Carcinogenesis of basal cell carcinomas: Genetics and molecular mechanisms

British Journal of Dermatology, Supplement

Volumn 146, Issue 61, 2002, Pages 17-19

  Lacour, J P ^a  

^a CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

Author keywords

Basal cell carcinoma; Gorlin syndrome; p53 gene; Patched gene; Skin cancer; UV radiation

Indexed keywords

PROTEIN P53; ZINC FINGER PROTEIN;

BASAL CELL CARCINOMA; CANCER GENETICS; CHROMOSOMAL LOCALIZATION; CONFERENCE PAPER; GENE LOCATION; GENE MUTATION; HUMAN; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; RADIATION EXPOSURE; SKIN CARCINOGENESIS; STRAIN DIFFERENCE; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE; ULTRAVIOLET B RADIATION;

EID: 0036241594     PISSN: 0366077X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.146.s61.5.x     Document Type: Conference Paper

References (9)

1. Basal cell carcinoma possibly originte from the outer root sheath and/or the bulge region of the vellus hair follicle
2. Mechanisms of induction of skin cancer by UV radiation
3. High levels of patched gene mutations in basal-cell carcinomas from patients with xeroderma pigmentosum
4. Activating Smoothened mutations in sporadic basal-cell carcinoma
5. Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene in basal cell carcinoma and medulloblastoma on chromosome 1p32
6. Gli1 protein is expressed in basal cell carcinomas, outer root sheath keratinocytes and a subpopulation of mesenchymal cells in normal human skin
7. Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
8. Basal cell carcinomas in mice overexpressing Sonic hedgehog
9. Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: A randomised controlled trial