The ionic bases of the action potential in isolated mouse cardiac Purkinje cell

Heart Rhythm

Volumn 10, Issue 1, 2013, Pages 80-87

  Vaidyanathan, Ravi ^a   O'Connell, Ryan P ^b   Deo, Makarand ^c   Milstein, Michelle L ^c   Furspan, Philip ^c   Herron, Todd J ^c   Pandit, Sandeep V ^c   Musa, Hassan ^c   Berenfeld, Omer ^c   Jalife, José ^c   Anumonwo, Justus M B ^c  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b Department of Molecular and Integrative Physiology ^*  (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Action potential duration; Ionic currents; Murine conduction system; Numerical model; Purkinje cell; Ventricular myocyte

Indexed keywords

CALCIUM CHANNEL T TYPE; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CELL ISOLATION; COMPUTER SIMULATION; CYTOSOL; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART VENTRICLE; MICROSCOPY; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; SODIUM CURRENT; VOLTAGE CLAMP;

ACTION POTENTIALS; ANIMALS; CALCIUM; HEART VENTRICLES; MICE; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; PURKINJE CELLS; SODIUM;

EID: 84872024995     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2012.10.002     Document Type: Article

References (35)

1. J.M. Anumonwo, Y.N. Tallini, F.J. Vetter, and J. Jalife Action potential characteristics and arrhythmogenic properties of the cardiac conduction system of the murine heart Circ Res 89 2001 329 335
2. C.M. Wolf, and C.I. Berul Inherited conduction system abnormalities - one group of diseases, many genes J Cardiovasc Electrophysiol 17 2006 446 455
3. J.M. Nerbonne Studying cardiac arrhythmias in the mouse - a reasonable model for probing mechanisms? Trends Cardiovasc Med 14 2004 83 93
4. J.M. Nerbonne, C.G. Nichols, T.L. Schwarz, and D. Escande Genetic manipulation of cardiac K(+) channel function in mice: what have we learned, and where do we go from here? Circ Res 89 2001 944 956
5. M. Cerrone, S.F. Noujaim, and E.G. Tolkacheva Arrhythmogenic mechanisms in a mouse model of catecholaminergic polymorphic ventricular tachycardia Circ Res 101 2007 1039 1048
6. T.J. Herron, M.L. Milstein, J. Anumonwo, S.G. Priori, and J. Jalife Purkinje cell calcium dysregulation is the cellular mechanism that underlies catecholaminergic polymorphic ventricular tachycardia Heart Rhythm 7 2010 1122 1128
7. G. Kang, S.F. Giovannone, and N. Liu Purkinje cells from RyR2 mutant mice are highly arrhythmogenic but responsive to targeted therapy Circ Res 107 2010 512 519
8. L. Li, S.A. Niederer, and W. Idigo A mathematical model of the murine ventricular myocyte: a data-driven biophysically based approach applied to mice overexpressing the canine NCX isoform Am J Physiol Heart Circ Physiol 299 2010 H1045 H1063
9. L. Miquerol, S. Meysen, and M. Mangoni Architectural and functional asymmetry of the His-Purkinje system of the murine heart Cardiovasc Res 63 2004 77 86
10. D. DiFrancesco The role of the funny current in pacemaker activity Circ Res 106 2010 434 446
11. + current Circ Res 94 2004 1332 1339
12. K1) by synapse associated protein-97. J Biol Chem 2010;285(36):28000-28009.
13. + currents in adult mouse ventricular myocytes J Gen Physiol 113 1999 661 678
14. L.L. Cribbs, B.L. Martin, E.A. Schroder, B.B. Keller, B.P. Delisle, and J. Satin Identification of the T-type calcium channel (Ca(v)3.1d) in developing mouse heart Circ Res 88 2001 403 407
15. 2+ channels J Biol Chem 286 2011 2433 2444
16. N. Ono, T. Yamaguchi, and H. Ishikawa Morphological varieties of the Purkinje fiber network in mammalian hearts, as revealed by light and electron microscopy Arch Histol Cytol 72 2009 139 149
17. S. Viragh, M.E. Stoeckel, and A. Porte Light and electron microscopic structure of the cardiac Purkinje fibers - review Physiol Bohemoslov 36 1987 233 242
18. G. Schram, M. Pourrier, P. Melnyk, and S. Nattel Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function Circ Res 90 2002 939 950
19. A. Zaza, G. Malfatto, and M.R. Rosen Electrophysiologic effects of ketanserin on canine Purkinje fibers, ventricular myocardium and the intact heart J Pharmacol Exp Ther 250 1989 397 405
20. + currents in cardiac Purkinje cells isolated from rabbit and dog J Mol Cell Cardiol 42 2007 378 389
21. W. Dun, and P.A. Boyden The Purkinje cell: 2008 style J Mol Cell Cardiol 45 2008 617 624
22. A.O. Verkerk, M.W. Veldkamp, and F. Abbate Two types of action potential configuration in single cardiac Purkinje cells of sheep Am J Physiol 277 1999 H1299 H1310
23. M. Vassalle The vicissitudes of the pacemaker current I (Kdd) of cardiac Purkinje fibers J Biomed Sci 14 2007 699 716
24. E.G. Lakatta, V.A. Maltsev, K.Y. Bogdanov, M.D. Stern, and T.M. Vinogradova Cyclic variation of intracellular calcium: a critical factor for cardiac pacemaker cell dominance Circ Res 92 2003 e45 e50
25. W. Shi, R. Wymore, and H. Yu Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues Circ Res 85 1999 e1 e6
26. + currents in rabbit heart Purkinje cells J Physiol 508 1998 811 823
27. W. Han, D. Chartier, D. Li, and S. Nattel Ionic remodeling of cardiac Purkinje cells by congestive heart failure Circulation 104 2001 2095 2100
28. W. Han, L. Zhang, G. Schram, and S. Nattel Properties of potassium currents in Purkinje cells of failing human hearts Am J Physiol Heart Circ Physiol 283 2002 H2495 H2503
29. N. Gaborit, S. Le Bouter, and V Szuts Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart J Physiol 582 2007 675 693
30. M. Allessie, J. Ausma, and U. Schotten Electrical, contractile and structural remodeling during atrial fibrillation Cardiovasc Res 54 2002 230 246
31. + currents in myocytes from left and right atria of adult mice Am J Physiol Heart Circ Physiol 285 2003 H1837 H1848
32. + current by overexpression of the long-QT syndrome HERG G628S mutation in transgenic mice Circ Res 83 1998 668 678
33. + current diversity in mouse ventricular myocytes J Physiol 521 1999 587 599
34. 2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes Circ Res 103 2008 1109 1119
35. Na2) in the plateau range in canine cardiac Purkinje single cells Exp Physiol 92 2007 161 173