PET imaging and biodistribution of chemically modified bacteriophage MS2

Molecular Pharmaceutics

Volumn 10, Issue 1, 2013, Pages 69-76

  Farkas, Michelle E ^a   Aanei, Ioana L ^a   Behrens, Christopher R ^a   Tong, Gary J ^a   Murphy, Stephanie T ^b   O'Neil, James P ^c   Francis, Matthew B ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

drug delivery; modified viruses; nanoparticles; PEGylation; PET imaging; protein modification

Indexed keywords

ANTINEOPLASTIC AGENT; COPPER 64; MACROGOL; MS2 VIRUS AGENT; TETRAXETAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG RETENTION; EX VIVO STUDY; IN VIVO STUDY; MOUSE; MS2 VIRUS; MUTANT; NEOPLASM; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SPLEEN; VIRUS CAPSID;

ANIMALS; CAPSID; CELL LINE, TUMOR; COPPER RADIOISOTOPES; FEMALE; LEVIVIRUS; MCF-7 CELLS; MICE; MICE, NUDE; POLYETHYLENE GLYCOLS; POSITRON-EMISSION TOMOGRAPHY; TISSUE DISTRIBUTION;

EID: 84872147044     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp3003754     Document Type: Article

References (35)

1. Steinmetz, N. F. Viral Nanoparticles as Platforms for Next-Generation Therapeutics and Imaging Devices Nanomedicine 2010, 6, 634-641
2. Yildiz, I.; Shukla, S.; Steinmetz, N. F. Applications of Viral Nanoparticles in Medicine Curr. Opin. Biotechnol. 2011, 22I, 901-908
3. Kaiser, C. R.; Flenniken, M. L.; Gillitzer, E.; Harmsen, A. L.; Harmsen, A. G.; Jutila, M. A.; Douglas, T.; Young, M. J. Biodistribution Studies of Protein Cage Nanoparticles Demonstrate Broad Tissue Distribution and Rapid Clearance In Vivo Int. J. Nanomed. 2007, 2, 715-733
4. Prasuhn, D. E.; Singh, P.; Strable, E.; Brown, S.; Manchester, M.; Finn, M. G. Plasma Clearance of Bacteriophage Qβ as a Function of Surface Charge J. Am. Chem. Soc. 2008, 130, 1328-1334
5. Rae, C. S.; Khor, I. W.; Wang, Q.; Destito, G.; Gonzalez, M. J.; Singh, P.; Thomas, D. M.; Estrada, M. N.; Powell, E.; Finn, M. G.; Manchester, M. Systemic Trafficking of Plant Virus Nanoparticles in Mice via the Oral Route Virology 2005, 343, 224-235
6. Singh, P.; Prasuhn, D.; Yeh, R. M.; Destito, G.; Rae, C. S.; Osborn, K.; Finn, M. G.; Manchester, M. Biodistribution, Toxicity, and Pathology of Cowpea Mosaic Virus Nanoparticles In Vivo J. Controlled Release 2007, 120, 41-50
7. Flexman, J. A.; Cross, D. J.; Lewellen, B. L.; Miyoshi, S.; Kim, Y.; Minoshima, S. Magnetically Targeted Viral Envelopes: A PET Investigation of Initial Biodistribution IEEE Trans. Nanobiosci. 2008, 7, 223-232
8. Hooker, J. M.; Kovacs, E. W.; Francis, M. B. Interior Surface Modification of Bacteriophage MS2 J. Am. Chem. Soc. 2004, 126, 3718-3719
9. Davis, J. E. Replication of Bacteriophage MS2 J. Mol. Biol. 1963, 6, 203-208
10. Valegard, K.; Liljas, L.; Fridborg, K.; Unge, T. The Three-Dimensional Structure of the Bacterial Virus MS2 Nature 1990, 345, 36-41
11. Cargile, B. J.; McLuckey, S. A.; Stephenson, J. L. Identification of Bacteriophage MS2 Coat Protein from E. coli. Lysates via Ion Trap Collisional Activation of Intact Protein Anal. Chem. 2001, 73, 1277-1285
12. Kovacs, E. W.; Hooker, J. M.; Romanini, D. W.; Holder, P. G.; Berry, K. E.; Francis, M. B. Dual-Surface-Modified Bacteriophage MS2 as an Ideal Scaffold for a Viral Capsid-Based Drug Delivery System Bioconjugate Chem. 2007, 18, 1140-1147
13. Datta, A.; Hooker, J. M.; Botta, M.; Francis, M. B.; Aime, S.; Raymond, K. N. High Relaxivity Gadolinium Hydroxypyridonate-Viral Capsid Conjugates: Nanosized MRI Contrast Agents J. Am. Chem. Soc. 2008, 130, 2546-2552
14. Hooker, J. M.; O'Neil, J. P.; Romanini, D. W.; Taylor, S. E.; Francis, M. B. Genome-Free Viral Capsids as Carriers for Positron Emission Tomography Radiolabels Mol. Imaging. Biol. 2008, 10, 182-191
15. Meldrum, T.; Seim, K. L.; Bajaj, V. S.; Palaniappan, K. K.; Wu, W.; Francis, M. B.; Wemmer, D. E.; Pines, A. A Xenon-Based Molecular Sensor Assembled on an MS2 Viral Capsid Scaffold J. Am. Chem. Soc. 2010, 132, 5936-5937
16. Wu, W.; Hsiao, S. C.; Carrico, Z. M.; Francis, M. B. Genome-Free Viral Capsids as Multivalent Carriers for Taxol Delivery Angew. Chem., Int. Ed. 2009, 48, 9493-9497
17. Stephanopoulous, N.; Tong, G. J.; Hsiao, S. C.; Francis, M. B. Dual-Surface Modified Virus Capsids for Targeted Delivery of Photodynamic Agents to Cancer Cells ACS Nano 2010, 4, 6014-6020
18. Tong, G. J.; Hsiao, S. C.; Carrico, Z. M.; Francis, M. B. Viral Capsid DNA Aptamer Conjugates as Multivalent Cell-Targeting Vehicles J. Am. Chem. Soc. 2009, 131, 11174-11178
19. Carrico, Z. M.; Romanini, D. W.; Mehl, R. A.; Francis, M. B. Oxidative Coupling of Peptides to a Virus Capsid Containing Unnatural Amino Acids Chem. Commun. 2008, 10, 1205-1207
20. O'Riordan, C. R.; Lachapelle, A.; Delgado, C.; Parkes, V.; Wadsworth, S. C.; Smith, A. E.; Francis, G. E. PEGylation of Adenovirus with Retention of Infectivity and Protection from Neutralizing Antibody In Vitro and In Vivo Hum. Gene Ther. 1999, 10, 1349-1358
21. Caliceti, P.; Veronese, F. M. Pharmacokinetic and Biodistribution Properties of Poly(Ethylene Glycol)-Protein Conjugates Adv. Drug Delivery Rev. 2003, 55, 1261-1277
22. Owens, D. E.; Peppas, N. A. Opsonization, Biodistribution, and Pharmacokinetics of Polymeric Nanoparticles Int. J. Pharm. 2006, 307, 93-102
23. Stephanopoulos, N.; Carrico, Z. M.; Francis, M. B. Nanoscale Integration of Sensitizing Chormophores and Porphyrins with Bacteriophage MS2 Angew. Chem., Int. Ed. 2009, 48, 9498-9502
24. Behrens, C. R.; Hooker, J. M.; Obermeyer, A. C.; Romanini, D. W.; Katz, E. M.; Francis, M. B. Rapid Chemoselective Bioconjugation Through the Oxidative Coupling of Anilines and Aminophenols J. Am. Chem. Soc. 2011, 133, 16398-16401
25. Mehl, R. A.; Anderson, J. C.; Santoro, S. W.; Wang, L.; Martin, A. B.; King, D. S.; Horn, D. M.; Schultz, P. G. Generation of a Bacterium with a 21 Amino Acid Genetic Code J. Am. Chem. Soc. 2003, 125, 935-939
26. Xie, J.; Schultz, P. G. A Chemical Toolkit for Proteins-An Expanded Genetic Code Nat. Rev. Mol. Cell Biol. 2006, 7, 775-782
27. Maeda, H.; Wu, J.; Sawa, T.; Matsumura, Y.; Hori, K. Vascular Permeability and the EPR Effect in Macromolecular Therapeutics: A Review J. Controlled Release 2000, 65, 271-284
28. Hathaway, H. J.; Butler, K. S.; Adolphi, N. L.; Lovato, D. M.; Belfon, R.; Fegan, D.; Monson, T. C.; Trujillo, J. E.; Tessier, T. E.; Bryant, H. C.; Huber, D. L.; Larson, R. S.; Flynn, E. R. Detection of breast cancer cells using targeted magnetic nanoparticles and ultra-sensitive magnetic field sensors Breast Cancer Res. 2011, 13, R108
29. Wang, M.; Thanou, M. Targeting Nanoparticles to Cancer Pharmacol. Res. 2010, 62, 90-99
30. Peiser, L.; Mukhopadhyay, S.; Gordon, S. Scavenger Receptors in Innate Immunity Curr. Opin. Immunol. 2002, 14, 123-128
31. Perracchia, M. T. Stealth Nanoparticles for Intravenous Administration STP Pharma Sci. 2003, 13, 155-161
32. Sofou, S. Radionuclide Carriers for Targeting of Cancer Int. J. Nanomed. 2008, 3, 181-199
33. Srivastava, A. S.; Kaido, T.; Carrier, E. Immunological Factors that Affect the In Vivo Fate of T7 Phage in the Mouse J. Virol. Methods 2004, 115, 99-104
34. Vitiello, C. L.; Merril, C. R.; Adhya, S. An Amino Acid Substitution in a Capsid Protein Enhances Phage Survival in Mouse Circulatory System More Than a 1000-fold Virus Res. 2005, 114, 101-103
35. Raja, K. S.; Wang, Q.; Gonzalez, M. J.; Manchester, M.; Johnson, J. E.; Finn, M. G. Hybrid Virus-Polymer Materials. 1. Synthesis and Properties of PEG-Decorated Cowpea Mosaic Virus Biomacromolecules 2003, 4, 472-476