Use of the Expanded Panel of BXD Mice Narrow QTL Regions in Ethanol-Induced Locomotor Activation and Motor Incoordination

Alcoholism: Clinical and Experimental Research

Volumn 37, Issue 1, 2013, Pages 170-183

  Dubose, Candis S ^a   Chesler, Elissa J ^b   Goldowitz, Dan ^c   Hamre, Kristin M ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b JACKSON LABORATORY   (United States)

^c Centre for Molecular Medicine and Therapeutics   (Canada)

Author keywords

Activity chamber; Alcohol; Candidate gene; QTL; Rotarod

Indexed keywords

ALCOHOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME 2; CHROMOSOME 5; CHROMOSOME 7; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; LOCOMOTION; MALE; MOTOR COORDINATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RECOMBINANT INBRED STRAIN; ROTAROD TEST; SEX;

ALCOHOL-RELATED DISORDERS; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; FEMALE; MALE; MICE; MICE, INBRED STRAINS; MOTOR ACTIVITY; QUANTITATIVE TRAIT LOCI; ROTAROD PERFORMANCE TEST;

MUS;

EID: 84871941716     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2012.01865.x     Document Type: Article

References (47)

1. Baker EJ, Galloway L, Jackson B, Schmoyer D, Snoddy J (2004) MuTrack: a genome analysis system for large-scale mutagenesis in the mouse. BMC Bioinformatics 5:11.
2. Chesler EJ, Lu L, Shou S, Qu Y, Gu J, Wang J, Hsu HC, Mountz JD, Baldwin N, Langston MA, Threadgill DW, Manly KF, Williams RW (2005) Genetic dissection of gene expression reveals polygenic and pleiotropic networks modulating brain structure and function. Nat Genet 37:233-242.
3. Crabbe JC, Phillips TJ, Gallaher EJ, Crawshaw LI, Mitchell SR (1996) Common genetic determinants of the ataxic and hypothermic effects of ethanol in BXD/Ty recombinant inbred mice: genetic correlations and quantitative trait loci. J Pharmacol Exp Ther 277:624-632.
4. Crabbe JC, Weigel RM (1987) Quantification of individual sensitivities to ethanol in selective breeding experiments: difference scores versus regression residuals. Alcohol Clin Exp Res 11:544-549.
5. Cunningham CL (1995) Localization of genes influencing ethanol-induced conditioned place preference and locomotor activity in BXD recombinant inbred mice. Psychopharmacology 120:28-41.
6. Demarest K, McCaughran J Jr, Mahjubi E, Cipp L, Hitzemann R (1999) Identification of an acute ethanol response quantitative trait locus on mouse chromosome 2. J Neurosci 19:549-561.
7. Downing C, Carosone-Link P, Bennett B, Johnson T (2006) QTL mapping for low-dose ethanol activation in the LXS recombinant inbred strains. Alcohol Clin Exp Res 30:1111-1120.
8. Downing C, Rodd-Henricks KK, Flaherty L, Dudek BC (2003) Genetic analysis of the psychomotor stimulant effect of ethanol. Genes Brain Behav 2:140-151.
9. Eisener-Dorman AF, Grabowski-Boase L, Steffy BM, Wiltshire T, Tarantino LM (2010) Quantitative trait locus and haplotype mapping in closely related inbred strains identifies a locus for open field behavior. Mamm Genome 21:231-246.
10. Fang M, Liu GW, Pan YM, Shen L, Li CS, Xi ZQ, Xiao F, Wang L, Chen D, Wang XF (2010) Abnormal expression and spatiotemporal change of Slit2 in neurons and astrocytes in temporal lobe epileptic foci: a study of epileptic patients and experimental animals. Brain Res 1324:14-23.
11. Faria RR, Lima Reuda AV, Sayuri C, Soares SL, Malta MB, Carrara-Nascimento PF, da Silva Alves A, Marcourakis T, Yonamine M, Scavone C, Giorgetti Britto LR, Camarini R (2008) Environmental modulation of ethanol-induced locomotor activity: correlation with neuronal activity in distinct brain regions of adolescent and adult Swiss mice. Brain Res 1239:127-140.
12. Flint J, Corley R, DeFries JC, Fulker DW, Gray JA, Miller S, Collins AC (1995) A simple genetic basis for a complex psychological trait in laboratory mice. Science 269:1432-1435.
13. Foroud T, Li TK (1999) Genetics of alcoholism: a review of recent studies in human and animal models. Am J Addict 8:261-278.
14. Gallaher EJ, Jones GE, Belknap JK, Crabbe JC (1996) Identification of genetic markers for initial sensitivity and rapid tolerance to ethanol-induced ataxia using quantitative trait locus analysis in BXD recombinant inbred mice. J Pharmacol Exp Ther 277:604-612.
15. Gershenfeld HK, Neumann PE, Mathis C, Crawley JN, Li X, Paul SM (1997) Mapping quantitative trait loci for open-field behavior in mice. Behav Genet 27:201-210.
16. Gill K, Boyle A, Lake K, Desaulniers N (2000) Alcohol-induced locomotor activation in C57BL/6J, A/J, and AXB/BXA recombinant inbred mice: strain distribution patterns and quantitative trait loci analysis. Psychopharmacology 150:412-421.
17. Gora-Maslak G, McClearn GE, Crabbe JC, Phillips TJ, Belknap JK, Plomin R (1991) Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology. Psychopharmacology 104:413-424.
18. Grisel JE, Metten P, Wenger CD, Merrill CM, Crabbe JC (2002) Mapping of quantitative trait loci underlying ethanol metabolism in BXD recombinant inbred mouse strains. Alcohol Clin Exp Res 26:610-616.
19. Hamre KM, Goldowitz D, Wilkinson S, Matthews DB (2007) Screening for ENU-induced mutations in mice that result in aberrant ethanol-related phenotypes. Behav Neurosci 121:665-678.
20. Heath AC, Madden PA, Bucholz KK, Dinwiddie SH, Slutske WS, Bierut LJ, Rohrbaugh JW, Statham DJ, Dunne MP, Whitfield JB, Martin NG (1999) Genetic differences in alcohol sensitivity and the inheritance of alcoholism risk. Psychol Med 29:1069-1081.
21. Hitzemann R, Cipp L, Demarest K, Mahjubi E, McCaughran J Jr (1998) Genetics of ethanol-induced locomotor activation: detection of QTLs in a C57BL/6J × DBA/2J F2 intercross. Mamm Genome 9:956-962.
22. Hitzemann R, Demarest K, Koyner J, Cipp L, Patel N, Rasmussen E, McCaughran J Jr (2000) Effect of genetic cross on the detection of quantitative trait loci and a novel approach to mapping QTLs. Pharmacol Biochem Behav 67:767-772.
23. Kang JS, Tian JH, Pan PY, Zald P, Li C, Deng C, Sheng ZH (2008) Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation. Cell 1:137-148.
24. Kirstein SL, Davidson KL, Ehringer MA, Sikela JM, Erwin VG, Tabakoff B (2002) Quantitative trait loci affecting initial sensitivity and acute functional tolerance to ethanol-induced ataxia and brain cAMP signaling in BXD recombinant inbred mice. J Pharmacol Exp Ther 302:1238-1245.
25. Koyner J, Demarest K, McCaughran J Jr, Cipp L, Hitzemann R (2000) Identification and time dependence of quantitative trait loci for basal locomotor activity in the BXD recombinant inbred series and a B6D2 F2 intercross. Behav Genet 30:159-170.
26. Lander ES, Botstein D (1989) Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121:185-199.
27. Magdaleno S, Northcutt GM, Curran T, Kurschner C (2002) mPPP1R1bB is a novel mouse protein phosphatase 1 targeting subunit whose mRNA is located in cell bodies and dendrites of neurons in four distinct regions of the brain. Brain Res Gene Expr Patterns 3-4:143-149.
28. Markel PD, DeFries JC, Johnson TE (1995) Use of repeated measures in an analysis of ethanol-induced loss of righting reflex in inbred long-sleep and short-sleep mice. Alcohol Clin Exp Res 19:299-304.
29. McIlwain KL, Merriweather MY, Yuva-Paylor LA, Paylor R (2001) The use of behavioral test batteries: effects of training history. Physiol Behav 73:705-717.
30. Monterrat C, Boal F, Grise F, Hémar A, Lang J (2006) Synaptotagmin 8 is expressed both as a calcium-insensitive soluble and membrane protein in neurons, neuroendocrine and endocrine cells. Biochim Biophys Acta 1:73-81.
31. Morse HC 3rd, Chused TM, Hartley JW, Mathieson BJ, Sharrow SO, Taylor BA (1979) Expression of xenotropic murine leukemia viruses as cell-surface gp70 in genetic crosses between strains DBA/2 and C57BL/6. J Exp Med 149:1183-1196.
32. Peirce JL, Lu L, Gu J, Silver LM, Williams RW (2004) A new set of BXD recombinant inbred lines from advanced intercross populations in mice. BMC Genet 5:7.
33. Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ (2010) High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains. Genes Brain Behav 9:129-159.
34. Phillips TJ, Burkhart-Kasch S, Terdal ES, Crabbe JC (1991) Response to selection for ethanol-induced locomotor activation: genetic analyses and selection response characterization. Psychopharmacology 103:557-566.
35. Phillips TJ, Huson M, Gwiazdon C, Burkhart-Kasch S, Shen EH (1995) Effects of acute and repeated ethanol exposures on the locomotor activity of BXD recombinant inbred mice. Alcohol Clin Exp Res 19:269-278.
36. Phillips TJ, Lessov CN, Harland RD, Mitchell SR (1996) Evaluation of potential genetic associations between ethanol tolerance and sensitization in BXD/Ty recombinant inbred mice. J Pharmacol Exp Ther 277:613-623.
37. Rhodes JS, Ford MM, Yu CH, Brown LL, Finn DA, Garland T Jr, Crabbe JC (2007) Mouse inbred strain differences in ethanol drinking to intoxication. Genes Brain Behav 6:1-18.
38. Rubinstein M, Phillips TJ, Bunzow JR, Falzone TL, Dziewczapolski G, Zhang G, Fang Y, Larson JL, McDougall JA, Chester JA, Saez C, Pugsley TA, Gershanik O, Low MJ, Grandy DK (1997) Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell 90:991-1001.
39. Schuckit MA (1992) Reaction to alcohol as a predictor of alcoholism. Clin Neuropharmacol 15(Suppl 1 Pt A):305A-306A.
40. Schuckit MA (1994) Low level of response to alcohol as a predictor of future alcoholism. Am J Psychiatry 151:184-189.
41. Servais L, Bearzatto B, Delvaux V, Noël E, Leach R, Brasseur M, Schiffmann SN, Guy C (2005) Effect of chronic ethanol ingestion on Purkinje and Golgi cell firing in vivo and on motor incoordination in mice. Brain Res 1055:171-179.
42. Steffensen SC, Bradley KD, Hansen DM, Wilcox JD, Wilcox RS, Allison DW, Merrill CB, Edwards JG (2011) The role of connexin-36 gap junction in alcohol intoxication and consumption. Synapse 65:695-707.
43. Tritto T, Dudek BC (1994) Differential activating effects of ethanol in C57BL/6Abg and DBA/2Abg mice. Alcohol 11:133-139.
44. Vaughn MG, Beaver KM, DeLisi M, Howard MO, Perron BE (2009) Dopamine D4 receptor gene exon III polymorphism associated with binge drinking attitudinal phenotype. Alcohol 43:179-184.
45. Watts JC, Drisaldi B, Ng V, Yang J, Strome B, Horne P, Sy MS, Yoong L, Young R, Mastrangelo P, Bergeron C, Fraser PE, Carlson GA, Mount HT, Schmitt-Ulms G, Westaway D (2007) The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections. EMBO J 17:4038-4050.
46. Williams RW, Bennett B, Lu L, Gu J, DeFries JC, Carosone-Link PJ, Rikke BA, Belknap JK, Johnson TE (2004) Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis. Mamm Genome 15:637-647.
47. Williams RW, Gu J, Qi S, Lu L (2001) The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis. Genome Biol 2:RESEARCH0046.