First synthesis and anticancer activity of novel naphthoquinone amides

European Journal of Medicinal Chemistry

Volumn 49, Issue , 2012, Pages 253-270

  Pradidphol, Narathip ^a   Kongkathip, Ngampong ^a   Sittikul, Pichamon ^a   Boonyalai, Nonlawat ^a   Kongkathip, Boonsong ^a  

^a KASETSART UNIVERSITY   (Thailand)

Author keywords

Anticancer activity; Cancer; Naphthoquinone amides; Structure activity relationships; Topoisomerase II

Indexed keywords

1 HYDROXY N[3 (1 HYDROXYNAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 NAPHTHAMIDE; 1 HYDROXY N[3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 NAPHTHAMIDE; 1 METHOXY N[3 (1 METHOXYNAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 NAPHTHAMIDE; 1 METHOXY N[3 (3 METHOXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 NAPHTHAMIDE; 2 HYDROXY N[3 (1 HYDROXYNAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL]BENZAMIDE; 2 HYDROXY N[3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL] 2,2 DIMETHYLPROPYL)BENZAMIDE; 2 METHOXY N[3 (1 METHOXYNAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL]BENZAMIDE; 2 METHOXY N[3 (3 METHOXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL]BENZAMIDE; 3 (1 METHOXYNAPHTHALEN 2 YL) 2,2 DIMETHYLPROPAN 1 AMINE; ANTINEOPLASTIC AGENT; AROMATIC COMPOUND; METHYL 2 [(1 METHOXYNAPHTHALEN 2 YL)METHYL] 2 METHYLPROPANOATE; N[3 (1 HYDROXYNAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 BENZAMIDE; N[3 (1 HYDROXYNAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 NAPHTHAMIDE; N[3 (1 METHOXYNAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 BENZAMIDE; N[3 (1 METHOXYNAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 NAPHTHAMIDE; N[3 (1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 1 HYDROXY 2 NAPHTHAMIDE; N[3 (1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 1 METHOXY 2 NAPHTHAMIDE; N[3 (1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 BENZAMIDE; N[3 (1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 HYDROXYBENZAMIDE; N[3 (1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 METHOXYBENZAMIDE; N[3 (1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 NAPHTHAMIDE; N[3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 BENZAMIDE; N[3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 METHOXYBENZAMIDE; N[3 (3 HYDROXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL] 2 NAPHTHAMIDE; N[3 (3 METHOXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL) 2 NAPHTHAMIDE; N[3 (3 METHOXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL) 2,2 DIMETHYLPROPYL]BENZAMIDE; NAPHTHALENE DERIVATIVE; NAPHTHOQUINONE AMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROXYLATION; MOLECULAR DOCKING;

AMIDES; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; NAPHTHOQUINONES; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84857233104     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.01.020     Document Type: Article

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