High-sensitivity detection of breast tumors in vivo by use of a pH-sensitive near-infrared fluorescence probe

Journal of Biomedical Optics

Volumn 17, Issue 7, 2012, Pages

  Mathejczyk, Julia Eva ^a   Pauli, Jutta ^b   Dullin, Christian ^c   Resch Genger, Ute ^b   Alves, Frauke ^a,c   Napp, Joanna ^a,c  

^a MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^b BAM FEDERAL INSTITUTE FOR MATERIALS RESEARCH AND TESTING   (Germany)

^c UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Breast tumor monitoring; Cyanine; Fluorescence lifetime imaging; Herceptin; In vivo near infrared fluorescence imaging; Optical probe; PH sensing

Indexed keywords

CARBOCYANINE; CYPHER 5 NHS ESTER; DIAGNOSTIC AGENT; FLUORESCENT DYE; MONOCLONAL ANTIBODY; TRASTUZUMAB; TUMOR MARKER;

ANIMAL; ARTICLE; BREAST TUMOR; CHEMISTRY; FEMALE; FLUORESCENCE MICROSCOPY; METHODOLOGY; MOUSE; NEAR INFRARED SPECTROSCOPY; NUDE MOUSE; PH; SENSITIVITY AND SPECIFICITY; TUMOR CELL LINE;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; BREAST NEOPLASMS; CARBOCYANINES; CELL LINE, TUMOR; FEMALE; FLUORESCENT DYES; HYDROGEN-ION CONCENTRATION; MICE; MICE, NUDE; MICROSCOPY, FLUORESCENCE; SENSITIVITY AND SPECIFICITY; SPECTROSCOPY, NEAR-INFRARED; TUMOR MARKERS, BIOLOGICAL;

EID: 84872051868     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.JBO.17.7.076028     Document Type: Article

References (49)

1. S. A. Hilderbrand and R. Weissleder, "Near-infrared fluorescence: application to in vivo molecular imaging," Curr. Opin. Chem. Biol. 14(1), 71-79 (2010).
2. F. Alves, J. Napp, and J. E. Mathejczyk, "Optical imaging in vivo with a focus on paediatric disease: technical progress, current preclinical and clinical applications and future perspectives," Pediatr. Radiol. 41(2), 161-175 (2011).
3. J. E. Mathejczyk et al., "Spectroscopically well-characterized RGD optical probe as a prerequisite for lifetime-gated tumor imaging," Mol. Imaging 10(6), 469-480 (2011).
4. E. McCormack et al., "In vivo optical imaging of acute myeloid leukemia by green fluorescent protein: time-domain autofluorescence decoupling, fluorophore quantification, and localization," Mol. Imaging 6(3), 193-204 (2007). (Pubitemid 47152706)
5. H. Kobayashi and P. L. Choyke, "Target-cancer-cell-specific activatable fluorescence imaging probes: rational design and in vivo applications," Acc. Chem. Res. 44(2), 83-90 (2011).
6. J. Napp et al., "Time-domain in vivo near infrared fluorescence imaging for evaluation of matriptase as a potential target for the development of novel, inhibitor-based tumor therapies," Int. J. Cancer 127(8), 1958-1974 (2010).
7. H. Lee et al., "Near-infrared pH-activatable fluorescent probes for imaging primary and metastatic breast tumors," Bioconjug. Chem. 22(4), 777-784 (2011).
8. R. Weissleder et al., "In vivo imaging of tumors with protease-activated near-infrared fluorescent probes," Nat. Biotechnol. 17(4), 375-378 (1999). (Pubitemid 29166041)
9. Y. Urano et al., "Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes," Nat. Med. 15(1), 104-109 (2009).
10. M. Ogawaetal., "In vivo molecular imaging of cancer with a quenching near-infrared fluorescent probe using conjugates of monoclonal antibodies and indocyanine green," Cancer Res. 69(4), 1268-1272 (2009).
11. M. Ogawaetal., "H-typedimer formation of fluorophores: amechanism for activatable, in vivo optical molecular imaging," ACS Chem. Biol. 4(7), 535-546 (2009).
12. M. Ogawa et al., "In vivo target-specific activatable near-infrared optical labeling of humanized monoclonal antibodies," Mol. Cancer Ther. 8(1), 232-239 (2009).
13. K. Licha and U. Resch-Genger, "Probes for optical imaging: new developments," Drug Discov. Today 8(2-4), e87-e94 (2011).
14. J. Napp et al., "Targeted luminescent NIR polymer-nanoprobes for in vivo imaging of tumor hypoxia," Anal. Chem. 83(23), 9039-9046 (2011).
15. P. A. Schornack and R. J. Gillies, "Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors," Neoplasia 5(2), 135-145 (2003). (Pubitemid 36369009)
16. R. A. Gatenby and R. J. Gillies, "Why do cancers have high aerobic glycolysis?," Nat. Rev. Cancer 4(11), 891-899 (2004). (Pubitemid 39472955)
17. C. Stock et al., "pH nanoenvironment at the surface of single melanoma cells," Cell Physiol. Biochem. 20(5), 679-686 (2007). (Pubitemid 47340628)
18. J. Han and K. Burgess, "Fluorescent indicators for intracellular pH," Chem. Rev. 110(5), 2709-2728 (2010).
19. Z. Zhang and S. Achilefu, "Design, synthesis and evaluation of near-infrared fluorescent pH indicators in a physiologically relevant range," Chem. Commun. (47), 5887-5889 (2005). (Pubitemid 43021906)
20. T. Nagano, K. Kiyose, and H. Kojima, "Functional near-infrared fluorescent probes," Chem. Asian J. 3(3), 506-515 (2008).
21. Y. A. Povrozin et al., "Near-infrared, dual-ratiometric fluorescent label for measurement of pH," Anal. Biochem. 390(2), 136-140 (2009).
22. D. J. Slamon et al., "Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer," Science 244(4905), 707-712 (1989). (Pubitemid 19147683)
23. A. Berchuck et al., "Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer," Cancer Res. 50(13), 4087-4091 (1990). (Pubitemid 20225635)
24. X. F Le, F. Pruefer, and R. C. Bast Jr, "HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways," Cell Cycle 4(1), 87-95 (2005). (Pubitemid 41038933)
25. D. J. Slamon et al., "Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene," Science 235(4785), 177-182 (1987). (Pubitemid 17231334)
26. A. Beletskii et al., "High-throughput phagocytosis assay utilizing a pH-sensitive fluorescent dye," Biotechniques 39(6), 894-897 (2005).
27. E. Nordberg et al., "Cellular studies of binding, internalization and retention of a radiolabeled EGFR-binding affibody molecule," Nucl. Med. Biol. 34(6), 609-618 (2007). (Pubitemid 47248288)
28. L. Gostring et al., "Quantification of internalization of EGFR-binding Affibody molecules: methodological aspects," Int. J. Oncol. 36(4), 757-763 (2010).
29. Y Hua et al., "A readily retrievable pool of synaptic vesicles," Nat. Neurosci. 14(7), 833-839 (2011).
30. J. Kurebayashi et al., "Isolation and characterization of a new human breast cancer cell line, KPL-4, expressing the Erb B family receptors and interleukin-6," Br. J. Cancer 79(5-6), 707-717 (1999). (Pubitemid 29082094)
31. J. M. du Manoir et al., "Strategies for delaying or treating in vivo acquired resistance to trastuzumab in human breast cancer xenografts," Clin. Cancer Res. 12(3 Pt 1), 904-916 (2006). (Pubitemid 43259873)
32. M. Grabolle et al., "Determination of the labeling density of fluorophore-biomolecule conjugates with absorption spectroscopy," Bioconjug. Chem. 23(2), 287-292 (2012).
33. U. Resch-Genger et al., "Traceability in fluorometry: Part Spectral II. fluorescence standards," J. Fluoresc. 15(3), 315-336 (2005). (Pubitemid 40963140)
34. C. Wurth et al., "Integrating sphere setup for the traceable measurement of absolute photoluminescence quantum yields in the NIR," Anal. Chem. 84(3), 1345-1352 (2012).
35. T. J. Collins, "ImageJ for microscopy," Biotechniques 43(Suppl 1), 25-30 (2007).
36. J. Missbach-Guentner et al., "Morphologic changes of mammary carcinomas in mice over time as monitored by flat-panel detector volume computed tomography," Neoplasia 10(7), 663-673 (2008). (Pubitemid 351883882)
37. G. Ma, P. Gallant, and L. McIntosh, "Sensitivity characterization of a time-domain fluorescence imager: eXplore Optix," Appl. Opt. 46(10), 1650-1657 (2007). (Pubitemid 46659531)
38. C. Dullin et al., "Semiautomatic landmark-based two-dimensional- three-dimensional image fusion in living mice: correlation of near-infrared fluorescence imaging of Cy5.5-labeled antibodies with flat-panel volume computed tomography," Mol. Imaging 8(1), 2-14 (2009).
39. D. Harari and Y Yarden, "Molecular mechanisms underlying ErbB2/HER2 action in breast cancer," Oncogene 19(53), 6102-6114 (2000). (Pubitemid 32059460)
40. W. J. Akers et al., "Predicting in vivo fluorescence lifetime behavior of near-infrared fluorescent contrast agents using in vitro measurements," J. Biomed. Opt. 13(5), 054042 (2008).
41. M. Ogawa et al., "Fluorophore-quencher based activatable targeted optical probes for detecting in vivo cancer metastases," Mol. Pharm. 6(2), 386-395 (2009).
42. Y. Hama et al., "A self-quenched galactosamine-serum albumin-rhodamineX conjugate: a ' smart' fluorescent molecular imaging probe synthesized with clinically applicable material for detecting peritoneal ovarian cancer metastases," Clin. Cancer Res. 13(21), 6335-6343 (2007). (Pubitemid 350075022)
43. A. J. Villaraza, D. E. Milenic, and M. W Brechbiel, "Improved speciation characteristics of PEGylated indocyanine green-labeled Panitumumab: revisiting the solution and spectroscopic properties of a near-infrared emitting anti-HER1 antibody for optical imaging of cancer," Bioconjug. Chem. 21(12), 2305-2312 (2010).
44. M. E. Cooper et al., "pH-sensitive cyanine dyes for biological applications," J. Fluoresc. 12(3-4), 425-429 (2002).
45. Y Matsumura and H. Maeda, "A new concept for macromolecular therapeutics in cancer-chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent SMANCS," Cancer Res. 46(12), 6387-6392 (1986). (Pubitemid 17221789)
46. R. M. Andersson et al., "Characterization of probe binding and comparison of its influence on fluorescence lifetime of two pH-sensitive benzo [c]xanthene dyes using intensity-modulated multiple-wavelength scanning technique," Anal. Biochem. 283(1), 104-110 (2000). (Pubitemid 30469757)
47. R. M. Andersson et al., "Fluorescence lifetime imaging of pH in cells: investigation of factors influencing the pH calibration lifetime," Opt. Diag. Living Cells 1(15), 242-248 (2000).
48. M. Solomon et al., "Detection of enzyme activity in orthotopic murine breast cancer by fluorescence lifetime imaging using a fluorescence resonance energy transfer-based molecular probe," J. Biomed. Opt. 16(6), 066019 (2011).
49. K. Kubota et al., "Intraoperative assessment of reconstructed vessels in living-donor liver transplantation, using a novel fluorescence imaging technique," J. Hepatobiliary Pancreat. Surg. 13(2), 100-104 (2006).