Human taste receptor-functionalized field effect transistor as a human-like nanobioelectronic tongue

Nano Letters

Volumn 13, Issue 1, 2013, Pages 172-178

  Song, Hyun Seok ^a   Kwon, Oh Seok ^a   Lee, Sang Hun ^a   Park, Seon Joo ^a   Kim, Un Kyung ^b   Jang, Jyongsik ^a   Park, Tai Hyun ^a  

^a Seoul National University   (South Korea)

^b Kyungpook National University   (South Korea)

Author keywords

antithyroid toxin; conducting polymer; field effect transistor; Human taste receptor; nanobioelectronic tongue; nanotube

Indexed keywords

ANTITHYROID TOXIN; CARBOXYLATED POLYPYRROLE NANOTUBES; CELL-BASED ASSAYS; EFFICIENT DETECTION; ESCHERICHIA COLI (E. COLI); FUNCTIONALIZED; HAPLOTYPES; HIGH SENSITIVITY; NANOBIOELECTRONIC TONGUE; REAL FOODS; SENSOR PLATFORM; TASTE RECEPTORS; TASTE SENSOR;

CONDUCTING POLYMERS; ESCHERICHIA COLI; NANOTUBES; POLYPYRROLES; SENSORS; THIOUREAS;

FIELD EFFECT TRANSISTORS;

G PROTEIN COUPLED RECEPTOR;

ARTICLE; HUMAN; METABOLISM; NANOTECHNOLOGY; TASTE BUD; THEORETICAL MODEL; TONGUE;

HUMANS; MODELS, THEORETICAL; NANOTECHNOLOGY; RECEPTORS, G-PROTEIN-COUPLED; TASTE BUDS; TONGUE;

MLCS; MLOWN;

EID: 84872114941     PISSN: 15306984     EISSN: 15306992     Source Type: Journal    
DOI: 10.1021/nl3038147     Document Type: Article

References (33)

1. Habara, M.; Ikezaki, H.; Toko, K. Study of Sweet Taste Evaluation Using Taste Sensor with Lipid/polymer Membranes Biosens. Bioelectron. 2004, 19, 1559-1563
2. Luong, J. H. T.; Bouvrette, P.; Male, K. B. Developments and Applications of Biosensors in Food Analysis Trends Biotechnol. 1997, 15, 369-377
3. Terry, L. A.; White, S. F.; Tigwell, L. J. The Application of Biosensors to Fresh Produce and The Wider Food Industry J. Agric. Food Chem. 2004, 53, 1309-1316
4. Wang, P.; Liu, Q.; Xu, Y.; Cai, H.; Li, Y. Olfactory and Taste Cell Sensor and Its Applications in Biomedicine Sens. Actuators A 2007, 139, 131-138
5. Sekhar, P. K.; Brosha, E. L.; Mukundan, R.; Garzon, F. H. Chemical Sensors for Environmental Monitoring and Homeland Security Electrochem. Soc. Interface 2010, 35-40
6. Winquist, F.; Wide, P.; Lundströma, I. An Electronic Tongue Based on Voltammetry Anal. Chim. Acta 1997, 357, 21-31
7. Litvinchuk, S.; Tanaka, H.; Miyatake, T.; Pasini, D.; Tanaka, T.; Bollot, G.; Mareda, J.; Matile, S. Sugar Sensing with Synthetic Multifunctional Pores Nat. Mater. 2007, 6, 576-580
8. Zhang, C.; Suslick, K. S. Colorimetric Sensor Arrays for The Analysis of Beers: a Feasibility Study J Agric. Food Chem. 2007, 55, 237-242
9. Kim, T. H.; Lee, S. H.; Lee, J.; Song, H. S.; Oh, E. H.; Park, T. H.; Hong, S. Single-Carbon-Atomic-Resolution Detection of Odorant Molecules Using a Human Olfactory Receptor-Based Bioelectronic Nose Adv. Mater. 2008, 21, 91-94
10. Yoon, H.; Lee, S. H.; Kwon, O. S.; Song, H. S.; Oh, E. H.; Park, T. H.; Jang, J. Polypyrrole Nanotubes Vonjugated with Human Olfactory Receptors: High-Performance Transducers for FET-Type Bioelectronic Noses Angew. Chem., Int. Ed. 2009, 48, 2755-2758
11. Lindemann, B. Receptors and Transduction in Taste Nature 2001, 413, 219-225
12. McLaughlin, S. K.; McKinnon, M. P. J. R. F. Gustducin is a Taste-Cell-Specific G Protein Closely Related to The Transducins Nature 1992, 357, 563-569
13. Drewnowski, A.; Gomez-Carneros, C. Bitter Taste, Phytonutrients, and The Consumer: a Review Am. J. Clin. Nutr. 2000, 72, 1424-1435
14. Mueller, K. L.; Hoon, M. A.; Erlenbach, I.; Chandrashekar, J.; Zuker, C. S.; Ryba, N. J. P. The Receptors and Coding Logic for Bitter Taste Nature 2005, 434, 225-229
15. Bufe, B.; Breslin, P. A. S.; Kuhn, C.; Reed, D. R.; Tharp, C. D.; Slack, J. P.; Kim, U.-K.; Drayna, D.; Meyerhof, W. The Molecular Basis of Individual Differences in Phenylthiocarbamide and Propylthiouracil Bitterness Perception Curr. Biol. 2005, 15, 322-327
16. Kim, U. -K.; Jorgenson, E.; Coon, H.; Leppert, M.; Risch, N.; Drayna, D. (2003) Positional Cloning of The Human Quantitative Trait Locus Underlying Taste Sensitivity to Phenylthiocarbamide Science 2003, 299, 1221-1225
17. Sandell, M. A.; Breslin, P. A. S. Variability in a Taste-Receptor Gene Determines Whether We Taste Toxins in Food Curr. Biol. 2006, 16, R792-R794
18. Wooding, S.; Gunn, H.; Ramos, P.; Thalmann, S.; Xing, C.; Meyerhof, W. Genetics and Bitter Taste Responses to Goitrin, a Plant Toxin Found in Vegetables Chem. Sens. 2010, 35, 685-692
19. Kwon, O. S.; Park, S. J.; Lee, J. S.; Park, E.; Kim, T.; Park, H.-W.; You, S. A.; Yoon, H.; Jang, J. Multidimensional Conducting Polymer Nanotubes for Ultrasensitive Chemical Nerve Agent Sensing Nano Lett. 2012, 12, 2797-2802
20. Lee, S. H.; Kwon, O. S.; Song, H. S.; Park, S. J.; Sung, J. H.; Jang, J.; Park, T. H. Mimicking The Human Smell Sensing Mechanism With an Artificial Nose Platform Biomaterials 2012, 33, 1722-1729
21. Kim, T. H.; Song, H. S.; Jin, H. J.; Lee, S. H.; Namgung, S.; Kim, U.-K.; Park, T. H.; Hong, S. "Bioelectronic Super-Taster Device" Based on Taste Receptor-Carbon Nanotube Hybrid Structures Lab Chip. 2011, 11, 2262-2267
22. Lobez, J. M.; Swager, T. M. Radiation Detection: Resistivity Responses in Functional Poly(olefin sulfone)/Carbon Nanotube Composites Angew. Chem., Int. Ed. 2010, 49, 95-98
23. Song, H. S.; Lee, S. H.; Oh, E. H.; Park, T. H. Expression, Solubilization and Purification of a Human Olfactory Receptor from Escherichia coli Curr. Microbiol. 2009, 59, 309-314
24. Kwon, O. S.; Hong, T. J.; Kim, S. K.; Jeong, J. H.; Hahn, J. S.; Jang, J. Hsp90-Functionalized Polypyrrole Nanotube FET Sensor for Anti-Cancer Agent Detection Biosens. Bioelectron. 2010, 25, 1307-1312
25. Kwon, O. S.; Park, S. J.; Jang, J. A High-Performance VEGF Aptamer Functionalized Polypyrrole Nanotube Biosensor Biomaterials 2010, 31, 4740-4747
26. Rubenstein, L. A.; Lanzara, R. G. Activation of G Protein-Coupled Receptors Entails Cysteine Modulation of Agonist Binding J. Mol. Struct.: THEOCHEM 1998, 430, 57-71
27. Rubenstein, L. A.; Zauhar, R. J.; Lanzara, R. G. Molecular Dynamics of a Biophysical Model for [beta] 2-Adrenergic and G Protein-Coupled Receptor Activation J. Mol. Graph. Modell. 2006, 25, 396-409
28. Bones, A. M.; Rossiter, J. T. The Myrosinase-Glucosinolate System, Its Organisation and Biochemistry Physiol. Plantarum. 1996, 97, 194-208
29. Cartea, M. E.; Velasco, P. Glucosinolates in Brassica Foods: Bioavailability in Food and Significance for Human Health Phytochem. Rev. 2008, 7, 213-229
30. Surridge, A. K.; Bell, D. J.; Ibrahim, K. M.; Hewitt, G. M. Population Structure and Genetic Variation of European Wild Rabbits (Oryctolagus Cuniculus) in East Anglia Heredity 1999, 82, 479-487
31. Byon, H. R.; Choi, H. C. Network Single-Walled Carbon Nanotube-Field Effect Transistors (SWNT-FETs) with Increased Schottky Contact Area for Highly Sensitive Biosensor Applications J. Am. Chem. Soc. 2006, 128, 2188-2189
32. Park, S. J.; Kwon, O. S.; Lee, S. H.; Song, H. S.; Park, T. H.; Jang, J. Ultrasensitive Flexible Graphene Based Field-Effect Transistor (FET)-Type Bioelectronic Nose Nano Lett. 2012, 12, 5082-5090
33. Kwon, O. S.; Ahn, S. R.; Park, S. J.; Song, H. S.; Lee, S. H.; Hong, J.-Y.; Lee, J. S.; You, S. A.; Yoon, H.; Park, T. H.; Jang, J. Ultrasensitive and Selective Recognition of Peptide Hormone Using Close-Packed Arrays of hPTHR-Conjugated Polymer Nanoparticles ACS Nano 2012, 6, 5549-5558