NF-κB activates fibronectin gene expression in rat hepatocytes

Biochemical and Biophysical Research Communications

Volumn 297, Issue 5, 2002, Pages 1218-1224

  Lee, Byung Heon ^a   Park, Seung Yoon ^a   Kang, Kae Bok ^a   Park, Rang Woon ^b   Kim, In San ^b  

^a Dongguk University College of Medicine   (South Korea)

^b Kyungpook National University School of Medicine   (South Korea)

Author keywords

Fibronectin; Hepatocyte; NF B

Indexed keywords

CYTOKINE; DIMER; FIBRONECTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; PROTEIN; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR; INTERLEUKIN 1; LUCIFERASE; TRANSCRIPTION FACTOR RELA;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL ASSAY; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION; LIVER CELL; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; ANIMAL; BINDING SITE; BIOSYNTHESIS; CELL CULTURE; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; LIVER; METABOLISM; NORTHERN BLOTTING; PHYSIOLOGY; PLASMID; PROTEIN BINDING; RAT; WESTERN BLOTTING;

ANIMALS; BINDING SITES; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELLS, CULTURED; FIBRONECTINS; GENE DELETION; GENE EXPRESSION REGULATION; HEPATOCYTES; INTERLEUKIN-1; LIVER; LUCIFERASES; MUTATION; NF-KAPPA B; PLASMIDS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RATS; RNA, MESSENGER; TRANSCRIPTION FACTOR RELA; TRANSFECTION;

EID: 0036025212     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02356-2     Document Type: Article

References (26)

1. R.O. Hynes, Fibronectins, Springer, New York, 1990.
2. J.W. Tamkun, R.O. Hynes, Plasma fibronectin is synthesized and secreted by hepatocytes, J. Biol. Chem. 258 (1983) 4641-4647.
3. F.G. Giancotti, E. Ruoslahtit, Integrin signaling, Science. 285 (1999) 1028-1032.
4. R.K. Assoian, Anchorage-dependent cell cycle progression, J. Cell. Biol. 136 (1997) 1-4.
5. D.C. Dean, J.J. McQuillan, S. Weintraub, Serum stimulation of fibronectin gene expression appears to result from rapid serum-induced binding of nuclear proteins to a cAMP response element, J. Biol. Chem. 265 (1990) 3522-3527.
6. C. Bowlus, J.J. McQuillan, D.C. Dean, Characterization of three different elements in the 5′-flanking region of the fibronectin gene which mediate a transcriptional response to cAMP, J. Biol. Chem. 266 (1991) 1122-1127.
7. Y. Shino, H. Shirasawa, T. Kinoshita, B. Simizu, Human papillomavirus type 16 E6 protein trasncriptionally modulates fibronectin gene expression by induction of protein complexes binding to the cyclic AMP response element, J. Virol. 71 (1997) 4310-4318.
8. T. Nakajima, T. Nakamura, S. Tsunoda, S. Nakada, K. Oda, E1A-responsive elements for repression of rat fibronectin gene transcription, Mol. Cell. Biol. 12 (1992) 2837-2846.
9. C. Liu, J. Yao, I. Belle, R.-P. Huang, E. Adamson, D. Mercola, The transcription factor EGR-1 suppresses transformation of human fibrosarcoma HT1080 cells by coordinated induction of transforming growth factor-β1, fibronectin, and plasminogen activator inhibitor-1, J. Biol. Chem. 274 (1999) 4400-4411.
10. C. Liu, J. Yao, D. Mercola, E. Adamson, The transcription factor EGR-1 directly transactivates the fibronectin gene and enhances attachment of human glioblastsoma cell line U251, J. Biol. Chem. 275 (2000) 20315-20323.
11. P.A. Baeuerle, The inducible transcription factor NF-κB: regulation by distinct protein subunits, Biochem. Biophys. Acta 1072 (1991) 63-80.
12. P.A. Baeuerle, V.R. Baichwal, NF-κB as a frequent target for immunosuppressive and anti-inflammatory molecules, Adv. Immunol. 65 (1997) 111-137.
13. B.-H. Lee, M.-S. Kim, J.-H. Rhew, R.-W. Park, B. Crombrugghe, I.-S. Kim, Transcriptional regulation of fibronectin gene by phorbol myristate acetate in hepatoma cells: a negative role for NF-κB, J. Cell. Biochem. 76 (2000) 437-451.
14. M.L. Schmitz, P.A. Baeuerle, The p65 subunit is responsible for the strong transcription activating potential of NF-κB, EMBO J. 10 (1991) 3805-3817.
15. J.A. Brockman, D.C. Scherer, T.A. McKinsey, S.M. Hall, X. Qi, W.A. Lee, D.W. Ballard, Coupling of a signal response domain in IκBα to multiple pathways for NF-κB activation, Mol. Cell. Biol. 15 (1995) 2809-2818.
16. T.G. Yi, H.M. Choi, R.W. Park, K.Y. Sohn, I.S. Kim, Transcriptional repression of type I procollagen genes during adipocyte differentiation, Exp. Mol. Med. 33 (2001) 269-275.
17. B.H. Lee, R.W. Park, K.Y. Sohn, I.S. Kim, Antagonistic regulation of protein kinase C-induced stimulation of fibronectin synthesis by cyclic AMP in human lung fibroblasts, Biochem. Mol. Biol. Int. 43 (1997) 383-390.
18. M.B. Urban, R. Schreck, P.A. Baeuerle, NF-κB contacts DNA by a heterodimer of the p50 and p65 subunit, EMBO J. 101 (1991) 1817-1825.
19. M. Ahmad, N. Marui, R.W. Alexander, R.M. Medford, Cell type-specific transactivation of the VCAM-1 promoter through an NF-kappa B enhancer motif, J. Biol. Chem. 270 (1995) 8976-8983.
20. K.A. Higgins, J.R. Perez, T.A. Coleman, K. Dorshkind, W.A. McComas, U.M. Sarmiento, C.A. Rosen, R. Narayanan, Antisense inhibition of the p65 subunit of NF-κB blocks tumorigenicity and causes tumor regression, Proc. Natl. Acad. Sci. USA. 90 (1993) 9901-9905.
21. C.K. Ritchie, A. Giordano, K. Khalili, Integrin involvement in glioblastoma multiforme: possible regulation by NF-κB, J. Cell. Physiol. 184 (2000) 214-221.
22. E.E. Qwarnstrom, C.O. Ostberg, G.L. Turk, C.A. Richardson, K. Bomsztyk, Fibronectin attachment activates the NF-κB p50/p65 heterodimer in fibroblasts and smooth muscle cells, J. Biol. Chem. 269 (1994) 30765-30768.
23. A.A. Beg, W.C. Sha, R.T. Bronson, S. Ghosh, D. Baltimore, Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB, Nature. 376 (1995) 167-170.
24. Y. Yamada, I. Kirillova, J.J. Peschon, N. Fausto, Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor, Proc. Natl. Acad. Sci. USA. 94 (1997) 1441-1446.
25. R. Taub, Blocking NF-κB in the liver: the good and bad news, Hepatology. 27 (1998) 1445-1446.
26. C. Hellebrand, C. Jobin, Y. Iimuro, L. Licato, B. Sartor, D.A. Brenner, Inhibition of NFκB in activated rat hepatic stellate cells by proteasome inhibitors and an IκB super-repressor, Hepatology 27 (1998) 1285-1295.