Morin sulphates/glucuronides enhance macrophage function in microgravity culture system

European Journal of Clinical Investigation

Volumn 35, Issue 9, 2005, Pages 591-596

  Hsieh, C L ^a,c   Chao, P D L ^b   Fang, Shih Hua ^b,d  

^a EMORY UNIVERSITY   (United States)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Macrophage; Microgravity; Morin sulphates glucuronides; Rotating wall vessel; Three dimensional culture

Indexed keywords

FLAVONOID; GLUCURONIDE; MORIN SULPHATE; SULFATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL TRANSFER; CONTROLLED STUDY; COSMONAUT; CYTOKINE PRODUCTION; IMMUNE SYSTEM; IMMUNOMODULATION; MACROPHAGE FUNCTION; MICROGRAVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

ANIMALS; ANTIOXIDANTS; CELL LINE; CYTOKINES; FLAVONOIDS; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MITOGENS; NITRIC OXIDE; WEIGHTLESSNESS SIMULATION;

EID: 24144458922     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2005.01551.x     Document Type: Article

References (41)

1. Nash PV, Konstantinova IV, Fuchs BB, Rakhmilevich AL, Lesnyak AT, Mastro AM. Effect of spaceflight on lymphocyte proliferation and interleukin-2 production. J Appl Physiol 1992;73:186S-90S.
2. Licato LL, Grimm EA. Multiple interleukin-2 signaling pathways differentially regulated by microgravity. Immunopharmacology 1999;44:273-9.
3. Walther I, Pippia P, Meloni MA, Turrini F, Mannu F, Cogoli A. Simulated microgravity inhibits the genetic expression of interleukin-2 and its receptor in mitogen-activated T lymphocytes. FEBS Lett 1998;436:115-8.
4. Cooper D, Pride MW, Brown EL, Risin D, Pellis NR. Suppression of antigen-specific lymphocyte activation in modeled microgravity. In Vitro Cell Dev Biol Anim 2001;37:63-5.
5. Schwarzenberg M, Pippia P, Meloni MA, Cossu G, Cogoli-Greuter M, Cogoli A. Signal transduction in T lymphocytes - a comparison of the data from space, the free fall machine and the random positioning machine. Adv Space Res 1999;24:793-800.
6. Kaur I, Simons ER, Castro VA, Mark Ott C, Pierson DL. Changes in neutrophil functions in astronauts. Brain Behav Immun 2004;18:443-50.
7. Rykova MP, Sonnenfeld G, Lesnyak AT, Taylor GR, Meshkov DO, Mandel AD et al. Effect of spaceflight on natural killer cell activity. J Appl Physiol 1992;73:196S-200S.
8. Mehta SK, Kaur I, Grimm EA, Smid C, Feeback DL, Pierson DL. Decreased non-MHC-restricted (CD56+) killer cell cytotoxicity after spaceflight. J Appl Physiol 2001;91:1814-8.
9. Taylor GR, Konstantinova I, Sonnenfeld G, Jennings R. Changes in the immune system during and after spaceflight. Adv Space Biol Med 1997;6:1-32.
10. Middleton E Jr, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000;52:673-751.
11. Adams DO, Hamilton TA. The cell biology of macrophage activation. Annu Rev Immunol 1984;2:283-318.
12. Kok LD, Wong YP, Wu TW, Chan HC, Kwok TT, Fung KP. Morin hydrate: a potential antioxidant in minimizing the free-radicals-mediated damage to cardiovascular cells by anti-tumor drugs. Life Sci 2000;67:91-9.
13. Ramanathan L, Das NP, Li QT. Studies on lipid oxidation in fish phospholipid liposomes. Biol Trace Elem Res 1994;40:59-70.
14. Hanasaki Y, Ogawa S, Fukui S. The correlation between active oxygens scavenging and antioxidative effects of flavonoids. Free Radic Biol Med 1994;16:845-50.
15. Francis AR, Shetty TK, Bhattacharya RK. Modulating effect of plant flavonoids on the mutagenicity of N-methyl-N′-nitro-N-nitrosoguanidine. Carcinogenesis 1989;10:1953-5.
16. Bhattacharya RK, Firozi PF. Effect of plant flavonoids on microsome catalyzed reactions of aflatoxin B1 leading to activation and DNA adduct formation. Cancer Lett 1988;39:85-91.
17. Raso GM, Meli R, Di Carlo G, Pacilio M, Di Carlo R. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci 2001;68:921-31.
18. Kim HK, Cheon BS, Kim YH, Kim SY, Kim HP. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem Pharmacol 1999;58:759-65.
19. Fang SH, Hou YC, Chang WC, Hsiu SL, Chao PD, Chiang BL. Morin sulfates/glucuronides exert anti-inflammatory activity on activated macrophages and decreased the incidence of septic shock. Life Sci 2003;74:743-56.
20. Chao PDL, Hsiu SL, Hou YC. Flavonoids in herbs: biological fates and potential interactions with xenobiotics. J Food Drug Analy 2002;11:135-45.
21. Hsiu SL, Tsao CW, Tsai YC, Ho HJ, Chao PD. Determinations of morin, quercetin and their conjugate metabolites in serum. Biol Pharm Bull 2001;24:967-9.
22. Schwartz RP, Wolf DA, Trinh TT. Horizontally rotated cell culture system with a coaxial tubular oxygenator. US Patent No. 5 026 650; 1991.
23. Schwartz RP, Wolf DA. Rotating bio-reactor cell culture apparatus. US Patent No. 4 988 623; 1991.
24. Schwartz RP, Goodwin TJ, Wolf DA. Cell culture for three-dimensional modeling in rotating-wall vessels: an application of simulated microgravity. J Tissue Cult Meth 1992;14:51-8.
25. Bakos A, Varkonyi A, Minarovits J, Batkai L. Effect of simulated microgravity on human lymphocytes. J Gravit Physiol 2001;8:69-70.
26. Sastry KJ, Nehete PN, Savary CA. Impairment of antigen-specific cellular immune responses under simulated microgravity conditions. In Vitro Cell Dev Biol Anim 2001;37:203-8.
27. Hales NW, Yamauchi K, Alicea A, Sundaresan A, Pellis NR, Kulkarni AD. A countermeasure to ameliorate immune dysfunction in in vitro simulated microgravity environment: role of cellularnucleotide nutrition. In Vitro Cell Dev Biol Anim 2002;38:213-7.
28. Martin A, Zhou A, Gordon RE, Henderson SC, Schwartz AE, Friedman EW et al. Thyroid organoid formation in simulated microgravity: influence of keratinocyte growth factor. Thyroid 2000;10:481-7.
29. Plett PA, Abonour R, Frankovitz SM, Orschell CM. Impact of modeled microgravity on migration, differentiation, and cell cycle control of primitive human hematopoietic progenitor cells. Exp Hematol 2004;32:773-81.
30. Sytkowski AJ, Davis KL. Erythroid cell growth and differentiation in vitro in the simulated microgravity environment of the NASA rotating wall vessel bioreactor. In Vitro Cell Dev Biol Anim 2001;37:79-83.
31. Pellis NR, Goodwin TJ, Risin D, McIntyre BW, Pizzini RP, Cooper D et al. Changes in gravity inhibit lymphocyte locomotion through type I collagen. In Vitro Cell Dev Biol Anim 1997;33:398-405.
32. Cooper D, Pellis NR. Suppressed PHA activation of T lymphocytes in simulated microgravity is restored by direct activation of protein kinase C. J Leukoc Biol 1998;63:550-62.
33. 15N]nitrate in biological fluids. Anal Biochem 1982;126:131-8.
34. Dubinin NP, Vaulina EN. Gravity, weightlessness and the genetic structures of organisms. Life Sci Space Res 1974;12:93-101.
35. Rhee HW, Zhau HE, Pathak S, Multani AS, Pennanen S, Visakorpi T et al. Permanent phenotypic and genotypic changes of prostate cancer cells cultured in a three-dimensional rotating-wall vessel. In Vitro Cell Dev Biol Anim 2001;37:127-40.
36. Khaoustov VI, Risin D, Pellis NR, Yoffe B. Microarray analysis of genes differentially expressed in HepG2 cells cultured in simulated microgravity: preliminary report. In Vitro Cell Dev Biol Anim 2001;37:84-8.
37. Brown J, O'Prey J, Harrison PR. Enhanced sensitivity of human oral tumours to the flavonol, morin, during cancer progression: involvement of the Akt and stress kinase pathways. Carcinogenesis 2003;24:171-7.
38. Heitzman ME, Neto CC, Winiarz E, Vaisberg AJ, Hammond GB. Ethnobotany, phytochemistry and pharmacology of Uncaria (Rubiaceae). Phytochemistry 2005;66:5-29.
39. Kitson RP, Ohashi M, Brunson KW, Goldfarb RH. Flavone acetic acid enhances accumulation of IL-2 activated NK cells within established metastases. In Vivo 1998;12:593-7.
40. Kong C, Xu X, Zhou B, Hu F, Zhang C, Zhang M. Two compounds from allelopathic rice accession and their inhibitory activity on weeds and fungal pathogens. Phytochemistry 2004;65:1123-8.
41. Middleton E Jr, Kandaswami C. Effects of flavonoids on immune and inflammatory cell functions. Biochem Pharmacol 1992;43:1167-79.