Endogenous acetylcholine rescues NMDA-induced long-lasting hippocampal cell damage via stimulation of muscarinic M1 receptors: Elucidation using organic hippocampal slice cultures

European Journal of Pharmacology

Volumn 699, Issue 1-3, 2013, Pages 150-159

  Inada, Chikako ^a   Thi Le, Xoan ^a   Tsuneyama, Koichi ^b   Fujiwara, Hironori ^a   Miyata, Takeshi ^a,c   Matsumoto, Kinzo ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c SOJO UNIVERSITY   (Japan)

Author keywords

Acetylcholinesterase inhibitors; Cholinergic system; Excitotoxicity; NMDA receptor; Organotypic hippocampal slice cultures; Rescuing protecting activity

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; CHOLINE ACETYLTRANSFERASE; DARIFENACIN; DONEPEZIL; GALANTAMINE; MECAMYLAMINE; MUSCARINIC M1 RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEURON SPECIFIC NUCLEAR PROTEIN; PIRENZEPINE; SCOPOLAMINE; TACRINE; VESICULAR ACETYLCHOLINE TRANSPORTER;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DAMAGE; CHOLINERGIC NERVE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DENTATE GYRUS; DRUG ANTAGONISM; ENZYME ACTIVITY; ENZYME INHIBITION; EXCITOTOXICITY; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ACETYLCHOLINE; ANIMALS; BLOTTING, WESTERN; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT ANTIBODY TECHNIQUE; GALANTAMINE; HIPPOCAMPUS; INDANS; MICE; MICE, INBRED ICR; N-METHYLASPARTATE; ORGAN CULTURE TECHNIQUES; PIPERIDINES; RECEPTOR, MUSCARINIC M1; TACRINE;

EID: 84872001250     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.11.061     Document Type: Article

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