Drug mixtures and ethanol as compound internal stimuli

Pharmacology Biochemistry and Behavior

Volumn 64, Issue 2, 1999, Pages 221-228

  Stolerman, I P ^a   Mariathasan, E A ^a   White, J A W ^a   Olufsen, K S ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Amphetamine; Chlordiazepoxide; Dizocilpine; Drug discrimination; Ethanol; Midazolam; Nicotine; Pentobarbitone

Indexed keywords

1 (3 TRIFLUOROMETHYLPHENYL)PIPERAZINE; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 5 METHOXY 3 (1,2,3,6 TETRAHYDRO 4 PYRIDYL) 1H INDOLE; ALCOHOL; CHLORDIAZEPOXIDE; DEXAMPHETAMINE; DIZOCILPINE; FLUMAZENIL; MECAMYLAMINE; MIDAZOLAM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NICOTINE; PENTOBARBITAL; SEROTONIN AGONIST;

ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DRUG ANTAGONISM; DRUG DISCRIMINATION; DRUG MIXTURE; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; METHODOLOGY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; STIMULUS GENERALIZATION; SUBCUTANEOUS DRUG ADMINISTRATION; TRAINING;

ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CENTRAL NERVOUS SYSTEM STIMULANTS; CHLORDIAZEPOXIDE; DEXTROAMPHETAMINE; DISCRIMINATION (PSYCHOLOGY); DIZOCILPINE MALEATE; DRUG INTERACTIONS; ETHANOL; EXCITATORY AMINO ACID ANTAGONISTS; GENERALIZATION, STIMULUS; HYPNOTICS AND SEDATIVES; MALE; MIDAZOLAM; NICOTINE; NICOTINIC AGONISTS; PENTOBARBITAL; PSYCHOTROPIC DRUGS; RATS; REINFORCEMENT SCHEDULE;

EID: 0032840411     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(99)00087-8     Document Type: Conference Paper

References (37)

1. Carlezon W.A. Jr., Haile C.N., Kosten T.A., Nestler E.J. Unique discriminative stimulus properties of the combination of MK-801 plus morphine. Harris L.S. Problems of drug dependence. 1996 NIDA monograph 174. 1997;214 U.S. Government Printing Office, Washington, DC.
2. Colpaert F.C., Janssen P.A.J. Agonist and antagonist effects of prototype opiate drugs in fentanyl dose-dose discrimination. Psychopharmacology (Berlin). 90:1986;222-228.
3. Colpaert F.C., Niemegeers C.J.E., Janssen P.A.J. Theoretical and methodological considerations on drug discrimination learning. Psychopharmacologia. 46:1976;169-177.
4. De Vry J., Slangen J.L. Effects of training dose on discrimination and cross-generalization of chlordiazepoxide, pentobarbital and ethanol in the rat. Psychopharmacology (Berlin). 88:1986;341-345.
5. Gauvin D.V., Holloway F.A. The discriminative stimulus properties of an ethanol-nicotine mixture in rats. J. Psychopharmacol. 7:1993;52-62.
6. Gauvin D.V., Moore K.R., Youngblood B.D., Holloway F.A. The discriminative stimulus properties of legal, over-the-counter stimulants administered singly and in binary and ternary combinations. Psychopharmacology (Berlin). 110:1993;309-319.
7. 1 agonist trifluoromethylphenylpiperazine (TFMPP) for the discriminative stimulus effects of ethanol. Effects of training dose Psychopharmacology (Berlin). 113:1993;26-30.
8. Grant K.A., Colombo G. Discriminative stimulus effects of ethanol. Effect of training dose on the substitution of N-methyl-D-aspartate antagonists J. Pharmacol. Exp. Ther. 264:1993;1241-1247.
9. Grant K.A., Colombo G., Gatto G.J. Characterization of the ethanol-like discriminative stimulus effects of 5-HT receptor agonists as a function of ethanol training dose. Psychopharmacology (Berlin). 133:1997;133-141.
10. Harrison Y.E., Jenkins J.A., Rocha B.A., Lytle D.A., Jung M.E., Oglesby M.W. Discriminative stimulus effects of diazepam, ketamine and their mixture. ethanol substitution patterns Behav. Pharmacol. 9:1998;31-40.
11. Holloway F.A., Michaelis R.C., Huerta P.L. Caffeine-phenylethylamine combinations mimic the amphetamine discriminative cue. Life Sci. 36:1985;723-730.
12. Mackintosh, N. J. The psychology of animal learning. New York: Academic Press; 1974.
13. Mariathasan E.A., Stolerman I.P. Drug discrimination studies in rats with caffeine and phenylpropanolamine administered separately and as mixtures. Psychopharmacology (Berlin). 109:1992;99-106.
14. Mariathasan E.A., Stolerman I.P. Discrimination of agonist-antagonist mixtures. Experiments with nicotine plus mecamylamine Behav. Pharmacol. 4:1993;555-561.
15. Mariathasan E.A., Stolerman I.P. Overshadowing of nicotine discrimination in rats. A model for behavioural mechanisms of drug interactions? Behav. Pharmacol. 4:1993;209-215.
16. Mariathasan E.A., Stolerman I.P. Functional relationships, previous history and the discrimination of a drug mixture in rats. Drug Alcohol Depend. 35:1994;117-125.
17. Mariathasan E.A., Garcha H.S., Stolerman I.P. Discriminative stimulus effects of amphetamine and pentobarbitone separately and as mixtures in rats. Behav. Pharmacol. 2:1991;405-415.
18. Mariathasan E.A., Olufsen K.S., Hölter S.M., Stolerman I.P., Spanagel R. Drug discrimination tests for interaction between nicotine and ethanol in rats. J. Psychopharmacol. Abstr. Book. 11:1997;A12.
19. Mariathasan E.A., Stolerman I.P., White J.W. Antagonism of AND and AND-OR drug mixture discrimination in rats. Drug Alcohol Depend. 44:1997;31-34.
20. Mariathasan E.A., Stolerman I.P., White J.-A.W. AND and AND-OR drug mixture discriminations in rats. Generalization to single drugs and drug mixtures Psychopharmacology (Berlin). 143:1999;54-63.
21. Mariathasan E.A., White J.W., Stolerman I.P. Training dose as a decisive factor for discrimination of a drug mixture in rats. Behav. Pharmacol. 7:1996;364-372.
22. McMillan D.E., Hardwick W.C. Effects of drug discrimination history on the generalization of pentobarbital to other drugs. J. Pharmacol. Exp. Ther. 278:1996;50-61.
23. McMillan D.E., Snodgrass S.H. Incomplete stimulus generalization from a mixture of d-amphetamine and morphine to different doses of the component drugs. Behav. Pharmacol. 4:1993;279-281.
24. Negus S.S., Gatch M.B., Mello N.K. Discriminative stimulus effects of a cocaine/heroin "speedball" combination in rhesus monkeys. J. Pharmacol. Exp. Ther. 285:1998;1123-1136.
25. Olufsen K.S., Stolerman I.P. The persistence of associative blocking in drug discrimination. Behav. Pharmacol. 7(Suppl. 1):1996;80.
26. Olufsen K.S., Stolerman I.P. Substitution of ethanol for drug mixtures. J. Psychopharmacol. (Suppl.). 11:1997;A12.
27. Rowlett J.K., Negus S.S., Shippenberg T.S., Mello N.K., Walsh S.L., Spealman R.D. Combined cocaine and opioid abuse. From neurobiology to the clinic Harris L.S. Problems of drug dependence 1997. NIDA monograph 178. 1998;55 U.S. Government Printing Office, Washington, DC.
28. Sanger D.J. Substitution by NMDA antagonists and other drugs in rats trained to discriminate ethanol. Behav. Pharmacol. 4:1993;523-528.
29. Schechter M.D., Lovano D.M. Ethanol-chlordiazepoxide interactions in the rat. Pharmacol. Biochem. Behav. 23:1985;927-930.
30. Shelton K.L., Balster R.L. Ethanol drug discrimination in rats. Substitution with GABA agonists and NMDA antagonists Behav. Pharmacol. 5:1994;441-450.
31. Shoaib M., Baumann M.H., Rothman R.B., Goldberg S.R., Schindler C.W. Behavioural and neurochemical characteristics of phentermine and fenfluramine administered separately and as a mixture in rats. Psychopharmacology (Berlin). 131:1997;296-306.
32. Signs S.A., Schechter M.D. The role of dopamine and serotonin receptors in the mediation of the ethanol interoceptive cue. Pharmacol. Biochem. Behav. 30:1988;55-64.
33. Stolerman I.P., Mariathasan E.A. Discrimination of an amphetamine-pentobarbitone mixture by rats in an AND-OR paradigm. Psychopharmacology (Berlin). 102:1990;557-560.
34. Stolerman I.P., White J.W. Impact of training history on discrimination of a drug mixture by rats. Behav. Pharmacol. 7:1996;483-494.
35. Stolerman I.P., Mariathasan E.A., Garcha H.S. Discriminative stimulus effects of drug mixtures in rats. Glennon R.A., Järbe T.U.C., Frankenheim J. Drug discrimination. applications to drug abuse Research. NIDA mnograph 116:1991;277-306 U.S. Government Printing Office, Washington, DC.
36. Stolerman I.P., Mariathasan E.A., White J.W. Implications of mixture research for discrimination of single drugs. Behav. Pharmacol. (Suppl.). 5:1994;18.
37. Stolerman I.P., Rauch R.J., Norris E.A. Discriminative stimulus effects of a nicotine-midazolam mixture in rats. Psychopharmacology (Berlin). 93:1987;250-256.