메뉴 건너뛰기




Volumn 73, Issue 1, 2013, Pages 428-438

α-catulin drives metastasis by activating ILK and driving an αvβ3 integrin signaling axis

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CATULIN; FIBRONECTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN ANTIBODY; INTEGRIN LINKED KINASE; ONCOPROTEIN; PROTEIN ANTIBODY; PROTEIN KINASE B; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR; VITRONECTIN RECEPTOR ANTIBODY;

EID: 84871955157     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-2095     Document Type: Article
Times cited : (30)

References (50)
  • 1
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011;61:212-36.
    • (2011) CA Cancer J Clin , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 2
    • 26444492532 scopus 로고    scopus 로고
    • Cancer invasion and metastasis
    • Wittekind C, Neid M. Cancer invasion and metastasis. Oncology 2005;69(Suppl 1):14-6.
    • (2005) Oncology , vol.69 , Issue.SUPPL. 1 , pp. 14-16
    • Wittekind, C.1    Neid, M.2
  • 3
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002;2:442-54.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 5
    • 0036488589 scopus 로고    scopus 로고
    • Role of integrins in cell invasion and migration
    • Hood JD, Cheresh DA. Role of integrins in cell invasion and migration. Nat Rev Cancer 2002;2:91-100.
    • (2002) Nat Rev Cancer , vol.2 , pp. 91-100
    • Hood, J.D.1    Cheresh, D.A.2
  • 6
    • 0032749370 scopus 로고    scopus 로고
    • Human α-catulin, a novel α-catenin-likemolecule with conserved genomic structure, but deviating alternative splicing
    • Janssens B, Staes K, van Roy F. Human α-catulin, a novel α-catenin-likemolecule with conserved genomic structure, but deviating alternative splicing. Biochim Biophys Acta 1999;1447:341-7.
    • (1999) Biochim Biophys Acta , vol.1447 , pp. 341-347
    • Janssens, B.1    Staes, K.2    Van Roy, F.3
  • 7
    • 0037160024 scopus 로고    scopus 로고
    • Association of Lbc Rho guanine nucleotide exchange factor with α-catenin-related protein, α-catulin/CTNNAL1, supports serumresponse factor activation
    • Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P, et al. Association of Lbc Rho guanine nucleotide exchange factor with α-catenin-related protein, α-catulin/CTNNAL1, supports serumresponse factor activation. J Biol Chem 2002;277:45361-70.
    • (2002) J Biol Chem , vol.277 , pp. 45361-45370
    • Park, B.1    Nguyen, N.T.2    Dutt, P.3    Merdek, K.D.4    Bashar, M.5    Sterpetti, P.6
  • 8
    • 0026778133 scopus 로고
    • The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    • Ridley AJ, Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 1992;70:389-99.
    • (1992) Cell , vol.70 , pp. 389-399
    • Ridley, A.J.1    Hall, A.2
  • 9
    • 41649118435 scopus 로고    scopus 로고
    • α-Catulin, a Rho signalling component, can regulate NF-κB through binding to IKK-β, and confers resistance to apoptosis
    • Wiesner C, Winsauer G, Resch U, Hoeth M, Schmid JA, van Hengel J, et al. α-Catulin, a Rho signalling component, can regulate NF-κB through binding to IKK-β, and confers resistance to apoptosis. Oncogene 2008;27:2159-69.
    • (2008) Oncogene , vol.27 , pp. 2159-2169
    • Wiesner, C.1    Winsauer, G.2    Resch, U.3    Hoeth, M.4    Schmid, J.A.5    Van Hengel, J.6
  • 12
    • 11144225205 scopus 로고    scopus 로고
    • Integrin-linked kinase: A cancer therapeutic target unique among its ILK
    • Hannigan G, Troussard AA, Dedhar S. Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat Rev Cancer 2005;5:51-63.
    • (2005) Nat Rev Cancer , vol.5 , pp. 51-63
    • Hannigan, G.1    Troussard, A.A.2    Dedhar, S.3
  • 13
    • 0030026679 scopus 로고    scopus 로고
    • Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase
    • Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J, et al. Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase. Nature1996;379:91-6.
    • (1996) Nature , vol.379 , pp. 91-96
    • Hannigan, G.E.1    Leung-Hagesteijn, C.2    Fitz-Gibbon, L.3    Coppolino, M.G.4    Radeva, G.5    Filmus, J.6
  • 14
    • 0035920145 scopus 로고    scopus 로고
    • Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: Critical roles for kinase activity and amino acids arginine 211 and serine 343
    • Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, et al. Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. J Biol Chem 2001;276:27462-9.
    • (2001) J Biol Chem , vol.276 , pp. 27462-27469
    • Persad, S.1    Attwell, S.2    Gray, V.3    Mawji, N.4    Deng, J.T.5    Leung, D.6
  • 15
    • 33646576837 scopus 로고    scopus 로고
    • Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma
    • Rosano L, Spinella F, Di Castro V, Dedhar S, Nicotra MR, Natali PG, et al. Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma. Mol Cancer Ther 2006;5:833-42.
    • (2006) Mol Cancer Ther , vol.5 , pp. 833-842
    • Rosano, L.1    Spinella, F.2    Di Castro, V.3    Dedhar, S.4    Nicotra, M.R.5    Natali, P.G.6
  • 16
    • 40949083412 scopus 로고    scopus 로고
    • Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival
    • McDonald PC, Oloumi A, Mills J, Dobreva I, Maidan M, Gray V, et al. Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Res 2008;68:1618-24.
    • (2008) Cancer Res , vol.68 , pp. 1618-1624
    • McDonald, P.C.1    Oloumi, A.2    Mills, J.3    Dobreva, I.4    Maidan, M.5    Gray, V.6
  • 17
    • 35248896777 scopus 로고    scopus 로고
    • Integrin-linked kinase is an essential mediator for T-cadherin-dependent signaling via Akt and GSK3β in endothelial cells
    • Joshi MB, Ivanov D, Philippova M, Erne P, Resink TJ. Integrin-linked kinase is an essential mediator for T-cadherin-dependent signaling via Akt and GSK3β in endothelial cells. FASEB J 2007;21:3083-95.
    • (2007) FASEB J , vol.21 , pp. 3083-3095
    • Joshi, M.B.1    Ivanov, D.2    Philippova, M.3    Erne, P.4    Resink, T.J.5
  • 19
    • 0141891463 scopus 로고    scopus 로고
    • Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival
    • Dai DL, Makretsov N, Campos EI, Huang C, Zhou Y, Huntsman D, et al. Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival. Clin Cancer Res 2003;9:4409-14.
    • (2003) Clin Cancer Res , vol.9 , pp. 4409-4414
    • Dai, D.L.1    Makretsov, N.2    Campos, E.I.3    Huang, C.4    Zhou, Y.5    Huntsman, D.6
  • 20
    • 78651273473 scopus 로고    scopus 로고
    • Expression of integrin-linked kinase in lung squamous cell carcinoma and adenocarcinoma: Correlation with E-cadherin expression, tumor microvessel density and clinical outcome
    • Yu J, Shi R, Zhang D, Wang E, Qiu X. Expression of integrin-linked kinase in lung squamous cell carcinoma and adenocarcinoma: correlation with E-cadherin expression, tumor microvessel density and clinical outcome. Virchows Arch 2011;458:99-107.
    • (2011) Virchows Arch , vol.458 , pp. 99-107
    • Yu, J.1    Shi, R.2    Zhang, D.3    Wang, E.4    Qiu, X.5
  • 21
    • 0031226737 scopus 로고    scopus 로고
    • Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line
    • Chu YW, Yang PC, Yang SC, Shyu YC, Hendrix MJ, Wu R, et al. Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line. Am J Respir Cell Mol Biol 1997;17:353-60.
    • (1997) Am J Respir Cell Mol Biol , vol.17 , pp. 353-360
    • Chu, Y.W.1    Yang, P.C.2    Yang, S.C.3    Shyu, Y.C.4    Hendrix, M.J.5    Wu, R.6
  • 22
    • 49149129916 scopus 로고    scopus 로고
    • Gene expression-based survival prediction in lung adenocarcinoma: A multi-site, blinded validation study
    • Shedden K, Taylor JM, Enkemann SA, Tsao MS, Yeatman TJ, Gerald WL, et al. Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study. Nat Med 2008;14:822-7.
    • (2008) Nat Med , vol.14 , pp. 822-827
    • Shedden, K.1    Taylor, J.M.2    Enkemann, S.A.3    Tsao, M.S.4    Yeatman, T.J.5    Gerald, W.L.6
  • 23
    • 0028981050 scopus 로고
    • Activation of NF-κB requires proteolysis of the inhibitor IκB-α: Signal-induced phosphorylation of IκB-α alone does not release active NF-κB
    • Lin YC, Brown K, Siebenlist U. Activation of NF-κB requires proteolysis of the inhibitor IκB-α: signal-induced phosphorylation of IκB-α alone does not release active NF-κB. Proc Natl Acad Sci U S A 1995;92:552-6.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 552-556
    • Lin, Y.C.1    Brown, K.2    Siebenlist, U.3
  • 24
    • 80051693575 scopus 로고    scopus 로고
    • Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK)-AKT-B cell lymphoma 2 (Bcl-2) pathway
    • Imanishi Y, Hu B, Xiao G, Yao X, Cheng SY. Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK)-AKT-B cell lymphoma 2 (Bcl-2) pathway. J Biol Chem 2011;286:29249-60.
    • (2011) J Biol Chem , vol.286 , pp. 29249-29260
    • Imanishi, Y.1    Hu, B.2    Xiao, G.3    Yao, X.4    Cheng, S.Y.5
  • 25
    • 79954596010 scopus 로고    scopus 로고
    • Slug confers resistance to the epidermal growth factor receptor tyrosine Kinase Inhibitor
    • Chang TH, Tsai MF, Su KY, Wu SG, Huang CP, Yu SL, et al. Slug confers resistance to the epidermal growth factor receptor tyrosine Kinase Inhibitor. Am J Respir Crit Care Med 2011;183:1071-9.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 1071-1079
    • Chang, T.H.1    Tsai, M.F.2    Su, K.Y.3    Wu, S.G.4    Huang, C.P.5    Yu, S.L.6
  • 28
    • 0033020670 scopus 로고    scopus 로고
    • The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells
    • Tu Y, Li F, Goicoechea S, Wu C. The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. Mol Cell Biol 1999;19:2425-34.
    • (1999) Mol Cell Biol , vol.19 , pp. 2425-2434
    • Tu, Y.1    Li, F.2    Goicoechea, S.3    Wu, C.4
  • 30
    • 3042708179 scopus 로고    scopus 로고
    • The PINCH-ILK-parvin complexes: Assembly, functions and regulation
    • Wu C. The PINCH-ILK-parvin complexes: assembly, functions and regulation. Biochim Biophys Acta 2004;1692:55-62.
    • (2004) Biochim Biophys Acta , vol.1692 , pp. 55-62
    • Wu, C.1
  • 31
    • 8744300054 scopus 로고    scopus 로고
    • Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion
    • Critchley DR. Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion. Biochem Soc Trans 2004;32:831-6.
    • (2004) Biochem Soc Trans , vol.32 , pp. 831-836
    • Critchley, D.R.1
  • 33
    • 33845702137 scopus 로고    scopus 로고
    • Modulation of Wnt3a-mediated nuclear (β)-catenin accumulation and activation by integrinlinked kinase inmammalian cells
    • Oloumi A, Syam S, Dedhar S. Modulation of Wnt3a-mediated nuclear (β)-catenin accumulation and activation by integrinlinked kinase inmammalian cells. Oncogene 2006;25:7747-57.
    • (2006) Oncogene , vol.25 , pp. 7747-7757
    • Oloumi, A.1    Syam, S.2    Dedhar, S.3
  • 34
    • 47749087950 scopus 로고    scopus 로고
    • Integrin-linked kinase-essential roles in physiology and cancer biology
    • McDonald PC, Fielding AB, Dedhar S. Integrin-linked kinase-essential roles in physiology and cancer biology. J Cell Sci 2008;121:3121-32.
    • (2008) J Cell Sci , vol.121 , pp. 3121-3132
    • McDonald, P.C.1    Fielding, A.B.2    Dedhar, S.3
  • 35
    • 34250774522 scopus 로고    scopus 로고
    • The role of integrin-linked kinase in melanoma cell migration, invasion, and tumor growth
    • Wong RP, Ng P, Dedhar S, Li G. The role of integrin-linked kinase in melanoma cell migration, invasion, and tumor growth. Mol Cancer Ther 2007;6:1692-700.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1692-1700
    • Wong, R.P.1    Ng, P.2    Dedhar, S.3    Li, G.4
  • 37
    • 84859059272 scopus 로고    scopus 로고
    • Downregulation of integrin-linked kinase inhibits epithelial-to- mesenchymal transition and metastasis in bladder cancer cells
    • Zhu J, Pan X, Zhang Z, Gao J, Zhang L, Chen J. Downregulation of integrin-linked kinase inhibits epithelial-to-mesenchymal transition and metastasis in bladder cancer cells. Cell Signal 2012;24:1323-32.
    • (2012) Cell Signal , vol.24 , pp. 1323-1332
    • Zhu, J.1    Pan, X.2    Zhang, Z.3    Gao, J.4    Zhang, L.5    Chen, J.6
  • 38
    • 31544439674 scopus 로고    scopus 로고
    • Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival
    • Troussard AA, McDonald PC, Wederell ED, Mawji NM, Filipenko NR, Gelmon KA, et al. Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival. Cancer Res 2006;66:393-403.
    • (2006) Cancer Res , vol.66 , pp. 393-403
    • Troussard, A.A.1    McDonald, P.C.2    Wederell, E.D.3    Mawji, N.M.4    Filipenko, N.R.5    Gelmon, K.A.6
  • 39
    • 33845722640 scopus 로고    scopus 로고
    • An essential role for the integrin-linked kinase-glycogen synthase kinase-3 β pathway during dendrite initiation and growth
    • Naska S, Park KJ, Hannigan GE, Dedhar S, Miller FD, Kaplan DR. An essential role for the integrin-linked kinase-glycogen synthase kinase-3 β pathway during dendrite initiation and growth. J Neurosci 2006;26:13344-56.
    • (2006) J Neurosci , vol.26 , pp. 13344-13356
    • Naska, S.1    Park, K.J.2    Hannigan, G.E.3    Dedhar, S.4    Miller, F.D.5    Kaplan, D.R.6
  • 40
    • 13944269898 scopus 로고    scopus 로고
    • The AKT/IκB kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-κB and β-catenin
    • Agarwal A, Das K, Lerner N, Sathe S, Cicek M, Casey G, et al. The AKT/IκB kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-κB and β-catenin. Oncogene 2005;24:1021-31.
    • (2005) Oncogene , vol.24 , pp. 1021-1031
    • Agarwal, A.1    Das, K.2    Lerner, N.3    Sathe, S.4    Cicek, M.5    Casey, G.6
  • 41
    • 39049143516 scopus 로고    scopus 로고
    • Wound repair and proliferation of bronchial epithelial cells regulated by CTNNAL1
    • Xiang Y, Tan YR, Zhang JS, Qin XQ, Hu BB, Wang Y, et al. Wound repair and proliferation of bronchial epithelial cells regulated by CTNNAL1. J Cell Biochem 2008;103:920-30.
    • (2008) J Cell Biochem , vol.103 , pp. 920-930
    • Xiang, Y.1    Tan, Y.R.2    Zhang, J.S.3    Qin, X.Q.4    Hu, B.B.5    Wang, Y.6
  • 42
    • 4344612243 scopus 로고    scopus 로고
    • NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
    • Huber MA, Azoitei N, Baumann B, Grunert S, Sommer A, Pehamberger H, et al. NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest 2004;114:569-81.
    • (2004) J Clin Invest , vol.114 , pp. 569-581
    • Huber, M.A.1    Azoitei, N.2    Baumann, B.3    Grunert, S.4    Sommer, A.5    Pehamberger, H.6
  • 43
    • 33645999706 scopus 로고    scopus 로고
    • NF-κB and IKK as therapeutic targets in cancer
    • Kim HJ, Hawke N, Baldwin AS. NF-κB and IKK as therapeutic targets in cancer. Cell Death Differ 2006;13:738-47.
    • (2006) Cell Death Differ , vol.13 , pp. 738-747
    • Kim, H.J.1    Hawke, N.2    Baldwin, A.S.3
  • 44
    • 84863280130 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptionalupregulation of Twist1
    • Li CW, Xia W, Huo L, Lim SO, Wu Y, Hsu JL, et al. Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptionalupregulation of Twist1. Cancer Res 2012;72:1290-300.
    • (2012) Cancer Res , vol.72 , pp. 1290-1300
    • Li, C.W.1    Xia, W.2    Huo, L.3    Lim, S.O.4    Wu, Y.5    Hsu, J.L.6
  • 45
    • 58149202128 scopus 로고    scopus 로고
    • Is NF-κB a good target for cancer therapy? Hopes and pitfalls
    • Baud V, Karin M. Is NF-κB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 2009;8:33-40.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 33-40
    • Baud, V.1    Karin, M.2
  • 46
    • 77957363101 scopus 로고    scopus 로고
    • Integrins as therapeutic targets: Lessons and opportunities
    • Cox D, Brennan M, Moran N. Integrins as therapeutic targets: lessons and opportunities. Nat Rev Drug Discov 2010;9:804-20.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 804-820
    • Cox, D.1    Brennan, M.2    Moran, N.3
  • 47
    • 53549102755 scopus 로고    scopus 로고
    • The tumor microenvironment and its role in promoting tumor growth
    • Whiteside TL. The tumor microenvironment and its role in promoting tumor growth. Oncogene 2008;27:5904-12.
    • (2008) Oncogene , vol.27 , pp. 5904-5912
    • Whiteside, T.L.1
  • 49
    • 0035313488 scopus 로고    scopus 로고
    • FGF and VEGF function in angiogenesis: Signalling pathways, biological responses and therapeutic inhibition
    • Cross MJ, Claesson-Welsh L. FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition. Trends Pharmacol Sci 2001;22:201-7.
    • (2001) Trends Pharmacol Sci , vol.22 , pp. 201-207
    • Cross, M.J.1    Claesson-Welsh, L.2
  • 50
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel RS. Tumor angiogenesis. N Engl J Med 2008;358:2039-49.
    • (2008) N Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.