Stabilization of the Tertiary Structure of the Cholera Toxin A1 Subunit Inhibits Toxin Dislocation and Cellular Intoxication

Journal of Molecular Biology

Volumn 393, Issue 5, 2009, Pages 1083-1096

  Massey, Shane ^a   Banerjee, Tuhina ^a   Pande, Abhay H ^a   Taylor, Michael ^a   Tatulian, Suren A ^b   Teter, Ken ^a  

^a UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CENTRAL FLORIDA   (United States)

Author keywords

cholera toxin; circular dichroism; endoplasmic reticulum associated degradation; surface plasmon resonance; toxin translocation

Indexed keywords

BACTERIAL TOXIN; CHOLERA TOXIN A1 SUBUNIT; GLYCEROL; PROTEASOME; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOPHYSICS; CHO CELL; CIRCULAR DICHROISM; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HELA CELL; HIGH TEMPERATURE; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SURFACE PLASMON RESONANCE; TEMPERATURE DEPENDENCE; THERMOSTABILITY; TOXICITY TESTING; TOXICOKINETICS; TOXIN ANALYSIS; TOXIN STRUCTURE;

CELL DEATH; CHOLERA TOXIN; ENDOPLASMIC RETICULUM; GLYCEROL; HELA CELLS; HUMANS; PEPTIDE HYDROLASES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; PROTEIN TRANSPORT; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; TIME FACTORS;

EID: 70350025562     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.09.013     Document Type: Article

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