Investigation of the capacity of low glass transition temperature excipients to minimize amorphization of sulfadimidine on comilling

Molecular Pharmaceutics

Volumn 10, Issue 1, 2013, Pages 386-396

  Curtin, Vincent ^a   Amharar, Youness ^a   Hu, Yun ^b   Erxleben, Andrea ^b   McArdle, Patrick ^b   Caron, Vincent ^a   Tajber, Lidia ^a   Corrigan, Owen I ^a   Healy, Anne Marie ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

amorphous; comilling; excipient; glass transition; solubility; thermal methods; vapor sorption; X ray diffraction

Indexed keywords

ADIPIC ACID; EXCIPIENT; GLUTARIC ACID; MALIC ACID; SUCCINIC ACID; SULFADIMIDINE;

ARTICLE; CONCENTRATION (PARAMETERS); CRYSTALLIZATION; GLASS TRANSITION TEMPERATURE; INFRARED SPECTROSCOPY; PRIORITY JOURNAL; SOLUBILITY; SPECTROSCOPY; THERMAL ANALYSIS; VAPOR; X RAY DIFFRACTION;

CRYSTALLIZATION; DRUG COMPOUNDING; EXCIPIENTS; GLASS; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SPECTROSCOPY, NEAR-INFRARED; SULFAMETHAZINE; TEMPERATURE; TRANSITION TEMPERATURE; X-RAY DIFFRACTION;

EID: 84872155860     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300529a     Document Type: Article

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