NMR imaging of cell phone radiation absorption in brain tissue

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 1, 2013, Pages 58-63

  Gultekin, David H ^a,b   Moeller, Lothar ^c  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c LUCENT TECHNOLOGIES   (United States)

Author keywords

Dipole antenna; Mobile communications; Nuclear shielding; RF safety; SAR

Indexed keywords

HYDROGEN;

ANIMAL TISSUE; ANTENNA; AQUEOUS SOLUTION; ARTICLE; BRAIN TISSUE; ELECTROMAGNETIC FIELD; EX VIVO STUDY; MOBILE PHONE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RADIATION ABSORPTION; RADIATION EXPOSURE; RADIATION SHIELD; RADIOFREQUENCY; TEMPERATURE; THERMAL ANALYSIS; THERMOMETRY;

ABSORPTION; ANIMALS; BODY TEMPERATURE; BRAIN; CATTLE; CELLULAR PHONE; GELS; HOT TEMPERATURE; MAGNETIC RESONANCE IMAGING; PROTONS; RADIO WAVES; THERMOMETRY;

BOVINAE;

EID: 84871999892     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1205598109     Document Type: Article

References (54)

1. International Commission on Non-Ionizing Radiation Protection (2008) ICNIRP statement on EMF-emitting new technologies. Health Phys 94(4):376-392.
2. World Health Organization (2010) WHO Research Agenda for Radiofrequency Fields (World Health Organization, Geneva, Switzerland).
3. Osepchuk JM, Petersen RC (2003) Historical review of RF exposure standards and the International Committee on Electromagnetic Safety (ICES). Bioelectromagnetics 6(Suppl 6):S7-S16. (Pubitemid 38622954)
4. International Commission on Non-Ionizing Radiation Protection (1998) Guidelines for limiting exposure to time-varying electric, magnetic, and electromagnetic fields (up to 300 GHz). Health Phys 74(4):494-522.
5. IEEE (2006) IEEE Standard for Safety Levels With Respect to Human Exposure to Radio Frequency Electromagnetic Fields, 3 kHz to 300 GHz [The Institute of Electrical and Electronics Engineers (IEEE), Inc., 3 Park Avenue, New York, NY 10016 USA].
6. International Telecommunication Union (2011) ICT Facts and Figures (International Telecommunication Union, Place des Nations, 1211 Geneva 20, Switzerland).
7. United Nations Population Fund (2011) The State of World Population 2011 (United Nations Population Fund, 605 Third Avenue, New York, NY 10158 USA).
8. CTIA (2011) Semi-Annual Wireless Industry Survey (CTIA-The Wireless Association, 1400 16th Street, NW Suite 600, Washington, DC 20036 USA).
9. Adair ER, Petersen RC (2002) Biological effects of radio-frequency/ microwave radiation. IEEE Trans Microw Theory Tech 50(3):953-962. (Pubitemid 34255214)
10. Lai H, Singh NP (1996) Single- and double-strand DNA breaks in rat brain cells after acute exposure to radiofrequency electromagnetic radiation. Int J Radiat Biol 69(4): 513-521. (Pubitemid 26156821)
11. Leszczynski D, Joenväärä S, Reivinen J, Kuokka R (2002) Non-thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: molecular mechanism for cancer- and blood-brain barrier-related effects. Differentiation 70(2-3):120-129. (Pubitemid 38230562)
12. Dewhirst MW, Lora-Michiels M, Viglianti BL, Dewey WC, Repacholi M (2003) Carcinogenic effects of hyperthermia. Int J Hyperthermia 19(3):236-251. (Pubitemid 36740797)
13. Blank M, Goodman R (2009) Electromagnetic fields stress living cells. Pathophysiology 16(2-3):71-78.
14. Frey AH (1979) Studies of the blood-brain-barrier - Preliminary findings and discussion. Radio Sci 14(65):349-350.
15. Salford LG, Brun A, Sturesson K, Eberhardt JL, Persson BR (1994) Permeability of the blood-brain barrier induced by 915 MHz electromagnetic radiation, continuous wave and modulated at 8, 16, 50, and 200 Hz. Microsc Res Tech 27(6):535-542. (Pubitemid 24111780)
16. Guy AW, Webb MD, Sorensen CC (1976) Determination of power absorption in man exposed to high-frequency electromagnetic-fields by thermographic measurements on scale models. IEEE T Bio-Med Eng 23(5):361-371.
17. Gandhi OP, Kang G (2002) Some present problems and a proposed experimental phantom for SAR compliance testing of cellular telephones at 835 and 1900 MHz. Phys Med Biol 47(9):1501-1518. (Pubitemid 34567833)
18. Christ A, Gosselin MC, Christopoulou M, Kühn S, Kuster N (2010) Age-dependent tissue-specific exposure of cell phone users. Phys Med Biol 55(7):1767-1783.
19. Volkow ND, et al. (2011) Effects of cell phone radiofrequency signal exposure on brain glucose metabolism. JAMA 305(8):808-813.
20. INTERPHONE Study Group (2010) Brain tumour risk in relation to mobile telephone use: results of the INTERPHONE international case-control study. Int J Epidemiol 39(3): 675-694.
21. US National Research Council (2008) Committee on Identification of Research Needs Relating to Potential Biological or Adverse Health Effects of Wireless Communications Devices: Identification of Research Needs Relating to Potential Biological or Adverse Health Effects of Wireless Communication Devices (National Academies Press, Washington, DC).
22. Baan R, et al.; WHO International Agency for Research on Cancer Monograph Working Group (2011) Carcinogenicity of radiofrequency electromagnetic fields. Lancet Oncol 12(7):624-626.
23. Ahlbom A, et al.; ICNIRP (International Commission for Non-Ionizing Radiation Protection) Standing Committee on Epidemiology) (2009) Epidemiologic evidence on mobile phones and tumor risk: A review. Epidemiology 20(5):639-652.
24. Kundi M (2009) The controversy about a possible relationship between mobile phone use and cancer. Environ Health Perspect 117(3):316-324.
25. Hardell L, Carlberg M, Hansson Mild K (2011) Re-analysis of risk for glioma in relation to mobile telephone use: Comparison with the results of the Interphone international case-control study. Int J Epidemiol 40(4):1126-1128.
26. IEEE (2003) Recommended practice for determining the peak spatial-average specific absorption rate (SAR) in the human head from wireless communications devices: Measurement techniques. IEEE Std 1528-2003 (IEEE, Inc., 3 Park Avenue, New York, NY 10016 USA).
27. Cardis E, et al. (2008) Distribution of RF energy emitted by mobile phones in anatomical structures of the brain. Phys Med Biol 53(11):2771-2783. (Pubitemid 351868604)
28. Gultekin DH, Gore JC (2010) Measurement of specific heat and specific absorption rate by nuclear magnetic resonance. Thermochim Acta 503-504:100-107.
29. Gultekin DH, Gore JC (2011) Simultaneous measurements of thermal conductivity, thermal diffusivity and specific heat by nuclear magnetic resonance imaging. Thermochim Acta 519(1-2):96-102.
30. Roberts DA, Detre JA, Bolinger L, Insko EK, Leigh JS, Jr. (1994) Quantitative magnetic resonance imaging of human brain perfusion at 1.5 T using steady-state inversion of arterial water. Proc Natl Acad Sci USA 91(1):33-37. (Pubitemid 24018637)
31. Rieke V, Butts Pauly K (2008) MR thermometry. J Magn Reson Imaging 27(2):376-390. (Pubitemid 351214044)
32. Schenck JF (1996) The role of magnetic susceptibility in magnetic resonance imaging: MRI magnetic compatibility of the first and second kinds. Med Phys 23(6): 815-850.
33. Bottomley PA, Andrew ER (1978) RF magnetic field penetration, phase shift and power dissipation in biological tissue: Implications for NMR imaging. Phys Med Biol 23(4):630-643. (Pubitemid 8380729)
34. Ramsey NF (1950) Magnetic shielding of nuclei in molecules. Phys Rev 78(6):699-703.
35. Hindman JC (1966) Proton Resonance shift of water in gas and liquid states. J Chem Phys 44(12):4582-4592.
36. Peters RD, Hinks RS, Henkelman RM (1998) Ex vivo tissue-type independence in proton-resonance frequency shift MR thermometry. Magn Reson Med 40(3):454-459. (Pubitemid 28391907)
37. Balzano Q (1999) Exposure metrics for RF epidemiology: Cellular phone handsets. Radiat Prot Dosimetry 83(1-2):165-169.
38. Wiart J, Dale C, Bosisio AV, Le Cornec A (2000) Analysis of the influence of the power control and discontinuous transmission on RF exposure with GSM mobile phones. IEEE T Electromagn C 42(4):376- 385.
39. Vrijheid M, et al. (2009) Determinants of mobile phone output power in a multinational study: Implications for exposure assessment. Occup Environ Med 66(10):664-671.
40. Kelsh MA, et al. (2011) Measured radiofrequency exposure during various mobile-phone use scenarios. J Expo Sci Environ Epidemiol 21(4):343-354.
41. Federal Communications Commission (2001) OET Bulletin 65 Supplement C (Federal Communications Commission, Washington, DC).
42. Council of the European Union (1999) Council recommendation of 12 July 1999 on the limitation of exposure of the general public to electromagnetic fields (0 Hz to 300 GHz). J Eur Communities 199:59-70.
43. Fukunaga M, et al. (2010) Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast. Proc Natl Acad Sci USA 107(8):3834-3839.
44. Foster KR, Glaser R (2007) Thermal mechanisms of interaction of radiofrequency energy with biological systems with relevance to exposure guidelines. Health Phys 92(6):609-620. (Pubitemid 46742943)
45. Burr JG, Krupp JH (1980) Real-time measurement of RFR energy distribution in the Macaca mulatta head. Bioelectromagnetics 1(1):21-34. (Pubitemid 11084799)
46. Rollins JD, Collins JS, Holden KR (2010) United States head circumference growth reference charts: Birth to 21 years. J Pediatr 156(6):907-913, e1-e2.
47. Jha R, Ahluwalia JC (1994) Test of the additivity rule for the estimation of standard partial molar heat capacities and volumes of some nonionic surfactants in aqueous solutions. J Phys Chem 98(37):9115-9118.
48. Bowman HF, Cravalho EG, Woods M (1975) Theory, measurement, and application of thermal properties of biomaterials. Annu Rev Biophys Bioeng 4(00):43-80.
49. Sevick J (2003) Understanding, Building, and Using Baluns and Ununs: Theory and Practical Designs for the Experimenter (CQ Communications, Hicksville, NY).
50. Kuster N, Balzano Q (1992) Energy-absorption mechanism by biological bodies in the near-field of dipole antennas above 300 MHz. IEEE T Veh Technol 41(1):17-23.
51. Hayes CE (2009) The development of the birdcage resonator: A historical perspective. NMR Biomed 22(9):908-918.
52. Ishihara Y, et al. (1995) A precise and fast temperature mapping using water proton chemical shift. Magn Reson Med 34(6):814 -823.
53. Haase A, Frahm J, Matthaei D, Hanicke W, Merboldt KD (1986) Flash imaging - Rapid NMR imaging using low flip-angle pulses. J Magn Reson 67(2):258-266.
54. Flynn TJ (1997) Two-dimensional phase unwrapping with minimum weighted discontinuity. J Opt Soc Am A Opt Image Sci Vis 14(10):2692-2701.