Characterization and mechanistic studies of DesII: A radical S-adenosyl-l-methionine enzyme involved in the biosynthesis of TDP-D-desosamine

Journal of the American Chemical Society

Volumn 131, Issue 39, 2009, Pages 14030-14042

  Szu, Ping Hui ^a,b   Ruszczycky, Mark W ^a   Choi, Sei Hyun ^a   Yan, Feng ^a,c   Liu, Hung Wen ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b STANFORD UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGLYCONES; BIOCHEMICAL STUDIES; BIOLOGICAL ACTIVITIES; CATALYTIC CYCLES; CATALYZED REACTIONS; D-GLUCOSE; DEAMINATION REACTION; DESOSAMINE; ENZYME SUPERFAMILIES; EPR SPECTROSCOPY; FLAVODOXIN; HYDROGEN ATOM ABSTRACTION; HYDROGEN-ATOM TRANSFER; MACROLIDE ANTIBIOTICS; MECHANISTIC STUDIES; PIKROMYCIN; S ADENOSYL L METHIONINES; STEADY-STATE KINETICS; STREPTOMYCES VENEZUELAE;

AMINATION; AMINES; ANTIBIOTICS; ATOMS; BIOCHEMISTRY; BIOSYNTHESIS; DEUTERIUM; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME ACTIVITY; ENZYMES; GLUCOSE; HYDROGEN; PARAMAGNETIC RESONANCE;

FREE RADICAL REACTIONS;

CARBOHYDRATE DERIVATIVE; DES2 ENZYME; DESOSAMINE; DEUTERIUM; FLAVODOXIN; FLAVODOXIN REDUCTASE; HISTIDINE; HYDROGEN; IRON; METHYMYCIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; S ADENOSYLMETHIONINE; S ADENOSYLMETHIONINE ENZYME; SULFUR; THYMIDINE DIPHOSPHATE; THYMIDINE DIPHOSPHATE [3-H 2]4 AMINO 4,6 DIDEOXY GLUCOSE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; DEAMINATION; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME RECONSTITUTION; ENZYME SPECIFICITY; ESCHERICHIA COLI;

FLAVODOXIN; IRON-SULFUR PROTEINS; METABOLIC NETWORKS AND PATHWAYS; NADH, NADPH OXIDOREDUCTASES; NUCLEOSIDE DIPHOSPHATE SUGARS; OXIDOREDUCTASES; S-ADENOSYLMETHIONINE;

EID: 70350113877     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja903354k     Document Type: Article

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