A role for p21-activated kinase 7 in the development of gastric cancer

FEBS Journal

Volumn 280, Issue 1, 2013, Pages 46-55

  Gu, Jun ^a   Li, Keqiang ^b   Li, Maolan ^a   Wu, Xiangsong ^a   Zhang, Lin ^a   Ding, Qichen ^a   Wu, Wenguang ^a   Yang, Jiahua ^a   Mu, Jiasheng ^a   Wen, Hao ^a   Ding, Qian ^a   Lu, Jianhua ^a   Hao, Yuan ^a   Chen, Lei ^a   Zhang, Wenjie ^a   Li, Songgang ^a   Liu, Yingbin ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b NINGBO NO 2 HOSPITAL   (China)

Author keywords

cell cycle arrest; cell proliferation; human gastric cancer; PAK7; RNA interference

Indexed keywords

CELL PROTEIN; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; MESSENGER RNA; P21 ACTIVATED KINASE 7; PROTEIN CDC25; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER CELL CULTURE; CANCER TISSUE; CELL CYCLE G0 PHASE; CELL CYCLE REGULATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INHIBITION KINETICS; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; P21 ACTIVATED KINASE 7 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; STOMACH CANCER; STOMACH CARCINOGENESIS; TUMOR GENE; UPREGULATION; WESTERN BLOTTING;

ADENOCARCINOMA; CDC25 PHOSPHATASES; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN D1; CYCLIN-DEPENDENT KINASE 2; FEMALE; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HUMANS; MALE; MIDDLE AGED; P21-ACTIVATED KINASES; RNA INTERFERENCE; STOMACH NEOPLASMS;

LENTIVIRUS;

EID: 84872014533     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12048     Document Type: Article

References (39)

1. Parkin DM, Bray F, Ferlay J, &, Pisani P, (2005) Global cancer statistics, 2002. CA Cancer J Clin 55, 74-108.
2. Harder J, &, Opitz OG, (2006) Gastric cancer-risk factors and medical therapy. Praxis (Bern 1994) 95, 1021-1028.
3. Ajani JA, (2005) Evolving chemotherapy for advanced gastric cancer. Oncologist 10 (Suppl 3), 49-58.
4. Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, Scarffe JH, Lofts FJ, Falk SJ, Iveson TJ, et al,. (2006) Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 355, 11-20.
5. Becker KF, Keller G, &, Hoefler H, (2000) The use of molecular biology in diagnosis and prognosis of gastric cancer. Surg Oncol 9, 5-11.
6. Bagrodia S, &, Cerione RA, (1999) Pak to the future. Trends Cell Biol 9, 350-355.
7. Roig J, &, Traugh JA, (2001) Cytostatic p21 G protein-activated protein kinase gamma-PAK. Vitam Horm 62, 167-198.
8. Bokoch GM, (2003) Biology of the p21-activated kinases. Annu Rev Biochem 72, 743-781.
9. Arias-Romero LE, &, Chernoff J, (2008) A tale of two Paks. Biol Cell 100, 97-108.
10. Kumar A, Molli PR, Pakala SB, Bui Nguyen TM, Rayala SK, &, Kumar R, (2009) PAK thread from amoeba to mammals. J Cell Biochem 107, 579-585.
11. Dummler B, Ohshiro K, Kumar R, &, Field J, (2009) Pak protein kinases and their role in cancer. Cancer Metastasis Rev 28, 51-63.
12. Molli PR, Li DQ, Murray BW, Rayala SK, &, Kumar R, (2009) PAK signaling in oncogenesis. Oncogene 28, 2545-2555.
13. Jaffer ZM, &, Chernoff J, (2002) p21-activated kinases: three more join the Pak. Int J Biochem Cell Biol 34, 713-717.
14. Dan C, Nath N, Liberto M, &, Minden A, (2002) PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells. Mol Cell Biol 22, 567-577.
15. Ching YP, Leong VY, Wong CM, &, Kung HF, (2003) Identification of an autoinhibitory domain of p21-activated protein kinase 5. J Biol Chem 278, 33621-33624.
16. Matenia D, Griesshaber B, Li XY, Thiessen A, Johne C, Jiao J, Mandelkow E, &, Mandelkow EM, (2005) PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin. Mol Biol Cell 16, 4410-4422.
17. Timm T, Matenia D, Li XY, Griesshaber B, &, Mandelkow EM, (2006) Signaling from MARK to tau: regulation, cytoskeletal crosstalk, and pathological phosphorylation. Neurodegener Dis 3, 207-217.
18. Pandey A, Dan I, Kristiansen TZ, Watanabe NM, Voldby J, Kajikawa E, Khosravi-Far R, Blagoev B, &, Mann M, (2002) Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain. Oncogene 21, 3939-3948.
19. Cotteret S, &, Chernoff J, (2006) Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. Mol Cell Biol 26, 3215-3230.
20. Cotteret S, Jaffer ZM, Beeser A, &, Chernoff J, (2003) p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol Cell Biol 23, 5526-5539.
21. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, et al,. (2007) Patterns of somatic mutation in human cancer genomes. Nature 446, 153-158.
22. Gong W, An Z, Wang Y, Pan X, Fang W, Jiang B, &, Zhang H, (2009) P21-activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration. Int J Cancer 125, 548-555.
23. Wang X, Gong W, Qing H, Geng Y, Zhang Y, Peng L, Zhang H, &, Jiang B, (2010) p21-activated kinase 5 inhibits camptothecin-induced apoptosis in colorectal carcinoma cells. Tumour Biol 31, 575-582.
24. Green DR, &, Evan GI, (2002) A matter of life and death. Cancer Cell 1, 19-30.
25. Massague J, (2004) G1 cell-cycle control and cancer. Nature 432, 298-306.
26. Kastan MB, &, Bartek J, (2004) Cell-cycle checkpoints and cancer. Nature 432, 316-323.
27. Sherr CJ, (1996) Cancer cell cycles. Science 274, 1672-1677.
28. Baldin V, Lukas J, Marcote MJ, Pagano M, &, Draetta G, (1993) Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev 7, 812-821.
29. Meyerson M, &, Harlow E, (1994) Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol Cell Biol 14, 2077-2086.
30. Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, &, Roberts JM, (1992) Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science 257, 1689-1694.
31. Kato J, Matsushime H, Hiebert SW, Ewen ME, &, Sherr CJ, (1993) Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev 7, 331-342.
32. Dowdy SF, Hinds PW, Louie K, Reed SI, Arnold A, &, Weinberg RA, (1993) Physical interaction of the retinoblastoma protein with human D cyclins. Cell 73, 499-511.
33. Blomberg I, &, Hoffmann I, (1999) Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases. Mol Cell Biol 19, 6183-6194.
34. Wang YN, McDonald JK, &, Wyatt RJ, (1987) Immunocytochemical localization of neuropeptide Y-like immunoreactivity in adrenergic and non-adrenergic neurons of the rat gastrointestinal tract. Peptides 8, 145-151.
35. Shimizu M, Saitoh Y, &, Itoh H, (1990) Immunohistochemical staining of Ha-ras oncogene product in normal, benign, and malignant human pancreatic tissues. Hum Pathol 21, 607-612.
36. Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, Rooney DL, Zhang M, Ihrig MM, McManus MT, et al,. (2003) A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 33, 401-406.
37. Livak KJ, &, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25, 402-408.
38. Mosmann T, (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65, 55-63.
39. Nunez R, (2001) DNA measurement and cell cycle analysis by flow cytometry. Curr Issues Mol Biol 3, 67-70.