Hedgehog signaling regulates the repair response in mouse liver damaged by irradiation

Radiation Research

Volumn 179, Issue 1, 2013, Pages 69-75

  Wang, Sihyung ^a   Hyun, Jeongeun ^a   Youn, Buhyun ^a   Jung, Youngmi ^a  

^a Pusan National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BIOLOGICAL MARKER; CASPASE 3; HERMES ANTIGEN; LAMININ; LAMININ BETA3; OSTEOGENIC PROTEIN 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER RADIOTHERAPY; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; FIBROGENESIS; HISTOPATHOLOGY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIPID STORAGE; LIVER CANCER; LIVER FIBROSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIATION DOSE; RADIATION INJURY; RADIATION INJURY REPAIR; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STELLATE CELL; STEM CELL; UPREGULATION;

ANIMALS; CELL PROLIFERATION; FEMALE; FIBROSIS; HEDGEHOG PROTEINS; HEPATIC STELLATE CELLS; LIVER; MICE; MICE, INBRED C57BL; MYOFIBROBLASTS; SIGNAL TRANSDUCTION; STEM CELLS; UP-REGULATION;

ERINACEIDAE; MUS;

EID: 84872110691     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR3091.1     Document Type: Article

References (41)

1. Du SS, Qiang M, Zeng ZC, Zhou J, Tan YS, Zhang ZY, et al. Radiation-induced liver fibrosis is mitigated by gene therapy inhibiting transforming growth factor-b signaling in the rat. Int J Radiat Oncol Biol Phys 2010; 78(5):1513-23.
2. Marx R, Johnson R, Kline S. Prevention of osteoradionecrosis: a randomized prospective clinical trial of hyperbaric oxygen versus penicillin. J Am Dent Assoc 1985; 111(1):49-54.
3. Jennings F, Arden A. Development of radiation pneumonitis time and dose factors. Arch Pathol Lab Med 1962; 74.
4. Zhao W, Diz D, Robbins M. Oxidative damage pathways in relation to normal tissue injury. Br J Radiol 2007; 80(1):S23-31. (Pubitemid 47517796)
5. Ehrhart E, Segarini P, Tsang M, Carroll AG, Barcellos-Hoff MH. Latent transforming growth factor beta1 activation in situ: quantitative and functional evidence after low-dose gammairradiation. FASEB J 1997; 11(12):991-1002. (Pubitemid 27425901)
6. Barcellos-Hoff M, Derynck R, Tsang M, Weatherbee J. Transforming growth factor-beta activation in irradiated murine mammary gland. J Clin Invest 1994; 93(2):892-5.
7. Riley P. Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int J Radiat Biol 1994; 65(1):27-33.
8. Giusti AM. Human cell membrane oxidative damage induced by single and fractionated doses of ionizing radiation: a fluorescence spectroscopy study. Int J Radiat Biol 1998; 74(5):595-605. (Pubitemid 28539459)
9. Martin M, Lefaix JL, Delanian S. TGF-b1 and radiation fibrosis: A master switch and a specific therapeutic target? Int J Radiat Oncol Biol Phys 2000; 47(2):277-90. (Pubitemid 30236366)
10. Yarnold J, Vozenin Brotons MC. Pathogenetic mechanisms in radiation fibrosis. Radiother Oncol 2010; 97(1):149-61.
11. Jeong WI, Do SH, Kim TH, Jeong DH, Hong IH, Ki MR, et al. Acute effects of fast neutron irradiation on mouse liver. J Radiat Res 2007; 48(3):233-40.
12. Chung SI, Seong J, Park YN, Kim WW, Oh HJ, Han KH. Identification of proteins indicating radiation-induced hepatic toxicity in cirrhotic rats. J Radiat Res 2010; 51(6):643-50.
13. Lee IJ, Seong J, Shim SJ, Han KH. Radiotherapeutic parameters predictive of liver complications induced by liver tumor radiotherapy. Int J Radiat Oncol Biol Phys 2009; 73(1):154-8.
14. Lawrence TS, Robertson JM, Anscher MS, Jirtle RL, Ensminger WD, Fajardo LF. Hepatic toxicity resulting from cancer treatment. Int J Radiat Oncol Biol Phys 1995; 31(5):1237-48.
15. Capps GW, Fulcher AS, Szucs RA, Turner MA. Imaging features of radiation-induced changes in the abdomen. Radiographics 1997; 17(6):1455-73. (Pubitemid 127466067)
16. Geraci J, Mariano M. Radiation hepatology of the rat: parenchymal and nonparenchymal cell injury. Radiat Res 1993; 136(2):205-13. (Pubitemid 24004685)
17. Geraci J, Jackson K, Mariano M, Leitch J. Hepatic injury after whole-liver irradiation in the rat. Radiat Res 1985; 101(3):508-18. (Pubitemid 15122088)
18. Seong J, Han KH, Park YN, Nam SH, Kim SH, Keum WS, et al. Lethal hepatic injury by combined treatment of radiation plus chemotherapy in rats with thioacetamide-induced liver cirrhosis. Int J Radiat Oncol Biol Phys 2003; 57(1):282-8. (Pubitemid 36959767)
19. Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 2001; 15(23):3059-32.
20. van den Brink GR. Hedgehog signaling in development and homeostasis of the gastrointestinal tract. Physiol Rev 2007; 87(4): 1343-75. (Pubitemid 350033824)
21. Varjosalo M, Taipale J. Hedgehog: functions and mechanisms. Genes Dev 2008; 22(18):2454-72.
22. Jung Y, Brown KD, Witek RP, Omenetti A, Yang L, Vandongen M, et al. Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans. Gastroenterology 2008; 134(5):1532-43.
23. Jung Y, Witek RP, Syn WK, Choi SS, Omenetti A, Premont R, et al. Signals from dying hepatocytes trigger growth of liver progenitors. Gut 2010; 59(5):655-65.
24. Rangwala F, Guy CD, Lu J, Suzuki A, Burchette JL, Abdelmalek MF, et al. Increased production of sonic hedgehog by ballooned hepatocytes. J Pathol 2011; 59.
25. Choi SS, Omenetti A, Witek RP, Moylan CA, Syn WK, Jung Y, et al. Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. Am J Physiol 2009; 297(6): G1093-106.
26. Jung Y, McCall SJ, Li YX, Diehl AM. Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis. Hepatology 2007; 45(5):1091-6. (Pubitemid 46775770)
27. Syn WK, Jung Y, Omenetti A, Abdelmalek M, Guy CD, Yang L, et al. Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. Gastroenterology 2009; 137(4):1478-88.
28. Sicklick JK, Li YX, Melhem A, Schmelzer E, Zdanowicz M, Huang J, et al. Hedgehog signaling maintains resident hepatic progenitors throughout life. Am J Physiol 2006; 290(5):G859-70.
29. Yang L, Wang Y, Mao H, Fleig S, Omenetti A, Brown KD, et al. Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. J Hepatol 2008; 48(1):98-06.
30. Jaal J, Dö rr W. Radiation-induced damage to mouse urothelial barrier. Radiother Oncol 2006; 80(2):250-62.
31. Li N, Zhang L, Li H, Fang B. Administration of granulocyte colony-stimulating factor ameliorates radiation-induced hepatic fibrosis in mice. Transplant Proc 2010; 3833-9.
32. Witek RP, Yang L, Liu R, Jung Y, Omenetti A, Syn WK, et al. Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells. Gastroenterology 2009; 136(1):320-30.
33. Thiery JP. Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 2003; 15(6):740-6. (Pubitemid 37487967)
34. Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, et al. BMP-7 counteracts TGF-b1-induced epithelial-tomesenchymal transition and reverses chronic renal injury. Nat Med 2003; 9(7):964-8. (Pubitemid 36889942)
35. Choi SS, Diehl AM. Epithelial-to-mesenchymal transitions in the liver. Hepatology 2009; 50(6):2007-13.
36. Zou Y, Bao Q, Kumar S, Hu M, Wang GY, Dai G. Four waves of hepatocyte proliferation linked with three waves of hepatic fat accumulation during partial hepatectomy-induced liver regeneration. PloS One 2012; 7(2):e30675.22.
37. Itagaki T, Shimizu I, Cheng X, Yuan Y, Oshio A, Tamaki K, et al. Opposing effects of oestradiol and progesterone on intracellular pathways and activation processes in the oxidative stress induced activation of cultured rat hepatic stellate cells. Gut 2005; 54(12): 1782-9. (Pubitemid 41697679)
38. Borkham-Kamphorst E, van Roeyen CRC, Ostendorf T, Floege J, Gressner AM, Weiskirchen R. Pro-fibrogenic potential of PDGF-D in liver fibrosis. J Hepatol 2007; 46(6):1064-74. (Pubitemid 46669736)
39. Omenetti A, Yang L, Li YX, McCall SJ, Jung Y, Sicklick JK, et al. Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation. Lab Invest 2007; 87(5): 499-14. (Pubitemid 46633127)
40. Witek RP, Stone WC, Karaca FG, Syn WK, Pereira TA, Agboola KM, et al. Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. Hepatology 2009; 50(5):1421-30.
41. Omenetti A, Porrello A, Jung Y, Yang L, Popov Y, Choi SS, et al. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest 2008; 118(10):3331.20.