Premature ejaculation: Current and future treatments

Asian Journal of Andrology

Volumn 10, Issue 1, 2008, Pages 102-109

  Gurkan, Levent ^a   Oommen, Matthew ^a   Hellstrom, Wayne J G ^a  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Ejaculation; Male sexual disorder; Premature ejaculation

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; CITALOPRAM; CLOMIPRAMINE; DAPOXETINE; DYCLONINE; EMLA; ESCITALOPRAM; FLUOXETINE; FLUVOXAMINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PAROXETINE; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; PRILOCAINE; PROSTAGLANDIN E1; ROBALZOTAN; SEROTONIN 1A ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; SILDENAFIL; SS CREAM; TEMPE; TRAMADOL; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG; VASODILATOR AGENT; VENLAFAXINE;

BEHAVIOR THERAPY; BLEEDING; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; DIZZINESS; DROWSINESS; DRUG APPROVAL; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG HALF LIFE; DRUG INDUCED HEADACHE; DRUG MECHANISM; DRUG WITHDRAWAL; DYSPEPSIA; EJACULATION DISORDER; ERECTILE DYSFUNCTION; FATIGUE; FLUSHING; FOOD AND DRUG ADMINISTRATION; HUMAN; HYPERHIDROSIS; LIBIDO DISORDER; LOOSE FECES; MALE SEXUAL DYSFUNCTION; MEDICAL LITERATURE; MONOTHERAPY; NAUSEA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OFF LABEL DRUG USE; OSTEOPOROSIS; PARESTHESIA; PEER REVIEW; PRACTICE GUIDELINE; PREMATURE EJACULATION; PRIAPISM; PSYCHOEDUCATION; REVIEW; RISK BENEFIT ANALYSIS; SIDE EFFECT; SKIN IRRITATION; SOMNOLENCE; UROLOGIC SURGERY; VIRTUAL REALITY; VOMITING; WEIGHT GAIN;

ANESTHETICS, LOCAL; BEHAVIOR THERAPY; CLOMIPRAMINE; EJACULATION; HUMANS; LIDOCAINE; MALE; PRILOCAINE; SEROTONIN UPTAKE INHIBITORS; SEXUAL DYSFUNCTION, PHYSIOLOGICAL;

EID: 37748998998     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1111/j.1745-7262.2008.00369.x     Document Type: Review

References (64)

1. Carson C, Gunn K. Premature ejaculation: Definition and prevalence. Int J Impot Res 2006; 18 (Suppl 1): S5-13.
2. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th edition. Text Revision. Washington, DC: American Psychiatric Association 2000.
3. Montague DK, Jarow J, Broderick GA, Dmochowski RR, Heaton JP, Lue TF, et al. AUA Erectile Dysfunction Guideline Update Panel. AUA guideline on the pharmacological management of premature ejaculation. J Urol 2004; 172: 290-4.
4. World Health Organization The ICD-10 classification of mental and behavioral disorders: Diagnostic criteria for research. Geneva: World Health Organization, 1993.
5. Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH. Proposal for a definition of lifelong premature ejaculation based on epidemiological stopwatch data. J Sex Med 2005; 2: 498-507.
6. Semans JH. Premature ejaculation: A new approach. South Med J 1956; 49: 353-8.
7. Masters WM, Johnson VE. Human Sexual Inadequacy. Boston: Little, Brown; 1970.
8. Hawton K, Catalan J, Martin P, Fagg J. Long-term outcome of sex therapy. Behav Res Ther 1986; 24: 665-75.
9. Rowland DL, Motofei IG. The aetiology of premature ejaculation and the mind-body problem: Implications for practice. Int J Clin Pract 2007; 61: 77-82.
10. Perelman MA. A new combination treatment for premature ejaculation: A sex therapist's perspective. J Sex Med 2006; 3: 1004-12.
11. Althof S. The psychology of premature ejaculation: Therapies and consequences. J Sex Med 2006; 3 (Suppl 4): 324-31.
12. Schapiro B. Premature ejaculation: A review of 1 130 cases. J Urol 1943; 3: 374-9.
13. Xin ZC, Chung WS, Choi YD, Seong DH, Choi YJ, Choi HK. Penile sensitivity in patients with primary premature ejaculation. J Urol 1996; 156: 979-81.
14. Vanden Broucke H, Everaert K, Peersman W, Claes H, Vanderschueren D, Van Kampen M. Ejaculation latency times and their relationship to penile sensitivity in men with normal sexual function. J Urol 2007; 177: 237-40.
15. Atikeler MK, Gecit I, Senol FA. Optimum usage of prilocainelidocaine cream in premature ejaculation. Andrologia 2002; 34: 356-9.
16. Busato W, Galindo CC. Topical anesthetic use for treating premature ejaculation: A double-blind, randomized, placebo-controlled study. BJU Int 2004; 93: 1018-21.
17. Choi HK, Jung GW, Moon KH, Xin ZC, Choi YD, Lee WH, et al. Clinical study of SS-cream in patients with lifelong premature ejaculation. Urology 2000; 55: 257-61.
18. Tian L, Xin ZC, Xin H, Fu J, Yuan YM, Liu WJ, et al. Effect of renewed SS-cream on spinal somatosensory evoked potential in rabbits. Asian J Androl 2004; 6: 15-8.
19. Dinsmore WW, Hackett G, Goldmeier D, Waldinger M, Dean J, Wright P, et al. Topical eutectic mixture for premature ejaculation (TEMPE): A novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation. BJU Int 2007; 99: 369-75.
20. Eaton H. Clomipramine in the treatment of premature ejaculation. J Int Med Res 1973; 1: 432-4.
21. Waldinger MD, Zwinderman AH, Schweitzer DH, Olivier B. Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: A systematic review and meta-analysis. Int J Impot Res 2004; 16: 369-81.
22. Waldinger MD, Zwinderman AH, Olivier B. On-demand treatment of premature ejaculation with clomipramine and paroxetine: A randomized, double-blind fixed-dose study with stopwatch assessment. Eur Urol 2004; 46: 510-5.
23. Rowland DL, Tai WL, Brummett K, Slob AK. Predicting responsiveness to the treatment of rapid ejaculation with 25 mg clomipramine as needed. Int J Impot Res 2004; 16: 354-7.
24. Balon R. SSRI-associated sexual dysfunction. Am J Psychiatry 2006; 163: 1504-9.
25. Wang WF, Chang L, Minhas S, Ralph DJ. Selective serotonin reuptake inhibitors in the treatment of premature ejaculation. Chin Med J (Engl) 2007; 120: 1000-6.
26. Waldinger MD, van De Plas A, Pattij T, van Oorschot R, Coolen LM, Veening JG, et al. The selective serotonin re-uptake inhibitors fluvoxamine and paroxetine differ in sexual inhibitory effects after chronic treatment. Psychopharmacology (Berl) 2002; 160: 283-9.
27. Kilic S, Ergin H, Baydinc YC. Venlafaxine extended release for the treatment of patients with premature ejaculation: A pilot, single-blind, placebo-controlled, fixed-dose crossover study on short-term administration of an antidepressant drug. Int J Androl 2005; 28: 47-52.
28. Halperin D, Reber G. Influence of antidepressants on hemostasis. Dialogues Clin Neurosci 2007; 9: 47-59.
29. Dent LA, Brown WC, Murney JD. Citalopram-induced priapism. Pharmacotherapy 2002; 22: 538-41.
30. Raeder MB, Bjelland I, Emil Vollset S, Steen VM. Obesity, dyslipidemia, and diabetes with selective serotonin reuptake inhibitors: The Hordaland Health Study. J Clin Psychiatry 2006; 67: 1974-82.
31. Haney EM, Chan BK, Diem SJ, Ensrud KE, Cauley JA, Barrett-Connor E, et al. For the Osteoporotic Fractures in Men Study Group. Association of low bone mineral density with selective serotonin reuptake inhibitor use by older men. Arch Intern Med 2007; 167: 1246-51.
32. Montejo AL, Llorca G, Izquierdo JA, Rico-Villademoros F. Incidence of sexual dysfunction associated with antidepressant agents: A prospective multicenter study of 1 022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction. J Clin Psychiatry 2001; 62 (Suppl 3): 10-21.
33. Waldinger MD. Premature ejaculation: Definition and drug treatment. Drugs 2007; 67: 547-68.
34. van Geffen EC, Hugtenburg JG, Heerdink ER, van Hulten RP, Egberts AC. Discontinuation symptoms in users of selective serotonin reuptake inhibitors in clinical practice: Tapering versus abrupt discontinuation. Eur J Clin Pharmacol 2005; 61: 303-7. Epub 2005 May 20.
35. Cohen D. Should the use of selective serotonin reuptake inhibitors in child and adolescent depression be banned? Psychother Psychosom 2007; 76: 5-14.
36. Gibbons RD, Brown CH, Hur K, Marcus SM, Bhaumik DK, Mann JJ. Relationship between antidepressants and suicide attempts: An analysis of the Veterans Health Administration data sets. Am J Psychiatry 2007; 164: 1044-9.
37. Waldinger MD, Zwinderman AH, Schweitzer DH, Olivier B. Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: A systematic review and meta-analysis. Int J Impot Res 2004; 16: 369-81.
38. Waldinger MD. Premature ejaculation: Definition and drug treatment. Drugs 2007; 67: 547-68.
39. Waldinger MD, Zwinderman AH, Olivier B. SSRIs and ejaculation: A double-blind, randomized, fixed-dose study with paroxetine and citalopram. J Clin Psychopharmacol 2001; 21: 556-60.
40. Safarinejad MR, Hosseini SY. Safety and efficacy of citalopram in the treatment of premature ejaculation: A double-blind placebo-controlled, fixed dose, randomized study. Int J Impot Res 2006; 18: 164-9.
41. Safarinejad MR. Safety and efficacy of escitalopram in the treatment of premature ejaculation: A double-blind, placebo-controlled, fixed-dose, randomized study. J Clin Psychopharmacol 2007; 27: 444-50.
42. Posternak MA, Zimmerman M. Dual reuptake inhibitors incur lower rates of tachyphylaxis than selective serotonin reuptake inhibitors: A retrospective study. J Clin Psychiatry 2005; 66: 705-7.
43. Dresser MJ, Kang D, Staehr P, Gidwani S, Guo C, Mulhall JP, et al. Pharmacokinetics of dapoxetine, a new treatment for premature ejaculation: Impact of age and effects of a high-fat meal. J Clin Pharmacol 2006; 46: 1023-9.
44. Hellstrom WJ, Heintz JW. Treatment of premature ejaculation: New drugs and treatment strategies. Curr Urol Rep 2006; 7: 473-8.
45. Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH. The majority of men with lifelong premature ejaculation prefer daily drug treatment: An observation study in a consecutive group of Dutch men. J Sex Med 2007; 4 (4 Pt 1): 1028-37.
46. Safarinejad MR, Hosseini SY. Safety and efficacy of tramadol in the treatment of premature ejaculation: A double-blind, placebo-controlled, fixed-dose, randomized study. J Clin Psychopharmacol 2006; 26: 27-31.
47. Salem EA, Wilson SK, Bissada NK, Delk JR, Hellstrom WJ, Cleves MA. Tramadol HCL has promise in on-demand use to treat premature ejaculation. J Sex Med 2007; 14; Epub ahead of print.
48. Laumann EO, Paik A, Rosen RC. The epidemiology of erectile dysfunction: results from the National Health and Social Life Survey. Int J Impot Res 1999; 11 (Suppl 1): S60-4.
49. Abdel-Hamid IA, El Naggar EA, El Gilany AH. Assessment of as needed use of pharmacotherapy and the pause-squeeze technique in premature ejaculation. Int J Impot Res 2001; 13: 41-5.
50. Wang WF, Wang Y, Minhas S, Ralph DJ. Can sildenafil treat primary premature ejaculation?A prospective clinical study. Int J Urol 2007; 14: 331-5.
51. McMahon CG, Stuckey BG, Andersen M, Purvis K, Koppiker N, Haughie S, et al. Efficacy of sildenafil citrate (Viagra) in men with premature ejaculation. J Sex Med 2005; 2: 368-75.
52. Atan A, Basar MM, Tuncel A, Ferhat M, Agras K, Tekdogan U. Comparison of efficacy of sildenafil-only, sildenafil plus topical EMLA cream, and topical EMLA-cream-only in treatment of premature ejaculation. Urology 2006; 67: 388-91.
53. Chen J, Mabjeesh NJ, Matzkin H, Greenstein A. Efficacy of sildenafil as adjuvant therapy to selective serotonin reuptake inhibitor in alleviating premature ejaculation. Urology 2003; 61: 197-200.
54. Li X, Zhang SX, Cheng HM, Zhang WD. Clinical study of sildenafil in the treatment of premature ejaculation complicated by erectile dysfunction. Zhonghua Nan Ke Xue 2003; 9: 266-9.
55. Fein RL. Intracavernous medication for treatment of premature ejaculation. Urology 1990; 35: 301-3.
56. Kim SW, Lee SH, Paick JS. In vivo rat model to measure hypogastric nerve stimulation-induced seminal vesicle and vasal pressure responses simultaneously. Int J Impot Res 2004; 16: 427-32.
57. Cavallini G. Alpha-1 blockade pharmacotherapy in primitive psychogenic premature ejaculation resistant to psychotherapy. Eur Urol 1995; 28: 126-30.
58. Basar MM, Yilmaz E, Ferhat M, Basar H, Batislam E. Terazosin in the treatment of premature ejaculation: A short-term follow-up. Int Urol Nephrol 2005; 37: 773-7.
59. Optale G, Pastore M, Marin S, Bordin D, Nasta A, Pianon C. Male sexual dysfunctions: Immersive virtual reality and multimedia therapy. Stud Health Technol Inform 2004; 99: 165-78.
60. Jan Wise ME, Watson JP. A new treatment for premature ejaculation: Case series for a desensitizing band. Sex and Relation Ther 2000; 15: 345-50.
61. Kim JJ, Kwak TI, Jeon BG, Cheon J, Moon DG. Effects of glans penis augmentation using hyaluronic acid gel for premature ejaculation. Int J Impot Res 2004; 16: 547-51.
62. Mulhall JP. Current and future pharmacotherapeutic strategies in treatment of premature ejaculation. Urology 2006; 67: 9-16.
63. Looney C, Thor KB, Ricca D, Marson L. Differential effects of simultaneous or sequential administration of paroxetine and WAY-100, 635 on ejaculatory behavior. Pharmacol Biochem Behav 2005; 82: 427-33.
64. Williamson IJ, Turner L, Woods K, Wayman CP, Van Der Graaf PH. The 5-HT1A receptor antagonist robalzotan enhances SSRI-induced ejaculation delay in the rat. Br J Pharmacol 2003; 138 (Suppl 1): PO32.