Dynamic growth and deposition of hygroscopic aerosols in the nasal airway of a 5-year-old child

International Journal for Numerical Methods in Biomedical Engineering

Volumn 29, Issue 1, 2013, Pages 17-39

  Kim, Jong Won ^a   Xi, Jinxiang ^a,b   Si, Xiuhua A ^c  

^a University of Arkansas at Little Rock   (United States)

^b CENTRAL MICHIGAN UNIVERSITY   (United States)

^c CALVIN COLLEGE   (United States)

Author keywords

Child nasal laryngeal airway; Condensation; Hygroscopic submicrometer aerosols; Nasal drug delivery; Respiratory dosimetry; Tobacco smoke

Indexed keywords

AEROSOL DEPOSITION; CHEMICAL SPECIES; CONDENSATION GROWTH; DYNAMIC GROWTH; HUMAN RESPIRATORY TRACT; HUMID ENVIRONMENT; HYGROSCOPIC EFFECT; HYGROSCOPIC GROWTH; LAGRANGIAN TRACKING; LOW REYNOLDS NUMBER; MULTISCALES; NASAL DRUG DELIVERY; PARTICLE GROWTH; SUBMICROMETERS; TEMPERATURE AND RELATIVE HUMIDITY; TOBACCO SMOKE; TRANSPORT MODELS;

AEROSOLS; BUBBLES (IN FLUIDS); COMPUTER SIMULATION; CONDENSATION; DEPOSITION; MAGNETIC RESONANCE IMAGING; PHYSIOLOGICAL MODELS; REYNOLDS NUMBER; TURBULENCE MODELS;

ATMOSPHERIC MOVEMENTS;

AEROSOL; ARTICLE; BIOLOGICAL MODEL; HUMAN; INTRANASAL DRUG ADMINISTRATION; MALE; NOSE CAVITY; PRESCHOOL CHILD;

ADMINISTRATION, INTRANASAL; AEROSOLS; CHILD, PRESCHOOL; HUMANS; MALE; MODELS, BIOLOGICAL; NASAL CAVITY;

EID: 84871946816     PISSN: 20407939     EISSN: 20407947     Source Type: Journal    
DOI: 10.1002/cnm.2490     Document Type: Article

References (76)

1. Kreyling WG, Semmler M, Moller W. Dosimetry and toxicology of ultrafine particles. Journal of Aerosol Medicine 2004; 17:140-152.
2. Kreyling WG, Semmler-Behnke M, Moller W. Ultrafine Particle-Lung Interactions: Does size matter? Journal of Aerosol Medicine 2006; 19:74-83.
3. Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang MY, Oberley T, Froines J, Nel A. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environmental Health Perspectives 2003; 111:455-460.
4. Oberdorster G, Utell MJ, Ultrafine Particls in the urban air: To the respiratory tract and beyond. Environmental Health Perspectives 2002; 110:A440-A441.
5. Kittelson DB. Engines and nanoparticles: A review. Journal of Aerosol Science 1998; 29:575-588.
6. Bernstein GM.A review of the influence of particle size, puff volume, and inhalation pattern on the deposition of cigarette smoke particles in the respiratory tract. Inhalation Toxicology 2004; 16:675-689.
7. Keith CH. Particle size studies on tobacco smoke. Beitraege zur Tabakforschung International 1982; 11:123-131.
8. ICRP. Human Respiratory Tract Model for Radiological Protection. Elsevier Science Ltd.: New York, 1994.
9. Mandell GL, Bennett JE, Bolin RD. Principles and Practices of Infectious Diseases. Churchhill LIvingstone: New York, 2004.
10. Martonen TB. Surrogate experimental models for studying particle deposition in the human respiratory tract: An overview. In Aerosols, Lee SD (ed.). Lewis Publishers: Chesea, Michigan, 1986.
11. Yang CP, Callagher RP, Weiss NS, Band PR, Thomas DB, Russel DA. Differences in incidence rates of cancers of the respiratory tract by anatomic subside and histological type: An etiologic implication. Journal of the National Cancer Institute 1989; 81:1828-1831.
12. U.S. Surgeon General Report. Children and secondhand smoke exposure-excerpts from the health consequences of involuntary exposure to tobacco smoke: a report of the Surgeon General, U.S. Department of Health and Human Services, 2007.
13. California EPA. Proposed identification of environmental tobacco smoke as a toxic air contaminant. Part B: Health effects, Sacramento, CA: California Environmental Protection Agency, Office of Environmental Health Hazard Assessment, 2005.
14. Ferron GA. The size of soluable aerosol particles as a function of the humidity of the air: Application to the human respiratory tract. Journal of Aerosol Science 1977; 3:251-267.
15. Ferron GA, Kreyling WG, Haider B. Inhalation of salt aerosol particles - II. Growth and deposition in the human respiratory tract. Journal of Aerosol Science 1988; 19:611-631.
16. Finlay WH, Stapleton KW. The effect on regional lung deposition of coupled heat and mass-transfer between hygroscopic droplets and their surrounding phase. Journal of Aerosol Science 1995; 26:655-670.
17. Li W, Hopke PK. Initial size distributions and hygroscopicity of indoor combustion aerosol particles. Aerosol Science and Technology 1993; 19:305-316.
18. Martonen TB, Bell KA, Phalen RF, Wilson AF, Ho A. Growth rate measurements and deposition modeling of hygroscopic aerosols in human tracheobronchial models. In Inhaled Particles V, Walton WH (ed.). Pergamon Press: Oxford, 1982; 93-107.
19. Zhang Z, Kleinstreuer C, Kim CS. Water vapor transport and its effects on the deposition of hygroscopic droplets in a human upper airway model. Aerosol Science and Technology 2006; 40:52-67.
20. Cinkotai FF. The behavior of sodium chloride particles in moist air. Journal of Aerosol Science 1971; 2:325-329.
21. Peng C, Chow AHL, Chan CK. Study of the hygroscopic properties of selected pharmaceutical aerosols using single particle levitation. Pharmaceutical Research 2000; 17:1104-1109.
22. Ferron GA, Oberdorster G, Hennenberg R. Estimation of the deposition of aerosolised drugs in the human respiratory tract due to hygroscopic growth. Journal of Aerosol Medicine 1989; 2:271.
23. Robinson R, Yu CP. Theoretical analysis of hygroscopic growth rate of mainstream and sidestream cigarette smoke particles in the human respiratory tract. Aerosol Science and Technology 1998; 28:21-32.
24. Zhang Z, Kleinstreuer C, Kim CS. Isotonic and hypertonic saline droplet deposition in a human upper airway model. Journal of Aerosol Medicine 2006; 19:184-198.
25. Longest PW, Xi J. Condensational growth may contribute to the enhanced deposition of cigarette smoke particles in the upper respiratory tract. Aerosol Science and Technology 2008; 42:579-602.
26. Ferron GA, Haider B, Kreyling WG. Conditions for measuring supersaturation in the human lung using aerosols. Journal of Aerosol Science 1984; 15:211-215.
27. Longest PW, Hindle M. Numerical model to characterize the size Increase of combination drug and hygroscopic excipient nanoparticle aerosols. Aerosol Science and Technology 2011; 45:884-899.
28. Longest PW, Tian G, Hindle M. Improving the lung delivery of nasally administered aerosols during noninvasive ventilation-an application of enhanced condensational growth (ECG). Journal of Aerosol Medicine and Pulmonary Drug Delivery 2011; 24:103-118.
29. Tian G, Longest PW, Su GG, Hindle M. Characterization of respiratory drug delivery with enhanced condensational growth using an individual path model of the entire tracheobronchial airways. Annals of Biomedical Engineering 2011; 39:1136-1153.
30. Xi J, Longest PW. Characterization of submicrometer aerosol deposition in extrathoracic airways during nasal exhalation. Aerosol Science and Technology 2009; 43:808-827.
31. Xi J, Si X, Kim JW, Berlinski A. Simulation of airflow and aerosol deposition in the nasal cavity of a 5-year-old child. Journal of Aerosol Science 2011; 42:156-173.
32. Wilcox DC.'Turbulence Modeling for CFD, 2nd Ed. DCW Industries, Inc.: California, 1998.
33. Bird RB, Steward WE, Lightfoot EN. Transport Phenomena. John Wiley & Sons: New York, 1960.
34. Green DW. Perry's Chemical Engineers' Handbook. McGraw-Hill: New York, 1997.
35. Xi J, Longest PW, Martonen TB. Effects of the laryngeal jet on nano- and microparticle transport and deposition in an approximate model of the upper tracheobronchial airways. Journal of Applied Physiology 2008; 104:1761-1777.
36. Xi J, Longest PW. Transport and deposition of micro-aerosols in realistic and simplified models of the oral airway. Annals of Biomedical Engineering 2007; 35:560-581.
37. Morsi SA, Alexander AJ. An investigation of particle trajectories in two-phase flow systems. Journal of Fluid Mechanics 1972; 55:193-208.
38. Li A, Ahmadi G. Dispersion and deposition of spherical particles from point sources in a turbulent channel flow. Aerosol Science and Technology 1992; 16:209-226.
39. Allen MD, Raabe OG. Slip correction measurements of spherical solid aerosol particles in an improved Millikan apparatus. Aerosol Science and Technology 1985; 4:269-286.
40. Hinds WC. Aerosol Technology: Properties, Behavior, and Measurement of Airborne Particles. John Wiley and Sons: New York, 1999.
41. Matida EA, Finlay WH, Grgic LB. Improved numerical simulation of aerosol deposition in an idealized mouth-throat. Journal of Aerosol Science 2004; 35:1-19.
42. Longest PW, Xi J. Effectiveness of direct Lagrangian tracking models for simulating nanoparticle deposition in the upper airways. Aerosol Science and Technology 2007; 41:380-397.
43. Longest PW, Kleinstreuer C. Computational models for simulating multicomponent aerosol evaporation in the upper respiratory airways. Aerosol Science and Technology 2005; 39:124-138.
44. Xi J, Longest PW. Numerical predictions of submicrometer aerosol deposition in the nasal cavity using a novel drift flux approach. International Journal of Heat and Mass Transfer 2008; 51:5562-5577.
45. Xi J, Longest PW. Effects of oral airway geometry characteristics on the diffusional deposition of inhaled nanoparticles. Journal of Biomechanical Engineering, Transactions of the ASME 2008; 130:16.
46. Ishizu Y, Ohta K, Okada T. The effect of moisture on the growth of cigarette smoke particles. Beitraege zur Tabakforschung International 1980; 10:161-168.
47. Eccles R.A role for the nasal cycle in respiratory defence. European Respiratory Journal 1996; 9:371-376.
48. Martonen TB. Deposition patterns of cigarette smoke in human airways. American Industrial Hygiene Association Journal 1992; 53:6-18.
49. Phalen RF, Oldham MJ, Mannix RC. Cigarette smoke deposition in the tracheobronchial tree: Evidence for colligative effects. Aerosol Science and Technology 1994; 20:215-226.
50. Pritchard JN, Black A. An estimation of the tar particulate material depositing in the respiratory tracts of healthy male middle- and low-tar cigarette smokers. In Aerosols: science, technology, and industrial applications of airborne particles, Liu B.Y.H., Pui D.Y.H., Fissan H (eds). Elsevier Science: New York, 1984; 989-992.
51. Schlesinger RB, Gurman JL, Lippmann M. Particle deposition within bronchial airways: Comparisons using constant and cyclic inspiratory flows. Annals of Occupational Hygiene 1982; 26:47-64.
52. Ingebrethsen BJ. The physical properties of mainstream cigarette smoke and their relationship to deposition in the respiratory tract. In Extrapolation of Dosimetric Relationships for Inhaled Particles and Gases, Crapo JD, Smolko ED, Miller FJ, Graham JA, Hayes AW (eds). Academic Press: San Diego, 1989.
53. Foos B, Marty M, Schwartz J, Bennett W, Moya J, Jarabek AM, Salmon AG. Focusing on Children's Inhalation Dosimetry and Health Effects for Risk Assessment: An Introduction. Journal of Toxicology and Environmental Health, Part A 2007; 71:149-165.
54. NRC.A Framework for Assessing teh Health Hazad Posed by Bioaerosols. The national Academies Press: Washington DC, 2008.
55. Capsoni S, Giannotta S, Cattaneo A. Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proceedings of the National Academy of Sciences of the United State of America 2002; 99:12432-12437.
56. Thorne RG, Pronk GJ, Padmanabhan V, Frey WH. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 2004; 127:481-496.
57. Hanson L, Frey W. Strategies for Intranasal Delivery of Therapeutics for the Prevention and Treatment of NeuroAIDS. Journal of Neuroimmune Pharmacology 2007; 2:81-86.
58. Doorly DJ, Taylor DJ, Gambaruto AM, Schroter RC, Tolley N. Nasal architecture: form and flow. Philosophical Transactions of the Royal Society a-Mathematical Physical and Engineering Sciences 2008; 366:3225-3246.
59. Rouadi P, Baroody FM, Abbott D, Naureckas E, Solway J, Naclerio RM.A technique to measure the ability of the human nose to warm and humidify air. Journal of Applied Physiology 1999; 87:400-406.
60. Kleinstreuer C, Zhang Z. Laminar-to-turbulent fluid-particle flows in a human airway model. International Journal of Multiphase Flow 2003; 29:271-289.
61. Kleinstreuer C, Zhang Z, Li Z. Modeling airflow and particle transport/deposition in pulmonary airways. Respiratory Physiology & Neurobiology 2008; 163:128-138.
62. Gurman JL, Lippmann M, Schlesinger RB. Particle deposition in replicate casts of the human upper trancheobronchial tree under constant and cyclic inspiratory flow. I. Experimental. Aerosol Science and Technology 1984; 3:245-252.
63. Kim CS, Garcia L. Particle Deposition in Cyclic Bifurcating Tube Flow. Aerosol Science and Technology 1991; 14:302-315.
64. Zhang Z, Kleinstreuer C, Kim CS. Cyclic micron-size particle inhalation and deposition in a triple bifurcation lung airway model. Journal of Aerosol Science 2002; 33:257-281.
65. Zhang Z, Kleinstreuer C. Transient airflow structures and particle transport in a sequentially branching lung airway model. Physics of Fluids 2002; 14:862-880.
66. Dendo RI, Phalen RF, C MR, Oldham MJ. Effects of breathing parameters on sidestream cigarette smoke deposition in a hollow tracheobronchial model. American Industrial Hygiene Association Journal 1998; 59:381-387.
67. Robinson RJ, Yu CP. Deposition of cigarette smoke particles in the human respiratory tract. Aerosol Science and Technology 2001; 34:202-215.
68. Fodil R, Brugel-Ribere L, Croce C, Sbirlea-Apiou G, Larger C, Papon J-Fo, Delclaux C, Coste A, Isabey D, Louis B. Inspiratory flow in the nose: a model coupling flow and vasoerectile tissue distensibility. Journal of Applied Physiology 2005; 98:288-295.
69. Bridger GP. Physiology Of Nasal Valve. Archives Of Otolaryngology 1970; 92:543-553.
70. Bridger GP, Proctor DF. Maximum Nasal Inspiratory Flow And Nasal Resistance. Annals Of Otology Rhinology And Laryngology 1970; 79:481-486.
71. Brancatisano T, Collett PW, Engel LA. Respiratory movements of the vocal cords. Journal of Applied Physiology 1983; 54:1269-1276.
72. Finlay WH. Estimating the type of hygroscopic behavior exhibited by aqueous droplets. Journal of Aerosol Medicine 1998; 11:221-229.
73. Hilberg O, Jensen FT, Pedersen OF. Nasal airway geometry: comparison between acoustic reflections and magnetic resonance scanning. Journal of Applied Physiology 1993; 75:2811-2819.
74. Pickering DN, Beardsmore CS. Nasal flow limitation in children. Pediatric Pulmonology 1999; 27:32-36.
75. Ohki M, Ogoshi T, Yuasa T, Kawano K, Kawano M. Extended observation of the nasal cycle using a portable rhinoflowmeter. Journal of Otolaryngology 2005; 34:346-349.
76. Mirza N, Kroger H, Doty RL. Influence of age on the 'nasal cycle'. Laryngoscope 1997; 107:62-66.