Spectroscopic, steady-state kinetic, and mechanistic characterization of the radical SAM enzyme QueE, which catalyzes a complex cyclization reaction in the biosynthesis of 7-deazapurines

Biochemistry

Volumn 52, Issue 1, 2013, Pages 188-198

  McCarty, Reid M ^a,c   Krebs, Carsten ^b   Bandarian, Vahe ^a  

^a University of Arizona   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACILLUS SUBTILIS; BIOSYNTHETIC PATHWAY; CATALYTIC CYCLES; COFACTORS; CYCLIZATION REACTIONS; DIVALENT METAL ION; ENZYMATIC TRANSFORMATION; HYDROGEN ATOM ABSTRACTION; MOSSBAUER; REACTION CATALYZED; REDUCTIVE CLEAVAGE; RING CONTRACTION; S ADENOSYL L METHIONINES; SPECTROSCOPIC FEATURES; STEADY-STATE KINETICS; SYNTHASES;

ABSTRACTING; AMINO ACIDS; BIOCHEMISTRY; BIOSYNTHESIS; CYCLIZATION; DEUTERIUM; HYDROGEN; KINETICS; MAGNESIUM; MAGNETIC RESONANCE; METAL IONS; PARAMAGNETISM;

CATALYSIS;

HYDROGEN; MAGNESIUM; PURINE DERIVATIVE; S ADENOSYLMETHIONINE;

ARTICLE; BACILLUS SUBTILIS; CATALYSIS; CYCLIZATION; DRUG SYNTHESIS; ELECTRON SPIN RESONANCE; ENZYME METABOLISM; MOSSBAUER SPECTROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; STEADY STATE;

BACILLUS SUBTILIS; BACTERIAL PROTEINS; CATALYSIS; CYCLIZATION; ELECTRON SPIN RESONANCE SPECTROSCOPY; GUANINE; IRON-SULFUR PROTEINS; KINETICS; PROTEIN STRUCTURE, QUATERNARY; PTERINS; S-ADENOSYLMETHIONINE; SPECTROSCOPY, MOSSBAUER;

BACILLUS SUBTILIS;

EID: 84872108164     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301156w     Document Type: Article

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