Unsymmetrically disubstituted urea derivatives: A potent class of antiglycating agents

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 6, 2009, Pages 2447-2451

  Khan, Khalid M ^a   Saeed, Sumayya ^a   Ali, Muhammad ^a   Gohar, Madiha ^a   Zahid, Javariya ^a   Khan, Ambreen ^a   Perveen, Shahnaz ^b   Choudhary, M Iqbal ^a  

^a UNIVERSITY OF KARACHI   (Pakistan)

^b PCSIR LABORATORIES COMPLEX   (Pakistan)

Author keywords

Antiglycation; Lead compounds; Substituent effects; Unsymmetrically disubstituted urea

Indexed keywords

ADVANCED GLYCATION END PRODUCT; N (2 BROMOPHENYL) N' (3 CHLOROPHENYL)UREA; N (3 BROMOPHENYL) N' (3 CHLOROPHENYL)UREA; N (3 BROMOPHENYL) N' PHENYLUREA; N (3 CHLOROPHENYL) N' (2 METHOXYPHENYL)UREA; N (3 CHLOROPHENYL) N' (3 METHOXYPHENYL)UREA; N (3 CHLOROPHENYL) N' (3,4 CHLOROPHENYL)UREA; N (3 CHLOROPHENYL) N' (4 METHOXYPHENYL)UREA; N (3 NITROPHENYL) N' PHENYLUREA; N (3,4 DIMETHYLPHENYL) N' PHENYLUREA; N (4 BROMOPHENYL) N' PHENYLUREA; N (4 METHOXYPHENYL) N' PHENYLUREA; RUTOSIDE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; DRUG SCREENING; DRUG SYNTHESIS; GLYCATION; IC 50; REACTION ANALYSIS;

GLUCOSE; MAGNETIC RESONANCE SPECTROSCOPY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; UREA;

EID: 62149128613     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.01.075     Document Type: Article

References (27)

1. Fournier J., Bruneau C., Dixneuf H., and Lécolier S. J. Org. Chem. 56 (1991) 4456
2. Groszek G. Org. Process Res. Dev. 6 (2002) 759
3. Emerson, J. C.; Steimel, L. H. U.S. Patent, App. 11/333155, 2007 (Assignee: JohnsonDiversey, Inc., USA).
4. Floersheimer, A.; Furet, P.; Manley, P. W.; Bold, G.; Boss, E.; Guagnano, V.; Vaupel, A. European Patent, App. EP20030755147, 2005 (Assignee: Novartis Pharma).
5. Thavonekham B. Synthesis (1997) 1189
6. Igarashi, S.; Futagawa, M.; Tanaka, N.; Kawamura, Y.; Morimoto, K. Japanese Patent, App. PCT/JP1998/000855, 1998.
7. Floersheimer, A.; Furet, P. U.S. Patent, App. 10/515113, 2006.
8. Bigi F., Maggi R., and Sartori G. Green Chem. 2 (2000) 140
9. Majer P., and Randad R.S. J. Org. Chem. 59 (1994) 1937
10. Knolker H.-J., Braxmeier T., and Schlechtingen G. Synlett (1996) 502
11. Brownlee M. Diabetes 43 (1994) 836
12. Peppa M., Uribarri J., and Vlassara H. Clin. Diabetes 21 (2003) 186
13. Monnier V.M. Arch. Biochem. Biophys. 419 (2003) 1
14. Vasan S., Foiles P., and Founds H. Arch. Biochem. Biophys. 419 (2003) 89
15. Hunt J.V., Bottoms M.A., and Mitchinson M.J. Biochem. J. 291 (1993) 529
16. Ahmed N. Diabetes Res. Clin. Pract. 67 (2005) 3
17. Ahmed M.S., and Ahmed N. Am. Soc. Nutrit. 136 (2006) 796S
18. Gugliucci A. J. Am. Osteopath. Assoc. 100 (2000) 621
19. Singh R., Barden A., Mori T., and Beilin L. Diabetologia 44 (2001) 129
20. Degenhardt T.P., Anderson N.L., Arrington D.D., Beattie R.J., and Basgen J.M. Kidney Int. 61 (2002) 939
21. Forbes J.M., Soulis T., Thallas V., Panagiotopoulos S., and Long D.M. Diabetologia 44 (2001) 108
22. Lehman T.D., and Ortwerth B.J. Biochim. Biophys. Acta 1535 (2001) 110
23. Price D.L., Rhett P.M., Thorpe S.R., and Baynes J.W. J. Biol. Chem. 276 (2001) 48967
24. Gugliucci A., and Menini T. Life Sci. 72 (2003) 2603
25. Hai S.M.A., Perveen S., Khan R.A., Khan K.M., and Afza N. Nat. Prod. Res. 17 (2003) 351
26. Perveen S., Hai S.M.A., Khan R.A., Khan K.M., Afza N., and Sarfaraz T.B. Synth. Commun. 35 (2005) 1663
27. Nakagawa T., Yokozawa T., Terasawa K., Shu S., and Juneja L.R. J. Agric. Food Chem. 50 (2002) 2418