Neuroprotective effect of repeated treatment with Hericium erinaceum in mice subjected to middle cerebral artery occlusion

Journal of Health Science

Volumn 56, Issue 3, 2010, Pages 296-303

  Hazekawa, Mai ^a,b   Kataoka, Aiko ^a   Hayakawa, Kazuhide ^a   Uchimasu, Takeshi ^a   Furuta, Riyo ^a   Irie, Keiichi ^a   Akitake, Yoshiharu ^a   Yoshida, Miyako ^a,b   Fujioka, Toshihiro ^a   Egashira, Nobuaki ^c   Oishi, Ryozo ^c   Mishima, Kenji ^a   Mishima, Kenichi ^a   Uchida, Takahiro ^b   Iwasaki, Katunori ^a   Fujiwara, Michihiro ^a  

^a FUKUOKA UNIVERSITY   (Japan)

^b MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^c KYUSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Cerebral ischemia; Hericium erinaceum; Middle cerebral artery occlusion; Nerve growth factor; Neuroprotection

Indexed keywords

FUNGAL EXTRACT; HERICIUM ERINACEUM EXTRACT; NERVE GROWTH FACTOR; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN LEVEL; BRAIN SLICE; CONTROLLED STUDY; CORPUS STRIATUM; FUNGUS; HERICIUM ERINACEUM; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NONHUMAN; TREATMENT DURATION;

HERICIUM ERINACEUM; MUS;

EID: 77953312388     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.56.296     Document Type: Article

References (34)

1. Kenmoku, H., Shimai, T., Toyokasu, T., Kato, N., Sassa, T. and Erinacine, Q. (2002) A new erinacine from Hericium erinaceum, and its biosynthetic route to erinacine C in the basidiomycete. Biosci. Biotechnol. Biochem., 66, 571-575.
2. Chang, R. (1996) Functional properties of edible mushrooms. Nutr. Rev., 54, S91-S93.
3. Choi, W. S., Kim, C. J., Park, B. S., Lee, S. E., Takeoka, G. R., Kim, D. G., Lanpiao, X. and Kim, J. H. (2005) Inhibitory effect on proliferation of vascular smooth muscle cells and protective effect on CCl(4)-induced hepatic damage of HEAI extract. J. Ethnopharmacol, 100, 176-179.
4. Jia, L. M., Liu, L., Dong, Q. and Fang, J. N. (2004) Structural investigation of a novel rhamnogluco-galactan isolated from the fruiting bodies of the fungus Hericium erinaceus. Carbohydr. Res., 339, 2667-2671.
5. Mizuno, T., Wasa, T., Ito, H., Suzuki, C. and Ukai, N. (1992) Antitumor-active polysaccharides isolated from the fruiting body of Hericium erinaceum, an edible and medicinal mushroom called yamabushi- take or houtou. Biosci. Biotechnol. Biochem., 56, 347-348.
6. Nakatsugawa, M., Takahashi, H., Takezawa, C, Nakajima, K., Harada, K., Sugawara, Y., Kobayashi, S., Kondo, T. and Abe, S. (2003) Hericium erinaceum (yamabushitake) extract-induced acute respiratory distress syndrome monitored by serum surfactant proteins. Intern. Med., 42, 1219-1222.
7. Lee, E. W., Shizuki, K., Hosokawa, S., Suzuki, M., Suganuma, H., Inakuma, T., Li, J., Ohnishi-Kameyama, M., Nagata, T., Furukawa, S. and Kawagishi, H. (2000) Two Novel Diterpenoids, Erinacines H and I from the mycelia of Hericium erinaceum. Biosci. Biotechnol. Biochem., 64, 2402-2405.
8. Kawagishi, H., Ando, M. and Mizuno, T. (1990) Hericenone A and B as cytotoxic principles from the mushroom Hericium erinaceum. Tetrahedron Letters, 31, 373-376.
9. Kawagishi, H., Masui, A., Tokuyama, S. and Nakamura, T. (2006) Erinacines J and K from the mycelia of Hericium erinaceum. Tetrahedron Lett, 62, 8463-8466.
10. Kawagishi, H., Ando, M., Sakamoto, H., Yoshida, S., Kojima, R, Ishiguro, Y., Ukai, N. and Furukawa, S. (1991) Hericenones C, D and E, stimulators of nerve growth factor (NGF)-synthesis, from the mushroom Hericium erinaceum. Tetrahedron Lett, 32,4561-564.
11. Kawagishi, H., Shimada, A., Shirai, R., Okamoto, K., Sakamoto, H., Ishiguro, Y. and Furukawa, S. (1994) Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum. Tetrahedron Lett, 35, 1569-1572.
12. Kawagishi, H., Shimada, A., Hosokawa, S., Mori, H., Sakamoto, H., Ishiguro, Y, Sakemi, S., Bordner, J., Kojima, N. and Furukawa, S. (1996) Erinacines E, F, and G, stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum. Tetrahedron Lett., 37, 7399-7402.
13. Mori, K., Inatomi, S., Ouchi, K., Azumi, Y and Tsuchida, T. (2009) Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother. Res., 23, 367-372.
14. Guegan, C, Onteniente, B., Makiura, Y, Merad Boudia, M., Ceballos, Picot I. and Sola, B. (1998) Reduction of cortical infarction and impairment of apoptosis in NGF transgenic mice subjected to permanent focal ischemia. Brain. Res. Mol. Brain Res., 55, 133-140.
15. Semkova, L, Wolz, R, Schilling, M. and Krieglstein, J. (1996) Selegiline enhances NGF synthesis and protects central nervous system neurons from excitotoxic and ischemic damage. Eur. J. Pharmacol, 315, 19-30.
16. Kong, S. Y, Li, Q. E, Yang, J. and He, L. (2007) The effect of butylphthalide on expression of NGF and BDNF in ischemia stroke tissue of rat cerebrum. Sichuan Da Xue Xue Bao Yi Xue Ban, 38, 400-403.
17. Chang, C. N., Yang, J. T., Lee, T. H., Cheng, W. C, Hsu, Y H. and Wu, J. H. (2005) Dexamethasone enhances upregulation of nerve growth factor mRNA expression in ischemic rat brain. J. Clin. Neuroscl, 12, 680-684.
18. Hayakawa, K., Mishima, K., Nozako, M., Hazekawa, M., Mishima, S., Fujioka, M., Orito, K., Egashira, N., Iwasaki, K. and Fujiwara, M. (2008) Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group boxlinhibiting mechanism. Stroke, 39, 951-958.
19. Mishima, K., Hayakawa, K., Abe, K., Ikeda, T., Egashira, N., Iwasaki, K. and Fujiwara, M. (2005) Cannabidiol prevents cerebral infarction via a serotonergic 5 hydroxytryptamine 1A receptor-dependent mechanism. Stroke, 36, 1077-1082.
20. Mori, K., Obara, Y, Hirota, M., Azumi, Y, Kinugasa, S., Inatomi, S. and Nakahata, N. (2008) Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol. Pharm. Bull, 31, 1727-1732.
21. Shimbo, M., Kawagishi, H. and Yokogoshi, H. (2005) Erinacine A increases catecholamine and nerve growth factor content in the central nervous system of rats. Nutr. Res., 25, 617-623.
22. Nagai, K., Chiba, A., Nishino, T., Kubota, T. and Kawagishi, H. (2006) Dilinoleoyl- phosphatidylethanolamine from Hericium erinaceum protects against ER stress-dependent Neuro 2a cell death via protein kinase C pathway. J. Nutr. Biochem., 17, 525-530.
23. Edagawa, Y, Smriga, M., Nishiyama, N. and Saito, H. (2001) Systemic administration of lentinan, a branched beta-glucan, enhances long-term potentiation in the rat dentate gyrus in vivo. Neurosci. Lett, 314, 139-142.
24. Takano, E, Yamaguchi, M., Shoda, S., Fu, Z. D. and Ohta, T. (2005) Toxicological studies on hot water extracts Pleurocybella porrigens (Pers.:Fr.) in mice. Natural Medicines, 59, 151-156.
25. Hosomi, N., Mizushige, K., Kitadai, M., Ohyama, H., Ichihara, S. L, Takahashi, T. and Matsuo, H. (1999) Induced hypertension treatment to improve cerebral ischemic injury after transient forebrain ischemia. Brain Res., 835, 188-196.
26. Diringer, M. N. and Axelrod, Y (2007) Hemodynamic manipulation in the neurointensive care unit: cerebral perfusion pressure therapy in head injury and hemodynamic augmentation for cerebral vasospasm. Curr. Opin. Crit Care, 13, 156-162.
27. Zhang, F, White, J. G. and Iadecola, C. (1994) Nitric oxide donors increase blood flow and reduce brain damage in focal ischemia: evidence that nitric oxide is beneficial in the early stages of cerebral ischemia. J. Cereb. Blood Flow Metab., 14, 217-226.
28. Morikawa, E., Moskowitz, M. A., Huang, Z., Yoshida, T., Irikura, K. and Dalkara, T. (1994) L- arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke, 25, 429-435.
29. Wityk, R. J. and Lewin, J. J., 3rd. (2006) Blood pressure management during acute ischaemic stroke. Expert Opin. Pharmacother., 7, 247-258.
30. Saito, T., Aoki, R, Hirai, H., Inagaki, T., Matsunaga, Y., Sakakibara, T., Sakemi, S., Suzuki, Y., Watanabe, S., Suga, O., Sujaku, T., Smogowicz, A. A., Truesdell, S. J., Wong, J. W., Nagahisa, A., Kojima, Y. and Kojima, N. (1998) Erinacine E as a kappa opioid receptor agonist and its new analogs from a basidiomycete, Hericium ramosum. J. Antibiot. (Tokyo), 51, 983-990.
31. Hiramatsu, M., Murasawa, H., Mori, H. and Kameyama, T. (1998) Reversion of muscarinic autoreceptor agonist-induced acetylcholine decrease and learning impairment by dynorphin A (1-13), an endogenous kappa-opioid receptor agonist. Br. J. Pharmacol, 123, 920-926.
32. Hiramatsu, M., Murasawa, H., Nabeshima, T. and Kameyama, T. (1998) Effects of U-50, 488H on scopolamine-, mecamylamine- and dizocilpine- induced learning and memory impairment in rats. J. Pharmacol. Exp. Then, 284, 858-867.
33. Kusumoto, K., Mackay, K. B. and McCulloch, J. (1992) The effect of the kappa-opioid receptor agonist CI-977 in a rat model of focal cerebral is-chaemia. Brain Res., 576, 147-151.
34. Chen, T. Y, Goyagi, T, Toung, T. J., Kirsch, J. R., Hum, P. D., Koehler, R. C. and Bhardwaj, A. (2004) Prolonged opportunity for ischemic neuroprotection with selective kappa-opioid receptor agonist in rats. Stroke, 35, 1180-1185.