Transforming rhinacanthin analogues from potent anticancer agents into potent antimalarial agents

Journal of Medicinal Chemistry

Volumn 53, Issue 3, 2010, Pages 1211-1221

  Kongkathip, Ngampong ^a   Pradidphol, Narathip ^a   Hasitapan, Komkrit ^a   Grigg, Ronald ^b   Kao, Wei Chun ^b   Hunte, Carola ^b   Fisher, Nicholas ^c   Warman, Ashley J ^c   Biagini, Giancarlo A ^c   Kongsaeree, Palangpon ^d   Chuawong, Pitak ^a   Kongkathip, Boonsong ^a  

^a KASETSART UNIVERSITY   (Thailand)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^d Mahidol University   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 3 (1,4 D IHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL 2 METHYLBUTANOATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL 2 ETHYLBUTANOATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL 2 METHYL OCTANOATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL 2 METHYLBUTANOATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL 2 METHYLPENTANOATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL 3 METHYLPENTANOATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL ACETATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL BUTYRATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL DECANOATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL DODECANOATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL HEPTANOATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL HEXANOATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL ISOBUTYRATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL ISOVALERATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL NONANOATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL OCTANOATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL PALMITATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL PENTANOATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL PROPIONATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL STEARATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL TETRADECANOATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL) 2,2 DIMETHYLPROPYL UNDECANOATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL)PROPYL ACETATE; 3 (1,4 DIHYDRO 2 HYDROXY 1,4 DIOXONAPHTHALEN 3 YL)PROPYL BUTYRATE; ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; MONOMER; RHINACANTHIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG SYNTHESIS; IC 50; NONHUMAN; PLASMODIUM FALCIPARUM; RAT; VERO CELL;

ANIMALS; ANTIMALARIALS; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; ELECTRON TRANSPORT COMPLEX III; ERYTHROCYTES; INHIBITORY CONCENTRATION 50; MALARIA, FALCIPARUM; MALE; MITOCHONDRIAL MEMBRANES; NAPHTHOQUINONES; PLASMODIUM FALCIPARUM; RATS; RATS, WISTAR; SACCHAROMYCES CEREVISIAE; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

EID: 77249142352     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901545z     Document Type: Article

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