-
1
-
-
0029739097
-
New perspectives on the definition of pain
-
Anand KJS, Craig KD. New perspectives on the definition of pain. Pain. 1996;67(1):3-6.
-
(1996)
Pain.
, vol.67
, Issue.1
, pp. 3-6
-
-
Anand, K.J.S.1
Craig, K.D.2
-
2
-
-
77955172408
-
Pain market
-
Melnikova I. Pain market. Nat Rev Drug Dis. 2010;9(8):589-590.
-
(2010)
Nat Rev Drug Dis.
, vol.9
, Issue.8
, pp. 589-590
-
-
Melnikova, I.1
-
3
-
-
52349113159
-
Common chronic pain conditions in developed and developing countries: Gender and age differences and comorbidity with depression-anxiety disorders
-
Tsang A, Von Korff M, Lee S, et al. Common chronic pain conditions in developed and developing countries: gender and age differences and comorbidity with depression-anxiety disorders. J Pain. 2008; 9(10):883-891.
-
(2008)
J Pain.
, vol.9
, Issue.10
, pp. 883-891
-
-
Tsang, A.1
Von Korff, M.2
Lee, S.3
-
4
-
-
0038061514
-
The management of persistent pain
-
Goucke RC. The management of persistent pain. Med J Aust. 2003; 178(9):444-447.
-
(2003)
Med J Aust.
, vol.178
, Issue.9
, pp. 444-447
-
-
Goucke, R.C.1
-
5
-
-
61549105014
-
Physiology and treatment of pain
-
Helms JE, Barone CP. Physiology and treatment of pain. Crit Care Nurse. 2008;28(6):38-49.
-
(2008)
Crit Care Nurse.
, vol.28
, Issue.6
, pp. 38-49
-
-
Helms, J.E.1
Barone, C.P.2
-
6
-
-
79551468717
-
Pain and death: Neurodegenerative disease mechanisms in the nociceptor
-
Reichling DB, Levine JD. Pain and death: neurodegenerative disease mechanisms in the nociceptor. Ann Neurol. 2011;69(1):13-21.
-
(2011)
Ann Neurol.
, vol.69
, Issue.1
, pp. 13-21
-
-
Reichling, D.B.1
Levine, J.D.2
-
7
-
-
70349904600
-
Neuropathic pain: A clinical perspective
-
Baron R. Neuropathic pain: a clinical perspective. Handb Exp Pharmacol. 2009;194:3-30.
-
(2009)
Handb Exp Pharmacol.
, vol.194
, pp. 3-30
-
-
Baron, R.1
-
8
-
-
79952199138
-
When does acute pain become chronic?
-
Voscopoulos C, Lema M. When does acute pain become chronic? Br J Anaesth. 2010;105(Suppl 1):i69-i85.
-
(2010)
Br J Anaesth.
, vol.105
, Issue.SUPPL. 1
-
-
Voscopoulos, C.1
Lema, M.2
-
9
-
-
0032890162
-
The induction of pain: An integrative review
-
Milan MJ. The induction of pain: an integrative review. Prog Neurobiol. 1999;57(1):1-164.
-
(1999)
Prog Neurobiol.
, vol.57
, Issue.1
, pp. 1-164
-
-
Milan, M.J.1
-
10
-
-
39049184645
-
Peripheral and central mechanisms of pain generation
-
Schaible HG. Peripheral and central mechanisms of pain generation. Handb Exp Pharmacol. 2007;177:3-28.
-
(2007)
Handb Exp Pharmacol.
, vol.177
, pp. 3-28
-
-
Schaible, H.G.1
-
11
-
-
0036829011
-
Can we conquer pain?
-
Scholz J, Woolf CJ. Can we conquer pain? Nat Neurosci. 2002;5(Suppl): 1062-1067.
-
(2002)
Nat Neurosci.
, vol.5
, Issue.SUPPL.
, pp. 1062-1067
-
-
Scholz, J.1
Woolf, C.J.2
-
12
-
-
77954357460
-
Neurobiological and clinical relationship between psychiatric disorders and chronic pain
-
Bras M, Dordevic V, Grequrek R, Bulajic M. Neurobiological and clinical relationship between psychiatric disorders and chronic pain. Psychiatr Danub. 2010;22(2):221-226.
-
(2010)
Psychiatr Danub.
, vol.22
, Issue.2
, pp. 221-226
-
-
Bras, M.1
Dordevic, V.2
Grequrek, R.3
Bulajic, M.4
-
13
-
-
33845682981
-
Pain and psychiatry: A critical analysis and pharmacological review
-
Marazziti D, Mungai F, Vivarelli L, Presta S, Dell'Osso B. Pain and psychiatry: a critical analysis and pharmacological review. Clin Pract Epidemiol Ment Health. 2006;2:31.
-
(2006)
Clin Pract Epidemiol Ment Health.
, vol.2
, pp. 31
-
-
Marazziti, D.1
Mungai, F.2
Vivarelli, L.3
Presta, S.4
Dell'Osso, B.5
-
14
-
-
33645748180
-
The pharmacotherapy of chronic pain: A review
-
Lynch ME, Watson CPN. The pharmacotherapy of chronic pain: a review. Pain Res Manage. 2006;11(1):11-38.
-
(2006)
Pain Res Manage.
, vol.11
, Issue.1
, pp. 11-38
-
-
Lynch, M.E.1
Watson, C.P.N.2
-
15
-
-
67349126560
-
Pharmacotherapy of chronic pain: A synthesis of recommendations from systematic reviews
-
Kroenke K, Krebs EE, Bair MJ. Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews. Gen Hosp Psychiatry. 2009;31(3):206-219.
-
(2009)
Gen Hosp Psychiatry.
, vol.31
, Issue.3
, pp. 206-219
-
-
Kroenke, K.1
Krebs, E.E.2
Bair, M.J.3
-
16
-
-
0003982534
-
-
Centers for Disease Control and Prevention. Atlanta, GA: Centers for Disease Control and Prevention. Available from: Accessed June 18
-
Centers for Disease Control and Prevention. National Hospital Ambulatory Medical Care Survey (NHAMCS). Atlanta, GA: Centers for Disease Control and Prevention. Available from: http://www.cdc. gov/nchs/ahcd.htm. Accessed June 18, 2011.
-
(2011)
National Hospital Ambulatory Medical Care Survey (NHAMCS).
-
-
-
17
-
-
72049129149
-
A difficult balance-pain management, drug safety, and the FDA
-
Woodcock J. A difficult balance-pain management, drug safety, and the FDA. N Eng J Med. 2009;361(22):2105-2107.
-
(2009)
N Eng J Med.
, vol.361
, Issue.22
, pp. 2105-2107
-
-
Woodcock, J.1
-
18
-
-
78751695197
-
Cardiovascular safety of nonsteroidal anti-inflammatory drugs: Network meta-analysis
-
Trelle S, Reichenbach S, Wandel S, et al. Cardiovascular safety of nonsteroidal anti-inflammatory drugs: network meta-analysis. BMJ. 2011; 342:c7086.
-
(2011)
BMJ.
, vol.342
-
-
Trelle, S.1
Reichenbach, S.2
Wandel, S.3
-
19
-
-
54049105404
-
Addiction to prescription opioids: Characteristics of the emerging epidemic and treatment with buprenorphine
-
Mendelson J, Flower K, Pletcher MJ, Galloway GP. Addiction to prescription opioids: characteristics of the emerging epidemic and treatment with buprenorphine. Exp Clin Psychopharmacol. 2008;16(5): 435-441.
-
(2008)
Exp Clin Psychopharmacol.
, vol.16
, Issue.5
, pp. 435-441
-
-
Mendelson, J.1
Flower, K.2
Pletcher, M.J.3
Galloway, G.P.4
-
20
-
-
21244478975
-
Therapeutic potential of cannabinoid receptor agonists as analgesic agents
-
Fox A, Bevan S. Therapeutic potential of cannabinoid receptor agonists as analgesic agents. Expert Opin Investig Drugs. 2005;14(6): 695-703.
-
(2005)
Expert Opin Investig Drugs.
, vol.14
, Issue.6
, pp. 695-703
-
-
Fox, A.1
Bevan, S.2
-
21
-
-
0035150352
-
Cannabinoid receptors and pain
-
Pertwee RG. Cannabinoid receptors and pain. Prog Neurobiol. 2001; 63(5):569-611.
-
(2001)
Prog Neurobiol.
, vol.63
, Issue.5
, pp. 569-611
-
-
Pertwee, R.G.1
-
22
-
-
34447542824
-
Targeting cannabinoid agonists for inflammatory and neuropathic pain
-
Cheng Y, Hitchcock SA. Targeting cannabinoid agonists for inflammatory and neuropathic pain. Expert Opin Investig Drugs. 2007;16(7):951-965.
-
(2007)
Expert Opin Investig Drugs.
, vol.16
, Issue.7
, pp. 951-965
-
-
Cheng, Y.1
Hitchcock, S.A.2
-
23
-
-
0029094470
-
Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
-
Galieque S, Mary S, Marchand J, et al. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem. 1995;232(1):54-61.
-
(1995)
Eur J Biochem.
, vol.232
, Issue.1
, pp. 54-61
-
-
Galieque, S.1
Mary, S.2
Marchand, J.3
-
24
-
-
0036399623
-
Cognitive, subjective dose-response effects of acute oral {increment}9-tetrahydrocannabinol (THC) in infrequent cannabis users
-
Curran HV, Brignell C, Fletcher S, Middleton P, Henry J. Cognitive, subjective dose-response effects of acute oral {increment}9-tetrahydrocannabinol (THC) in infrequent cannabis users. Psychopharmacology. 2002;164(1):61-70.
-
(2002)
Psychopharmacology.
, vol.164
, Issue.1
, pp. 61-70
-
-
Curran, H.V.1
Brignell, C.2
Fletcher, S.3
Middleton, P.4
Henry, J.5
-
25
-
-
34347351175
-
The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats
-
Robinson L, Goonawardena AV, Pertwee RG, Hampson RE, Riedel G. The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats. Br J Pharmacol. 2007;151(5): 688-700.
-
(2007)
Br J Pharmacol.
, vol.151
, Issue.5
, pp. 688-700
-
-
Robinson, L.1
Goonawardena, A.V.2
Pertwee, R.G.3
Hampson, R.E.4
Riedel, G.5
-
26
-
-
0025954862
-
Characterization and localization of cannabinoid receptors in rat brain: A quantitative in vitro autoradiographic study
-
Herkenham M, Lynn AB, Johnson MR, Melvin LS, de Costa BR, Rice KC. Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J Neurosci. 1991;11(2):563-583.
-
(1991)
J Neurosci.
, vol.11
, Issue.2
, pp. 563-583
-
-
Herkenham, M.1
Lynn, A.B.2
Johnson, M.R.3
Melvin, L.S.4
de Costa, B.R.5
Rice, K.C.6
-
27
-
-
0027078685
-
Isolation and structure of a brain constituent that binds to the cannabinoid receptor
-
Devane WA, Hanus L, Breuer A, et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science. 1992;258(5090):1946-1949.
-
(1992)
Science.
, vol.258
, Issue.5090
, pp. 1946-1949
-
-
Devane, W.A.1
Hanus, L.2
Breuer, A.3
-
28
-
-
84884474728
-
Pharmacological actions of cannabinoids
-
Pertwee RG. Pharmacological actions of cannabinoids. Handb Exp Pharmacol. 2005;168:1-51.
-
(2005)
Handb Exp Pharmacol.
, vol.168
, pp. 1-51
-
-
Pertwee, R.G.1
-
29
-
-
70349333074
-
Cannabinoids as pharmacotherapies for neuropathic pain: From the bench to the bedside
-
Rahn EJ, Hohman AG. Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside. Neurotheraptics. 2009;6(4):713-737.
-
(2009)
Neurotheraptics.
, vol.6
, Issue.4
, pp. 713-737
-
-
Rahn, E.J.1
Hohman, A.G.2
-
30
-
-
71449090224
-
Latest advances in cannabinoid receptor agonists
-
Thakur GA, Tichkule R, Bajaj S, Makriyannis A. Latest advances in cannabinoid receptor agonists. Expert Opin Ther Patents. 2009;19(12): 1647-1673.
-
(2009)
Expert Opin Ther Patents.
, vol.19
, Issue.12
, pp. 1647-1673
-
-
Thakur, G.A.1
Tichkule, R.2
Bajaj, S.3
Makriyannis, A.4
-
31
-
-
78650388462
-
2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats
-
2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats. Br J Pharmacol. 2011;162(2):428-440.
-
(2011)
Br J Pharmacol.
, vol.162
, Issue.2
, pp. 428-440
-
-
Hsieh, G.C.1
Pai, M.2
Chandran, P.3
-
34
-
-
0041836218
-
2-cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS
-
2-cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proc Natl Acad Sci U S A. 2003;100(18):10529-10533.
-
(2003)
Proc Natl Acad Sci U S A.
, vol.100
, Issue.18
, pp. 10529-10533
-
-
Ibrahim, M.M.1
Deng, H.2
Zvonok, A.3
-
38
-
-
34250202493
-
Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain
-
Giblin GMP, O'Shaughnessy CT, Naylor A, et al. Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain. J Med Chem. 2007; 50(11):2597-2600.
-
(2007)
J Med Chem.
, vol.50
, Issue.11
, pp. 2597-2600
-
-
Giblin, G.M.P.1
O'Shaughnessy, C.T.2
Naylor, A.3
-
40
-
-
78649497663
-
2 Cannabinoid receptor ligands: Structural insights into the design of a novel inverse agonist series
-
2 Cannabinoid receptor ligands: structural insights into the design of a novel inverse agonist series. J Med Chem. 2010; 53(22):7918-7931.
-
(2010)
J Med Chem.
, vol.53
, Issue.22
, pp. 7918-7931
-
-
El Bakali, J.1
Muccioli, G.G.2
Renault, N.3
-
41
-
-
58149200910
-
Transient receptor potential channels: Targeting pain at the source
-
Patapoutian A, Tate S, Woolf CJ. Transient receptor potential channels: targeting pain at the source. Nat Rev Drug Dis. 2009;8(1):55-68.
-
(2009)
Nat Rev Drug Dis.
, vol.8
, Issue.1
, pp. 55-68
-
-
Patapoutian, A.1
Tate, S.2
Woolf, C.J.3
-
42
-
-
70349659983
-
The transient receptor potential vanilloid-1 channel in thermoregulation: Thermosensor it is not
-
Romanovsky AA, Almeida MC, Garami A, et al. The transient receptor potential vanilloid-1 channel in thermoregulation: thermosensor it is not. Pharmacol Rev. 2009;61(3):228-261.
-
(2009)
Pharmacol Rev.
, vol.61
, Issue.3
, pp. 228-261
-
-
Romanovsky, A.A.1
Almeida, M.C.2
Garami, A.3
-
44
-
-
34547448651
-
TRP channels: Targets for the relief of pain
-
Levine JD, Haber NA. TRP channels: targets for the relief of pain. Biochim Biophys Acta. 2007;1772(8):989-1003.
-
(2007)
Biochim Biophys Acta.
, vol.1772
, Issue.8
, pp. 989-1003
-
-
Levine, J.D.1
Haber, N.A.2
-
45
-
-
77955970833
-
Targeting TRPV1 as an alternative approach to narcotic analgesic to treat chronic pain conditions
-
Premkumar LS. Targeting TRPV1 as an alternative approach to narcotic analgesic to treat chronic pain conditions. AAPS J. 2010;12(3):361-370.
-
(2010)
AAPS J.
, vol.12
, Issue.3
, pp. 361-370
-
-
Premkumar, L.S.1
-
46
-
-
58149483491
-
TRPV1 antagonists: The challenges for therapeutic targeting
-
Joshi NK, Szallasi A. TRPV1 antagonists: the challenges for therapeutic targeting. Trends Mol Med. 2009;15(1):14-22.
-
(2009)
Trends Mol Med.
, vol.15
, Issue.1
, pp. 14-22
-
-
Joshi, N.K.1
Szallasi, A.2
-
47
-
-
58149107126
-
Clinical development of TRPV1 antagonists: Targeting a pivotal point in the pain pathway
-
Gunthorpe MJ, Chizh BA. Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway. Drug Discov Today. 2009;14(1-2):56-67.
-
(2009)
Drug Discov Today.
, vol.14
, Issue.1-2
, pp. 56-67
-
-
Gunthorpe, M.J.1
Chizh, B.A.2
-
48
-
-
33646677987
-
Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development
-
Rami HK, Thompson M, Stemp G, et al. Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development. Bioorg Med Chem Lett. 2006;16(12): 3287-3291.
-
(2006)
Bioorg Med Chem Lett.
, vol.16
, Issue.12
, pp. 3287-3291
-
-
Rami, H.K.1
Thompson, M.2
Stemp, G.3
-
49
-
-
34547560453
-
Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationship of 4-oxopyrimidines leading to the selection of a clinical candidate
-
Doherty EM, Bannon AW, Bo Y, et al. Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationship of 4-oxopyrimidines leading to the selection of a clinical candidate. J Med Chem. 2007;50(15): 3515-3527.
-
(2007)
J Med Chem.
, vol.50
, Issue.15
, pp. 3515-3527
-
-
Doherty, E.M.1
Bannon, A.W.2
Bo, Y.3
-
50
-
-
34547556499
-
Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties
-
Wang HL, Katon J, Balan C, et al. Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties. J Med Chem. 2007;50(15):3528-3539.
-
(2007)
J Med Chem.
, vol.50
, Issue.15
, pp. 3528-3539
-
-
Wang, H.L.1
Katon, J.2
Balan, C.3
-
51
-
-
39149117718
-
Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl) urea (ABT-102) as a potent TRPV1 antagonist for pain management
-
Gomtsyan A, Bayburt EK, Schmidt RG, et al. Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl) urea (ABT-102) as a potent TRPV1 antagonist for pain management. J Med Chem. 2008;51(3):392-395.
-
(2008)
J Med Chem.
, vol.51
, Issue.3
, pp. 392-395
-
-
Gomtsyan, A.1
Bayburt, E.K.2
Schmidt, R.G.3
-
52
-
-
60049089359
-
Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia
-
Honore P, Chandran P, Hernandez G, et al. Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia. Pain. 2009;142(1-2):27-35.
-
(2009)
Pain.
, vol.142
, Issue.1-2
, pp. 27-35
-
-
Honore, P.1
Chandran, P.2
Hernandez, G.3
-
53
-
-
79954584227
-
Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial
-
Rowbotham MC, Nothaft W, Duan WR, et al. Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial. Pain. 2011;152(5):1192-2000.
-
(2011)
Pain.
, vol.152
, Issue.5
, pp. 1192-2000
-
-
Rowbotham, M.C.1
Nothaft, W.2
Duan, W.R.3
-
54
-
-
34250201413
-
The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain
-
Westaway SM. The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain. J Med Chem. 2007;50(11):2589-2596.
-
(2007)
J Med Chem.
, vol.50
, Issue.11
, pp. 2589-2596
-
-
Westaway, S.M.1
-
55
-
-
0035211065
-
P2X receptors and nociception
-
Chizh BA, Illes P. P2X receptors and nociception. Pharmacol Rev. 2001;53(4):553-568.
-
(2001)
Pharmacol Rev.
, vol.53
, Issue.4
, pp. 553-568
-
-
Chizh, B.A.1
Illes, P.2
-
56
-
-
0345767141
-
Crossing the pain barrier: P2 receptors as targets for novel analgesics
-
Kennedy C, Assis TS, Currie J, Rowan EG. Crossing the pain barrier: P2 receptors as targets for novel analgesics. J Physiol. 2003;553(Pt 3):683-694.
-
(2003)
J Physiol.
, vol.553
, Issue.PART 3
, pp. 683-694
-
-
Kennedy, C.1
Assis, T.S.2
Currie, J.3
Rowan, E.G.4
-
57
-
-
22844436446
-
P2X receptors: Targets for novel analgesics?
-
Kennedy C. P2X receptors: targets for novel analgesics? Neuroscientist. 2005;11(4):345-356.
-
(2005)
Neuroscientist.
, vol.11
, Issue.4
, pp. 345-356
-
-
Kennedy, C.1
-
58
-
-
46449134214
-
Purinergic signaling and disorders of the central nervous system
-
Burnstock G. Purinergic signaling and disorders of the central nervous system. Nat Rev Drug Dis. 2008;7(8):575-590.
-
(2008)
Nat Rev Drug Dis.
, vol.7
, Issue.8
, pp. 575-590
-
-
Burnstock, G.1
-
59
-
-
67649639047
-
Signaling at purinergic P2X receptors
-
Surprenant A, North RA. Signaling at purinergic P2X receptors. Annu Rev Physiol. 2009;71:333-359.
-
(2009)
Annu Rev Physiol.
, vol.71
, pp. 333-359
-
-
Surprenant, A.1
North, R.A.2
-
61
-
-
77951590103
-
P2X purinergic receptor ligands: Recently patented compounds
-
Gunosewoyo H, Kassiou M. P2X purinergic receptor ligands: recently patented compounds. Expert Opin Ther Pat. 2010;20(5):625-646.
-
(2010)
Expert Opin Ther Pat.
, vol.20
, Issue.5
, pp. 625-646
-
-
Gunosewoyo, H.1
Kassiou, M.2
-
62
-
-
33745142545
-
Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists
-
Nelson DW, Gregg RJ, Kort ME, et al. Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists. J Med Chem. 2006;49(12):3659-3666.
-
(2006)
J Med Chem.
, vol.49
, Issue.12
, pp. 3659-3666
-
-
Nelson, D.W.1
Gregg, R.J.2
Kort, M.E.3
-
63
-
-
43949128068
-
Structure-activity relationship studies on Ń-aryl carbohydrazide P2X7 antagonists
-
Nelson DW, Sarris K, Kalvin DM, et al. Structure-activity relationship studies on Ń-aryl carbohydrazide P2X7 antagonists. J Med Chem. 2008;51(10):3030-3034.
-
(2008)
J Med Chem.
, vol.51
, Issue.10
, pp. 3030-3034
-
-
Nelson, D.W.1
Sarris, K.2
Kalvin, D.M.3
-
64
-
-
66249113481
-
Discovery and biological evaluation of novel cyanoguanidine P2X7 antagonists with analgesic activity in a rat model of neuropathic pain
-
Medrano AP, Donnelly-Roberts DL, Honore P, et al. Discovery and biological evaluation of novel cyanoguanidine P2X7 antagonists with analgesic activity in a rat model of neuropathic pain. J Med Chem. 2009;52(10):3366-3376.
-
(2009)
J Med Chem.
, vol.52
, Issue.10
, pp. 3366-3376
-
-
Medrano, A.P.1
Donnelly-Roberts, D.L.2
Honore, P.3
-
65
-
-
37849008468
-
Discovery of potent and selective adamantane-based small-molecule P2X7 receptor antagonists/ interleukin-1β inhibitors
-
Furber M, Alcaraz L, Bent JE, et al. Discovery of potent and selective adamantane-based small-molecule P2X7 receptor antagonists/ interleukin-1β inhibitors. J Med Chem. 2007;50(24):5882-5885.
-
(2007)
J Med Chem.
, vol.50
, Issue.24
, pp. 5882-5885
-
-
Furber, M.1
Alcaraz, L.2
Bent, J.E.3
-
66
-
-
66249138835
-
Antagonists of the P2X7 receptor. From lead identification to drug development
-
Guile SD, Alcaraz L, Birkinshaw TN, et al. Antagonists of the P2X7 receptor. From lead identification to drug development. J Med Chem. 2009;52(10):3123-3141.
-
(2009)
J Med Chem.
, vol.52
, Issue.10
, pp. 3123-3141
-
-
Guile, S.D.1
Alcaraz, L.2
Birkinshaw, T.N.3
-
67
-
-
13444271955
-
Targeting glia to control clinical pain: An idea whose time has come
-
Watkins LR, Maier SF. Targeting glia to control clinical pain: an idea whose time has come. Drug Discov Today. 2004;1(1):83-88.
-
(2004)
Drug Discov Today.
, vol.1
, Issue.1
, pp. 83-88
-
-
Watkins, L.R.1
Maier, S.F.2
-
68
-
-
57749200564
-
Pathological and protective roles of glia in chronic pain
-
Milligan ED, Watkins LR. Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci. 2009;10(1):23-36.
-
(2009)
Nat Rev Neurosci.
, vol.10
, Issue.1
, pp. 23-36
-
-
Milligan, E.D.1
Watkins, L.R.2
-
69
-
-
70349984436
-
Current challenges in glia-pain biology
-
McMahon SB, Malcangio M. Current challenges in glia-pain biology. Neuron. 2009;64(1):46-54.
-
(2009)
Neuron.
, vol.64
, Issue.1
, pp. 46-54
-
-
McMahon, S.B.1
Malcangio, M.2
-
70
-
-
76349102800
-
Spinal astrocytes in pain processing: Nonneuronal cells as therapeutic targets
-
Svensson CI, Brodin E. Spinal astrocytes in pain processing: nonneuronal cells as therapeutic targets. Mol Interv. 2010;10(1):25-38.
-
(2010)
Mol Interv.
, vol.10
, Issue.1
, pp. 25-38
-
-
Svensson, C.I.1
Brodin, E.2
-
71
-
-
77956652648
-
Microglia-neuronal signaling in neuropathic pain hypersensitivity 2.0
-
Beggs S, Salter MW. Microglia-neuronal signaling in neuropathic pain hypersensitivity 2.0. Curr Opin Neurobiol. 2010;20(4):474-480.
-
(2010)
Curr Opin Neurobiol.
, vol.20
, Issue.4
, pp. 474-480
-
-
Beggs, S.1
Salter, M.W.2
|