A single N-acetylgalactosamine residue at threonine 106 modifies the dynamics and structure of interferon α2a around the glycosylation site

Journal of Biological Chemistry

Volumn 288, Issue 1, 2013, Pages 247-254

  Ghasriani, Houman ^a,b   Belcourt, Pascal J F ^a,c   Sauvé, Simon ^a   Hodgson, Derek J ^a   Brochu, Denis ^d   Gilbert, Michel ^d   Aubin, Yves ^a,b,c  

^a HEALTH CANADA   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c CARLETON UNIVERSITY   (Canada)

^d NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ENHANCEMENT MEASUREMENTS; HETERONUCLEAR; HIGH RESOLUTION; ISOTOPICALLY LABELED; O-LINKED GLYCOPROTEINS; STRUCTURE AND DYNAMICS; THREE-DIMENSIONAL STRUCTURE; TIME-SCALES;

AMINO ACIDS; DYNAMICS; ESCHERICHIA COLI; ESTERIFICATION; GLUCOSE; GLYCOSYLATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

GLYCOPROTEINS;

ALPHA2A INTERFERON; GLYCOPROTEIN; MONOSACCHARIDE; N ACETYLGALACTOSAMINE; N ACETYLGALACTOSAMINE[13C,15N]ALPHA2A INTERFERON; THREONINE; UNCLASSIFIED DRUG;

ADDITION REACTION; ARTICLE; BIOLOGICAL ACTIVITY; HUMAN; IN VITRO STUDY; ISOTOPE LABELING; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN GLYCOSYLATION; PROTEIN METABOLISM; PROTEIN POLYMORPHISM; PROTEIN STRUCTURE; PROTEIN SYNTHESIS;

ACETYLGALACTOSAMINE; COMPUTATIONAL BIOLOGY; DISULFIDES; ESCHERICHIA COLI; GLYCOPROTEINS; GLYCOSYLATION; HUMANS; INTERFERON-ALPHA; INTERFERONS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PEPTIDES; POLYSACCHARIDES; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; THREONINE;

ESCHERICHIA COLI;

EID: 84872081065     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.413252     Document Type: Article

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