Target-cancer-cell-specific activatable fluorescence imaging probes: Rational design and in vivo applications

Accounts of Chemical Research

Volumn 44, Issue 2, 2011, Pages 83-90

  Kobayashi, Hisataka ^a   Choyke, Peter L ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENT DYE;

ANIMAL; ARTICLE; CHEMISTRY; DRUG DESIGN; HUMAN; METABOLISM; METHODOLOGY; MOLECULAR IMAGING; NEOPLASM; PATHOLOGY; PHOTOCHEMISTRY; SPECTROFLUOROMETRY;

ANIMALS; DRUG DESIGN; FLUORESCENT DYES; HUMANS; MOLECULAR IMAGING; NEOPLASMS; PHOTOCHEMICAL PROCESSES; SPECTROMETRY, FLUORESCENCE;

EID: 79951590463     PISSN: 00014842     EISSN: 15204898     Source Type: Journal    
DOI: 10.1021/ar1000633     Document Type: Article

References (24)

1. Weissleder, R.; Pittet, M. J. Imaging in the era of molecu (Pubitemid 351483372)
2. Alford, R.; Ogawa, M.; Choyke, P. L.; Kobayashi, H. Molecular probes for the in vivo imaging of cancer Mol. BioSyst. 2009, 5, 1279-1291
3. Wu, A. M.; Senter, P. D. Arming antibodies: prospects and challenges for immunoconjugates Nat. Biotechnol. 2005, 23, 1137-1146 (Pubitemid 41486395)
4. Louie, A. Y.; Huber, M. M.; Ahrens, E. T.; Rothbacher, U.; Moats, R.; Jacobs, R. E.; Fraser, S. E.; Meade, T. J. In vivo visualization of gene expression using magnetic resonance imaging Nat. Biotechnol. 2000, 18, 321-325 (Pubitemid 30159486)
5. Weissleder, R.; Tung, C. H.; Mahmood, U.; Bogdanov, A., Jr. vivo imaging of tumors with protease-activated near-infrared fluorescent probes Nat. Biotechnol. 1999, 17, 375-378 (Pubitemid 29166041)
6. Aime, S.; Delli Castelli, D.; Terreno, E. Novel pH-reporter MRI contrast agents Angew. Chem., Int. Ed. 2002, 41, 4334-4336 (Pubitemid 35398271)
7. Zhang, S.; Wu, K.; Sherry, A. D. A Novel pH-Sensitive MRI Contrast Agent Angew. Chem., Int. Ed. 1999, 38, 3192-3194 (Pubitemid 29533893)
8. Kobayashi, H.; Ogawa, M.; Alford, R.; Choyke, P. L.; Urano, Y. New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging Chem. Rev. 2010, 110, 2620-2640
9. Mahmood, U.; Tung, C. H.; Bogdanov, A., Jr.; Weissleder, R. Near-infrared optical imaging of protease activity for tumor detection Radiology 1999, 213, 866-870
10. Tung, C. H.; Bredow, S.; Mahmood, U.; Weissleder, R. Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imaging Bioconjugate Chem. 1999, 10, 892-896 (Pubitemid 29456379)
11. Hama, Y.; Urano, Y.; Koyama, Y.; Kamiya, M.; Bernardo, M.; Paik, R. S.; Shin, I. S.; Paik, C. H.; Choyke, P. L.; Kobayashi, H. A target cell-specific activatable fluorescence probe for in vivo molecular imaging of cancer based on a self-quenched avidin-rhodamine conjugate Cancer Res. 2007, 67, 2791-2799 (Pubitemid 46548968)
12. Urano, Y.; Asanuma, D.; Hama, Y.; Koyama, Y.; Barrett, T.; Kamiya, M.; Nagano, T.; Watanabe, T.; Hasegawa, A.; Choyke, P. L.; Kobayashi, H. Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes Nat. Med. 2009, 15, 104-109
13. Hama, Y.; Urano, Y.; Koyama, Y.; Gunn, A. J.; Choyke, P. L.; Kobayashi, H. A self-quenched galactosamine-serum albumin-rhodamineX conjugate: a smart fluorescent molecular imaging probe synthesized with clinically applicable material for detecting peritoneal ovarian cancer metastases Clin. Cancer Res. 2007, 13, 6335-6343 (Pubitemid 350075022)
14. Ogawa, M.; Regino, C. A.; Choyke, P. L.; Kobayashi, H. In vivo target-specific activatable near-infrared optical labeling of humanized monoclonal antibodies Mol. Cancer Ther. 2009, 8, 232-239
15. Weissleder, R. A clearer vision for in vivo imaging Nat. Biotechnol. 2001, 19, 316-317
16. Ogawa, M.; Kosaka, N.; Choyke, P. L.; Kobayashi, H. In vivo molecular imaging of cancer with a quenching near-infrared fluorescent probe using conjugates of monoclonal antibodies and indocyanine green Cancer Res. 2009, 69, 1268-1272
17. Ogawa, M.; Kosaka, N.; Urano, Y.; Choyke, P. L.; Kobayashi, H. Activatable optical imaging probes with various fluorophore-quencher combinations SPIE Proc. 2009, 7190, 6449-6418
18. Ogawa, M.; Kosaka, N.; Longmire, M. R.; Urano, Y.; Choyke, P. L.; Kobayashi, H. Fluorophore-quencher based activatable targeted optical probes for detecting in vivo cancer metastases Mol. Pharmaceutics 2009, 6, 386-395
19. Ogawa, M.; Kosaka, N.; Urano, Y.; Choyke, P. L.; Kobayashi, H. Activatable optical imaging probes with various fluorophore-quencher combinations Proc. SPIE 2009, 7190, 71900Z
20. Packard, B. Z.; Komoriya, A.; Toptygin, D. D.; Ludwig, B. Structural Characteristics of Fluorophores That Form Intramolecular H-Type Dimers in a Protease Substrate J. Phys. Chem. B 1997, 101, 5070-5074 (Pubitemid 127617311)
21. Halterman, R. L.; Moore, J. L.; Mannel, L., M. Disrupting aggregation of tethered rhodamine B dyads through inclusion in cucurbit[7]uril J. Org. Chem. 2008, 73, 3266-3269 (Pubitemid 351543982)
22. Ogawa, M.; Kosaka, N.; Choyke, P. L.; Kobayashi, H. H-type dimer formation of fluorophores: a mechanism for activatable, in vivo optical molecular imaging ACS Chem. Biol. 2009, 4, 535-546
23. Urano, Y.; Kamiya, M.; Kanda, K.; Ueno, T.; Hirose, K.; Nagano, T. Evolution of fluorescein as a platform for finely tunable fluorescence probes J. Am. Chem. Soc. 2005, 127, 4888-4894 (Pubitemid 40489642)
24. Ogawa, M.; Kosaka, N.; Choyke, P. L.; Kobayashi, H. High Sensitivity Detection of Cancer in vivo using a Dual-Controlled Activation Fluorescent Imaging Probe Based on H-dimer Formation and pH Activation Mol. BioSyst. 2010, 6, 888-893