Detection of enzyme activity in orthotopic murine breast cancer by fluorescence lifetime imaging using a fluorescence resonance energy transfer-based molecular probe

Journal of Biomedical Optics

Volumn 16, Issue 6, 2011, Pages

  Solomon, Metasebya ^a,b   Guo, Kevin ^a   Sudlow, Gail P ^a   Berezin, Mikhail Y ^a   Barry Edwards, W ^a   Achilefu, Samuel ^a,b   Akersa, Walter J ^a  

^a WASHINGTON UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

Breast cancer; Fluorescence energy transfer; Molecular imaging; Time domain

Indexed keywords

ALTERNATIVE METHODS; BREAST CANCER; BREAST CANCER MODELS; CLINICAL APPLICATION; ENZYME-MEDIATED HYDROLYSIS; FLUORESCENCE ENERGY TRANSFER; FLUORESCENCE IMAGING; FLUORESCENCE LIFETIME IMAGING; FLUORESCENCE LIFETIMES; FLUORESCENCE RESONANCE; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENCE YIELD; FLUORESCENT REPORTER; IN-VIVO; INTENSITY-BASED; MOLECULAR ACTIVITIES; MOLECULAR IMAGING; MOLECULAR PROBES; NON-INVASIVE DETECTION; ORTHOTOPIC; PEPTIDE LINKERS; TIME DOMAIN; TUMOR TISSUES;

DISEASES; ENERGY TRANSFER; ENZYME ACTIVITY; PROBES; RESONANCE; TIME DOMAIN ANALYSIS; TISSUE;

FLUORESCENCE;

MURINAE;

DIAGNOSTIC AGENT; FLUORESCENT DYE; TUMOR MARKER; VITRONECTIN RECEPTOR;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; ENZYMOLOGY; EXPERIMENTAL NEOPLASM; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY; MOLECULAR IMAGING; MOUSE; NUDE MOUSE; REGRESSION ANALYSIS; TISSUE DISTRIBUTION; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENT DYES; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHAVBETA3; LEAST-SQUARES ANALYSIS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, NUDE; MOLECULAR IMAGING; NEOPLASM TRANSPLANTATION; TISSUE DISTRIBUTION; TUMOR MARKERS, BIOLOGICAL;

EID: 80455141562     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3594153     Document Type: Article

References (23)

1. E. K. Sloan, N. Pouliot, K. L. Stanley, J. Chia, J. M. Moseley, D. K. Hards, and R. L. Anderson, "Tumor-specific expression of alphavbeta3 integrin promotes spontaneous metastasis of breast cancer to bone," Breast Cancer Res. 8(2), R20 (2006).
2. R. Roy, J. Yang, and M. A. Moses, "Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer," J. Clin. Oncol. 27(31), 5287-5297 (2009).
3. C. Bremer, S. Bredow, U. Mahmood, R. Weissleder, and C. H. Tung, "Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in amousemodel," Radiology 221(2), 523-529 (2001). (Pubitemid 33043440)
4. B. P. Himelstein, R. Canete-Soler, E. J. Bernhard, D. W. Dilks, and R. J. Muschel, "Metalloproteinases in tumor progression: the contribution of MMP-9," Invasion & Metastasis. 14(1-6), 246-258.
5. B. Fingleton, Matrix metalloproteinase inhibitors for cancer therapy:the current situation and future prospects. Expert Opinion on Therapeutic Targets 7(3), 385-397 (2003). (Pubitemid 36722223)
6. R. Weissleder, C. H. Tung, U. Mahmood, and A. Bogdanov, Jr., "In vivo imaging of tumors with protease-activated near-infrared fluorescent probes," Nat. Biotechnol. 17(4), 375-378 (1999). (Pubitemid 29166041)
7. V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, "Looking and listening to light: the evolution of whole-body photonic imaging," Nat. Biotechnol. 23(3), 313-320 (2005). (Pubitemid 41094419)
8. S. Achilefu, "Lighting up tumors with receptor-specific optical molecular probes," Technol. Cancer Res. Treat. 3(4), 393-409 (2004). (Pubitemid 39096612)
9. C.W. Chang, M.Wu, S. D. Merajver, and M. A. Mycek, "Physiological fluorescence lifetime imaging microscopy improves Forster resonance energy transfer detection in living cells," J. Biomed. Opt. 14(6), 060502 (2009).
10. M. Y. Berezin, and S. Achilefu, "Fluorescence lifetime measurements and biological imaging," Chem. Rev. 110(5), 2641-2684.
11. J. A. Levitt, D. R. Matthews, S. M. Ameer-Beg, and K. Suhling, "Fluorescence lifetime and polarization-resolved imaging in cell biology," Curr. Opin. Biotechnol. 20(1), 28-36 (2009).
12. S. V. Koushik and S. S. Vogel, "Energy migration alters the fluorescence lifetime of Cerulean: implications for fluorescence lifetime imaging Forster resonance energy transfer measurements," J. Biomed. Opt. 13(3), 031204 (2008).
13. U. Mahmood and R. Weissleder, "Near-infrared optical imaging of proteases in cancer," Molecular Cancer Therapeutics 2(5), 489-496 (2003).
14. R. L. Scherer, J. O. McIntyre, and L. M. Matrisian, "Imaging matrix metalloproteinases in cancer," Cancer Metastasis Rev. 27(4), 679-690 (2008).
15. "NCI Imaging Camp."
16. S. Achilefu, S. Bloch, M. A. Markiewicz, T. Zhong, Y. Ye, R. B. Dorshow, B. Chance, and K. Liang, "Synergistic effects of lightemitting probes and peptides for targeting and monitoring integrin expression," Proc. Natl. Acad. Sci. U S A 102(22), 7976-7981 (2005). (Pubitemid 40781048)
17. S. Achilefu, R. B. Dorshow, J. E. Bugaj, and R. Rajagopalan, "Novel receptor-targeted fluorescent contrast agents for in vivo tumor imaging," Invest. Radiol. 35(8), 479-485 (2000). (Pubitemid 30622015)
18. J. E. Bugaj, S. Achilefu, R. B. Dorshow, and R. Rajagopalan, "Novel fluorescent contrast agents for optical imaging of in vivo tumors based on a receptor-targeted dye-peptide conjugate platform," J. Biomed. Opt. 6(2), 122-133 (2001). (Pubitemid 32546877)
19. K. Tao, M. Fang, J. Alroy, and G. G. Sahagian, "Imagable 4T1 model for the study of late stage breast cancer," BMC Cancer 8, 228 (2008).
20. A. Daniele, A. F. Zito, G. Giannelli, R. Divella, M. Asselti, A. Mazzocca, A. Paradiso, and M. Qua, "Expression of metalloproteinases MMP-2 and MMP-9 in sentinel lymph node and serum of patients with metastatic and non-metastatic breast cancer," Anticancer Res. 30(9), 3521-3527.
21. P. M. McGowan andM. J. Duffy, "Matrix metalloproteinase expression and outcome in patients with breast cancer: analysis of a published database," Ann. Oncol. 19(9), 1566-1572 (2008).
22. J. Baeten, J. Haller, H. Shih, and V. Ntziachristos, "In vivo investigation of breast cancer progression by use of an internal control," Neoplasia 11(3), 220-227 (2009).
23. C. Bremer, C. H. Tung, and R. Weissleder, "In vivo molecular target assessment of matrix metalloproteinase inhibition," Nat. Med. 7(6), 743-748 (2001). (Pubitemid 32588033)