Synthesis of novel naphthoquinone aliphatic amides and esters and their anticancer evaluation

European Journal of Medicinal Chemistry

Volumn 60, Issue , 2013, Pages 271-284

  Kongkathip, Boonsong ^a   Akkarasamiyo, Sunisa ^a   Hasitapan, Komkrit ^a   Sittikul, Pichamon ^a   Boonyalai, Nonlawat ^a   Kongkathip, Ngampong ^a  

^a KASETSART UNIVERSITY   (Thailand)

Author keywords

Anticancer activity; Cancer; Naphthoquinone aliphatic amide; Naphthoquinone aliphatic ester; Topoisomerase II

Indexed keywords

3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL 2 METHYL BUTANOIC ACID; 3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL 2 METHYL OCTANOIC ACID; 3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL 2 METHYL PENTANOIC ACID; 3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL 2 METHYL PROPANOIC ACID; 3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL HEPTANOIC ACID; 3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL HEXANOIC ACID; 3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL NONANOIC ACID; 3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL OCTANOIC ACID; 3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL PROPANOIC ACID; ALIPHATIC CARBOXYLIC ACID; AMIDE; ANTINEOPLASTIC AGENT; CARBON; DNA TOPOISOMERASE (ATP HYDROLYSING); ESTER DERIVATIVE; N [3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 METHYL OCTANAMIDE; N [3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 METHYL PENTANAMIDE; N [3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 METHYLBUTANAMIDE; N [3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 METHYLPROPANAMIDE; N [3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] HEPTANAMIDE; N [3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] HEXANAMIDE; N [3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] OCTANAMIDE; N [3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL]DECANAMIDE; N [3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL]DODECANAMIDE; N [3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL]HEXADECANAMIDE; N [3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL]NONAMIDE; N [3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL]TETRADECANAMIDE; N [3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL]UNDECANAMIDE; NAPHTHOQUINONE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN KB; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ENZYME ACTIVITY; IC 50; MOLECULAR DOCKING; NONHUMAN; VERO CELL;

AMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CERCOPITHECUS AETHIOPS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ESTERS; HUMANS; KB CELLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHOQUINONES; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

EID: 84872099296     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.12.006     Document Type: Article

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