Toll-like receptor 4 has an essential role in early skin wound healing

Journal of Investigative Dermatology

Volumn 133, Issue 1, 2013, Pages 258-267

  Chen, Lin ^a   Guo, Shujuan ^a   Ranzer, Matthew J ^a   Dipietro, Luisa A ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DERMATITIS; ENZYME PHOSPHORYLATION; EPIDERMIS; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOREGULATION; IN VITRO STUDY; INFLAMMATORY INFILTRATE; INNATE IMMUNITY; KERATINOCYTE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SKIN INJURY; WILD TYPE; WOUND CLOSURE; WOUND HEALING;

EID: 84872183283     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2012.267     Document Type: Article

References (48)

1. Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4: 499-5111
2. Asea A, Rehli M, Kabingu E et al. (2002) Novel signal transduction pathway utilized by extracellular HSP70: Role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem 277:15028-344
3. Baker BS, Ovigne JM, Powles AV et al. (2003) Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: Modulation of TLR expression in chronic plaque psoriasis. Br J Dermatol 148:670-99
4. Becker CE, O'Neill LA (2007) Inflammasomes in inflammatory disorders: The role of TLRs and their interactions with NLRs. Semin Immunopathol 29:239-488
5. Bettinger DA, Pellicane JV, Tarry WC et al. (1994) The role of inflammatory cytokines in wound healing: Accelerated healing in endotoxin-resistant mice. J Trauma 36:810-33
6. Biragyn A, Ruffini PA, Leifer CA et al. (2002) Toll-like receptor 4- dependent activation of dendritic cells by beta-defensin 2. Science 298: 1025-99
7. Chen JD, Kim JP, Zhang K et al. (1993) Epidermal growth factor (EGF) promotes human keratinocyte locomotion on collagen by increasing the alpha 2 integrin subunit. Exp Cell Res 209:216-233
8. Chen L, Arbieva ZH, Guo S et al. (2010) Positional differences in the wound transcriptome of skin and oral mucosa. BMC Genomics 11:4711
9. Dasu MR, Hawkins HK, Barrow RE et al. (2004) Gene expression profiles from hypertrophic scar fibroblasts before and after IL-6 stimulation. J Pathol 202:476-855
10. Dvir A, Milner Y, Chomsky O et al. (1991) The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers. J Cell Biol 113:857-655
11. Dybdahl B, Wahba A, Lien E et al. (2002) Inflammatory response after open heart surgery: Release of heat-shock protein 70 and signaling through tolllike receptor-4. Circulation 105:685-900
12. Frantz S, Vincent KA, Feron O et al. (2005) Innate immunity and angiogenesis. Circ Res 96:15-266
13. Gallucci RM, Simeonova PP, Matheson JM et al. (2000) Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice. FASEB J 14:2525-311
14. Ghazizadeh M, Tosa M, Shimizu H et al. (2007) Functional implications of the IL-6 signaling pathway in keloid pathogenesis. J Invest Dermatol 127:98-1055
15. Grone A (2002) Keratinocytes and cytokines. Vet Immunol Immunopathol 88:1-122
16. Horton MR, Burdick MD, Strieter RM et al. (1998) Regulation of hyaluronaninduced chemokine gene expression by IL-10 and IFN-gamma in mouse macrophages. J Immunol 160:3023-300
17. Hoshino K, Takeuchi O, Kawai T et al. (1999) Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product. J Immunol 162:3749-522
18. Jiang D, Liang J, Fan J et al. (2005) Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med 11:1173-99
19. Jobin N, Garrel DR, Bernier J (2000) Increased burn-induced immunosuppression in lipopolysaccharide-resistant mice. Cell Immunol 200: 65-755
20. Johnson GB, Brunn GJ, Kodaira Y et al. (2002) Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J Immunol 168:5233-99
21. Kollisch G, Kalali BN, Voelcker V et al. (2005) Various members of the Tolllike receptor family contribute to the innate immune response of human epidermal keratinocytes. Immunology 114:531-411
22. Lebre MC, van der Aar AM, van Baarsen L et al. (2007) Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9. J Invest Dermatol 127:331-411
23. Longaker MT, Whitby DJ, Adzick NS et al. (1990) Studies in fetal wound healing, VI. Second and early third trimester fetal wounds demonstrate rapid collagen deposition without scar formation. J Pediatr Surg 25: 63-688
24. Martin P (1997) Wound healing - aiming for perfect skin regeneration. Science 276:75-811
25. Martin P, Leibovich SJ (2005) Inflammatory cells during wound repair: The good, the bad and the ugly. Trends Cell Biol 15:599-6077
26. Martinon F, Tschopp J (2005) NLRs join TLRs as innate sensors of pathogens. Trends Immunol 26:447-544
27. Maung AA, Fujimi S, Miller ML et al. (2005) Enhanced TLR4 reactivity following injury is mediated by increased p38 activation. J Leukoc Biol 78:565-733
28. McDonald B, Pittman K, Menezes GB et al. (2010) Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science 330: 362-266
29. Miller LS, Modlin RL (2007) Toll-like receptors in the skin. Semin Immunopathol 29:15-266
30. Ohashi K, Burkart V, Flohe S et al. (2000) Cutting edge: Heat shock protein 600 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 164:558-611
31. Okamura Y, Watari M, Jerud ES et al. (2001) The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem 276:10229-333
32. Park JS, Gamboni-Robertson F, He Q et al. (2006) High mobility group box 11 protein interacts with multiple Toll-like receptors. Am J Physiol Cell Physiol 290:C917-244
33. Park JS, Svetkauskaite D, He Q et al. (2004) Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem 279:7370-77
34. Poltorak A, He X, Smirnova I et al. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene. Science 282:2085-88
35. Rheinwald JG, Green H (1977) Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes. Nature 265:421-44
36. Saltzman WM (1999) Delivering tissue regeneration. Nat Biotechnol 17: 534-55
37. Schrementi ME, Ferreira AM, Zender C et al. (2008) Site-specific production of TGF-beta in oral mucosal and cutaneous wounds. Wound Repair Regen 16:80-66
38. Smiley ST, King JA, Hancock WW (2001) Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol 167: 2887-944
39. Song PI, Park YM, Abraham T et al. (2002) Human keratinocytes express functional CD14 and toll-like receptor 4. J Invest Dermatol 119:424-322
40. Szpaderska AM, Zuckerman JD, DiPietro LA (2003) Differential injury responses in oral mucosal and cutaneous wounds. J Dent Res 82:621-66
41. Takeda K, Akira S (2005) Toll-like receptors in innate immunity. Int Immunol 17:1-144
42. Taylor KR, Trowbridge JM, Rudisill JA et al. (2004) Hyaluronan fragments stimulate endothelial recognition of injury through TLR4. J Biol Chem 279:17079-844
43. Termeer C, Benedix F, Sleeman J et al. (2002) Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med 195:99-1111
44. Uchi H, Terao H, Koga T et al. (2000) Cytokines and chemokines in the epidermis. J Dermatol Sci 24(Suppl 1):S29-388
45. Vabulas RM, Ahmad-Nejad P, Ghose S et al. (2002) HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J Biol Chem 277:15107-122
46. Wang H, Bloom O, Zhang M et al. (1999) HMG-1 as a late mediator of endotoxin lethality in mice. Science 285:248-511
47. Wang J, Hori K, Ding J et al. (2011) Toll-like receptors expressed by dermal fibroblasts contribute to hypertrophic scarring. J Cell Physiol 226:1265-733
48. Watanabe H, Gaide O, Petrilli V et al. (2007) Activation of the IL-1betaprocessing inflammasome is involved in contact hypersensitivity. J Invest Dermatol 127:1956-633