Electromagnetic fields stress living cells

Pathophysiology

Volumn 16, Issue 2-3, 2009, Pages 71-78

  Blank, Martin ^a   Goodman, Reba ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Biosynthesis; DNA; Electromagnetic fields; ELF; RF

Indexed keywords

ARTICLE; CANCER RISK; CELL STRESS; DNA SEQUENCE; DNA STRAND BREAKAGE; ELECTROMAGNETIC FIELD; ELECTRON TRANSPORT; GENE MUTATION; HUMAN; INTERACTIONS WITH DNA; NONHUMAN; PHYSIOLOGICAL STRESS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RADIATION EXPOSURE; RADIATION SAFETY; RADIOFREQUENCY; SIGNAL TRANSDUCTION; SPECTRUM;

EID: 67650696006     PISSN: 09284680     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pathophys.2009.01.006     Document Type: Article

References (62)

1. Goodman R., Bassett C.A.L., and Henderson A. Pulsing electromagnetic fields induce cellular transcription. Science 220 (1983) 1283-1285
2. Goodman R., and Henderson A. Exposure of salivary gland cells to low frequency electromagnetic fields alters polypeptide synthesis. PNAS 85 (1988) 3928-3932
3. Blank M. Protein and DNA interactions with electromagnetic fields. Electromagn Biol Med 28 (2008) 3-23
4. Adey W.R. Tissue interactions with non-ionizing electromagnetic fields. Physiol Rev 61 (1981) 435-514
5. Lin H., Blank M., and Goodman R. A magnetic field responsive domain in the human HSP70 promoter. J Cell Biochem 75 (1999) 170-176
6. Lin H., Blank M., Rossol-Haseroth K., and Goodman R. Regulating genes with electromagnetic response elements. J Cell Biochem 81 (2001) 143-148
7. REFLEX Project Report, 2004, A summary of the final report can be found at http://www.verum-foundation.de/www2004/html/pdf/euprojekte01/REFLEX_ProgressSummary_231104.pdf.
8. Lai H., and Singh N.P. Acute exposure to a 60 Hz magnetic field increases DNA strand breaks in rat brain cells. Bioelectromagnetics 18 (1997) 156-165
9. Bioinitiative Report, edited by C. Sage, D. Carpenter, A Scientific Perspective on Health Risk of Electromagnetic Fields, published online 31 August 2007 http://www.bioinitiative.org/report/index.htm.
10. Blank M., Khorkova O., and Goodman R. Changes in polypeptide distribution stimulated by different levels of EM and thermal stress. Bioelectrochem Bioenerg 33 (1994) 109-114
11. Goodman R., Blank M., Lin H., Khorkova O., Soo L., Weisbrot D., and Henderson A.S. Increased levels of hsp70 transcripts are induced when cells are exposed to low frequency electromagnetic fields. Bioelectrochem Bioenerg 33 (1994) 115-120
12. Kultz D., and Molecular. Evolutionary basis of the cellular stress response. Ann Rev Physiol 67 (2005) 225-257
13. Goodman R., and Blank M. Magnetic field stress induces expression of hsp70. Cell Stress Chaperones 3 (1998) 79-88
14. Ritossa F.M. A new puffing pattern induced by a temperature shock and DNP in Drosophila. Experientia Basel 18 (1962) 571-573
15. de Pomerai D.I., Daniells C., David H., Allan J., Duce I., Mutwakil M., Thomas D., Sewell P., Tattersall J., and Jones D. Non-thermal heat-shock response to microwaves. Nature 6785 (2000) 417-418
16. Czyz J., Guan K., Zeng Q., Nikolova T., Meister A., Schönborn F., Schuderer I., Kuster N., and Wobus A.M. High frequency electromagnetic fields (GSM signals) affect gene expression levels in tumor suppressor p53-deficient embryonic stem cells. Bioelectromagnetics 25 (2004) 296-307
17. Taira T., Negishi Y., Kihara F., Iguchi-Ariga S.M.M., and Ariga H. H. c-myc protein complex binds to two sites in human hsp70 promoter region. Biochim Biophys Acta 1130 (1992) 166-174
18. Topol J., Ruden D.M., and Parker C.S. Sequences required for in vitro transcriptional activation of a drosophila hsp70 gene. Cell 42 (1985) 527-537
19. Albertini A., Zucchini B., Noera G., Cadossi R., Napoleone C.P., and Pierangeli A. Protective effect of low frequency low energy policy electromagnetic fields on acute experimental myocardial infarcts in rats. Bioelectromagnetics 20 (1999) 372-377
20. Di Carlo A., Farrell J.M., and Litovitz T. A simple experiment to study electromagnetic field effects: protection induced by short-term exposures to 60 Hz magnetic fields. Bioelectromagnetics 19 (1998) 498-500
21. Shallom J.M., DiCarlo A.L., Ko D., Penafiel L.M., and Nakai A. Microwave exposure induces hsp70 and confers protection against hypoxia in chick embryos. J Cell Biochem 86 (2002) 490-496
22. George I., Geddis M., Lill Z., Lin H., Gomez T., Blank M., Oz M., and Goodman R. Myocardial function improved by electromagnetic fields induction of stress protein hsp70. J Cellular Physiol 216 (2008) 816-823 published online: doi:10.1002/jcp.21461
23. Friedman J., Kraus S., Hauptman Y., Schiff Y., and Seger R. Mechanism of short-term ERK activation by electromagnetic fields at mobile phone frequencies. Biochem J 405 (2007) 559-568
24. Jin M., Blank M., and Goodman R. ERK1/2 phosphorylation, induced by electromagnetic fields, diminishes during neoplastic transformation. J Cell Biochem 78 (2000) 371-379
25. Leszczynski D., Joenvaara S., Reivinen J., and Kuokka R. Non-thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: molecular mechanism for cancer-and blood-brain barrier-related effects. Differentiation 70 (2002) 120-129
26. Simko M. Induction of cell activation processes by low frequency electromagnetic fields. ScientificWorldJournal 4 Suppl. 2 (2004) 4-22
27. Marais R., Wynne J., and Treisman R. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73 (1993) 381-393
28. Janecht R., Ernst W.H., Pigoud V., and Nordheim A. Activation of TCF Elk-1 by MAP kinases. EMBO J 12 (1993) 5097-5104
29. Gille H., Kortenjann M., Thomae O., Moomaw C., Slaughter C., Cobb M.H., and Shaw P.E. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J 14 (1995) 951-962
30. Sgambato V., Vanhouttte P., Pages C., Rogard M., Hipskind L., Besson M.J., and Caboche J. In vivo expression and regulation of Elk-1, a target of the extracellular-regulated kinase signaling pathway, in the rat brain. J. Neurosci 18 (1998) 214-226
31. Leszczynski D., Nylund R., Joevaara S., and Reivinen J. Applicability of discovery science approach to determine biological effects of mobile phone radiation. Proteonomics 4 (2004) 426-431
32. Hook G.J., Zhang P., Lagroye I., Li L.E., Higashikubo R., Moros E.G., Starube W.L., Pickard W.F., Baty J.D., and Roti-Roti J.L. Measurement of DNA damage and apoptosis in Molt-4 cells after in vitro exposure to radio frequency radiation. Radiat Res 161 (2004) 193-200
33. Weisbrot D., Lin H., Ye L., Blank M., and Goodman R. Effects of mobile phone radiation on growth and development in Drosophila melanogaster. J Cell Biochem 89 (2003) 48-55
34. Rao S., and Henderson A.S. Regulation of c-fos is affected by electromagnetic fields. J Cell Biochem 63 (1996) 358-365
35. Johnson D.L., and Johnson S.A.S. RNA metabolism and oncogenesis. Science 320 (2008) 461-462
36. Cotgreave I.A. Biological stress responses to radio frequency electromagnetic radiation: are mobile phones really so (heat) shocking?. Arch Biochem Biophys 435 (2005) 227-240
37. Jin M., Lin H., Han L., Opler M., Maurer S., Blank M., and Goodman R. Biological and technical variables in myc expression in HL60 cells exposed to 60 Hz electromagnetic fields. Bioelectrochem Bioenerg 44 (1997) 111-120
38. Liburdy R.P., Sloma T.R., Sokolic R., and Yaswen P. ELF magnetic fieklds, breast cancer, and melatonin: 60 Hz fields block melatonin's oncostatic action on ER+ breast cancer cell proliferation. J Pineal Res 14 (1993) 89-97
39. Lin H., Head M., Blank M., Han L., Jin M., and Goodman R. Myc-mediated transactivation of HSP70 expression following exposure to magnetic fields. J Cell Biochem 69 (1998) 181-188
40. Ivancsits S., Pilger A., Diem F., Jahn O., and Rudiger H. Cell type-specific genotoxic effects of intermittent extremely low-frequency electromagnetic fields. Mutation Res 583 (2005) 184-188
41. Lantow M., Lupke M., Frahm J., Mattsson M.O., Kuster N., and Simko M. ROS release and Hsp70 expression after exposure to 1,800 MHz radiofrequency electromagnetic fields in primary human monocytes and lymphocytes. Radiat Environ Biophys 45 (2006) 55-62
42. Simko M., Hartwig C., Lantow M., Lupke M., Mattsson M.O., Rahman Q., and Rollwitz J. Hsp70 expression and free radical release after exposure to non-thermal radio-frequency electromagnetic fields and ultrafine particles in human Mono Mac 6 cells. Toxicol Lett 161 (2006) 73-82
43. Blank M., and Soo L. Enhancement of cytochrome oxidase activity in 60 Hz magnetic fields. Bioelectrochem Bioenerg 45 (1998) 253-259
44. Blank M., and Soo L. Electromagnetic acceleration of the Belousov-Zhabotinski reaction. Bioelectrochem 61 (2003) 93-97
45. Blank M., and Soo L. Surface free energy as the potential in oligomeric equilibria: prediction of hemoglobin disaggregation constant. Bioelectrochem Bioenerg 17 (1987) 349-360
46. Lai H., and Singh N.P. Interaction of microwaves and a temporally incoherent magnetic field on single and double DNA strand breaks in rat brain cells. Electromagn Biol Med 24 (2005) 23-29
47. Blank M. A proposed explanation for effects of electric and magnetic fields on the Na,K-ATPase in terms of interactions with electrons. Bioelectromagnetics 26 (2005) 591-597
48. Blank M., and Soo L. The threshold for alternating current inhibition of the Na,K-ATPase. Bioelectromagnetics 13 (1992) 329-333
49. Blank M., and Soo L. The threshold for Na,K-ATPase stimulation by electromagnetic fields. Bioelectrochem Bioenerg 40 (1996) 63-65
50. Wan C., Fiebig T., Kelley S.O., Treadway C.R., and Barton J.K. Femtosecond dynamics of DNA-mediated electron transfer. Proc Nat Acad Sci U S A 96 (1999) 6014-6019
51. Blank M. Electric stimulation of protein synthesis in muscle. Adv Chem 250 (1995) 143-153
52. Blank M., and Goodman R. Initial interactions in electromagnetic field-induced biosynthesis. J Cell Physiol 199 (2004) 359-363
53. Blank M., and Goodman R. A mechanism for stimulation of biosynthesis by electromagnetic fields: charge transfer in DNA and base pair separation. J Cell Physiol 214 (2008) 20-26
54. Fecko C.J., Eaves J.D., Loparo J.J., Tokmakoff A., and Geissler P.L. Ultrafast hydrogen-bond dynamics in infrared spectroscopy of water. Science 301 (2003) 1698-1701
55. Litovitz T.A., Kraus D., and Mullins J.M. Effect of coherence time of the applied magnetic field on ornithine decarboxylase activity. Biochem Biophys Res Comm 178 (1991) 862-865
56. Litovitz T.A., Kraus D., Penafiel M., Elson E.C., and Mullins J.M. The role of coherence time in the effect of microwaves on ornithine decarboxylase activity. Bioelectromagnetics 14 (1993) 395-403
57. Mullins J.M., Litovitz T.A., Penafiel M., Desta A., and Krause A. Intermittent noise affects EMF- induced ODC activity. Bioelectrochem Bioenerg 44 (1998) 237-242
58. Mullins J.M., Penafiel L.M., Juutilainen J., and Litovitz T.A. Dose-response of electromagnetic field-induced ornithine decarboxylase activity. Bioelectrochem Bioenerg 48 (1999) 193-199
59. Blank M., and Soo L. Electromagnetic acceleration of electron transfer reactions. J Cell Biochem 81 (2001) 278-283
60. Di Carlo A.L., Mullins J.M., and Litovitz T.A. Thresholds for EM field-induced hypoxia protection: evidence for a primary, electric field effect. Bioelectrochem 52 (2000) 9-16
61. Ahlbom H., Day N., Feychting M., Roman E., Skinner J., Dockerty J., Linet M., McBride M., Michaelis J., Olsen J.H., Tynes T., and Verkasalo P.K. A pooled analysis of magneticfields and childhood leukemia. Brit J Cancer 83 (2000) 692-698
62. Greenland S., Sheppard A.R., Kaune W.T., Poole C., and Kelsh M.A.A. Pooled Analysis of Magnetic Fields, Wire Codes, and Childhood Leukemia. Epidemiology 11 (2000) 624-634