Accuracy in the diagnosis of non-melanoma skin cancer

Non-Surgical Treatment of Keratinocyte Skin Cancer

Volumn , Issue , 2010, Pages 51-72

  Mogensen, Mette ^a   Jemec, Gregor B E ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84872126995     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-540-79341-0_6     Document Type: Chapter

References (168)

1. Mogensen M, Jemec GB. Diagnosis of nonmelanoma skin cancer/keratinocyte carcinoma: A review of diagnostic accuracy of nonmelanoma skin cancer diagnostic tests and technologies. Dermatol Surg. 2007;33:1158-74.
2. Marghoob AA, Swindle LD, Moricz CZ, et al Instruments and new technologies for the in vivo diagnosis of melanoma. J Am Acad Dermatol. 2003;49:777-97.
3. Wahie S, Lawrence CM. Wound complications following diagnostic skin biopsies in dermatology inpatients. Arch Dermatol. 2007;143:1267-71.
4. Hallock GG, Lutz DA. Prospective study of the accuracy of the surgeon's diagnosis in 2000 excised skin tumors. Plast Reconstr Surg. 1998;101:1255-61.
5. Gluud C, Gluud LL. Evidence based diagnostics. BMJ. 2005;330:724-6.
6. Knottnerus, J André. The evidence base of clinical diagnosis. Spain: BMJ Books, 2002.
7. Whited JD, Horner RD, Hall RP, et al The infl uence of history on interobserver agreement for diagnosing actinic keratoses and malignant skin lesions. J Am Acad Dermatol. 1995;33:603-7.
8. Whited JD, Hall RP. Diagnostic accuracy and precision in assessing dermatologic disease. Problem or promise? Arch Dermatol. 1997;133:1409-15.
9. Schwartzberg JB, Elgart GW, Romanelli P, et al Accuracy and predictors of basal cell carcinoma diagnosis. Dermatol Surg. 2005;31:534-7.
10. Morrison A, O'Loughlin S, Powell FC. Suspected skin malignancy: A comparison of diagnoses of family practitioners and dermatologists in 493 patients. Int J Dermatol. 2001;40:104-7.
11. Leffell DJ, Chen YT, Berwick M, et al Interobserver agreement in a community skin cancer screening setting. J Am Acad Dermatol. 1993;28:1003-5.
12. Har-Shai Y, Hai N, Taran A, et al Sensitivity and positive predictive values of presurgical clinical diagnosis of excised benign and malignant skin tumors: A prospective study of 835 lesions in 778 patients. Plast Reconstr Surg. 2001;108: 1982-9.
13. Ek EW, Giorlando F, Su SY, et al Clinical diagnosis of skin tumours: how good are we? ANZ J Surg. 2005;75:415-20.
14. Davis DA, Donahue JP, Bost JE, et al The diagnostic concordance of actinic keratosis and squamous cell carcinoma. J Cutan Pathol. 2005;32:546-51.
15. Cooper SM, Wojnarowska F. The accuracy of clinical diagnosis of suspected premalignant and malignant skin lesions in renal transplant recipients. Clin Exp Dermatol. 2002;27: 436-8.
16. Su SY, Giorlando F, Ek EW, et al Incomplete excision of basal cell carcinoma: A prospective trial. Plast Reconstr Surg. 2007;120:1240-8.
17. Tan PY, Ek E, Su S, et al Incomplete excision of squamous cell carcinoma of the skin: A prospective observational study. Plast Reconstr Surg. 2007;120:910-6.
18. Feit NE, Dusza SW, Marghoob AA. Melanomas detected with the aid of total cutaneous photography. Br J Dermatol. 2004;150:706-14.
19. Robinson JK, Fisher SG, Turrisi RJ. Predictors of skin selfexamination performance. Cancer. 2002;95:135-46.
20. Russell EB, Carrington PR, Smoller BR. Basal cell carcinoma: A comparison of shave biopsy versus punch biopsy techniques in subtype diagnosis. J Am Acad Dermatol. 1999;41:69-71.
21. Bakis S, Irwig L, Wood G, et al Exfoliative cytology as a diagnostic test for basal cell carcinoma: A meta-analysis. Br J Dermatol. 2004;150:829-36.
22. Vega-Memije E, Martinez-de-Larios N, Waxtein LM, et al Cytodiagnosis of cutaneous basal and squamous cell carcinoma. Int J Dermatol. 2000;39:116-20.
23. Christensen E, Bofi n A, Guethmundsdottir I, et al Cytological diagnosis of basal cell carcinoma and actinic keratosis, using Papanicolaou and May-Grunwald-Giemsa stained cutaneous tissue smear. Cytopathology. 2007.
24. Saldanha G, Fletcher A, Slater DN. Basal cell carcinoma: A dermatopathological and molecular biological update. Br J Dermatol. 2003;148:195-202.
25. Walling HW, Fosko SW, Geraminejad PA, et al Aggressive basal cell carcinoma: presentation, pathogenesis, and management. Cancer Metastasis Rev. 2004;23:389-402.
26. Lind AC, Bewtra C, Healy JC, et al Prospective peer review in surgical pathology. Am J Clin Pathol. 1995;104:560-6.
27. Olhoffer IH, Lazova R, Leffell DJ. Histopathologic misdiagnoses and their clinical consequences. Arch Dermatol. 2002;138:1381-3.
28. Brochez L, Verhaeghe E, Grosshans E, et al Inter-observer variation in the histopathological diagnosis of clinically suspicious pigmented skin lesions. J Pathol. 2002;196: 459-66.
29. Kamiya M, Ichiki Y, Kamiya H, et al Detection of nonmelanoma skin cancer micrometastases in lymph nodes by using reverse transcriptase-polymerase chain reaction for keratin 19 mRNA. Br J Dermatol. 2003;149:998-1005.
30. Biesterfeld S, Josef J. Differential diagnosis of keratoacanthoma and squamous cell carcinoma of the epidermis by MIB-1 immunohistometry. Anticancer Res. 2002;22: 3019-23.
31. Trotter MJ, Bruecks AK. Interpretation of skin biopsies by general pathologists: diagnostic discrepancy rate measured by blinded review. Arch Pathol Lab Med. 2003;127: 1489-92.
32. Jagdeo J, Weinstock MA, Piepkorn M, et al Reliability of the histopathologic diagnosis of keratinocyte carcinomas. J Am Acad Dermatol. 2007;57:279-84.
33. Lacour JP. Carcinogenesis of basal cell carcinomas: genetics and molecular mechanisms. Br J Dermatol. 2002; 146(Suppl 61):17-9.
34. Ortonne JP. From actinic keratosis to squamous cell carcinoma. Br J Dermatol. 2002;146(Suppl 61):20-3.
35. Park WS, Lee HK, Lee JY, et al p53 mutations in solar keratoses. Hum Pathol. 1996;27:1180-4.
36. Wong CS, Strange RC, Lear JT. Basal cell carcinoma. BMJ. 2003;327:794-8.
37. Jovanovic DL, Katic V, Jovanovic B. Value of preoperative determination of skin tumor thickness with 20-MHz ultrasound. Arch Dermatol. 2005;141:269-70.
38. Karaman GC, Karaman CZ, Sendur N, et al Power Doppler ultrasonography for the evaluation of skin tumors other than malignant melanoma. Eur Radiol. 2001;11:1111-6.
39. Moore JV, Allan E. Pulsed ultrasound measurements of depth and regression of basal cell carcinomas after photodynamic therapy: relationship to probability of 1-year local control. Br J Dermatol. 2003;149:1035-40.
40. Allan E, Pye DA, Levine EL, et al Non-invasive pulsed ultrasound quantifi cation of the resolution of basal cell carcinomas after photodynamic therapy. Lasers Med Sci. 2002;17:230-7.
41. Gupta AK, Turnbull DH, Foster FS, et al High frequency 40-MHz ultrasound. A possible noninvasive method for the assessment of the boundary of basal cell carcinomas. Dermatol Surg. 1996;22:131-6.
42. Harland CC, Bamber JC, Gusterson BA, et al High frequency, high resolution B-scan ultrasound in the assessment of skin tumours. Br J Dermatol. 1993;128:525-32.
43. Gropper CA, Stiller MJ, Shupack JL, et al Diagnostic highresolution ultrasound in dermatology. Int J Dermatol. 1993;32:243-50.
44. Jemec GB, Gniadecka M, Ulrich J. Ultrasound in dermatology. Part I. High frequency ultrasound. Eur J Dermatol. 2000;10:492-7.
45. Lassau N, Spatz A, Avril MF, et al Value of high-frequency US for preoperative assessment of skin tumors. Radiographics. 1997;17:1559-65.
46. Marques J, Cueto L, Roldan F, et al Ultrasound study of skin tumors. Radiologia. 2002;44(2):55-60.
47. Vaillant L, Grognard C, Machet L, et al High resolution ultrasound imaging to assess skin tumors prior to cryosurgery. Annales de Dermatologie et de Venereologie. 1998; 125(8):500-4.
48. Gross U, Suter L, Hundeiker M. 20-MHz sonography as a planning aid in the therapy of skin tumours. Aktuelle Dermatologie. 1993;19(1-2):32-5.
49. Costa P, Ghillani M, Papadia F, et al Superfi cial ultrasound in the assessment of skin tumours: indications and limitations. Rivista Italiana di Chirurgia Plastica. 1992; 24(3): 263-9.
50. Nitsche N, Hoffmann K, Iro H. Ultrasound diagnosis of skin tumours. HNO 1992;40(3):97-100.
51. Edwards C, Al-Aboosi MM, Marks R. The use of A-scan ultrasound in the assessment of small skin tumours. Br J Dermatol. 1989;121(3):297-304.
52. Hoffmann K, Stucker M, el-Gammal S, et al Digital 20 MHz sonography of basalioma in the B-scan. Hautarzt. 1990; 41:333-9.
53. el Gammal S, Auer T, Hoffmann K, et al Non-invasive methods of the skin, chapter 5.6 "high-resolution ultrasound of the human epidermis". Boca Raton, FL: CRC, 1995.
54. el Gammal S, El Gammal C, Altmeyer PJ, et al Highresolution sonography of the skin. Chapter 30 non-invasive methods of the skin, 2nd edn. Boca Raton, FL: CRC/Taylor & Francis, 2006.
55. Serup J, Keiding J, Fullerton A, et al High-frequency ultrasound examination of the skin. Chapter 56 non-invasive methods of the skin epidermis, 2nd edn. Boca Raton, FL: CRC/Taylor & Francis, 2006.
56. Wortsman XC, Holm EA, Wulf HC, et al Real-time spatial compound ultrasound imaging of skin. Skin Res Technol. 2004;10:23-31.
57. Bessoud B, Lassau N, Koscielny S, et al High-frequency sonography and color Doppler in the management of pigmented skin lesions. Ultrasound Med Biol. 2003;29: 875-9.
58. Desai TD, Desai AD, Horowitz DC, et al The use of highfrequency ultrasound in the evaluation of superfi cial and nodular basal cell carcinomas. Dermatol Surg. 2007;33: 1220-7.
59. Uhara H, Hayashi K, Koga H, et al Multiple hypersonographic spots in basal cell carcinoma. Dermatol Surg. 2007;33:1215-9.
60. Ruocco E, Argenziano G, Pellacani G, et al Noninvasive imaging of skin tumors. Dermatol Surg. 2004;30:301-10.
61. Schmid-Wendtner MH, Burgdorf W. Ultrasound scanning in dermatology. Arch Dermatol. 2005;141:217-24.
62. Miga MI, Rothney MP, Ou JJ. Modality independent elastography (MIE): potential applications in dermoscopy. Med Phys. 2005;32:1308-20.
63. Langevin HM, Rizzo DM, Fox JR, et al Dynamic morphometric characterization of local connective tissue network structure in humans using ultrasound. BMC Syst Biol. 2007;1:25.
64. Deprez JF, Cloutier G, Schmitt C, et al 3D Ultrasound elastography for early detection of lesions. Evaluation on a pressure ulcer mimicking phantom. Conf Proc IEEE Eng Med Biol Soc. 2007;1:79-82.
65. Dr. Nakajima. The evaluation method of elastography. 2007.
66. Claridge E, Cotton S, Hall P, et al From colour to tissue histology: physics-based interpretation of images of pigmented skin lesions. Med Image Anal. 2003;7:489-502.
67. Steiner R, Kunzi RK, Scharffetter KK. Optical coherence tomography: clinical applications in dermatology. Med Laser Appl. 2003;18(3):249-259.
68. Peris K, Altobelli E, Ferrari A, et al Interobserver agreement on dermoscopic features of pigmented basal cell carcinoma. Dermatol Surg. 2002;28:643-5.
69. Zalaudek I, Giacomel J, Argenziano G, et al Dermoscopy of facial nonpigmented actinic keratosis. Br J Dermatol. 2006;155:951-6.
70. Argenziano G, Zalaudek I, Corona R, et al Vascular structures in skin tumors: A dermoscopy study. Arch Dermatol. 2004;140:1485-9.
71. Zalaudek I, Argenziano G, Leinweber B, et al Dermoscopy of Bowen's disease. Br J Dermatol. 2004;150:1112-6.
72. Kreusch JF. Vascular patterns in skin tumors. Clin Dermatol. 2002;20:248-54.
73. Hee MR, Huang D, Swanson EA, et al Polarization-sensitive low-coherence refl ectometer for birefringence characterization and ranging. J Opt Soc Am. 1992;B 9: 903-8.
74. Aalders MC, Triesscheijn M, Ruevekamp M, et al Doppler optical coherence tomography to monitor the effect of photodynamic therapy on tissue morphology and perfusion. J Biomed Opt. 2006;11:044011.
75. Gambichler T, Moussa G, Sand M, et al Applications of optical coherence tomography in dermatology. J Dermatol Sci. 2005;40:85-94.
76. Thomas MW, Grichnik JM, Izatt JA. Three-dimensional images and vessel rendering using optical coherence tomography. Arch Dermatol. 2007;143:1468-9.
77. Abuzahra F, Baron JM. Optical coherence tomography of the skin: A diagnostic light look. Hautarzt. 2006;57:646-7.
78. Andretzky P, Lindner MW, Herrmann JM, Schultz A, Konzog M, Kiesewetter F, Hausler G. Optical coherence tomography by spectral radar: dynamic range estimation and in vivo measurements of skin. SPIE. 1998;3567: 78-87.
79. Barton JK, Gossage KW, Xu W, et al Investigating sun-damaged skin and actinic keratosis with optical coherence tomography: A pilot study. Technol Cancer Res Treat. 2003; 2:525-35.
80. Bechara FG, Gambichler T, Stucker M, et al Histomorphologic correlation with routine histology and optical coherence tomography. Skin Res Technol. 2004;10: 169-73.
81. Gladkova ND, Petrova GA, Nikulin NK, et al In vivo optical coherence tomography imaging of human skin: norm and pathology. Skin Res Technol. 2000;6:6-16.
82. Jensen LK, Thrane L, Andersen PE, Tycho A, Pedersen F, Andersson-Engels S, Bendsoe N, Svanberg S, Svanberg K. Optical coherence tomography in clinical examination of non-pigmented skin malignancies. Proc SPIE-OSA Biomedical Optics, SPIE 2003;5140:160-7.
83. Olmedo JM, Warschaw KE, Schmitt JM, et al Optical coherence tomography for the characterization of basal cell carcinoma in vivo: A pilot study. J Am Acad Dermatol. 2006;55:408-12.
84. Olmedo JM, Warschaw KE, Schmitt JM, et al Correlation of thickness of basal cell carcinoma by optical coherence tomography in vivo and routine histologic fi ndings: A pilot study. Dermatol Surg. 2007;33:421-5.
85. Welzel J, Lankenau E, Birngruber R, et al Optical coherence tomography of the human skin. J Am Acad Dermatol. 1997; 37:958-63.
86. Welzel J. Optical coherence tomography in dermatology: A review. Skin Res Technol. 2001;7:1-9.
87. Pierce MC, Strasswimmer J, Park BH, et al Advances in optical coherence tomography imaging for dermatology. J Invest Dermatol. 2004;123:458-63.
88. Strasswimmer J, Pierce MC, Park B, et al Characterization of basal cell carcinoma by multifunctional optical coherence tomography. J Invest Dermatol. 2003;121:156.
89. Gambichler T, Orlikov A, Vasa R, et al In vivo optical coherence tomography of basal cell carcinoma. J Dermatol Sci. 2007;45:167-73.
90. Gambichler T, Matip R, Moussa G, et al In vivo data of epidermal thickness evaluated by optical coherence tomography: Effects of age, gender, skin type, and anatomic site. J Dermatol Sci. 2006;44:145-52.
91. Mogensen M, Morsy HA, Thrane L, et al Morphology and epidermal thickness of normal skin imaged by optical coherence tomography. Dermatology. 2008;217:14-20.
92. Gambichler T, Regeniter P, Bechara FG, et al Characterization of benign and malignant melanocytic skin lesions using optical coherence tomography in vivo. J Am Acad Dermatol. 2007.
93. Korde VR, Bonnema GT, Xu W, et al Using optical coherence tomography to evaluate skin sun damage and precancer. Lasers Surg Med. 2007;39:687-95.
94. Gambichler T, Orlikov A, Vasa R, et al In vivo optical coherence tomography of basal cell carcinoma. J Dermatol Sci. 2007;45(3):167-73.
95. Wilder-Smith P, Jung WG, Brenner M, et al In vivo optical coherence tomography for the diagnosis of oral malignancy. Lasers Surg Med. 2004;35:269-75.
96. Petrova GA, Derpalyek E, Gladkova N, Feldchtein F, Nikulin N, Donchenko E, Gelikonov V, Kamensky V. Optical coherence tomography using tissue clearing for skin disease diagnosis. Proc SPIE 5140, 2003, pp. 168-186.
97. Buchwald HJ, Muller A, Kampmeier J, et al Optical coherence tomography versus ultrasound biomicroscopy of conjunctival and eyelid lesions. Klinische Monatsblatter fur Augenheilkunde. 2003;220(12):822-829.
98. Strasswimmer J, Pierce MC, Park BH, et al Polarizationsensitive optical coherence tomography of invasive basal cell carcinoma. J Biomed Opt. 2004;9:292-8.
99. Mogensen M, Joergensen TM, Nürnberg BM, Morsy HA, Thomsen JB, Thrane L, Jemec GB. Assessment of optical coherence tomography imaging in the diagnosis of non-melanoma skin cancer and benign lesions versus normal skin: observer-blinded evaluation by dermatologists and pathologists. Dermatol Surg. 2009;35:1-8.
100. Fujimoto JG, Pitris C, Boppart SA, et al Optical coherence tomography: An emerging technology for biomedical imaging and optical biopsy. Neoplasia. 2000;2:9-25.
101. Kollias N, Stamatas GN. Optical non-invasive approaches to diagnosis of skin diseases. J Investig Dermatol Symp Proc. 2002;7(1):64-75.
102. Selkin B, Rajadhyaksha M, Gonzalez S, et al In vivo confocal microscopy in dermatology. Dermatol Clin. 2001; 19:369-77.
103. Chung VQ, Dwyer PJ, Nehal KS, et al Use of ex vivo confocal scanning laser microscopy during Mohs surgery for nonmelanoma skin cancers. Dermatol Surg. 2004;30: 1470-8.
104. Gerger A, Koller S, Weger W, et al Sensitivity and specifi city of confocal laser-scanning microscopy for in vivo diagnosis of malignant skin tumors. Cancer 2006; 107: 193-200.
105. Ulrich M, Maltusch A, Rowert-Huber J, et al Actinic keratoses: non-invasive diagnosis for fi eld cancerisation. Br J Dermatol. 2007;156(Suppl 3):13-7.
106. Gonzalez S, Tannous Z. Real-time, in vivo confocal refl ectance microscopy of basal cell carcinoma. J Am Acad Dermatol. 2002;47:869-74.
107. Gonzalez S, Gilaberte-Calzada Y, Gonzalez-Rodriguez A, et al In vivo refl ectance-mode confocal scanning laser microscopy in dermatology. Adv Dermatol. 2004;20: 371-87.
108. Agero AL, Busam KJ, venuto-Andrade C, et al Refl ectance confocal microscopy of pigmented basal cell carcinoma. J Am Acad Dermatol. 2006;54:638-43.
109. Nori S, Rius-Diaz F, Cuevas J, et al Sensitivity and specifi city of refl ectance-mode confocal microscopy for in vivo diagnosis of basal cell carcinoma: A multicenter study. J Am Acad Dermatol. 2004;51:923-30.
110. Tannous Z, Torres A, Gonzalez S. In vivo real-time confocal refl ectance microscopy: A noninvasive guide for Mohs micrographic surgery facilitated by aluminum chloride, an excellent contrast enhancer. Dermatol Surg. 2003;29: 839-46.
111. Yaroslavsky AN, Barbosa J, Neel V, et al Combining multispectral polarized light imaging and confocal microscopy for localization of nonmelanoma skin cancer. J Biomed Opt. 2005;10:14011.
112. Uchigasaki S, Suzuki H, Inoue K. Merkel cells in the vellus hair follicles of human facial skin: A study using confocal laser microscopy. J Dermatol. 2004;31:218-22.
113. Goldgeier M, Fox CA, Zavislan JM, et al Noninvasive imaging, treatment, and microscopic confi rmation of clearance of basal cell carcinoma. Dermatol Surg. 2003;29: 205-10.
114. Suihko C, Swindle LD, Thomas SG, et al Fluorescence fi bre-optic confocal microscopy of skin in vivo: microscope and fl uorophores. Skin Res Technol. 2005; 11: 254-67.
115. Gniadecka M, Wulf HC, Nielsen OF, et al Distinctive molecular abnormalities in benign and malignant skin lesions: Studies by Raman spectroscopy. Photochem Photobiol. 1997; 66:418-23.
116. Gniadecka M, Philipsen PA, Sigurdsson S, et al Melanoma diagnosis by Raman spectroscopy and neural networks: Structure alterations in proteins and lipids in intact cancer tissue. J Invest Dermatol. 2004;122:443-9.
117. McIntosh LM, Jackson M, Mantsch HH, et al Infrared spectra of basal cell carcinomas are distinct from non-tumor-bearing skin components. J Invest Dermatol. 1999;112:951-6.
118. Nijssen A, Bakker Schut TC, Heule F, et al Discriminating basal cell carcinoma from its surrounding tissue by Raman spectroscopy. J Invest Dermatol. 2002;119:64-9.
119. Onizawa K, Yoshida H, Saginoya H. Chromatic analysis of autofl uorescence emitted from squamous cell carcinomas arising in the oral cavity: A preliminary study. Int J Oral Maxillofac Surg. 2000;29:42-6.
120. Panjehpour M, Julius CE, Phan MN, et al Laser-induced fl uorescence spectroscopy for in vivo diagnosis of non-melanoma skin cancers. Lasers Surg Med. 2002;31: 367-73.
121. Sigurdsson S, Philipsen PA, Hansen LK, et al Detection of skin cancer by classifi cation of Raman spectra. IEEE Trans Biomed Eng. 2004;51:1784-93.
122. Stenquist B, Ericson MB, Strandeberg C, et al Bispectral fl uorescence imaging of aggressive basal cell carcinoma combined with histopathological mapping: A preliminary study indicating a possible adjunct to Mohs micrographic surgery. Br J Dermatol. 2006;154:305-9.
123. Svanberg K, Wang I, Colleen S, et al Clinical multi-colour fl uorescence imaging of malignant tumours-initial experience. Acta Radiol. 1998;39:2-9.
124. McIntosh LM, Summers R, Jackson M, et al Towards noninvasive screening of skin lesions by near-infrared spectroscopy. J Invest Dermatol. 2001;116:175-81.
125. Choi J, Choo J, Chung H, et al Direct observation of spectral differences between normal and basal cell carcinoma (BCC) tissues using confocal Raman microscopy. Biopolymers. 2005;77:264-72.
126. Inaguma M, Hashimoto K. Porphyrin-like fl uorescence in oral cancer: in vivo fl uorescence spectral characterization of lesions by use of a near-ultraviolet excited autofl uorescence diagnosis system and separation of fl uorescent extracts by capillary electrophoresis. Cancer. 1999; 86: 2201-11.
127. Na R, Stender IM, Wulf HC. Can autofl uorescence demarcate basal cell carcinoma from normal skin? A comparison with protoporphyrin IX fl uorescence. Acta DermVenereol. 2001;81:246-9.
128. Brancaleon L, Durkin AJ, Tu JH, et al In vivo fl uorescence spectroscopy of nonmelanoma skin cancer. Photochem Photobiol. 2001;73:178-83.
129. Sterenborg NJ, Thomsen S, Jacques SL, et al In vivo fl uorescence spectroscopy and imaging of human skin tumors. Dermatol Surg. 1995;21:821-2.
130. Ericson MB, Uhre J, Strandeberg C, et al Bispectral fl uorescence imaging combined with texture analysis and linear discrimination for correlation with histopathologic extent of basal cell carcinoma. J Biomed Opt. 2005; 10:034009.
131. Andersson-Engels S, Canti G, Cubeddu R, et al Preliminary evaluation of two fl uorescence imaging methods for the detection and the delineation of basal cell carcinomas of the skin. Lasers Surg Med. 2000;26:76-82.
132. Onizawa K, Okamura N, Saginoya H, et al Characterization of autofl uorescence in oral squamous cell carcinoma. Oral Oncol. 2003;39:150-6.
133. Palero JA, de Bruijn HS, van der Ploeg van den Heuvel, et al Spectrally resolved multiphoton imaging of in vivo and excised mouse skin tissues. Biophys J. 2007;93: 992-1007.
134. Konig K, Ehlers A, Riemann I, et al Clinical two-photon microendoscopy. Microsc Res Tech. 2007;70:398-402.
135. Skala MC, Riching KM, Bird DK, et al In vivo multiphoton fl uorescence lifetime imaging of protein-bound and free nicotinamide adenine dinucleotide in normal and precancerous epithelia. J Biomed Opt. 2007;12:024014.
136. Paoli J, Smedh M, Wennberg AM, et al Multiphoton laser scanning microscopy on non-melanoma skin cancer: morphologic features for future non-invasive diagnostics. J Invest Dermatol. 2007;128(5):1248-55.
137. Tehrani H, Walls J, Price G, et al A novel imaging technique as an adjunct to the in vivo diagnosis of nonmelanoma skin cancer. Br J Dermatol. 2006;155:1177-83.
138. Tehrani H, Walls J, Price G, et al A prospective comparison of spectrophotometric intracutaneous analysis to clinical judgment in the diagnosis of nonmelanoma skin cancer. Ann Plast Surg. 2007;58:209-11.
139. Terstappen K, Larko O, Wennberg AM. Pigmented basal cell carcinoma-comparing the diagnostic methods of SIAscopy and dermoscopy. Acta Derm Venereol. 2007;87: 238-42.
140. Pickwell E, Cole BE, Fitzgerald AJ, et al In vivo study of human skin using pulsed terahertz radiation. Phys Med Biol. 2004;49:1595-607.
141. Woodward RM, Cole BE, Wallace VP, et al Terahertz pulse imaging in refl ection geometry of human skin cancer and skin tissue. Phys Med Biol. 2002;47:3853-63.
142. Woodward RM, Wallace VP, Pye RJ, et al Terahertz pulse imaging of ex vivo basal cell carcinoma. J Invest Dermatol. 2003;120:72-8.
143. Wallace VP, Fitzgerald AJ, Shankar S, et al Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo. Br J Dermatol. 2004;151:424-32.
144. Emtestam L, Nicander I, Stenstrom M, et al Electrical impedance of nodular basal cell carcinoma: A pilot study. Dermatology. 1998;197:313-6.
145. Aberg P, Nicander I, Holmgren U, et al Assessment of skin lesions and skin cancer using simple electrical impedance indices. Skin Res Technol. 2003;9:257-61.
146. Aberg P, Geladi P, Nicander I, et al Non-invasive and microinvasive electrical impedance spectra of skin cancer-a comparison between two techniques. Skin Res Technol. 2005;11:281-6.
147. Kuzmina N, Talme T, Lapins, et al Non-invasive preoperative assessment of basal cell carcinoma of nodular and superfi cial types. Skin Res Technol. 2005;11:196-200.
148. Fosko SW, Hu W, Cook TF, et al Positron emission tomography for basal cell carcinoma of the head and neck. Arch Dermatol. 2003;139:1141-6.
149. Sigg MB, Steinert H, Gratz K, et al Staging of head and neck tumors: [18F]fl uorodeoxyglucose positron emission tomography compared with physical examination and conventional imaging modalities. J Oral Maxillofac Surg. 2003;61:1022-9.
150. Querleux B. Nuclear Magnetic Resonance (NMR) examination of the skin in vivo. Chapter 36 non-inasive methods of the skin., 2nd edn. Boca Raton, FL: CRC/Taylor & Francis, 2006.
151. Lanka B, Turner M, Orton C, et al Cross-sectional imaging in non-melanoma skin cancer of the head and neck. Clin Radiol. 2005;60:869-77.
152. Williams LS, Mancuso AA, Mendenhall WM. Perineural spread of cutaneous squamous and basal cell carcinoma: CT and MR detection and its impact on patient management and prognosis. Int J Radiat Oncol Biol Phys. 2001; 49:1061-9.
153. Whited JD, Hall RP, Simel DL, et al Primary care clinicians' performance for detecting actinic keratoses and skin cancer. Arch Intern Med. 1997;157:985-90.
154. Oliveria SA, Chau D, Christos PJ, et al Diagnostic accuracy of patients in performing skin self-examination and the impact of photography. Arch Dermatol. 2004;140: 57-62.
155. Westbrook RH, Goyal N, Gawkrodger DJ. Diagnostic accuracy for skin cancer: comparison of general practitioner with dermatologist and dermatopathologist. J Dermatolog Treat. 2006;17:57-8.
156. Renshaw AA, Pinnar NE, Jiroutek MR, et al Blinded review as a method for quality improvement in surgical pathology. Arch Pathol Lab Med. 2002;126:961-3.
157. Stucker M, Horstmann I, Nuchel C, et al Blood fl ow compared in benign melanocytic naevi, malignant melanomas and basal cell carcinomas. Clin Exp Dermatol. 1999;24: 107-11.
158. Schroder RJ, Maurer J, Zlowodski M, et al Vascularization of malignant and benign skin tumours measured by D-galactose-based signal-enhanced colour Doppler sonography. Acta Radiol. 2001;42:294-301.
159. Bertolotto M, Serafi ni G, Dogliotti L, et al Primary and secondary malignancies of the penis: ultrasound features. Abdom Imaging. 2005;30:108-12.
160. Lont AP, Besnard AP, Gallee MP, et al A comparison of physical examination and imaging in determining the extent of primary penile carcinoma. BJU Int 2003; 91: 493-5.
161. Zalaudek I, Argenziano G, Soyer HP, et al Three-point checklist of dermoscopy: An open internet study. Br J Dermatol. 2006;154:431-7.
162. Zalaudek I. Dermoscopy subpatterns of nonpigmented skin tumors. Arch Dermatol. 2005;141:532.
163. Chin CW, Foss AJ, Stevens A, et al Differences in the vascular patterns of basal and squamous cell skin carcinomas explain their differences in clinical behaviour. J Pathol. 2003;200:308-13.
164. Menzies SW. Dermoscopy of pigmented basal cell carcinoma. Clin Dermatol. 2002;20:268-9.
165. Welzel J, Lankenau E, Birngruber R, et al Optical coherence tomography of the human skin. J Am Acad Dermatol 1997;37:958-63.
166. Gerger A, Horn M, Koller S, et al Confocal examination of untreated fresh specimens from basal cell carcinoma: implications for microscopically guided surgery. Arch Dermatol. 2005;141:1269-74.
167. Sauermann K, Gambichler T, Wilmert M, et al Investigation of basal cell carcinoma [correction of carcionoma] by confocal laser scanning microscopy in vivo. Skin Res Technol. 2002;8:141-7.
168. Aghassi D, Anderson RR, Gonzalez S. Confocal laser microscopic imaging of actinic keratoses in vivo: A preliminary report. J Am Acad Dermatol. 2000;43:42-8.