken AJ, Daneo-Moore L Shockman GD (1976) Inhibition of wall autolysis in Streptococcus faecalis by lipoteichoic acid and lipids. J Bacteriol 126 : 192 197.
40. Costerton JW, Cheng KJ, Geesey GG, Ladd TI, Nickel JC, Dasgupta M Marrie TJ (1987) Bacterial biofilms in nature and disease. Annu Rev Microbiol 41 : 435 464.
41. Courtin P, Miranda G, Guillot A et al 2006) Peptidoglycan structure analysis of Lactococcus lactis reveals the presence of an l,d-carboxypeptidase involved in peptidoglycan maturation. J Bacteriol 188 : 5293 5298.
42. Dagkessamanskaia A, Moscoso M, Henard V et al 2004) Interconnection of competence, stress and CiaR regulons in Streptococcus pneumoniae: competence triggers stationary phase autolysis of ciaR mutant cells. Mol Microbiol 51 : 1071 1086.
43. Daniel RA Errington J (2003) Control of cell morphogenesis in bacteria: two distinct ways to make a rod-shaped cell. Cell 113 : 767 776.
44. Davies C, White SW Nicholas RA (2001) Crystal structure of a deacylation-defective mutant of penicillin-binding protein 5 at 2.3-A resolution. J Biol Chem 276 : 616 623.
45. de Boer WR, Kruyssen FJ Wouters JT (1981) Cell wall turnover in batch and chemostat cultures of Bacillus subtilis. J Bacteriol 145 : 50 60.
46. de Boer WR, Meyer PD, Jordens CG, Kruyssen FJ Wouters JT (1982) Cell wall turnover in growing and nongrowing cultures of Bacillus subtilis. J Bacteriol 149 : 977 984.
47. De Las Rivas B, Garcia JL, Lopez R Garcia P (2002) Purification and polar localization of pneumococcal LytB, a putative endo-beta-N- acetylglucosaminidase: the chain-dispersing murein hydrolase. J Bacteriol 184 : 4988 5000.
48. Demchick P Koch AL (1996) The permeability of the wall fabric of Escherichia coli and Bacillus subtilis. J Bacteriol 178 : 768 773.
49. Denome SA, Elf PK, Henderson TA, Nelson DE Young KD (1999) Escherichia coli mutants lacking all possible combinations of eight penicillin binding proteins: viability, characteristics, and implications for peptidoglycan synthesis. J Bacteriol 181 : 3981 3993.
50. Desvaux M, Dumas E, Chafsey I Hebraud M (2006) Protein cell surface display in gram-positive bacteria: from single protein to macromolecular protein structure. FEMS Microbiol Lett 256 : 1 15.
51. Dhalluin A, Bourgeois I, Pestel-Caron M et al 2005) Acd, a peptidoglycan hydrolase of Clostridium difficile with N-acetylglucosaminidase activity. Microbiology 151 : 2343 2351.
52. Downing KJ, Mischenko VV, Shleeva MO et al 2005) Mutants of Mycobacterium tuberculosis lacking three of the five rpf-like genes are defective for growth in vivo and for resuscitation in vitro. Infect Immun 73 : 3038 3043.
53. Draft MJ, Burnham JC Yamamoto Y (1985) Lysis of Phormidium iridum by Myxococcus fulvus in continuous flow cultures. J Appl Bacteriol 59 : 73 80.
54. Dubrac S Msadek T (2004) Identification of genes controlled by the essential YycG/YycF two-component system of Staphylococcus aureus. J Bacteriol 186 : 1175 1181.
55. Dziarski R (2003) Recognition of bacterial peptidoglycan by the innate immune system. Cell Mol Life Sci 60 : 1793 1804.
56. Dziarski R Gupta D (2005) Peptidoglycan recognition in innate immunity. J Endotoxin Res 11 : 304 310.
57. Dziarski R Gupta D (2006) The peptidoglycan recognition proteins (PGRPs). Genome Biol 7 : 232.
58. Eckert C, Lecerf M, Dubost L, Arthur M Mesnage S (2006) Functional analysis of AtlA, the major N-acetylglucosaminidase of Enterococcus faecalis. J Bacteriol 188 : 8513 8519.
59. Ehlert K, Höltje J-V Templin MF (1995) Cloning and expression of a murein hydrolase lipoprotein from Escherichia coli. Mol Microbiol 16 : 761 768.
60. Ellermeier CD, Hobbs EC, Gonzalez-Pastor JE Losick R (2006) A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin. Cell 124 : 549 559.
61. Engel H, van Leeuwen A, Dijkstra A Keck W (1992) Enzymatic preparation of 1,6-anhydro-muropeptides by immobilized murein hydrolases from Escherichia coli fused to staphylococcal protein A. Appl Microbiol Biotechnol 37 : 772 783.
62. Errington J (2003) Regulation of endospore formation in Bacillus subtilis. Nat Rev Microbiol 1 : 117 126.
63. Fabret C Hoch JA (1998) A two-component signal transduction system essential for growth of Bacillus subtilis: implications for anti-infective therapy. J Bacteriol 180 : 6375 6383.
64. Fernandez-Tornero C, Lopez R, Garcia E, Gimenez-Gallego G Romero A (2001) A novel solenoid fold in the cell wall anchoring domain of the pneumococcal virulence factor LytA. Nat Struct Biol 8 : 1020 1024.
65. Fernandez-Tornero C, Garcia E, Lopez R, Gimenez-Gallego G Romero A (2002) Two new crystal forms of the choline-binding domain of the major pneumococcal autolysin: insights into the dynamics of the active homodimer. J Mol Biol 321 : 163 173.
66. Firczuk M Bochtler M (2007) Mutational analysis of peptidoglycan amidase MepA. Biochemistry 46 : 120 128.
67. Firczuk M, Mucha A Bochtler M (2005) Crystal structures of active LytM. J Mol Biol 354 : 578 590.
68. Fischer W, Rosel P Koch HU (1981) Effect of alanine ester substitution and other structural features of lipoteichoic acids on their inhibitory activity against autolysins of Staphylococcus aureus. J Bacteriol 146 : 467 475.
69. Fonze E, Vermeire M, Nguyen-Disteche M, Brasseur R Charlier P (1999) The crystal structure of a penicilloyl-serine transferase of intermediate penicillin sensitivity. The DD-transpeptidase of Streptomyces K15. J Biol Chem 274 : 21853 21860.
70. Foster SJ (1992) Analysis of the autolysins of Bacillus subtilis 168 during vegetative growth and differentiation by using renaturing polyacrylamide gel electrophoresis. J Bacteriol 174 : 464 470.
71. Foster SJ (1995) Molecular characterization and functional analysis of the major autolysin of Staphylococcus aureus 8325/4. J Bacteriol 177 : 5723 5725.
72. Foster SJ Johnstone K (1988) Germination-specific cortex-lytic enzyme is activated during triggering of Bacillus megaterium KM spore germination. Mol Microbiol 2 : 727 733.
73. Foster SJ Johnstone K (1990) Pulling the trigger: the mechanism of bacterial spore germination. Mol Microbiol 4 : 137 141.
74. Foster SJ Popham DL (2002) Structure and synthesis of cell wall, spore cortex, teichoic acids, S-layers and capsules. Bacillus subtilis and its Closest Relatives: from Genes to Cells (Sonenshein AL, Hoch JA Losick R, eds), pp. 21 41. ASM Press, Washington, DC.
75. Fukushima T, Yamamoto H, Atrih A, Foster SJ Sekiguchi J (2002) A polysaccharide deacetylase gene (pdaA) is required for germination and for production of muramic delta-lactam residues in the spore cortex of Bacillus subtilis. J Bacteriol 184 : 6007 6015.
76. Fukushima T, Afkham A, Kurosawa S, Tanabe T, Yamamoto H Sekiguchi J (2006) A new d,l-endopeptidase gene product, YojL (renamed CwlS), plays a role in cell separation with LytE and LytF in Bacillus subtilis. J Bacteriol 188 : 5541 5550.
77. Fukushima T, Yao Y, Kitajima T, Yamamoto H Sekiguchi J (2007) Characterization of new l,d-endopeptidase gene product CwlK (previous YcdD) that hydrolyzes peptidoglycan in Bacillus subtilis. Mol Genet Genomics 278 : 371 383.
78. Gallant CV, Daniels C, Leung JM, Ghosh AS, Young KD, Kotra LP Burrows LL (2005) Common beta-lactamases inhibit bacterial biofilm formation. Mol Microbiol 58 : 1012 1024.
79. Garcia DL Dillard JP (2006) AmiC functions as an N-acetylmuramyl-l- alanine amidase necessary for cell separation and can promote autolysis in Neisseria gonorrhoeae. J Bacteriol 188 : 7211 7221.
80. Garcia P, Paz Gonzalez M, Garcia E, Garcia JL Lopez R (1999a) The molecular characterization of the first autolytic lysozyme of Streptococcus pneumoniae reveals evolutionary mobile domains. Mol Microbiol 33 : 128 138.
81. Garcia P, Gonzalez MP, Garcia E, Lopez R Garcia JL (1999b) LytB, a novel pneumococcal murein hydrolase essential for cell separation. Mol Microbiol 31 : 1275 1277.
82. Ghuysen JM (1968) Use of bacteriolytic enzymes in determination of wall structure and their role in cell metabolism. Bacteriol Rev 32 (suppl) : 425 464.
83. Gilbert HJ (2007) Cellulosomes: microbial nanomachines that display plasticity in quaternary structure. Mol Microbiol 63 : 1568 1576.
84. Gilmore ME, Bandyopadhyay D, Dean AM, Linnstaedt SD Popham DL (2004) Production of muramic δ-lactam in Bacillus subtilis spore peptidoglycan. J Bacteriol 186 : 80 89.
85. Gittins JR, Phoenix DA Pratt JM (1994) Multiple mechanisms of membrane anchoring of Escherichia coli penicillin-binding proteins. FEMS Microbiol Rev 13 : 1 12.
86. Goffin C Ghuysen JM (1998) Multimodular penicillin-binding proteins: an enigmatic family of orthologs and paralogs. Microbiol Mol Biol Rev 62 : 1079 1093.
87. Gonzalez-Pastor JE, Hobbs EC Losick R (2003) Cannibalism by sporulating bacteria. Science 301 : 510 513.
88. Goodell EW (1985) Recycling of murein by Escherichia coli. J Bacteriol 163 : 305 310.
89. Goodell EW Schwarz U (1983) Cleavage and resynthesis of peptide cross bridges in Escherichia coli murein. J Bacteriol 156 : 136 140.
90. Goodell EW Schwarz U (1985) Release of cell wall peptides into culture medium by exponentially growing Escherichia coli. J Bacteriol 162 : 391 397.
91. Goodell EW, Lopez R Tomasz A (1976) Suppression of lytic effect of beta lactams on Escherichia coli and other bacteria. Proc Natl Acad Sci USA 73 : 3293 3297.
92. Guinane CM, Cotter PD, Ross RP Hill C (2006) Contribution of penicillin-binding protein homologs to antibiotic resistance, cell morphology, and virulence of Listeria monocytogenes EGDe. Antimicrob Agents Chemother 50 : 2824 2828.
93. Guiral S, Mitchell TJ, Martin B Claverys J-P (2005) Competence-programmed predation of noncompetent cells in the human pathogen Streptococcus pneumoniae: genetic requirements. Proc Natl Acad Sci USA 102 : 8710 8715.
94. Harris F, Brandenburg K, Seydel U Phoenix D (2002) Investigations into the mechanisms used by the C-terminal anchors of Escherichia coli penicillin-binding proteins 4, 5, 6 and 6b for membrane interaction. Eur J Biochem 269 : 5821 5829.
95. Heidrich C, Templin MF, Ursinus A et al 2001) Involvement of N-acetylmuramyl-l-alanine amidases in cell separation and antibiotic-induced autolysis of Escherichia coli. Mol Microbiol 41 : 167 178.
96. Heidrich C, Ursinus A, Berger J, Schwarz H Höltje J-V (2002) Effects of multiple deletions of murein hydrolases on viability, septum cleavage, and sensitivity to large toxic molecules in Escherichia coli. J Bacteriol 184 : 6093 6099.
97. Heilmann C, Hussain M, Peters G Götz F (1997) Evidence for autolysin-mediated primary attachment of Staphylococcus epidermidis to a polystyrene surface. Mol Microbiol 24 : 1013 1024.
98. Heinrich P, Rosenstein R, Bohmer M, Sonner P Götz F (1987) The molecular organization of the lysostaphin gene and its sequences repeated in tandem. Mol Gen Genet 209 : 563 569.
99. Henderson TA, Templin M Young KD (1995) Identification and cloning of the gene encoding penicillin-binding protein 7 of Escherichia coli. J Bacteriol 177 : 2074 2079.
100. Herbold DR Glaser L (1975a) Interaction of N-acetylmuramic acid l-alanine amidase with cell wall polymers. J Biol Chem 250 : 7231 7238.
101. Herbold DR Glaser L (1975b) Bacillus subtilis N-acetylmuramic acid l-alanine amidase. J Biol Chem 250 : 1676 1682.
102. Heymer B Schmidt WC (1975) Purification and characterization of a Streptomyces albus endo-N-acetylmuramidase lytic for group A and other beta haemolytic streptococci. Microbios 12 : 51 66.
103. Höltje J-V (1995) From growth to autolysis: the murein hydrolases in Escherichia coli. Arch Microbiol 164 : 243 254.
104. Höltje J-V (1996a) A hypothetical holoenzyme involved in the replication of the murein sacculus of Escherichia coli. Microbiology 142 : 1911 1918.
105. Höltje J-V (1996b) Bacterial lysozymes. Lysozymes: Model Enzymes in Biochemistry and Biology (Jolles P, ed), pp. 65 74. Birkhäuser Verlag, Basel, Switzerland.
106. Höltje J-V (1996c) Molecular interplay of murein synthases and murein hydrolases in Escherichia coli. Microb Drug Resist 2 : 99 103.
107. Höltje J-V (1998) Growth of the stress-bearing and shape-maintaining murein sacculus of Escherichia coli. Microbiol Mol Biol Rev 62 : 181 203.
108. Höltje J-V Tomasz A (1975) Lipoteichoic acid: a specific inhibitor of autolysin activity in pneumococcus. Proc Natl Acad Sci USA 72 : 1690 1694.
109. Höltje J-V Tuomanen EI (1991) The murein hydrolases of Escherichia coli: properties, functions and impact on the course of infections in vivo. J Gen Microbiol 137 : 441 454.
110. Höltje J-V, Mirelman D, Sharon N Schwarz U (1975) Novel type of murein transglycosylase in Escherichia coli. J Bacteriol 124 : 1067 1076.
111. Höltje J-V, Kopp U, Ursinus A Wiedemann B (1994) The negative regulator of beta-lactamase induction AmpD is a N-acetyl-anhydromuramyl-l- alanine amidase. FEMS Microbiol Lett 122 : 159 164.
112. Horsburgh GJ, Atrih A Foster SJ (2003a) Characterization of LytH, a differentiation-associated peptidoglycan hydrolase of Bacillus subtilis involved in endospore cortex maturation. J Bacteriol 185 : 3813 3820.
113. Horsburgh GJ, Atrih A, Williamson MP Foster SJ (2003b) LytG of Bacillus subtilis is a novel peptidoglycan hydrolase: the major active glucosaminidase. Biochemistry 42 : 257 264.
114. Hourdou ML, Duez C, Joris B, Vacheron MJ, Guinand M, Michel G Ghuysen JM (1992) Cloning and nucleotide sequence of the gene encoding the gamma-d-glutamyl-l-diamino acid endopeptidase II of Bacillus sphaericus. FEMS Microbiol Lett 70 : 165 170.
115. Hourdou ML, Guinand M, Vacheron MJ et al 1993) Characterization of the sporulation-related gamma-d-glutamyl-(l)meso-diaminopimelic-acid-hydrolysing peptidase I of Bacillus sphaericus NCTC 9602 as a member of the metallo(zinc) carboxypeptidase A family. Modular design of the protein. Biochem J 292 : 563 570.
116. Howell A, Dubrac S, Andersen KK, Noone D, Fert J, Msadek T Devine K (2003) Genes controlled by the essential YycG/YycF two-component system of Bacillus subtilis revealed through a novel hybrid regulator approach. Mol Microbiol 49 : 1639 1655.
117. Huard C, Miranda G, Wessner F, Bolotin A, Hansen J, Foster SJ Chapot-Chartier MP (2003) Characterization of AcmB, an N-acetylglucosaminidase autolysin from Lactococcus lactis. Microbiology 149 : 695 705.
118. Huard C, Miranda G, Redko Y, Wessner F, Foster SJ Chapot-Chartier MP (2004) Analysis of the peptidoglycan hydrolase complement of Lactococcus lactis: identification of a third N-acetylglucosaminidase, AcmC. Appl Environ Microbiol 70 : 3493 3499.
119. Hughes RC, Tanner PJ Stokes E (1970) Cell-wall thickening in Bacillus subtilis. Comparison of thickened and normal walls. Biochem J 120 : 159 170.
120. Ishikawa S, Yamane K Sekiguchi J (1998) Regulation and characterization of a newly deduced cell wall hydrolase gene (cwlJ) which affects germination of Bacillus subtilis spores. J Bacteriol 180 : 1375 1380.
121. Jacobs C, Joris B, Jamin M et al 1995) AmpD, essential for both beta-lactamase regulation and cell wall recycling, is a novel cytosolic N-acetylmuramyl-l-alanine amidase. Mol Microbiol 15 : 553 559.
122. Jacobs C, Frere JM Normark S (1997) Cytosolic intermediates for cell wall biosynthesis and degradation control inducible beta-lactam resistance in gram-negative bacteria. Cell 88 : 823 832.
123. Jolles P (1996) Lysozymes: Model Enzymes in Biochemistry and Biology. Birkhäuser, Basel.
124. Jolliffe LK, Doyle RJ Streips UN (1981) The energized membrane and cellular autolysis in Bacillus subtilis. Cell 25 : 753 763.
125. Jones LJ, Carballido-Lopez R Errington J (2001) Control of cell shape in bacteria: helical, actin-like filaments in Bacillus subtilis. Cell 104 : 913 922.
126. Joris B, Englebert S, Chu CP, Kariyama R, Daneo-Moore L, Shockman GD Ghuysen JM (1992) Modular design of the Enterococcus hirae muramidase-2 and Streptococcus faecalis autolysin. FEMS Microbiol Lett 70 : 257 264.
127. Kaiser D (2003) Coupling cell movement to multicellular development in myxobacteria. Nat Rev Microbiol 1 : 45 54.
128. Kaiser D (2004) Signaling in myxobacteria. Annu Rev Microbiol 58 : 75 98.
129. Kajimura J, Fujiwara T, Yamada S et al 2005) Identification and molecular characterization of an N-acetylmuramyl-l-alanine amidase Sle1 involved in cell separation of Staphylococcus aureus. Mol Microbiol 58 : 1087 1101.
130. Karamanos Y (1997) Endo-N-acetyl-beta-d-glucosaminidases and their potential substrates: structure/function relationships. Res Microbiol 148 : 661 671.
131. Kawamura T Shockman GD (1983) Purification and some properties of the endogenous, autolytic N-acetylmuramoylhydrolase of Streptococcus faecium, a bacterial glycoenzyme. J Biol Chem 258 : 9514 9521.
132. Keck W Schwarz U (1979) Escherichia coli murein-dd-endopeptidase insensitive to beta-lactam antibiotics. J Bacteriol 139 : 770 774.
133. Keck W, van Leeuwen AM, Huber M Goodell EW (1990) Cloning and characterization of mepA, the structural gene of the penicillin-insensitive murein endopeptidase from Escherichia coli. Mol Microbiol 4 : 209 219.
134. Keep NH, Ward JM, Cohen-Gonsaud M Henderson B (2006) Wake up! Peptidoglycan lysis and bacterial non-growth states. Trends Microbiol 14 : 271 276.
135. Kishida H, Unzai S, Roper DI, Lloyd A, Park SY Tame JR (2006) Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics. Biochemistry 45 : 783 792.
136. Koch AL (1990) Additional arguments for the key role of "smart" autolysins in the enlargement of the wall of gram-negative bacteria. Res Microbiol 141 : 529 541.
137. Koch AL Doyle RJ (1985) Inside-to-outside growth and turnover of the wall of gram-positive rods. J Theor Biol 117 : 137 157.
138. Koch AL, Kirchner G, Doyle RJ Burdett ID (1985) How does a Bacillus split its septum right down the middle? Ann Inst Pasteur Microbiol 136A : 91 98.
139. Komatsuzawa H, Sugai M, Nakashima S, Yamada S, Matsumoto A, Oshida T Suginaka H (1997) Subcellular localization of the major autolysin, ATL and its processed proteins in Staphylococcus aureus. Microbiol Immunol 41 : 469 479.
140. Koraimann G (2003) Lytic transglycosylases in macromolecular transport systems of gram-negative bacteria. Cell Mol Life Sci 60 : 2371 2388.
141. Korndorfer IP, Danzer J, Schmelcher M, Zimmer M, Skerra A Loessner MJ (2006) The crystal structure of the bacteriophage PSA endolysin reveals a unique fold responsible for specific recognition of Listeria cell walls. J Mol Biol 364 : 678 689.
142. Korsak D, Vollmer W Markiewicz Z (2005a) Listeria monocytogenes EGD lacking penicillin-binding protein 5 (PBP5) produces a thicker cell wall. FEMS Microbiol Lett 251 : 281 288.
143. Korsak D, Liebscher S Vollmer W (2005b) Susceptibility to antibiotics and beta-lactamase induction in murein hydrolase mutants of Escherichia coli. Antimicrob Agents Chemother 49 : 1404 1409.
144. Korza HJ Bochtler M (2005) Pseudomonas aeruginosa ld-carboxypeptidase, a serine peptidase with a Ser-His-Glu triad and a nucleophilic elbow. J Biol Chem 280 : 40802 40812.
145. Kraft AR, Templin MF Höltje J-V (1998) Membrane-bound lytic endotransglycosylase in Escherichia coli. J Bacteriol 180 : 3441 3447.
146. Kraft AR, Prabhu J, Ursinus A Höltje J-V (1999) Interference with murein turnover has no effect on growth but reduces beta-lactamase induction in Escherichia coli. J Bacteriol 181 : 7192 7198.
147. Kuroda A Sekiguchi J (1993) High-level transcription of the major Bacillus subtilis autolysin operon depends on expression of the sigma D gene and is affected by a sin (flaD) mutation. J Bacteriol 175 : 795 801.
148. Kuroda A, Asami Y Sekiguchi J (1993) Molecular cloning of a sporulation-specific cell wall hydrolase gene of Bacillus subtilis. J Bacteriol 175 : 6260 6268.
149. Lawrence PJ Strominger JL (1970) Biosynthesis of the peptidoglycan of bacterial cell walls XVI. The reversible fixation of radioactive penicillin G to the d-alanine carboxypeptidase of Bacillus subtilis. J Biol Chem 245 : 3660 3666.
150. Lazarevic V, Margot P, Soldo B Karamata D (1992) Sequencing and analysis of the Bacillus subtilis lytRABC divergon: a regulatory unit encompassing the structural genes of the N-acetylmuramoyl-l-alanine amidase and its modifier. J Gen Microbiol 138 (Part 9) : 1949 1961.
151. Leung AK, Duewel HS, Honek JF Berghuis AM (2001) Crystal structure of the lytic transglycosylase from bacteriophage lambda in complex with hexa-N-acetylchitohexaose. Biochemistry 40 : 5665 5673.
152. Lewis K (2000) Programmed death in bacteria. Microbiol Mol Biol Rev 64 : 503 514.
153. Liepinsh E, Genereux C, Dehareng D, Joris B Otting G (2003) NMR structure of Citrobacter freundii AmpD, comparison with bacteriophage T7 lysozyme and homology with PGRP domains. J Mol Biol 327 : 833 842.
154. Loessner MJ (2005) Bacteriophage endolysins - current state of research and applications. Curr Opin Microbiol 8 : 480 487.
155. Loessner MJ, Wendlinger G Scherer S (1995) Heterogeneous endolysins in Listeria monocytogenes bacteriophages: a new class of enzymes and evidence for conserved holin genes within the siphoviral lysis cassettes. Mol Microbiol 16 : 1231 1241.
156. Lommatzsch J, Templin MF, Kraft AR, Vollmer W Höltje J-V (1997) Outer membrane localization of murein hydrolases: MltA, a third lipoprotein lytic transglycosylase in Escherichia coli. J Bacteriol 179 : 5465 5470.
157. Lopez R, Garcia E Ronda C (1981) Bacteriophages of Streptococcus pneumoniae. Rev Infect Dis 3 : 212 223.
158. Low LY, Yang C, Perego M, Osterman A Liddington RC (2005) Structure and lytic activity of a Bacillus anthracis prophage endolysin. J Biol Chem 280 : 35433 35439.
159. Lu JZ, Fujiwara T, Komatsuzawa H, Sugai M Sakon J (2006) Cell wall-targeting domain of glycylglycine endopeptidase distinguishes among peptidoglycan cross-bridges. J Biol Chem 281 : 549 558.
160. Marcyjaniak M, Odintsov SG, Sabala I Bochtler M (2004) Peptidoglycan amidase MepA is a LAS metallopeptidase. J Biol Chem 279 : 43982 43989.
161. Margot P Karamata D (1992) Identification of the structural genes for N-acetylmuramoyl-l-alanine amidase and its modifier in Bacillus subtilis 168: inactivation of these genes by insertional mutagenesis has no effect on growth or cell separation. Mol Gen Genet 232 : 359 366.
162. Margot P, Mauel C Karamata D (1994) The gene of the N- acetylglucosaminidase, a Bacillus subtilis 168 cell wall hydrolase not involved in vegetative cell autolysis. Mol Microbiol 12 : 535 545.
163. Margot P, Pagni M Karamata D (1999) Bacillus subtilis 168 gene lytF encodes a gamma-d-glutamate-meso-diaminopimelate muropeptidase expressed by the alternative vegetative sigma factor, sigmaD. Microbiology 145 : 57 65.
164. Markiewicz Z, Glauner B Schwarz U (1983) Murein structure and lack of dd- and ld-carboxypeptidase activities in Caulobacter crescentus. J Bacteriol 156 : 649 655.
165. Martin PK, Li T, Sun D, Biek DP Schmid MB (1999) Role in cell permeability of an essential two-component system in Staphylococcus aureus. J Bacteriol 181 : 3666 3673.
166. Meador-Parton J Popham DL (2000) Structural analysis of Bacillus subtilis spore peptidoglycan during sporulation. J Bacteriol 182 : 4491 4499.
167. Meberg BM, Paulson AL, Priyadarshini R Young KD (2004) Endopeptidase penicillin-binding proteins 4 and 7 play auxiliary roles in determining uniform morphology of Escherichia coli. J Bacteriol 186 : 8326 8336.
168. Meisel U, Höltje J-V Vollmer W (2003) Overproduction of inactive variants of the murein synthase PBP1B causes lysis in Escherichia coli. J Bacteriol 185 : 5342 5348.
169. Mengin-Lecreulx D Lemaitre B (2005) Structure and metabolism of peptidoglycan and molecular requirements allowing its detection by the Drosophila innate immune system. J Endotoxin Res 11 : 105 111.
170. Mengin-Lecreulx D, van Heijenoort J Park JT (1996) Identification of the mpl gene encoding UDP-N-acetylmuramate: l-alanyl-gamma-d-glutamyl-meso- diaminopimelate ligase in Escherichia coli and its role in recycling of cell wall peptidoglycan. J Bacteriol 178 : 5347 5352.
171. Mercier C, Durrieu C, Briandet R, Domakova E, Tremblay J, Buist G Kulakauskas S (2002) Positive role of peptidoglycan breaks in lactococcal biofilm formation. Mol Microbiol 46 : 235 243.
172. Milohanic E, Jonquieres R, Cossart P, Berche P Gaillard JL (2001) The autolysin Ami contributes to the adhesion of Listeria monocytogenes to eukaryotic cells via its cell wall anchor. Mol Microbiol 39 : 1212 1224.
173. Monterroso B, Lopez-Zumel C, Garcia JL, Saiz JL, Garcia P, Campillo NE Menendez M (2005) Unravelling the structure of the pneumococcal autolytic lysozyme. Biochem J 391 : 41 49.
174. Moriyama R, Fukuoka H, Miyata S et al 1999) Expression of a germination-specific amidase, SleB, of Bacilli in the forespore compartment of sporulating cells and its localization on the exterior side of the cortex in dormant spores. J Bacteriol 181 : 2373 2378.
175. Morlot C, Noirclerc-Savoye M, Zapun A, Dideberg O Vernet T (2004) The d,d-carboxypeptidase PBP3 organizes the division process of Streptococcus pneumoniae. Mol Microbiol 51 : 1641 1648.
176. Morlot C, Pernot L, Le Gouellec A, Di Guilmi AM, Vernet T, Dideberg O Dessen A (2005) Crystal structure of a peptidoglycan synthesis regulatory factor (PBP3) from Streptococcus pneumoniae. J Biol Chem 280 : 15984 15991.
177. Moscoso M Claverys JP (2004) Release of DNA into the medium by competent Streptococcus pneumoniae: kinetics, mechanism and stability of the liberated DNA. Mol Microbiol 54 : 783 794.
178. Mukamolova GV, Kaprelyants AS, Young DI, Young M Kell DB (1998) A bacterial cytokine. Proc Natl Acad Sci USA 95 : 8916 8921.
179. Mukamolova GV, Murzin AG, Salina EG, Demina GR, Kell DB, Kaprelyants AS Young M (2006) Muralytic activity of Micrococcus luteus Rpf and its relationship to physiological activity in promoting bacterial growth and resuscitation. Mol Microbiol 59 : 84 98.
180. Mulder L, Lefebvre B, Cullimore J Imberty A (2006) LysM domains of Medicago truncatula NFP protein involved in Nod factor perception. Glycosylation state, molecular modeling and docking of chitooligosaccharides and Nod factors. Glycobiology 16 : 801 809.
181. Nambu T, Minamino T, Macnab RM Kutsukake K (1999) Peptidoglycan- hydrolyzing activity of the FlgJ protein, essential for flagellar rod formation in Salmonella typhimurium. J Bacteriol 181 : 1555 1561.
182. Nelson DE Young KD (2001) Contributions of PBP 5 and dd-carboxypeptidase penicillin binding proteins to maintenance of cell shape in Escherichia coli. J Bacteriol 183 : 3055 3064.
183. Ng WL, Robertson GT, Kazmierczak KM, Zhao J, Gilmour R Winkler ME (2003) Constitutive expression of PcsB suppresses the requirement for the essential VicR (YycF) response regulator in Streptococcus pneumoniae R6. Mol Microbiol 50 : 1647 1663.
184. Ng WL, Kazmierczak KM Winkler ME (2004) Defective cell wall synthesis in Streptococcus pneumoniae R6 depleted for the essential PcsB putative murein hydrolase or the VicR (YycF) response regulator. Mol Microbiol 53 : 1161 1175.
185. Nicholas RA, Krings S, Tomberg J, Nicola G Davies C (2003) Crystal structure of wild-type penicillin-binding protein 5 from Escherichia coli: implications for deacylation of the acyl-enzyme complex. J Biol Chem 278 : 52826 52833.
186. Nugroho FA, Yamamoto H, Kobayashi Y Sekiguchi J (1999) Characterization of a new sigma-K-dependent peptidoglycan hydrolase gene that plays a role in Bacillus subtilis mother cell lysis. J Bacteriol 181 : 6230 6237.
187. Odintsov SG, Sabala I, Marcyjaniak M Bochtler M (2004) Latent LytM at 1.3A resolution. J Mol Biol 335 : 775 785.
188. Ohnishi R, Ishikawa S Sekiguchi J (1999) Peptidoglycan hydrolase LytF plays a role in cell separation with CwlF during vegetative growth of Bacillus subtilis. J Bacteriol 181 : 3178 3184.
189. Oliver JD (2005) The viable but nonculturable state in bacteria. J Microbiol 43 : 93 100.
190. Oshida T, Sugai M, Komatsuzawa H, Hong YM, Suginaka H Tomasz A (1995) A Staphylococcus aureus autolysin that has an N-acetylmuramoyl-l-alanine amidase domain and an endo-beta-N-acetylglucosaminidase domain: cloning, sequence analysis, and characterization. Proc Natl Acad Sci USA 92 : 285 289.
191. Paidhungat M, Ragkousi K Setlow P (2001) Genetic requirements for induction of germination of spores of Bacillus subtilis by Ca(2+)-dipicolinate. J Bacteriol 183 : 4886 4893.
192. Park JT (1995) Why does Escherichia coli recycle its cell wall peptides? Mol Microbiol 17 : 421 426.
193. Park JT (1996) The convergence of murein recycling research with beta-lactamase research. Microb Drug Resist 2 : 105 112.
194. Patton TG, Yang SJ Bayles KW (2006) The role of proton motive force in expression of the Staphylococcus aureus cid and lrg operons. Mol Microbiol 59 : 1395 1404.
195. Pei J Grishin NV (2005) COG3926 and COG5526: a tale of two new lysozyme-like protein families. Protein Sci 14 : 2574 2581.
196. Piggot PJ Hilbert DW (2004) Sporulation of Bacillus subtilis. Curr Opin Microbiol 7 : 579 586.
197. Ponting CP, Aravind L, Schultz J, Bork P Koonin EV (1999) Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer. J Mol Biol 289 : 729 745.
198. Pooley HM (1976) Turnover and spreading of old wall during surface growth of Bacillus subtilis. J Bacteriol 125 : 1127 1138.
199. Pooley HM Shockman GD (1970) Relationship between the location of autolysin, cell wall synthesis, and the development of resistance to cellular autolysis in Streptococcus faecalis after inhibition of protein synthesis. J Bacteriol 103 : 457 466.
200. Popham DL, Helin J, Costello CE Setlow P (1996) Muramic lactam in peptidoglycan of Bacillus subtilis spores is required for spore outgrowth but not for spore dehydration or heat resistance. Proc Natl Acad Sci USA 93 : 15405 15410.
201. Popham DL, Gilmore ME Setlow P (1999) Roles of low-molecular-weight penicillin-binding proteins in Bacillus subtilis spore peptidoglycan synthesis and spore properties. J Bacteriol 181 : 126 132.
202. Powell AJ, Liu ZJ, Nicholas RA Davies C (2006) Crystal structures of the lytic transglycosylase MltA from N. gonorrhoeae and E. coli: insights into interdomain movements and substrate binding. J Mol Biol 359 : 122 136.
203. Priyadarshini R, Popham DL Young KD (2006) Daughter cell separation by penicillin-binding proteins and peptidoglycan amidases in Escherichia coli. J Bacteriol 188 : 5345 5355.
204. Rashid MH, Mori M Sekiguchi J (1995) Glucosaminidase of Bacillus subtilis: cloning, regulation, primary structure and biochemical characterization. Microbiology 141 : 2391 2404.
205. Rau A, Hogg T, Marquardt R Hilgenfeld R (2001) A new lysozyme fold. Crystal structure of the muramidase from Streptomyces coelicolor at 1.65 A resolution. J Biol Chem 276 : 31994 31999.
206. Reichenbach H (1999) The ecology of the myxobacteria. Environ Microbiol 1 : 15 21.
207. Reid CW, Blackburn NT, Legaree BA, Auzanneau FI Clarke AJ (2004) Inhibition of membrane-bound lytic transglycosylase B by NAG-thiazoline. FEBS Lett 574 : 73 79.
208. Rice KC Bayles KW (2003) Death's toolbox: examining the molecular components of bacterial programmed cell death. Mol Microbiol 50 : 729 738.
209. Romeis T Höltje J-V (1994a) Penicillin-binding protein 7/8 of Escherichia coli is a DD-endopeptidase. Eur J Biochem 224 : 597 604.
210. Romeis T Höltje J-V (1994b) Specific interaction of penicillin-binding proteins 3 and 7/8 with soluble lytic transglycosylase in Escherichia coli. J Biol Chem 269 : 21603 21607.
211. Romeis T, Vollmer W Höltje J-V (1993) Characterization of three different lytic transglycosylases in Escherichia coli. FEMS Microbiol Lett 111 : 141 146.
212. Rosenbluh A Rosenberg E (1993) Developmental lysis and auticides. Myxobacteria II (Dworkin M Kaiser D, eds), pp. 213 233. American Society for Microbioloy, Washington, DC.
213. Sauvage E, Herman R, Petrella S, Duez C, Bouillenne F, Frere JM Charlier P (2005) Crystal structure of the Actinomadura R39 DD-peptidase reveals new domains in penicillin-binding proteins. J Biol Chem 280 : 31249 31256.
214. Sauvage E, Duez C, Herman R et al 2007) Crystal structure of the Bacillus subtilis penicillin-binding protein 4a, and its complex with a peptidoglycan mimetic peptide. J Mol Biol 371 : 528 539.
215. Sauvage E, Charlier P, Terrak M Ayala JA (2008) The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis. FEMS Microbiol Rev 32 : 234 258.
216. Scheurwater E, Reid CW Clarke AJ (2007) Lytic transglycosylases: bacterial space-making autolysins. Int J Biochem Cell Biol, doi :
217. Schmidt DM, Hubbard BK Gerlt JA (2001) Evolution of enzymatic activities in the enolase superfamily: functional assignment of unknown proteins in Bacillus subtilis and Escherichia coli as l-Ala-d/l-Glu epimerases. Biochemistry 40 : 15707 15715.
218. Schuster C, Dobrinski B Hakenbeck R (1990) Unusual septum formation in Streptococcus pneumoniae mutants with an alteration in the d,d-carboxypeptidase penicillin-binding protein 3. J Bacteriol 172 : 6499 6505.
219. Scott JR Barnett TC (2006) Surface proteins of gram-positive bacteria and how they get there. Annu Rev Microbiol 60 : 397 423.
220. Sekiguchi J, Akeo K, Yamamoto H, Khasanov FK, Alonso JC Kuroda A (1995) Nucleotide sequence and regulation of a new putative cell wall hydrolase gene, cwlD, which affects germination in Bacillus subtilis. J Bacteriol 177 : 5582 5589.
221. Serizawa M, Yamamoto H, Yamaguchi H, Fujita Y, Kobayashi K, Ogasawara N Sekiguchi J (2004) Systematic analysis of SigD-regulated genes in Bacillus subtilis by DNA microarray and Northern blotting analyses. Gene 329 : 125 136.
222. Seto H Tomasz A (1975) Protoplast formation and leakage of intramembrane cell components: induction by the competence activator substance of pneumococci. J Bacteriol 121 : 344 353.
223. Shockman GD (1992) The autolytic ('suicidase') system of Enterococcus hirae: from lysine depletion autolysis to biochemical and molecular studies of the two muramidases of Enterococcus hirae ATCC 9790. FEMS Microbiol Lett 79 : 261 267.
224. Shockman GD Höltje J-V (1994) Microbial peptidoglycan (murein) hydrolases. Bacterial Cell Wall (Ghuysen J-M Hakenbeck R, eds), pp. 131 166. Elsevier, Amsterdam.
225. Shockman GD, Daneo-Moore L, Kariyama R Massidda O (1996) Bacterial walls, peptidoglycan hydrolases, autolysins, and autolysis. Microb Drug Resist 2 : 95 98.
226. Singh BN (1947) Myxobacteria in soils and compost; their distribution, number and lytic action on bacteria. J Gen Microbiol 1 : 1 10.
227. Smith TJ Foster SJ (1995) Characterization of the involvement of two compensatory autolysins in mother cell lysis during sporulation of Bacillus subtilis 168. J Bacteriol 177 : 3855 3862.
228. Smith TJ, Blackman SA Foster SJ (2000) Autolysins of Bacillus subtilis: multiple enzymes with multiple functions. Microbiology 146 : 249 262.
229. Sogaard-Andersen L (2004) Cell polarity, intercellular signalling and morphogenetic cell movements in Myxococcus xanthus. Curr Opin Microbiol 7 : 587 593.
230. Steen A, Buist G, Horsburgh GJ, Venema G, Kuipers OP, Foster SJ Kok J (2005) AcmA of Lactococcus lactis is an N-acetylglucosaminidase with an optimal number of LysM domains for proper functioning. Febs J 272 : 2854 2868.
231. Stefanova ME, Tomberg J, Olesky M, Holtje JV, Gutheil WG Nicholas RA (2003) Neisseria gonorrhoeae penicillin-binding protein 3 exhibits exceptionally high carboxypeptidase and beta-lactam binding activities. Biochemistry 42 : 14614 14625.
232. Steinmoen H, Teigen A Havarstein LS (2003) Competence-induced cells of Streptococcus pneumoniae lyse competence-deficient cells of the same strain during cocultivation. J Bacteriol 185 : 7176 7183.
233. Strynadka NCJ James MNG (1996) Lysozyme: a model enzyme in protein crystallography. Lysozymes: Model Enzymes in Biochemistry and Biology (Jolles P, ed), pp. 185 222. Birkhäuser Verlag, Basel.
234. Stubbs KA, Balcewich M, Mark BL Vocadlo DJ (2007) Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC mediated beta-lactam resistance. J Biol Chem 282 : 21382 21391.
235. Sudo S Dworkin M (1972) Bacteriolytic enzymes produced by Myxococcus xanthus. J Bacteriol 110 : 236 245.
236. Takahashi J, Komatsuzawa H, Yamada S et al 2002) Molecular characterization of an atl null mutant of Staphylococcus aureus. Microbiol Immunol 46 : 601 612.
237. Templin MF, Ursinus A Höltje J-V (1999) A defect in cell wall recycling triggers autolysis during the stationary growth phase of Escherichia coli. EMBO J 18 : 4108 4117.
238. Thunnissen AM, Dijkstra AJ, Kalk KH, Rozeboom HJ, Engel H, Keck W Dijkstra BW (1994) Doughnut-shaped structure of a bacterial muramidase revealed by X-ray crystallography. Nature 367 : 750 753.
239. Thunnissen AM, Isaacs NW Dijkstra BW (1995a) The catalytic domain of a bacterial lytic transglycosylase defines a novel class of lysozymes. Proteins 22 : 245 258.
240. Thunnissen AM, Rozeboom HJ, Kalk KH Dijkstra BW (1995b) Structure of the 70-kDa soluble lytic transglycosylase complexed with bulgecin A. Implications for the enzymatic mechanism. Biochemistry 34 : 12729 12737.
241. Tomasz A (1974) The role of autolysins in cell death. Ann N Y Acad Sci 235 : 439 447.
242. Tomasz A (1979a) From penicillin-binding proteins to the lysis and death of bacteria: a 1979 view. Rev Infect Dis 1 : 434 467.
243. Tomasz A (1979b) The mechanism of the irreversible antimicrobial effects of penicillins: how the beta-lactam antibiotics kill and lyse bacteria. Annu Rev Microbiol 33 : 113 137.
244. Tomasz A (1980) On the mechanism of the irreversible antimicrobial effects of beta-lactams. Philos Trans R Soc Lond B Biol Sci 289 : 303 308.
245. Uehara T Park JT (2003) Identification of MpaA, an amidase in Escherichia coli that hydrolyzes the gamma-d-glutamyl-meso-diaminopimelate bond in murein peptides. J Bacteriol 185 : 679 682.
246. Uehara T Park JT (2004) The N-acetyl-d-glucosamine kinase of Escherichia coli and its role in murein recycling. J Bacteriol 186 : 7273 7279.
247. Uehara T Park JT (2007) An anhydro-N-acetylmuramyl-l-alanine amidase with broad specificity tethered to the outer membrane of Escherichia coli. J Bacteriol 189 : 5634 5641.
248. Uehara T, Suefuji K, Valbuena N, Meehan B, Donegan M Park JT (2005) Recycling of the anhydro-N-acetylmuramic acid derived from cell wall murein involves a two-step conversion to N-acetylglucosamine-phosphate. J Bacteriol 187 : 3643 3649.
249. Uehara T, Suefuji K, Jaeger T, Mayer C Park JT (2006) MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall. J Bacteriol 188 : 1660 1662.
250. Ursinus A Höltje J-V (1994) Purification and properties of a membrane-bound lytic transglycosylase from Escherichia coli. J Bacteriol 176 : 338 343.
251. Ursinus A, van den Ent F, Brechtel S, de Pedro M, Höltje J-V, Löwe J Vollmer W (2004) Murein (peptidoglycan) binding property of the essential cell division protein FtsN from Escherichia coli. J Bacteriol 186 : 6728 6737.
252. van Asselt EJ, Thunnissen AM Dijkstra BW (1999a) High resolution crystal structures of the Escherichia coli lytic transglycosylase Slt70 and its complex with a peptidoglycan fragment. J Mol Biol 291 : 877 898.
253. van Asselt EJ, Dijkstra AJ, Kalk KH, Takacs B, Keck W Dijkstra BW (1999b) Crystal structure of Escherichia coli lytic transglycosylase Slt35 reveals a lysozyme-like catalytic domain with an EF-hand. Structure Fold Des 7 : 1167 1180.
254. van Asselt EJ, Kalk KH Dijkstra BW (2000) Crystallographic studies of the interactions of Escherichia coli lytic transglycosylase Slt35 with peptidoglycan. Biochemistry 39 : 1924 1934.
255. van Straaten KE, Dijkstra BW, Vollmer W Thunnissen AM (2005) Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold. J Mol Biol 352 : 1068 1080.
256. van Straaten KE, Barends TR, Dijkstra BW Thunnissen AM (2007) Structure of Escherichia coli Lytic Transglycosylase MltA with bound Chitohexaose: implications for peptidoglycan-binding and cleavage. J Biol Chem 282 : 21197 21205.
257. Vazquez-Laslop N, Lee H, Hu R Neyfakh AA (2001) Molecular sieve mechanism of selective release of cytoplasmic proteins by osmotically shocked Escherichia coli. J Bacteriol 183 : 2399 2404.
258. Vollmer W (2007) Structural variation in the glycan strands of bacterial peptidoglycan. FEMS Microbiol Rev 32 : 287 306.
259. Vollmer W Bertsche U (2007) Murein (peptidoglycan) structure, architecture and biosynthesis in Escherichia coli. Biochimica et Biophysica Acta (BBA) - Biomembranes, doi :
260. Vollmer W Höltje J-V (2001) Morphogenesis of Escherichia coli. Curr Opin Microbiol 4 : 625 633.
261. Vollmer W, Pilsl H, Hantke K, Höltje J-V Braun V (1997) Pesticin displays muramidase activity. J Bacteriol 179 : 1580 1583.
262. Vollmer W, von Rechenberg M Höltje J-V (1999) Demonstration of molecular interactions between the murein polymerase PBP1B, the lytic transglycosylase MltA, and the scaffolding protein MipA of Escherichia coli. J Biol Chem 274 : 6726 6734.
263. Vollmer W, Blanot D de Pedro MA (2008) Peptidoglycan structure and architecture. FEMS Microbiol Rev 32 : 149 167.
264. von Rechenberg M, Ursinus A Höltje J-V (1996) Affinity chromatography as a means to study multienzyme complexes involved in murein synthesis. Microb Drug Resist 2 : 155 157.
265. Vötsch W Templin MF (2000) Characterization of a beta-N-acetylglucosaminidase of Escherichia coli and elucidation of its role in muropeptide recycling and beta-lactamase induction. J Biol Chem 275 : 39032 39038.
266. Weidel W Pelzer H (1964) Bagshaped macromolecules - a new outlook on bacterial cell walls. Advances in Enzymology 26 : 193 232.
267. Whisstock JC Lesk AM (1999) SH3 domains in prokaryotes. Trends Biochem Sci 24 : 132 133.
268. Wuenscher MD, Kohler S, Bubert A, Gerike U Goebel W (1993) The iap gene of Listeria monocytogenes is essential for cell viability, and its gene product, p60, has bacteriolytic activity. J Bacteriol 175 : 3491 3501.
269. Yamada S, Sugai M, Komatsuzawa H, Nakashima S, Oshida T, Matsumoto A Suginaka H (1996) An autolysin ring associated with cell separation of Staphylococcus aureus. J Bacteriol 178 : 1565 1571.
270. Yamaguchi H, Furuhata K, Fukushima T, Yamamoto H Sekiguchi J (2004) Characterization of a new Bacillus subtilis peptidoglycan hydrolase gene, yvcE (named cwlO), and the enzymatic properties of its encoded protein. J Biosci Bioeng 98 : 174 181.
271. Yamamoto H, Kurosawa S Sekiguchi J (2003) Localization of the vegetative cell wall hydrolases LytC, LytE, and LytF on the Bacillus subtilis cell surface and stability of these enzymes to cell wall-bound or extracellular proteases. J Bacteriol 185 : 6666 6677.
272. Yang JC, Van Den Ent F, Neuhaus D, Brevier J Löwe J (2004) Solution structure and domain architecture of the divisome protein FtsN. Mol Microbiol 52 : 651 660.
273. Young R (1992) Bacteriophage lysis: mechanism and regulation. Microbiol Rev 56 : 430 481.
274. Zahrl D, Wagner M, Bischof K et al 2005) Peptidoglycan degradation by specialized lytic transglycosylases associated with type III and type IV secretion systems. Microbiology 151 : 3455 3467.