Interoceptive conditioning with the nicotine stimulus: Extinction learning as a method for assessing stimulus similarity across doses

Behavioural Pharmacology

Volumn 24, Issue 1, 2013, Pages 45-54

  Polewan, Robert J ^a,b   Savala, Stephanie A ^a   Bevins, Rick A ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^b STEPHEN F AUSTIN STATE UNIVERSITY   (United States)

Author keywords

drug discrimination; goal tracking; Pavlovian conditioning; rat; smoking; tobacco

Indexed keywords

NICOTINE; SODIUM CHLORIDE; SUCROSE;

ANIMAL EXPERIMENT; ARTICLE; DISCRIMINATION LEARNING; INTEROCEPTIVE CONDITIONING; MALE; NONHUMAN; PATTERN RECOGNITION; RAT; STIMULUS; TASK PERFORMANCE;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CONDITIONING, CLASSICAL; DISCRIMINATION LEARNING; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTINCTION, PSYCHOLOGICAL; GANGLIONIC STIMULANTS; LEARNING DISORDERS; MALE; NEURONS; NICOTINE; NICOTINIC AGONISTS; RATS; RATS, SPRAGUE-DAWLEY; SMOKING;

EID: 84872070205     PISSN: 09558810     EISSN: 14735849     Source Type: Journal    
DOI: 10.1097/FBP.0b013e32835d5278     Document Type: Article

References (61)

1. Balster RL (1988). Drugs as chemical stimuli. In: Colpaert FC, Balster RL, editors. Psychopharmacology series 4: transduction mechanisms of drug stimuli. NY: Springer; pp. 3-11.
2. Benowitz NL (2008). Neurobiology of nicotine addiction: implications for smoking cession treatment. Am J Med 121:S3-S10.
3. Besheer J, Palmatier MI, Metschke DM, Bevins RA (2004). Nicotine as a signal for the presence or absence of sucrose reward: Pavlovian drug appetitive conditioning preparation in rats. Psychopharmacology (Berl) 172:108-117.
4. Bevins RA (2009). Altering the motivational function of nicotine through conditioning processes. In: Bevins RA, Caggiula AR, editors. Volume 55 of the Nebraska symposium on motivation: the motivational impact of nicotine and its role in tobacco use. New York, NY: Springer Science + Business Media; pp. 111-129.
5. Bevins RA, Murray JE (2011). Internal stimuli generated by abused substances: role of Pavlovian conditioning and its implications for drug addiction. In: Scachtan TR, Reilly S, editors. Associative learning and conditioning; human and non-human applications. New York, NY: Oxford University Press; pp. 270-289.
6. Bevins RA, Palmatier MI (2003). Nicotine-conditioned locomotor sensitization in rats: assessment of the US-preexposure effect. Behav Brain Res 143: 65-74.
7. Bevins RA, Palmatier MI (2004). Extending the role of associative learning processes in nicotine addiction. Behav Cogn Neurosci Rev 3:143-158.
8. Bevins RA, Jensen HC, Hinze TS, Besheer J (1999). Taste quality and extinction of a conditioned taste aversion in rats. Anim Learn Behav 27:358-366.
9. Bevins RA, Barrett ST, Polewan RJ, Pittenger ST, Swalve N, Charntikov S (2012). Disentangling the nature of the nicotine stimulus. Behav Processes 90:28-33.
10. Blough DS (1975). Steady state data and a quantitative model of operant generalization and discrimination. J Exp Psychol Anim Behav Processes 1:3-21.
11. Boakes RA (1977). Performance on learning to associate a stimulus with positive reinforcement. In: Davis H, Hurwitz HMB, editors. Operant-Pavlovian interactions. Hillsdale, NJ: Lawrence Erlbaum Associates; pp. 67-101.
12. Bouton ME (1991). Context and retrieval in extinction and in other examples of interference in simple associative learning. In: Dachowski L, Flaherty CF, editors. Current topics in animal learning: brain, emotion, and cognition. Hillsdale, NJ, US: Erlbaum; pp. 25-53.
13. Bouton ME (1993). Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. Psychol Bull 114:80-99.
14. Bouton ME (2002). Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. Biol Psychiatry 52:976-986.
15. Bouton ME, Sunsay C (2003). Importance of trial versus accumulating time across trials in partially reinforced appetitive conditioning. J Exp Psychol Anim Behav Processes 29:62-77.
16. Caggiula AR, Donny EC, White AR, Chaudhri N, Booth S, Gharib MA, et al. (2001). Cue dependency of nicotine self-administration and smoking. Pharmacol Biochem Behav 70:515-530.
17. Center for Disease Control (2009). Cigarette smoking among adults and trends in smoking cessation-United States, 2008. Morb Mortal Wkly Rep 58:1227-1232.
18. Center for Disease Control (2011). Smoking & tobacco use. Available at: http://www. cdc. gov/tobacco/data-statistics/fact-sheets/index. htm [Accessed 12 May 2012].
19. Costa DSJ, Boakes RA (2009). Context blocking in rat autoshaping: sign-tracking verses goal-tracking. Learn Motiv 40:178-185.
20. Damaj MI, Creasy KR, Welch SP, Rosecrans JA, Aceto MD, Martin BR (1995). Comparative pharmacology of nicotine and ABT-418, a new nicotinic agonist. Psychopharmacology (Berl) 120:483-490.
21. Danna CL, Elmer GI (2010). Disruption of conditioned reward associated by typical and atypical antipsychotics. Pharmacol Biochem Behav 96:40-47.
22. Davis M, Myers KM (2002). The role of glutamate and gamma-aminobutyric acid in fear extinction: clinical implications for exposure therapy. Biol Psychiatry 52:998-1007.
23. Delamater AR (1995). Outcome-selective effects of intertrial reinforcement in a Pavlovian appetitive conditioning paradigm with rats. Anim Learn Behav 23:31-39.
24. Delamater AR (2004). Experimental extinction in Pavlovian conditioning: behavioural and neuroscience perspectives. Q J Exp Psychol B 57:97-132.
25. Dion AM, Sanderson SC, Murrin LC, Bevins RA (2012). Diminished conditioned responding to the nicotine stimulus by antidepressant drugs with differing specificity for the serotonin and norepinephrine transporter. Pharmacol Biochem Behav 100:419-424.
26. Estes WK (1950). Toward a statistical theory of learning. Psychol Rev 57:94-104.
27. Fawell BJ, Ayres JJB (1979). Stimulus-reinforcer and response-reinforcer relations in the control of conditioned appetitive head poking (goal-tracking) in rats. Learn Motiv 10:295-312.
28. Garret BE, Rose CA, Henningfield JE (2001). Tobacco addiction and pharmacological interventions. Expert Opin Pharmacother 2:1545-1555.
29. Goldberg SR, Risner ME, Stolerman IP, Reavill C, Garcha HS (1989). Nicotine and some related compounds: effects on schedule-controlled behaviour and discriminative properties in rats. Psychopharmacology (Berl) 97: 295-302.
30. Jutkiewicz EM, Brooks EA, Kynaston AD, Rice KC, Woods JH (2011). Patterns of nicotinic receptor antagonism: nicotine discrimination studies. J Pharmacol Exp Ther 339:194-202.
31. Kaempf GL, Kallman MJ (1987). A comparison of testing procedures on the discriminative morphine stimulus. Psychopharmacology (Berl) 91:56-60.
32. Konorski J (1948). Conditioned reflexes and neuron organization. Cambridge, UK: Cambridge University Press.
33. LeSage MG, Shelley D, Ross JT, Carroll FI, Corrigal WA (2009). Effects of the nicotinic receptor partial agonists varenicline and cytisine on the discriminative stimulus effects of nicotine in rats. Pharmacol Biochem Behav 91:461-467.
34. Murray JE, Bevins RA (2007a). Behavioral and neuropharmacological characterization on nicotine as a conditioned stimulus. Eur J Pharmacol 561:91-104.
35. Murray JE, Bevins RA (2007b). The conditioned stimulus effects of nicotine vary as a function of training dose. Behav Pharmacol 18:707-716.
36. Murray JE, Bevins RA (2009). Acquired appetitive responding to intravenous nicotine reflects a Pavlovian conditioned association. Behav Neurosci 123:97-108.
37. Murray JE, Walker AW, Polewan RJ, Bevins RA (2010). An examination of NMDA receptor contribution to conditioned responding evoked by the conditional stimulus effects of nicotine. Psychopharmacology (Berl) 213:131-141.
38. National Research Council (1996). Guide for the care and use of laboratory animals. Washington, DC: National Academy Press.
39. Paterson NE, Min W, Hackett A, Lowe D, Hanania T, Caldarone B, Ghavami A (2010). The high-affinity nAChR partial agonists varenicline and sazetidine-A exhibit reinforcing properties in rats. Prog Neuropsychopharmacol Biol Psychiatry 34:1455-1464.
40. Pavlov IP (1927). Conditioned reflexes. London: Oxford University Press.
41. Perkins KA (2009). Sex difference in nicotine reinforcement and reward: influences on the persistence of tobacco smoking. In: Bevins RA, Caggiula AR, editors. The motivational impact of nicotine and its role in tobacco use: the 55th Nebraska symposium on motivation. New York, NY: Springer; pp. 143-169.
42. Perkins KA, Donny E, Caggiula AR (1999). Sex differences in nicotine effects and self-administration: review of human and animal evidence. Nicotine Tob Res 1:301-315.
43. Quirk GJ, Mueller D (2008). Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacology 33:56-72.
44. Rauhut AS, Thomas BL, Ayres JJB (2001). Treatments that weaken Pavlovian conditioned fear and thwart its renewal in rats: implications for treating human phobias. J Exp Psychol Anim Behav Process 27:99-114.
45. Reichel CM, Linkugel JD, Bevins RA (2007). Nicotine as a conditioned stimulus: impact of attention-deficit/hyperactivity disorder medications. Exp Clin Psychopharmacol. 15:pp. 501-509.
46. Reichel CM, Murray JE, Barr JD, Bevins RA (2010). Extinction with varenicline and nornicotine, but not ABT-418, weakens conditioned responding evoked by the interoceptive stimulus effects of nicotine. Neuropharmacology 58:1237-1245.
47. Rescorla RA (1997). Spontaneous recovery after Pavlovian conditioning with multiple outcomes. Anim Learn Behav 25:99-107.
48. Rescorla RA (2001). Retraining of extinguished Pavlovian stimuli. J Exp Psychol Anim Behav Process 27:115-124.
49. Rescorla RA (2006). Deepened extinction from compound stimuli presentation. J Exp Psychol Anim Behav Process 32:135-144.
50. Rose JE (2009). New findings on nicotine addiction and treatment. In: Bevins RA, Caggiula AR, editors. The motivational impact of nicotine and its role in tobacco use: the 55th Nebraska symposium on motivation. New York, NY: Springer; pp. 131-141.
51. Schröter M, Collins SE, Frittrang T, Buchkremer G, Batra A (2006). Randomized controlled trial of relapse prevention and a standard behavioral intervention with adult smokers. Addict Behav 31:1259-1264.
52. Smith JW, Mogg A, Tafi E, Peacey E, Pullar I, Szekeres P, Tricklebank M (2007). Ligands selective for a4b2 but not a3b4 or a7 nicotinic receptors generalise to the nicotine discriminative stimulus in the rat. Psychopharmacology (Berl) 190:157-170.
53. Spence KW(1936). The nature of discrimination learning in animals. Psychol Rev 43:427-449.
54. Spence KW(1937). The differential response in animals to stimuli varying within a single dimension. Psychol Rev 44:430-444.
55. Stolerman IP, Garcha HS, Pratt JA, Kumar R (1984). Role of training dose in discrimination of nicotine and related compounds in rats. Psychopharmacology (Berl) 84:413-419.
56. Stolerman IP, Mariathasan EA, White J-AW, Olufsen KS (1999). Drug mixtures and ethanol as compound internal stimuli. Pharmacol Biochem Behav 64:221-228.
57. Struthers AM, Wilkinson JL, Dwoskin LP, Crooks PA, Bevins RA (2009). Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine. Pharmacol Biochem Behav 94:319-328.
58. Thorndike EL (1913). Educational psychology: Vol. II. The psychology of learning. New York: Columbia University, Teachers College.
59. Wagner AR (2008). Evolution of an elemental theory of Pavlovian conditioning. Learn Behav 36:253-263.
60. Wilkinson JL, Murray JE, Li C, Wiltgen SM, Penrod RD, Berg SA, Bevins RA (2006). Interoceptive Pavlovian conditioning with nicotine as the conditional stimulus varies as a function of the number of conditioning trials and unpaired sucrose deliveries. Behav Pharmacol 17:161-172.
61. Wilkinson JL, Carroll FI, Bevins RA (2010). An investigation of bupropion substitution for the interoceptive stimulus effects of nicotine. J Psychopharmacol 24:817-828.