Epithelial wnt ligand secretion is required for adult hair follicle growth and regeneration

Journal of Investigative Dermatology

Volumn 133, Issue 1, 2013, Pages 31-41

  Myung, Peggy S ^a   Takeo, Makoto ^b   Ito, Mayumi ^b   Atit, Radhika P ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CELL PROTEIN; WNT PROTEIN;

ANIMAL TISSUE; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIUM; GENE; GENE DELETION; HAIR CELL; HAIR FOLLICLE; HAIR GROWTH; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; STEM CELL; UPREGULATION; WLS GENE;

EID: 84872175906     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2012.230     Document Type: Article

References (41)

1. Andl T, Reddy ST, Gaddapara T et al. (2002) WNT signals are required for the initiation of hair follicle development. Dev Cell 2:643-533
2. Banziger C, Soldini D, Schutt C et al. (2006) Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. Cell 125:509-222
3. Bartscherer K, Pelte N, Ingelfinger D et al. (2006) Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell 125:523-333
4. Blanpain C, Lowry WE, Geoghegan A et al. (2004) Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell 118:635-488
5. Carpenter AC, Rao S, Wells JM et al. (2010) Generation of mice with a conditional null allele for Wntless. Genesis 48:554-88
6. Chen D, Jarrell A, Guo C et al. (2012) Dermal beta-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation. Development 139:1522-333
7. Cotsarelis G, Sun TT, Lavker RM (1990) Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61:1329-377
8. DasGupta R, Fuchs E (1999) Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development 126:4557-688
9. Enshell-Seijffers D LC, Kashiwagi M, Morgan BA (2010) B-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair. Dev Cell 18:633-422
10. Gat U, DasGupta R, Degenstein L et al. (1998) De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell 95:605-144
11. Goodman RM, Thombre S, Firtina Z et al. (2006) Sprinter: A novel transmembrane protein required for Wg secretion and signaling. Development 133:4901-111
12. Greco V, Chen T, Rendl M et al. (2009) A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell 4:155-699
13. Huelsken J, Vogel R, Erdmann B et al. (2001) beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 105:533-455
14. Ito M, Kizawa K (2001) Expression of calcium-binding S100 proteins A4 and A6 in regions of the epithelial sac associated with the onset of hair follicle regeneration. J Invest Dermatol 116:956-633
15. Ito M, Kizawa K, Toyoda M et al. (2002) Label-retaining cells in the bulge region are directed to cell death after plucking, followed by healing from the surviving hair germ. J Invest Dermatol 119:1310-66
16. Ito M, Yang Z, Andl T et al. (2007) Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature 447:316-200
17. Jho EH, Zhang T, Domon C et al. (2002) Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol 22:1172-833
18. Kishimoto J, Burgeson RE, Morgan BA (2000) Wnt signaling maintains the hair-inducing activity of the dermal papilla. Genes Dev 14:1181-55
19. Liu H, Fergusson MM, Castilho RM et al. (2007) Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317:803-66
20. Liu Y, Lyle S, Yang Z et al. (2003) Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge. J Invest Dermatol 121:963-88
21. Lo Celso C, Prowse DM, Watt FM (2004) Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours. Development 131:1787-999
22. Lowry WE, Blanpain C, Nowak JA et al. (2005) Defining the impact of betacatenin//Tcf transactivation on epithelial stem cells. Genes Dev 19: 1596-6111
23. Lyle S, Christofidou-Solomidou M, Liu Y et al. (1998) The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci 111(Part 21):3179-888
24. Merrill BJ, Gat U, DasGupta R et al. (2001) Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. Genes Dev 15:1688-7055
25. Millar S (2002) Molecular mechanisms regulating hair follicle development. J invest Dermatol 118:216-255
26. Morris RJ, Liu Y, Marles L et al. (2004) Capturing and profiling adult hair follicle stem cells. Nat Biotechnol 22:411-77
27. Myung P, Ito M (2012) Dissecting the bulge in hair regeneration. J Clin Invest 122:448-544
28. Nguyen H, Merrill BJ, Polak L et al. (2009) Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet 41:1068-755
29. Nguyen H, Rendl M, Fuchs E (2006) Tcf3 governs stem cell features and represses cell fate determination in skin. Cell 127:171-833
30. Niemann C, Owens DM, Hulsken J et al. (2002) Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours. Development 129: 95-1099
31. Oshima H, Rochat A, Kedzia C et al. (2001) Morphogenesis and renewal of hair follicles from adult multipotent stem cells. Cell 104:233-455
32. Rabbani P, Takeo M, Chou W et al. (2011) Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration. Cell 145:941-555
33. Reddy S, Andl T, Bagasra A et al. (2001) Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mech Dev 107:69-822
34. Schmidt-Ullrich R, Paus R (2005) Molecular principles of hair follicle induction and morphogenesis. Bioessays 27:247-611
35. Soma T, Fujiwara S, Shirakata Y et al. (2012) Hair-inducing ability of human dermal papilla cells cultured under Wnt/beta-catenin signalling activation. Exp Dermatol 21:307-99
36. Sun TT, Cotsarelis G, Lavker RM (1991) Hair follicular stem cells: The bulgeactivation hypothesis. J Invest Dermatol 96:77S-8S
37. Trempus CS, Morris RJ, Bortner CD et al. (2003) Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. J Invest Dermatol 120:501-111
38. van Amerongen R, Nusse R (2009) Towards an integrated view of Wnt signaling in development. Development 136:3205-144
39. Van Mater D, Kolligs FT, Dlugosz AA et al. (2003) Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice. Genes Dev 17: 1219-244
40. Vasioukhin V, Degenstein L, Wise B et al. (1999) The magical touch: Genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc Natl Acad Sci USA 96:8551-66
41. Zhang Y, Tomann P, Andl T et al. (2009) Reciprocal requirements for EDA// EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell 17:49-611